DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fliI and fli-1

DIOPT Version :9

Sequence 1:	NP_525097.1	Gene:	fliI / 33110	FlyBaseID:	FBgn0000709	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_498913.2	Gene:	fli-1 / 176215	WormBaseID:	WBGene00001443	Length:	1257	Species:	Caenorhabditis elegans

Alignment Length:	1277	Identity:	613/1277 - (48%)
Similarity:	847/1277 - (66%)	Gaps:	54/1277 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VLPFVRGVDFTKNDFSA-TFPSSMRQMSRVQWLTLDRTQLAEIPEELGHLQKLEHLSLNHNRLEK 66
            ||.||:|:||:.||||. .||..:.||:::.||.|:.::|.::|:||.....||||.:.||:|..
Worm     5 VLQFVKGIDFSGNDFSGDRFPHDVEQMTQMTWLKLNDSKLEQVPDELSRCANLEHLQMAHNQLIS 69

  Fly    67 IFGELTELSCLRSLDLRHNQLKNSGIPPELFHLEELTTLDLSHNKLKEVPEGLERAKNLIVLNLS 131
            :.|||::|..|||:.:|.|.||.:|||.::|.:::||.:|||.|:|:|||..||.||..||||||
Worm    70 VHGELSDLPRLRSVIVRDNNLKTAGIPTDIFRMKDLTIIDLSRNQLREVPTNLEYAKGSIVLNLS 134

  Fly   132 NNQIESIPTPLFIHLTDLLFLDLSHNRLETLPPQTRRLINLKTLDLSHNPLELFQLRQLPSLQSL 196
            .|.||:||..:..:|.||||||||:|:|:.||||.|||..|::|.||:|||..|||:||||:.||
Worm   135 YNNIETIPNSVCANLIDLLFLDLSNNKLDMLPPQIRRLSMLQSLKLSNNPLNHFQLKQLPSMTSL 199

  Fly   197 EVLKMSGTQRTLLNFPTSIDSLANLCELDLSHNSLPKLPDCVYNVVTLVRLNLSDNELTELTAGV 261
            .||.||.|.|||.|.|.::|.:.||.::|.|.|:||.:|:.::.:..|.:||||.|::.:|....
Worm   200 SVLHMSNTNRTLDNIPPTLDDMHNLRDVDFSENNLPIVPEALFKLRNLRKLNLSGNKIEKLNMTE 264

  Fly   262 ELWQRLESLNLSRNQLVALPAALCKLPKLRRLLVNDNKLNFEGIPSGIGKLGALEVFSAANNLLE 326
            ..|:.||:||:|.|||..||..:.||.:|.:|...:|:|.|||||||||||..|.|...:.|.||
Worm   265 GEWENLETLNMSHNQLTVLPDCVVKLTRLTKLYAANNQLTFEGIPSGIGKLIQLTVLHLSYNKLE 329

  Fly   327 MVPEGLCRCGALKQLNLSCNRLITLPDAIHLLEGLDQLDLRNNPELVMPPKPSEASKATSLEFYN 391
            :||||:.||..|::|.|..|||||||:.||||..|..|||..|..|||||||::|.|  .|.|||
Worm   330 LVPEGISRCVKLQKLKLDHNRLITLPEGIHLLPDLKVLDLHENENLVMPPKPNDARK--KLAFYN 392

  Fly   392 IDFSLQTQLRLAGAAVPP-----SMPSSATPKDSTARKIRLRRGPRSEGDQDAA-KVLKGMKDVA 450
            |||||:.|.::||....|     |:.|....:|:.||:....|..:.:.||.:| ||::||..:|
Worm   393 IDFSLEHQRKIAGQMTSPSSSISSVHSGGARQDALARRKEFIRRRKQQADQQSADKVIQGMSKIA 457

  Fly   451 ------KDKDNEAGAVPEDGKPESLKPKRWDESLEKPQ--LDYSKFFEKDDGQLPGLTIWEIENF 507
                  .:|..|    .|:.:.|:.....|.:::||.:  :|||..|::|.|...|:.:||||||
Worm   458 GVGAALTEKQQE----EEERQLEAKSAVNWKKNIEKNRRHIDYSDIFDEDVGSDEGMWVWEIENF 518

  Fly   508 LPNKIEEVVHGKFYEGDCYIVLKTKFDDLGLLDWEIFFWIGNEATLDKRACAAIHAVNLRNFLGA 572
            .|:.::|..||:||:.|.|:||||..:..|.|...||:|:|..|:|||..|:|:|||.|||.|.|
Worm   519 YPSIMDEAFHGQFYDADAYLVLKTTREASGQLRHAIFYWLGEHASLDKGMCSAVHAVGLRNHLNA 583

