DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fliI and scin

DIOPT Version :9

Sequence 1:	NP_525097.1	Gene:	fliI / 33110	FlyBaseID:	FBgn0000709	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	XP_002939059.1	Gene:	scin / 100495760	XenbaseID:	XB-GENE-957027	Length:	714	Species:	Xenopus tropicalis

Alignment Length:	813	Identity:	235/813 - (28%)
Similarity:	349/813 - (42%)	Gaps:	149/813 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   485 YSKFFEKDDGQLPGLTIWEIENFLPNKIEEVVHGKFYEGDCYIVLKT------KFDDLGLLDWEI 543
            |.|.|| :.||..||.||.|||.....:.:.::|.||.||.|:||.|      |:.||
Frog     4 YHKQFE-NAGQSTGLQIWRIENMDLVPVPKTLYGNFYVGDAYLVLNTIAKNNSKYYDL------- 60

  Fly   544 FFWIGNEATLDKRACAAIHAVNLRNFLGARCRTVREEQGDESEQFLSLFETEVIYIEGGRTATGF 608
            .:|:|.|.:.|:...|||:.|.|..|||.:....||.||.||..|:..|:..:.|..|| .|:||
Frog    61 HYWLGKECSQDESTAAAIYTVQLDEFLGGKPVQYREIQGHESSAFVGYFKGGIKYKAGG-VASGF 124

  Fly   609 YTI-------EEMIHITRLYLVHAYGATIHLEPVAPAITSLDPRHAFVLDLGTHIYIWMGERSKN 666
            ..:       :.::||....:|.|       ..|..:.::.:....|::|||..||.|.|.....
Frog   125 QHVVTNELGAQRLLHIKGRRVVRA-------TEVPLSWSNFNSGDCFIVDLGAVIYQWCGSECNK 182

  Fly   667 TLNSKARLMAEKISKTERKNKCEIQLERQGEESAEFWQGLGM-----TSEEADAAEPPKEHVPED 726
            ....||..:|..|...|:..:.:|.:..:|.|..|..:.||.     ..::||       .|.:|
Frog   183 YERLKAAQVAHGIRDNEKNGRAQIIVVEEGSEPNELTKVLGAKPQLPAGDDAD-------DVADD 240

  Fly   727 YQPVQPRLYQVQLGMGYLELPQVELPEQKLCHTLLNSKHVYILDCYTD--LFVWFGKKSTRLVRA 789
            ......:||.|....|.::: .|...:......:|.|:..:|||...|  :|||.||.:....|.
Frog   241 TNRKNVKLYMVSDASGSMKV-SVVAEQSPFSKAMLLSEECFILDHSGDKKIFVWKGKNANTEERK 304

  Fly   790 AAVKLSRELFNMMDRPDYALVMRVPEGNEMQIFRTKFAGWDE-VMAVDFTRTAKSVAKTGANLTQ 853
            ||:|.:.:....|:.|....:..:||..|..||:..|..|.| ..:..|.:.  .|.:..||:.|
Frog   305 AAMKTAEQFIQQMNYPATTQIQVLPEEGETPIFKQFFKDWKERHQSEGFGQV--YVTERIANIKQ 367

  Fly   854 WARQQETRTDLAALFMPRQSAMPLAEAEQLEEEWNY---DLEMMEAFVLENKKFVRLPEEELGRF 915
                    .|.        .|..|.|:.::..:.|.   ....:|.|.:|:...|.:.....|:|
Frog   368 --------IDF--------DASKLHESPEMAAQHNMVDDGSGKVEIFRVESCGRVPIEPNTFGQF 416

  Fly   916 YTGECYVFLCRYCIPIEEPENGSEDGANPAADVSKSSANNQPEDEIQCVVYFWQGRNAGNMGWLT 980
            |.|:||:.|..|...:                                ::|.|||..| ....||
Frog   417 YGGDCYIILYTYAKGL--------------------------------IIYTWQGAKA-TRDELT 448

