DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fliI and LOC100496020

DIOPT Version :9

Sequence 1:	NP_525097.1	Gene:	fliI / 33110	FlyBaseID:	FBgn0000709	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	XP_017950415.2	Gene:	LOC100496020 / 100496020	-ID:	-	Length:	715	Species:	Xenopus tropicalis

Alignment Length:	799	Identity:	230/799 - (28%)
Similarity:	353/799 - (44%)	Gaps:	137/799 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   494 GQLPGLTIWEIENFLPNKIEEVVHGKFYEGDCYIVLKTKFDDLGLLD-WEIFFWIGNEATLDKRA 557
            |:..||.||.||......:.|..:|.||.||.|::|.|  .|.||.. :.:.:|:|||.|.|:..
Frog    12 GKKTGLQIWRIEKMDLAPVPESFYGSFYVGDAYVILNT--IDRGLYKIYHLHYWLGNECTQDEST 74

  Fly   558 CAAIHAVNLRNFLGARCRTVREEQGDESEQFLSLFETEVIYIEGGRTATGF-YTIEEMIHITRLY 621
            .|.|..|.|..:||......||.||.||.:||..|:..:.|..|| .|:|| :.|...:...|
Frog    75 AAVIFTVQLDEYLGGSPVQYRELQGHESTEFLGHFKDGIKYQAGG-IASGFQHVITNDLSARR-- 136

  Fly   622 LVHAYG-ATIHLEPVAPAITSLDPRHAFVLDLGTHIYIWMGERSKNTLNSKARLMAEKISKTERK 685
            |:|..| ..:....|..:.:|.:....|::|:|..||.|.|.:|......||..:|..|...||:
Frog   137 LLHIKGRRVVRATEVPLSWSSFNSGDCFIIDVGPEIYQWCGSKSNKYERLKAAQVATSIRNNERQ 201

  Fly   686 NKCEIQLERQGEESAEFWQGLGMTSEEADAAEPPKEHVPE--DYQPV--------QPRLYQVQLG 740
            .:..:.:..|..|.....|.||           |...:||  |...|        ..:||.|...
Frog   202 GRSNLTVVEQFSEPPSLMQILG-----------PMPVLPEGDDDTDVTADVTNRKMAKLYMVSDA 255

  Fly   741 MGYLELPQVELPEQKLCHTLLNSKHVYILDCYTD--LFVWFGKKSTRLVRAAAVKLSRELFNMMD 803
            .|.::...|. .|......:|.|...:|||. :|  :|||.||.:....:..|:|.:.:....|:
Frog   256 SGTMQTTLVS-EENPFSMPMLLSDECFILDS-SDKKIFVWKGKGANVNEKKHAIKTAEDFIKKMN 318

  Fly   804 RPDYALVMRVPEGNEMQIFRTKFAGW-----DEVMAVDFTRTAKSVAKTGANLTQWARQQETRTD 863
            .|....::.:|||.|..||:..|..|     .|.:...||:            .|.|:.::...|
Frog   319 YPATTQIIVLPEGGETPIFKQYFKDWKDKEQSEGLGKVFTK------------EQIAQIEQIPFD 371

  Fly   864 LAALFMPRQSAMPLAEAEQLEEEWNYDLEMMEAFVLENKKFVRLPEEELGRFYTGECYVFLCRYC 928
            ...|   ..||...|:...|::...:    :|.:.:|....|.|..|..|:||.|:||:
Frog   372 ATKL---HTSARMAAQHNMLDDGSGH----VEIWRIEKNARVPLDPETYGQFYGGDCYI------ 423

  Fly   929 IPIEEPENGSEDGANPAADVSKSSANNQPEDEIQCVVYFWQGRNAGNMGWLTF----TFTLQKKF 989
                               :..::.|.|.      ::|.|||.|||. ..||:    |..|.:..
Frog   424 -------------------IMYTTLNGQK------IIYTWQGANAGK-DELTYSAFLTVQLDRSL 462

