DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fliI and AVIL

DIOPT Version :9

Sequence 1:	NP_525097.1	Gene:	fliI / 33110	FlyBaseID:	FBgn0000709	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_006567.3	Gene:	AVIL / 10677	HGNCID:	14188	Length:	819	Species:	Homo sapiens

Alignment Length:	808	Identity:	224/808 - (27%)
Similarity:	343/808 - (42%)	Gaps:	148/808 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   497 PGLTIWEIENFLPNKIEEVVHGKFYEGDCYIVLKTKFDDLGLLDWEIFFWIGNEATLDKRACAAI 561
            ||:.:|.||......:....||.|||||||::|.|: ....||..:|.||||.:::.|:::||||
Human    14 PGIIVWRIEKMELALVPVSAHGNFYEGDCYVILSTR-RVASLLSQDIHFWIGKDSSQDEQSCAAI 77

  Fly   562 HAVNLRNFLGARCRTVREEQGDESEQFLSLFETEVIYIEGGRTATGFYTIEEMIHITRLY----L 622
            :...|.::||......||.|..||:.|...|:..:||.:|| .|:|...:|     |..|    |
Human    78 YTTQLDDYLGGSPVQHREVQYHESDTFRGYFKQGIIYKQGG-VASGMKHVE-----TNTYDVKRL 136

  Fly   623 VHAYG-ATIHLEPVAPAITSLDPRHAFVLDLGTHIYIWMGERSKNTLNSKARLMAEKISKTERKN 686
            :|..| ..|....|..:..|.:....|:||||..|..|.|..|.:....||.|:|:.|...||..
Human   137 LHVKGKRNIRATEVEMSWDSFNRGDVFLLDLGKVIIQWNGPESNSGERLKAMLLAKDIRDRERGG 201

  Fly   687 KCEIQLERQGEESAEFWQGLGMTSEEADAAEPPKEHVPED-------YQPVQP------------ 732
            :.:|                |:...:.:||.|....|.:|       .:|..|
Human   202 RAKI----------------GVIEGDKEAASPELMKVLQDTLGRRSIIKPTVPDEIIDQKQKSTI 250

  Fly   733 RLYQVQLGMGYLELPQVELPEQKLCHTLLNSKHVYILD-CYTDLFVWFGKKSTRLVRAAAVKLSR 796
            .||.:....|  :|...|:..:.|...|||....|||| ..|.::||.||.:|:..:.||:..:.
Human   251 MLYHISDSAG--QLAVTEVATRPLVQDLLNHDDCYILDQSGTKIYVWKGKGATKAEKQAAMSKAL 313

  Fly   797 ELFNMMDRPDYALVMRVPEGNEMQIFRTKFAGW---DEVMAVDFTRTAKSVAKTGANLTQWARQQ 858
            ....|...|....|..|.:|.|..:|:..|..|   |:.|.:..|.:...:||.          .
Human   314 GFIKMKSYPSSTNVETVNDGAESAMFKQLFQKWSVKDQTMGLGKTFSIGKIAKV----------F 368

  Fly   859 ETRTDLAALFMPRQSAMPLAEAEQLEEEWNYDLEMMEAFVLENKKFVRLPEEELGRFYTGECYVF 923
            :.:.|:..|    .:...:|..|::.::.|..:|:..   :||.:.|.:..:..|.||.|:||:.
Human   369 QDKFDVTLL----HTKPEVAAQERMVDDGNGKVEVWR---IENLELVPVEYQWYGFFYGGDCYLV 426

  Fly   924 LCRYCIPIEEPENGSEDGANPAADVSKSSANNQPEDEIQCVVYFWQGRNAGNMGWLTFTFTLQKK 988
            |..|                        ..|.:|..    ::|.||||:|.           |.:
Human   427 LYTY------------------------EVNGKPHH----ILYIWQGRHAS-----------QDE 452

  Fly   989 FKAMFGEELEV----------VRIFQQQENLKFMSHFKRKFIIHTGKRKDKAHTAKGKSPVEFFH 1043
            ..|...:.:||          ||:....|...||:.||.|.:|..|....|.: |:...||..|.
Human   453 LAASAYQAVEVDRQFDGAAVQVRVRMGTEPRHFMAIFKGKLVIFEGGTSRKGN-AEPDPPVRLFQ 516