  Fly   981 FTFTLQKKFKAMFGEELEVVRIFQQQENLKFMSHFKRK-FIIHTGKRKDKAHTAKGKSP---VEF 1041
            .:..|..:.....|::...||:.|.:|....:|.||.| .||:    ||......|::|   |..
Frog   449 ASAFLTVQLDRSLGDQAVQVRVTQGKEPPHLLSLFKDKPLIIY----KDGTSRKGGQTPPSAVRL 509

  Fly  1042 FHLRSNGGALTTRLIQINPDAVHLNSTFCYILHVPFETEDDSQSGIVYVWIGSKACNEEAKLVQD 1106
            |.:|.|...: ||:|:::.||..|||...::|.:      .:.||  |.|||..|..||.|
Frog   510 FQIRKNLSTI-TRIIEVDTDASLLNSNDVFVLKL------KNNSG--YKWIGKGASGEEEK---- 561

  Fly  1107 IAEQMFNSPWVSLQILNEGDEPENFFWVALGGRKPYDTDA-----EYMNYTRLFRCSNERGYYTV 1166
            .||.:.|.....:..:.||.||:. ||.||.|:|.|.|.|     ..:|..|||.|||:.|.:.:
Frog   562 AAEYIANVLRCKVSKIAEGQEPDE-FWSALNGKKKYQTSALLESKSIVNPPRLFGCSNKTGRFLI 625

  Fly  1167 AEKCADFCQDDLADDDIMILDNGEHVFLWMGPRCSEVEVKLAYKSAQVYIQH-----------MR 1220
            .|...:|.|||||:||:|:||..|.||||:|...:|.|.|.:.|||:.||:.           :.
Frog   626 EEVPGEFTQDDLAEDDVMLLDTHEQVFLWIGKDANEQEKKESLKSAKQYIETDPSGRDKGIPIVS 690

  Fly  1221 IKQPERPRKLFLTMKNKESRRFTKCFHGWSAFK 1253
            :||...|            ..||..|..|.:.|
Frog   691 VKQGHEP------------PNFTGWFMAWDSNK 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fliI	NP_525097.1	leucine-rich repeat	7..30	CDD:275380
		leucine-rich repeat	31..53	CDD:275380
		LRR_8	53..112	CDD:290566
		leucine-rich repeat	54..76	CDD:275380
		LRR_RI	70..304	CDD:238064
		leucine-rich repeat	77..101	CDD:275380
		LRR_8	101..159	CDD:290566
		leucine-rich repeat	102..124	CDD:275380
		leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	149..171	CDD:275380
		LRR_8	152..231	CDD:290566
		leucine-rich repeat	172..195	CDD:275380
		leucine-rich repeat	196..220	CDD:275380
		leucine-rich repeat	221..243	CDD:275380
		LRR_8	243..300	CDD:290566
		leucine-rich repeat	244..266	CDD:275380
		leucine-rich repeat	267..289	CDD:275380
		leucine-rich repeat	290..314	CDD:275380
		LRR_8	315..370	CDD:290566
		leucine-rich repeat	315..335	CDD:275380
		leucine-rich repeat	338..360	CDD:275378
		gelsolin_S1_like	491..602	CDD:200446	42/116 (36%)
		gelsolin_like	618..706	CDD:200436	20/87 (23%)
		gelsolin_S3_like	729..828	CDD:200448	28/100 (28%)
		gelsolin_like	920..1015	CDD:200436	18/94 (19%)
		gelsolin_S5_like	1037..1141	CDD:200444	36/106 (34%)
		gelsolin_S6_like	1151..1250	CDD:200447	39/109 (36%)
scin	XP_002939059.1	gelsolin_S1_like	8..119	CDD:200446	44/118 (37%)
		gelsolin_S2_like	134..223	CDD:200445	22/95 (23%)
		gelsolin_S3_like	243..343	CDD:200448	28/100 (28%)
		gelsolin_S4_like	387..483	CDD:200449	26/128 (20%)
		gelsolin_S5_like	505..595	CDD:200444	35/103 (34%)
		gelsolin_S6_like	610..708	CDD:200447	39/109 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010