DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tty and TTYH2

DIOPT Version :9

Sequence 1:	NP_542443.4	Gene:	tty / 33109	FlyBaseID:	FBgn0015558	Length:	970	Species:	Drosophila melanogaster
Sequence 2:	NP_116035.5	Gene:	TTYH2 / 94015	HGNCID:	13877	Length:	534	Species:	Homo sapiens

Alignment Length:	548	Identity:	160/548 - (29%)
Similarity:	259/548 - (47%)	Gaps:	65/548 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 YKVPVIAKLLHALPHYNITFHKINSTFRPNDEIYLESLGILGSVPAALLIVSLLGLLFYLMTRC- 74
            |..|.....||::||..:....:||||.|.||.|.|||..||.|.|..|.::|:.|:.||:..|
Human     8 YIAPWWVVWLHSVPHVGLRLQPVNSTFSPGDESYQESLLFLGLVAAVCLGLNLIFLVAYLVCACH 72

  Fly    75 CDR----KPRPAHS--ITSLKVALSIVTVMCCAAIGLGLYGNDDLHNGLLEVLTAGRKVDNLVTT 133
            |.|    :.:..||  ||...|...::   ||||:|:|.|||.:.::|..:::.:   :|:...|
Human    73 CRRDDAVQTKQHHSCCITWTAVVAGLI---CCAAVGVGFYGNSETNDGAYQLMYS---LDDANHT 131

  Fly   134 IRNQTHILENTLTNRIR----PQLVELADIFDQPVSNQTALSKLFVSLNIVQ---GNVTLATNAA 191
            ......::..| |.:::    ..|..|::||       .|......:|..:|   |:|.:..:..
Human   132 FSGIDALVSGT-TQKMKVDLEQHLARLSEIF-------AARGDYLQTLKFIQQMAGSVVVQLSGL 188

  Fly   192 SDIRRPLMGISMTHFLTRGDQWELIRWPGTVATLALLLVLCAVLLVGVARHSRCALILFSVCGLL 256
            ...|...|  .:|....:....|..||...:....|.||:|.:..:|:|:.|:|.|.....||.|
Human   189 PVWREVTM--ELTKLSDQTGYVEYYRWLSYLLLFILDLVICLIACLGLAKRSKCLLASMLCCGAL 251

  Fly   257 AVTGSWLMSGLYLSSSVAVGDLCISPADFLVSTAPRDLPTNVLLHYTQCEPGHTNPFTQRLRESQ 321
            ::..||.......|::||..|.|::|..|:::.....:.|.|..:|..|....::||.|.|...|
Human   252 SLLLSWASLAADGSAAVATSDFCVAPDTFILNVTEGQISTEVTRYYLYCSQSGSSPFQQTLTTFQ 316

  Fly   322 NSLNNARSAMATVMKISLVLFKSSGLQPKLGAVNADLNSSERLLTQLTALVDCKAVHHNFLAAAR 386
            .:|...:..:|.:::.::.||.::  :..|.|:...|||||..|.||||:|||:.:|.::|.|..
Human   317 RALTTMQIQVAGLLQFAVPLFSTA--EEDLLAIQLLLNSSESSLHQLTAMVDCRGLHKDYLDALA 379

  Fly   387 GLCEGGLLGLVLMLIASFIAAILLTIMVWVDSHTWIYIRKRN-DYAQVDEPSYISHPAPQNHQQM 450
            |:|..||.||:.:.:.||:||:..:.|:......|.:...|| ||..:|:..      |.|.|..
Human   380 GICYDGLQGLLYLGLFSFLAALAFSTMICAGPRAWKHFTTRNRDYDDIDDDD------PFNPQAW 438

  Fly   451 MNAARTLPRNHNGHF-SPPVISGSHT-LQHPSKRQQHEMMAHAHIQQNM-RAMGTHTLGRLPSHN 512
            ..||.:.||.....| |.....||.| ||.|:     :.:::|.:.:.| :||   ..||.|.:.
Human   439 RMAAHSPPRGQLHSFCSYSSGLGSQTSLQPPA-----QTISNAPVSEYMNQAM---LFGRNPRYE 495

  Fly   513 HSPTHMTGPNNAAAVAAAANAAANMPPT 540
            :.|  :.|             .|:.|||
Human   496 NVP--LIG-------------RASPPPT 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tty	NP_542443.4	Tweety_N	10..429	CDD:143653	129/432 (30%)
TTYH2	NP_116035.5	Tweety_N	7..422	CDD:143653	128/431 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155098
Domainoid	1	1.000	181	1.000	Domainoid score	I3482
eggNOG	1	0.900	-	-		E1_KOG4433
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	196	1.000	Inparanoid score	I3816
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D318605at33208
OrthoFinder	1	1.000	-	-		FOG0000987
OrthoInspector	1	1.000	-	-		mtm8671
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12424
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7666
SonicParanoid	1	1.000	-	-		X806
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.890