Protein Alignment tty and Ttyh3

DIOPT Version :10

• Sequence 1: NP_542443.4
• Gene: tty / 33109
• FlyBaseID: FBgn0015558
• Length: 970
• Species: Drosophila melanogaster
• Sequence 2: XP_030110765.1
• Gene: Ttyh3 / 78339
• MGIID: 1925589
• Length: 543
• Species: Mus musculus
• Alignment Length: 511
• Identity: 136/511 - (26%)
• Similarity: 231/511 - (45%)
• Gaps: 38/511 - (7%)

  Fly    44 YLESLGILGSVPAALLIVSLLGLLFYLMTRCCDRKPRPAH---SITSLKVALSIVTVMCCAAIGL 105
            ::.:|.:||:...|.|.:.||.||||....||.|:....|   ........:.|.|::|.|.|.:
Mouse    56 WVPALLLLGATALACLALDLLFLLFYSFWLCCRRRKTDEHLDADCCCTAWCVIITTLVCSAGIAV 120

  Fly   106 GLYGNDDLHNGLLEVLTAGRKVDNLVTTIRNQTHILENTLTNRIRPQLVELADIFDQPVSNQTAL 170
            |.|||.:..:|:.....:.|..:..|..::::.......|.....|.|..|    ::.::.:...
Mouse   121 GFYGNGETSDGIHRATYSLRHANRTVAGVQDRVWDTAAALNRTAEPNLQSL----ERQLAGRQEP 181

  Fly   171 SKLFVSLNIVQGNVTLATNAASDIRRPLMGISMTHFLTRGDQWELIRWPGTVATLALLLVLCAVL 235
            .:....|..:.|.:...|.|....|.|  |:|:.....:.|.::..||.|.:..|.|.:::|.::
Mouse   182 LRAVQRLQTLLGTLLGYTAAIPFWRNP--GVSLEVLAEQVDLYDWYRWLGYLGLLLLDVIICLLV 244

  Fly   236 LVGVARHSRCALILFSVCGLLAVTGSWLMSGLYLSSSVAVGDLCISPADFLVSTAPRD--LPTNV 298
            |||:.|.|:..|:...:.|:||:..||...||.|:.||...|.|:.|..|:.......  |..::
Mouse   245 LVGLIRSSKGILVGVCLLGVLALVISWGALGLELAVSVGSSDFCVDPDTFVTKMVEEHSVLSGDI 309

  Fly   299 LLHYTQCEPGHTNPFTQRLRESQNSLNNARSAMATVMKISLVLFKSSGLQPKLGAVNADLNSSER 363
            |.:|..|.|..||||.|:|..|..:|...:..:|.:::  .|..:....:..|..|...||.:|.
Mouse   310 LQYYLACSPRATNPFQQKLSGSHKALVEMQDVVAELLR--NVPREHPATKDPLLRVQEVLNGTEV 372

  Fly   364 LLTQLTALVDCKAVHHNFLAAARGLCEGGLLGLVLMLIASFIAAILLTIMVWVDSHTWIYIRKRN 428
            .|..|||||||:::|.:::.|..|.|..|:.||:.:.:.||:.|::.:.:|....|||...|..:
Mouse   373 NLQHLTALVDCRSLHLDYVQALTGFCYDGVEGLIYLALFSFVTALMFSSIVCSIPHTWQQKRGPD 437

  Fly   429 DYAQVDEPSYISHPAP-QNHQQM----MNAARTLPRNHNGHFSPPVISGSHTLQHPSKRQQHEMM 488
            |..:.:     :.|.| |.|..:    |.:..:...::....|.|  :.:||:   |.....|.|
Mouse   438 DDGEEE-----TAPGPRQAHDSLYRVHMPSLYSCGSSYGSEASIP--AAAHTV---SNAPVTEYM 492

  Fly   489 AHAHIQQNMRAMGTHTLGRLPSHNHSPTHMTGPNN-AAAVAAAANAAANMPPTTQA 543
            :.....||.|...|..:||     .||.    |:. .||:.:.::|.....|...|
Mouse   493 SQNANFQNPRCENTPLIGR-----ESPP----PSRYLAALDSGSHAGWQFKPMDSA 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tty	NP_542443.4	Tweety_N	10..429	CDD:143653	109/389 (28%)
Ttyh3	XP_030110765.1	Tweety	80..452	CDD:461475	104/384 (27%)