  Fly   573 RCRTVREEQGDESEQFLSLFETEVIYIEGGRTATGFYTIEEMIHITRLYLVHAYGATIHLEPVAP 637
            .|||.|||..||:|:||:||..|::|||||||.:||||.|:..|:||||.....|..:.:|||..
Worm   584 TCRTQREEMNDETEEFLTLFGEEIVYIEGGRTISGFYTTEKPAHLTRLYRAGVNGTAVEMEPVPL 648

  Fly   638 AITSLDPRHAFVLDLGTHIYIWMGERSKNTLNSKARLMAEKISKTERKNKCEIQLERQGEESAEF 702
            ::.|||||..|:||.|..|:||.|.:|:.|:::||||.||:::|.:||.|.||:..||.....||
Worm   649 SVESLDPRFCFLLDAGETIWIWSGYKSRITVSNKARLFAERLNKRDRKGKSEIETCRQARCPPEF 713

  Fly   703 WQGLGMTSEEADAAEPPK------EHVPEDYQPVQPRLYQVQLGMGYLELPQVELPEQKLCHTLL 761
            ||.|        ...|.|      |||||.:...:.:||:|.:|||:|||||||||:......:|
Worm   714 WQAL--------TGNPDKPQGAIVEHVPEGFVAERKKLYKVNIGMGFLELPQVELPKGIAKQDML 770

  Fly   762 NSKHVYILDCYTDLFVWFGKKSTRLVRAAAVKLSRELFNMMDRPDYALVMRVPEGNEMQIFRTKF 826
            .||.|::||..:|:|:|.|||:.||::.|..||..||..|:||||||.|.|..||.|..:||:||
Worm   771 GSKGVFVLDSNSDIFLWIGKKANRLLKMAGQKLVVELHQMIDRPDYAQVYRETEGEESMMFRSKF 835

  Fly   827 AGWDEVMAVDFTRTAKSVAKTGANLTQWARQQETRTDLAALFMPRQSAMPLAEAEQLEEEWNYDL 891
            |||||::.||:|||:.||.:.........:....|.||||||:.||.:|...|:|:|.|:.||||
Worm   836 AGWDEIVPVDYTRTSDSVQRVPDLKVIVKKDNMMRADLAALFLERQPSMSYEESEELMEDCNYDL 900

  Fly   892 EMMEAFVLENKKFVRLPEEELGRFYTGECYVFLCRYCIPIEEPENGSEDGANPAADVSKSSANNQ 956
            |:||:||||.||||:||::|.|.|||.:||||||||.:..||.|.|.::          ...:::
Worm   901 ELMESFVLEGKKFVKLPQKEFGIFYTMDCYVFLCRYAVMPEEDEEGEDE----------HDEDDK 955

  Fly   957 PEDEIQCVVYFWQGRNAGNMGWLTFTFTLQKKFKAMFGEELEVVRIFQQQENLKFMSHFKRKFII 1021
            ||.:.:|||||||||:|.|||||.|||.||..|:.:|.::|||||::|||||.||:|||||||:|
Worm   956 PEMDFKCVVYFWQGRDASNMGWLNFTFQLQPNFEEIFKDKLEVVRMYQQQENHKFLSHFKRKFLI 1020

  Fly  1022 HTGKRKDKAHTAKGKSPVEFFHLRSNGGALTTRLIQINPDAVHLNSTFCYILHVPF-ETEDDSQS 1085
            ..| |:.......||.| |.|.:|:||.::..|.||::..|..|.|.||::|.:|| |.|:|...
Worm  1021 KRG-RRGLTKNLGGKWP-ELFQMRANGSSVCNRTIQVDCQANQLCSAFCHMLRIPFKEIEEDGHR 1083

  Fly  1086 GIVYVWIGSKACNEEAKLVQDIAEQMF----NSPWVSLQILNEGDEPENFFWVALGGRKPYDTDA 1146
            |:||||:|..:...|.:..:.:|..:.    ::.:..::: .||:|.|. ||..|||:|.|:||:
Worm  1084 GVVYVWMGKDSDPREHEFARQVASDLVVRDDDNDFRIVEV-QEGEENEE-FWKVLGGKKKYETDS 1146

  Fly  1147 EYMNYTRLFRCSNERGYYTVAEKCADFCQDDLADDDIMILDNGEHVFLWMGPRCSEVEVKLAYKS 1211
            .::.:||||||:||:||:.::||..|||||||.||||||||||:.||||:|.|.|::|.||:|::
Worm  1147 SFVKHTRLFRCTNEKGYFAISEKTVDFCQDDLDDDDIMILDNGDAVFLWIGARSSDIEAKLSYQA 1211

