DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fliI and viln-1

DIOPT Version :9

Sequence 1:	NP_525097.1	Gene:	fliI / 33110	FlyBaseID:	FBgn0000709	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_491442.1	Gene:	viln-1 / 172089	WormBaseID:	WBGene00015691	Length:	918	Species:	Caenorhabditis elegans

Alignment Length:	1036	Identity:	214/1036 - (20%)
Similarity:	368/1036 - (35%)	Gaps:	268/1036 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   287 LPKLRRLLVNDN-----KLNFEGIPSGIGKLGALEVFSAANNLLEMVPEGLCRCGALKQLNLSCN 346
            :.:|::.|:..|     |.|.|..|  |.|:...:..::.||..|.......|..|::|...|.|
Worm     2 IAQLQKSLIQQNSTFEKKNNVEVAP--IAKISLKDRLASLNNSAEQWKSRPERQPAVQQRRTSAN 64

  Fly   347 RLITLPDAIHLLEGLDQLDLRNNPELVMPPKPSEASKATSLEFYNIDFSLQTQLRLAGAAVPPSM 411
            .|..|| .....:.|.|...|.....|:..||.:.:......|              |:....|.
Worm    65 VLQDLP-IFQRAQQLHQQQQRPQSFPVVQEKPCDITSGLKKFF--------------GSNPTTSG 114

  Fly   412 PSSATPKDS--TARKIRLRRGPRSEGDQDA--AKVLKGMKDVAKDKDNEAGAVPEDGKPESLKPK 472
            .||:.||.|  ||         .::.|.||  :|....:|.|.              :|.:...|
Worm   115 ASSSLPKISEITA---------SNDIDLDAISSKATPVLKTVT--------------RPRAPNRK 156

  Fly   473 RWDESL---EKPQLDYSKFFEKDDGQLPGLTIWEIENFLPNKIEEVVHGKFYEGDCYIVLKTKFD 534
            :.|:|.   |:.:||..|..|:      ...:.|.|   |.|:|
Worm   157 KSDKSSTFDERIRLDAVKIDEE------AFAVVEEE---PEKLE--------------------- 191

  Fly   535 DLGLLDWEIFFWIGNEATLDKRACAAIHAVNLRNFLGARCRTVREEQGDESEQFLSLF-ETEVIY 598
                              ..::|.|||.        ||:       |..:|...:|.: :..:|.
Worm   192 ------------------TQEQAIAAIQ--------GAK-------QLLKSPTKVSPYPDVMLIQ 223

  Fly   599 IEGGRTATGFYTIEEMIHITRLYLVHAYGATIHLEPVAPAITSLDPRHAFVLDLGTHIYIWMGER 663
            :.|.:                         .:.:..||||::|:.....||:....|:..:.|..
Worm   224 VRGSK-------------------------NVDVRLVAPAMSSVHEVACFVVVHQKHLMKYEGLY 263

  Fly   664 SKNTLNSKA-RLMAEKISKTERKNKCEIQLERQGEESAEFWQGLGMTSEEADAAEPPKEHVPEDY 727
            |.....:|| :|..|.:.|::.....|..:...|...:...:.|..:.....::|....|.....
Worm   264 SNILEKTKASQLCIEILGKSDLNCTAESIVTVTGASRSTLSKLLFCSENSESSSENNNYHQASSV 328

  Fly   728 QPVQPRLYQVQLGMGYLELPQVELPE-----QKLCHTLLNSKHVYILDCYTDLFVWFGKKSTRLV 787
            :|.:..:.::.|   .|.:......|     ::|.:.::....|.|.|..::::||.|:.|.::.
Worm   329 EPFETTVAKLNL---VLRIAGDNTAETCSRRERLSYEIMKPSEVLIFDFGSEIYVWTGRYSNKVS 390

  Fly   788 RAAAVKLSREL---------FNMMD--------RPDYALVMRVPEGNEMQIFRTKFAGWDEVMAV 835
            .|.|.:.:::|         |.:.|        ||::.|..::.:|....:|:.||:.|.|
Worm   391 SAYAQEYAKQLMKKPVKNGKFILGDAESIDQDGRPEWTLSRKIHQGVLDTLFKAKFSDWPE---- 451

  Fly   836 DFTRTAKSVAKTGANLTQWARQQETRT--------------DLAALFMPRQSAMPLAEAEQLE-E 885
              ||...:..|..|.:::  :..|.:|              ||....:..|...|:...|..| :
Worm   452 --TREVLTTCKPRALISK--KNPEVKTYEDVKVVNQDDEVADLVERMLQEQELDPILVLEDQEID 512