  Fly   990 KAMFGEELEVVRIFQQQENLKFMSHFKRK-FIIHTGKRKDKAHTAKGKSPVEFFHLRSNGGALTT 1053
            ||...:    .|:.|.:|....:|.||.| .||:......|...|..: |:..|.:|.|.|:: |
Frog   463 KAGATQ----TRVPQGKEPAHLLSVFKDKPLIIYKDGTSRKGVQAPPR-PIRLFQVRKNLGSI-T 521

  Fly  1054 RLIQINPDAVHLNSTFCYILHVPFETEDDSQSGIVYVWIGSKACNEE----AKLVQDIAEQMFNS 1114
            |:.:::.||..||:...::|    :..|:|    ..:||| |..||:    ||.:..:
Frog   522 RIAEVDADATSLNANDAFVL----KMRDNS----AVMWIG-KGANEDEIEGAKYLVKV------- 570

  Fly  1115 PWVSLQILN--EGDEPENFFWVALGGRKPYDT----DAEYMNY-TRLFRCSNERGYYTVAEKCAD 1172
              ::|:.:|  ||:||: .||..|||:|.|.|    :....:: .|||.|||:.|.:.|.|...:
Frog   571 --LNLRAINIAEGEEPD-IFWTTLGGKKTYQTSPLLETRLEDHPPRLFGCSNKTGRFVVEEVPGE 632

  Fly  1173 FCQDDLADDDIMILDNGEHVFLWMGPRCSEVEVKLAYKSAQVYIQHMRIKQPE-RPRKLFLT--M 1234
            |.|:|:|:||:|:||..|.:|||:|...:|||.|.:..||:.|:|    ..|. |.:.:.:|  .
Frog   633 FTQEDMAEDDVMMLDTWEQIFLWIGKDANEVEKKESLVSAKKYLQ----TDPSGRDKDIPITTVK 693

  Fly  1235 KNKESRRFTKCFHGWSAFK 1253
            :..|...||..|..|.:.|
Frog   694 QGNEPLSFTGWFLAWDSNK 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fliI	NP_525097.1	leucine-rich repeat	7..30	CDD:275380
		leucine-rich repeat	31..53	CDD:275380
		LRR_8	53..112	CDD:290566
		leucine-rich repeat	54..76	CDD:275380
		LRR_RI	70..304	CDD:238064
		leucine-rich repeat	77..101	CDD:275380
		LRR_8	101..159	CDD:290566
		leucine-rich repeat	102..124	CDD:275380
		leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	149..171	CDD:275380
		LRR_8	152..231	CDD:290566
		leucine-rich repeat	172..195	CDD:275380
		leucine-rich repeat	196..220	CDD:275380
		leucine-rich repeat	221..243	CDD:275380
		LRR_8	243..300	CDD:290566
		leucine-rich repeat	244..266	CDD:275380
		leucine-rich repeat	267..289	CDD:275380
		leucine-rich repeat	290..314	CDD:275380
		LRR_8	315..370	CDD:290566
		leucine-rich repeat	315..335	CDD:275380
		leucine-rich repeat	338..360	CDD:275378
		gelsolin_S1_like	491..602	CDD:200446	41/108 (38%)
		gelsolin_like	618..706	CDD:200436	23/88 (26%)
		gelsolin_S3_like	729..828	CDD:200448	29/108 (27%)
		gelsolin_like	920..1015	CDD:200436	21/98 (21%)
		gelsolin_S5_like	1037..1141	CDD:200444	33/109 (30%)
		gelsolin_S6_like	1151..1250	CDD:200447	38/102 (37%)
LOC100496020	XP_017950415.2	gelsolin_S1_like	8..119	CDD:200446	41/108 (38%)
		gelsolin_S2_like	136..223	CDD:200445	23/88 (26%)
		gelsolin_S3_like	244..343	CDD:200448	28/100 (28%)
		gelsolin_S4_like	387..484	CDD:200449	31/136 (23%)
		gelsolin_S5_like	507..595	CDD:200444	33/107 (31%)
		gelsolin_S6_like	611..709	CDD:200447	38/101 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010