  Fly  1212 AQVYIQHMRIKQPERPRKLFLTMKNKESRRFTKCFHGWSAFK 1253
            ||||...||:|..|:|||..|.::.:||.||.||||.||..|
Worm  1212 AQVYHASMRMKANEKPRKFMLAVRGRESCRFRKCFHAWSKMK 1253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fliI	NP_525097.1	leucine-rich repeat	7..30	CDD:275380	12/23 (52%)
		leucine-rich repeat	31..53	CDD:275380	7/21 (33%)
		LRR_8	53..112	CDD:290566	28/58 (48%)
		leucine-rich repeat	54..76	CDD:275380	11/21 (52%)
		LRR_RI	70..304	CDD:238064	117/233 (50%)
		leucine-rich repeat	77..101	CDD:275380	11/23 (48%)
		LRR_8	101..159	CDD:290566	35/57 (61%)
		leucine-rich repeat	102..124	CDD:275380	13/21 (62%)
		leucine-rich repeat	125..148	CDD:275380	12/22 (55%)
		leucine-rich repeat	149..171	CDD:275380	16/21 (76%)
		LRR_8	152..231	CDD:290566	45/78 (58%)
		leucine-rich repeat	172..195	CDD:275380	14/22 (64%)
		leucine-rich repeat	196..220	CDD:275380	12/23 (52%)
		leucine-rich repeat	221..243	CDD:275380	7/21 (33%)
		LRR_8	243..300	CDD:290566	23/56 (41%)
		leucine-rich repeat	244..266	CDD:275380	8/21 (38%)
		leucine-rich repeat	267..289	CDD:275380	12/21 (57%)
		leucine-rich repeat	290..314	CDD:275380	15/23 (65%)
		LRR_8	315..370	CDD:290566	29/54 (54%)
		leucine-rich repeat	315..335	CDD:275380	9/19 (47%)
		leucine-rich repeat	338..360	CDD:275378	14/21 (67%)
		gelsolin_S1_like	491..602	CDD:200446	58/110 (53%)
		gelsolin_like	618..706	CDD:200436	41/87 (47%)
		gelsolin_S3_like	729..828	CDD:200448	50/98 (51%)
		gelsolin_like	920..1015	CDD:200436	49/94 (52%)
		gelsolin_S5_like	1037..1141	CDD:200444	37/108 (34%)
		gelsolin_S6_like	1151..1250	CDD:200447	60/98 (61%)
fli-1	NP_498913.2	leucine-rich repeat	9..33	CDD:275380	12/23 (52%)
		LRR_RI	<13..162	CDD:238064	74/148 (50%)
		LRR_8	32..90	CDD:290566	23/57 (40%)
		leucine-rich repeat	35..56	CDD:275380	7/20 (35%)
		leucine-rich repeat	57..79	CDD:275380	11/21 (52%)
		LRR_8	78..138	CDD:290566	32/59 (54%)
		leucine-rich repeat	80..104	CDD:275380	11/23 (48%)
		leucine-rich repeat	105..128	CDD:275380	14/22 (64%)
		LRR_RI	129..373	CDD:238064	128/243 (53%)
		leucine-rich repeat	129..151	CDD:275380	12/21 (57%)
		LRR_8	130..185	CDD:290566	33/54 (61%)
		leucine-rich repeat	152..174	CDD:275380	16/21 (76%)
		leucine-rich repeat	175..198	CDD:275380	14/22 (64%)
		LRR_8	197..257	CDD:290566	27/59 (46%)
		leucine-rich repeat	199..223	CDD:275380	12/23 (52%)
		leucine-rich repeat	224..246	CDD:275380	7/21 (33%)
		LRR_8	245..303	CDD:290566	23/57 (40%)
		leucine-rich repeat	247..269	CDD:275380	8/21 (38%)
		leucine-rich repeat	270..292	CDD:275380	12/21 (57%)
		leucine-rich repeat	293..317	CDD:275380	15/23 (65%)
		LRR_8	317..372	CDD:290566	29/54 (54%)
		leucine-rich repeat	318..338	CDD:275380	9/19 (47%)
		leucine-rich repeat	341..363	CDD:275378	14/21 (67%)
		gelsolin_S1_like	502..613	CDD:200446	58/110 (53%)
		gelsolin_like	629..717	CDD:200436	41/87 (47%)
		gelsolin_S3_like	738..837	CDD:200448	50/98 (51%)
		gelsolin_like	928..1014	CDD:200436	49/95 (52%)
		gelsolin_S5_like	1034..1141	CDD:200444	38/109 (35%)
		ADF_gelsolin	1151..1250	CDD:301701	60/98 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158264
Domainoid	1	1.000	317	1.000	Domainoid score	I678
eggNOG	1	0.900	-	-		E2759_KOG0444
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11092
Inparanoid	1	1.050	1167	1.000	Inparanoid score	I105
Isobase	1	0.950	-	0	Normalized mean entropy	S2261
OMA	1	1.010	-	-		QHG52569
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	1	1.000	-	-		FOG0007001
OrthoInspector	1	1.000	-	-		oto20247
orthoMCL	1	0.900	-	-		OOG6_106545
Panther	1	1.100	-	-	LDO	PTHR11977
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2528
SonicParanoid	1	1.000	-	-		X5098
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750