  Fly   886 EWNYDL--EMMEAFVLENKKFVRLPEEELGRFYTGECYVFLCRYCIP---IEEPENGSEDGANPA 945
            ...:|:  |....:||..:....: ||....|.:..|||...:|.|.   :...:.|.|:    .
Worm   513 RKIHDVISEDRSLWVLRGEVLQSI-EEFTEHFDSRRCYVLRWKYRIQKSGVRRIKTGKEE----E 572

  Fly   946 ADVSKSSANNQPEDEIQCVVYFWQGRNAGNMGWLTFTFTLQKKFKAMFGEELE-----VVRIFQQ 1005
            .:..:|          :...::|.|.:         |...|....|:..:|::     .:||...
Worm   573 RETGRS----------RIAFWYWLGEH---------TTPKQHGLCALRIKEIDRDNSPRIRIADG 618

  Fly  1006 QENLKFMSHFKRKFIIHTGKRKDKAHTAKGKSPVEFFHLRSNGGALTTRLIQINPDAVHLNSTFC 1070
            .|...|::.|..||::.:...:.|        |:..: :.....:..|.|.:|:.....|.|...
Worm   619 NEPALFLALFDGKFMVSSDISEMK--------PLRRY-VVIGANSRETSLREIDDLNSPLRSHAA 674

  Fly  1071 YILHVPFETEDD--SQSGIVYVWIGSKACNEEAKLVQDIAEQMFNSPWV---SLQILNEGDEPEN 1130
            ||     |.|.|  ..|.:|   .|:....::...|...||.|.....|   |.:|..|||: ::
Worm   675 YI-----EVEKDILGPSSVV---CGANCTEDQVHFVLAHAEYMRQKAGVKGNSAEIEVEGDK-KS 730

  Fly  1131 FFWVALGGRKPYDTDAEYMNYTRLFRCSNERGYYTVAEK-CA-DFCQDDLADDDIMILDNGEHVF 1193
            ..||...|||      ..|...|||...:|:..:....| || .|.|..|  .:.:::|.|:.::
Worm   731 RSWVNSNGRK------RAMRVWRLFDNESEQVNHLSGHKNCAFTFSQQVL--KETILIDVGDALW 787

  Fly  1194 LWMGPRCSEVEVKLAYKSAQVYIQHMRIKQPERPRKLFLTMKNKESRRFTKCFHGWSAFKV 1254
            ||    ..||....|.|.|:.|     .|....|.|  :..|..|..:|...|..|..|:|
Worm   788 LW----SEEVITTFALKVAEKY-----WKDRSGPAK--VVYKGAEPEQFKGLFMKWEMFEV 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fliI	NP_525097.1	leucine-rich repeat	7..30	CDD:275380
		leucine-rich repeat	31..53	CDD:275380
		LRR_8	53..112	CDD:290566
		leucine-rich repeat	54..76	CDD:275380
		LRR_RI	70..304	CDD:238064	5/21 (24%)
		leucine-rich repeat	77..101	CDD:275380
		LRR_8	101..159	CDD:290566
		leucine-rich repeat	102..124	CDD:275380
		leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	149..171	CDD:275380
		LRR_8	152..231	CDD:290566
		leucine-rich repeat	172..195	CDD:275380
		leucine-rich repeat	196..220	CDD:275380
		leucine-rich repeat	221..243	CDD:275380
		LRR_8	243..300	CDD:290566	3/17 (18%)
		leucine-rich repeat	244..266	CDD:275380
		leucine-rich repeat	267..289	CDD:275380	0/1 (0%)
		leucine-rich repeat	290..314	CDD:275380	9/28 (32%)
		LRR_8	315..370	CDD:290566	14/54 (26%)
		leucine-rich repeat	315..335	CDD:275380	3/19 (16%)
		leucine-rich repeat	338..360	CDD:275378	6/21 (29%)
		gelsolin_S1_like	491..602	CDD:200446	15/111 (14%)
		gelsolin_like	618..706	CDD:200436	17/88 (19%)
		gelsolin_S3_like	729..828	CDD:200448	24/120 (20%)
		gelsolin_like	920..1015	CDD:200436	18/102 (18%)
		gelsolin_S5_like	1037..1141	CDD:200444	28/108 (26%)
		gelsolin_S6_like	1151..1250	CDD:200447	27/100 (27%)
viln-1	NP_491442.1	ADF_gelsolin	218..296	CDD:387665	18/102 (18%)
		gelsolin_like	<362..446	CDD:200436	17/83 (20%)
		ADF_gelsolin	545..628	CDD:387665	18/105 (17%)
		ADF_gelsolin	<779..832	CDD:387665	17/63 (27%)
		VHP	883..918	CDD:128458
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920