  Fly  1044 LRSNGGALTTRLIQINPDAVHLNSTFCYILHVPFETEDDSQSGIVYVWIGSKACNEEAKLVQDIA 1108
            :..|..: .|:.:::...|..|||...::|....|.         |:|.|..:..:|..:.:::|
Human   517 IHGNDKS-NTKAVEVPAFASSLNSNDVFLLRTQAEH---------YLWYGKGSSGDERAMAKELA 571

  Fly  1109 EQMFNSPWVSLQILNEGDEPENFFWVALGGRKPYDTDAEYMN-----YTRLFRCSNERGYYTVAE 1168
            ..:.:.   |...:.||.||.. ||..|||:.||..|.....     .:|||.|||:.|.:.|.|
Human   572 SLLCDG---SENTVAEGQEPAE-FWDLLGGKTPYANDKRLQQEILDVQSRLFECSNKTGQFVVTE 632

  Fly  1169 KCADFCQDDLADDDIMILDNGEHVFLWMGPRCSEVEVKLAYKSAQVYIQ-HMRIKQPERPRKLFL 1232
             ..||.||||...|:|:||..:.||||:|...:..|.:.|..:||.|:. |...:.|:.|  :.:
Human   633 -ITDFTQDDLNPTDVMLLDTWDQVFLWIGAEANATEKESALATAQQYLHTHPSGRDPDTP--ILI 694

  Fly  1233 TMKNKESRRFTKCF-----HGWSAFKVY 1255
            ..:..|...||..|     :.|||.|.|
Human   695 IKQGFEPPIFTGWFLAWDPNIWSAGKTY 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fliI	NP_525097.1	leucine-rich repeat	7..30	CDD:275380
		leucine-rich repeat	31..53	CDD:275380
		LRR_8	53..112	CDD:290566
		leucine-rich repeat	54..76	CDD:275380
		LRR_RI	70..304	CDD:238064
		leucine-rich repeat	77..101	CDD:275380
		LRR_8	101..159	CDD:290566
		leucine-rich repeat	102..124	CDD:275380
		leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	149..171	CDD:275380
		LRR_8	152..231	CDD:290566
		leucine-rich repeat	172..195	CDD:275380
		leucine-rich repeat	196..220	CDD:275380
		leucine-rich repeat	221..243	CDD:275380
		LRR_8	243..300	CDD:290566
		leucine-rich repeat	244..266	CDD:275380
		leucine-rich repeat	267..289	CDD:275380
		leucine-rich repeat	290..314	CDD:275380
		LRR_8	315..370	CDD:290566
		leucine-rich repeat	315..335	CDD:275380
		leucine-rich repeat	338..360	CDD:275378
		gelsolin_S1_like	491..602	CDD:200446	40/104 (38%)
		gelsolin_like	618..706	CDD:200436	25/92 (27%)
		gelsolin_S3_like	729..828	CDD:200448	31/111 (28%)
		gelsolin_like	920..1015	CDD:200436	21/104 (20%)
		gelsolin_S5_like	1037..1141	CDD:200444	26/103 (25%)
		gelsolin_S6_like	1151..1250	CDD:200447	36/104 (35%)
AVIL	NP_006567.3	Core. /evidence=ECO:0000250	1..731		224/808 (28%)
		gelsolin_S1_like	7..118	CDD:200446	40/104 (38%)
		Polyphosphoinositide binding. /evidence=ECO:0000250	109..116		2/6 (33%)
		gelsolin_S2_like	133..223	CDD:200445	27/105 (26%)
		Polyphosphoinositide binding. /evidence=ECO:0000250	135..143		3/7 (43%)
		gelsolin_S3_like	247..345	CDD:200448	29/99 (29%)
		gelsolin_S4_like	389..489	CDD:200449	30/141 (21%)
		gelsolin_S5_like	510..600	CDD:200444	26/103 (25%)
		gelsolin_S6_like	615..712	CDD:200447	36/99 (36%)
		Required for interaction with F-actin. /evidence=ECO:0000269\|PubMed:29058690	628..819		34/98 (35%)
		Headpiece. /evidence=ECO:0000250	731..819
		VHP	784..819	CDD:128458
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820