DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fliI and Scin

DIOPT Version :9

Sequence 1:	NP_525097.1	Gene:	fliI / 33110	FlyBaseID:	FBgn0000709	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_001139668.1	Gene:	Scin / 20259	MGIID:	1306794	Length:	715	Species:	Mus musculus

Alignment Length:	793	Identity:	219/793 - (27%)
Similarity:	352/793 - (44%)	Gaps:	107/793 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   482 QLDYSKFFEKDDGQLPGLTIWEIENFLPNKIEEVVHGKFYEGDCYIVLKTKFDDLGLLDWEIFFW 546
            :|.:.:|...  ||..||.:|.:|......:.:..:|.||.||.|:||.|.....| ..:.:.||
Mouse     4 ELQHPEFARA--GQQAGLQVWRVEKLELVPVPQGAYGDFYVGDAYLVLHTTKSSRG-FSYRLHFW 65

  Fly   547 IGNEATLDKRACAAIHAVNLRNFLGARCRTVREEQGDESEQFLSLFETEVIYIEGG------RTA 605
            :|.|.:.|:...|||..|.:.::||.:....||.||.||..|:..|:..:.|..||      ...
Mouse    66 LGKECSQDESTAAAIFTVQMDDYLGGKPVQSRELQGYESTDFVGYFKGGLKYKAGGVASGLNHVL 130

  Fly   606 TGFYTIEEMIHITRLYLVHAYGATIHLEPVAPAITSLDPRHAFVLDLGTHIYIWMGERSKNTLNS 670
            |...|.:.::|:....:|.|....:..|       |.:....|::||||.||.|.|.........
Mouse   131 TNDLTAKRLLHVKGRRVVRATEVPLSWE-------SFNKGDCFIIDLGTEIYQWCGSSCNKYERL 188

  Fly   671 KARLMAEKISKTERKNKCEIQLERQGEESAEFWQGLGMTSEEADAAEPPKEHVPEDYQPVQPRLY 735
            ||..:|..|...|||.:.::.:..:|.|.:|..:.||...|..| .:...:.|.:.......:||
Mouse   189 KASQVAIGIRDNERKGRSQLIVVEEGSEPSELMKVLGRKPELPD-GDNDDDVVADISNRKMAKLY 252

  Fly   736 QVQLGMGYLELPQVELPEQKLCHTLLNSKHVYILD--CYTDLFVWFGKKSTRLVRAAAVKLSREL 798
            .|....|.:::..| ..|......:|.|:..:|||  ....:|||.||.:....|..|:|.:.|.
Mouse   253 MVSDASGSMKVTLV-AEENPFSMGMLLSEECFILDHGAAKQIFVWKGKNANPQERKTAMKTAEEF 316

  Fly   799 FNMMDRPDYALVMRVPEGNEMQIFRTKFAGW-DEVMAVDFTRTAKSVAKTGANLTQWARQ-QETR 861
            ...|.......:..:|||.|..||:..|..| |:..:..|.:         ..:|:...| ::..
Mouse   317 LQKMKYSTNTQIQVLPEGGETPIFKQFFKDWKDKDQSDGFGK---------VYITEKVAQIKQIP 372

  Fly   862 TDLAALFMPRQSAMPLAEAEQLEEEWNYDLEMMEAFVLENKKFVRLPEEELGRFYTGECYVFLCR 926
            .|.:.|    .|:..:|....:.::.:..:|:..   :||...|::.....|.||.|:||:.|..
Mouse   373 FDASKL----HSSPQMAAQHNMVDDGSGGVEIWR---VENSGRVQIDPSSYGEFYGGDCYIILYT 430

  Fly   927 YCIPIEEPENGSEDGANPAADVSKSSANNQPEDEIQCVVYFWQGRNAGNMGWLTFTFTLQKKFKA 991
            |                             |..:|   :|.|||.|| ....||.:..|..:...
Mouse   431 Y-----------------------------PRGQI---IYTWQGANA-TRDELTMSAFLTVQLDR 462

  Fly   992 MFGEELEVVRIFQQQENLKFMSHFKRK-FIIH---TGKRKDKAHTAKGKSPVEFFHLRSNGGALT 1052
            ..|.:...||:.|.:|....:|.||.| .||:   |.|::.:|..    .|...|.:|.|..::
Mouse   463 SLGGQAVQVRVSQGKEPAHLLSLFKDKPLIIYKNGTSKKEGQAPA----PPTRLFQVRRNLASI- 522

  Fly  1053 TRLIQINPDAVHLNSTFCYILHVPFETEDDSQSGIVYVWIGSKACNEEAKLVQDIAEQMFNSPWV 1117
            ||:::::.||..|||...::|.:|      ..:|  ::|||..|..||.|..:.:|:.:    ..
Mouse   523 TRIVEVDVDANSLNSNDTFVLKLP------RNNG--FIWIGKGASQEEEKGAEYVADVL----KC 575

  Fly  1118 SLQILNEGDEPENFFWVALGGRKPY------DTDAEYMNYTRLFRCSNERGYYTVAEKCADFCQD 1176
            ....:.||.|||. ||.:||||..|      :|.|| .:..||:.|||:.|.:.:.|...:|.||
Mouse   576 KASRIQEGKEPEE-FWNSLGGRGDYQTSPLLETRAE-DHPPRLYGCSNKTGRFIIEEVPGEFTQD 638

  Fly  1177 DLADDDIMILDNGEHVFLWMGPRCSEVEVKLAYKSAQVYIQHMRIKQP---ERPRKLFLTMKNKE 1238
            |||:||:|:||..|.:|:|:|...:|||.|.:.|||::|::    ..|   ::...:.:..:..|
Mouse   639 DLAEDDVMLLDAWEQIFIWIGKDANEVEKKESVKSAKMYLE----TDPSGRDKRTPIVIIKQGHE 699

  Fly  1239 SRRFTKCFHGWSA 1251
            ...||..|.||.:
Mouse   700 PPTFTGWFLGWDS 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fliI	NP_525097.1	leucine-rich repeat	7..30	CDD:275380
		leucine-rich repeat	31..53	CDD:275380
		LRR_8	53..112	CDD:290566
		leucine-rich repeat	54..76	CDD:275380
		LRR_RI	70..304	CDD:238064
		leucine-rich repeat	77..101	CDD:275380
		LRR_8	101..159	CDD:290566
		leucine-rich repeat	102..124	CDD:275380
		leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	149..171	CDD:275380
		LRR_8	152..231	CDD:290566
		leucine-rich repeat	172..195	CDD:275380
		leucine-rich repeat	196..220	CDD:275380
		leucine-rich repeat	221..243	CDD:275380
		LRR_8	243..300	CDD:290566
		leucine-rich repeat	244..266	CDD:275380
		leucine-rich repeat	267..289	CDD:275380
		leucine-rich repeat	290..314	CDD:275380
		LRR_8	315..370	CDD:290566
		leucine-rich repeat	315..335	CDD:275380
		leucine-rich repeat	338..360	CDD:275378
		gelsolin_S1_like	491..602	CDD:200446	36/110 (33%)
		gelsolin_like	618..706	CDD:200436	23/87 (26%)
		gelsolin_S3_like	729..828	CDD:200448	28/100 (28%)
		gelsolin_like	920..1015	CDD:200436	21/94 (22%)
		gelsolin_S5_like	1037..1141	CDD:200444	33/103 (32%)
		gelsolin_S6_like	1151..1250	CDD:200447	36/101 (36%)
Scin	NP_001139668.1	Actin-severing. /evidence=ECO:0000255	1..363		102/379 (27%)
		gelsolin_S1_like	10..121	CDD:200446	37/113 (33%)
		Polyphosphoinositide binding. /evidence=ECO:0000250	112..119		1/6 (17%)
		gelsolin_S2_like	136..225	CDD:200445	24/95 (25%)
		Polyphosphoinositide binding. /evidence=ECO:0000250	138..146		1/7 (14%)
		gelsolin_S3_like	246..346	CDD:200448	28/100 (28%)
		Ca(2+)-dependent actin binding	364..715		116/412 (28%)
		gelsolin_S4_like	390..486	CDD:200449	29/131 (22%)
		gelsolin_S5_like	508..598	CDD:200444	33/103 (32%)
		gelsolin_S6_like	613..711	CDD:200447	36/101 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820