DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tty and Ttyh3

DIOPT Version :9

Sequence 1:	NP_542443.4	Gene:	tty / 33109	FlyBaseID:	FBgn0015558	Length:	970	Species:	Drosophila melanogaster
Sequence 2:	XP_030110765.1	Gene:	Ttyh3 / 78339	MGIID:	1925589	Length:	543	Species:	Mus musculus

Alignment Length:	511	Identity:	136/511 - (26%)
Similarity:	231/511 - (45%)	Gaps:	38/511 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 YLESLGILGSVPAALLIVSLLGLLFYLMTRCCDRKPRPAH---SITSLKVALSIVTVMCCAAIGL 105
            ::.:|.:||:...|.|.:.||.||||....||.|:....|   ........:.|.|::|.|.|.:
Mouse    56 WVPALLLLGATALACLALDLLFLLFYSFWLCCRRRKTDEHLDADCCCTAWCVIITTLVCSAGIAV 120

  Fly   106 GLYGNDDLHNGLLEVLTAGRKVDNLVTTIRNQTHILENTLTNRIRPQLVELADIFDQPVSNQTAL 170
            |.|||.:..:|:.....:.|..:..|..::::.......|.....|.|..|    ::.::.:...
Mouse   121 GFYGNGETSDGIHRATYSLRHANRTVAGVQDRVWDTAAALNRTAEPNLQSL----ERQLAGRQEP 181

  Fly   171 SKLFVSLNIVQGNVTLATNAASDIRRPLMGISMTHFLTRGDQWELIRWPGTVATLALLLVLCAVL 235
            .:....|..:.|.:...|.|....|.|  |:|:.....:.|.::..||.|.:..|.|.:::|.::
Mouse   182 LRAVQRLQTLLGTLLGYTAAIPFWRNP--GVSLEVLAEQVDLYDWYRWLGYLGLLLLDVIICLLV 244

  Fly   236 LVGVARHSRCALILFSVCGLLAVTGSWLMSGLYLSSSVAVGDLCISPADFLVSTAPRD--LPTNV 298
            |||:.|.|:..|:...:.|:||:..||...||.|:.||...|.|:.|..|:.......  |..::
Mouse   245 LVGLIRSSKGILVGVCLLGVLALVISWGALGLELAVSVGSSDFCVDPDTFVTKMVEEHSVLSGDI 309

  Fly   299 LLHYTQCEPGHTNPFTQRLRESQNSLNNARSAMATVMKISLVLFKSSGLQPKLGAVNADLNSSER 363
            |.:|..|.|..||||.|:|..|..:|...:..:|.:::  .|..:....:..|..|...||.:|.
Mouse   310 LQYYLACSPRATNPFQQKLSGSHKALVEMQDVVAELLR--NVPREHPATKDPLLRVQEVLNGTEV 372

  Fly   364 LLTQLTALVDCKAVHHNFLAAARGLCEGGLLGLVLMLIASFIAAILLTIMVWVDSHTWIYIRKRN 428
            .|..|||||||:::|.:::.|..|.|..|:.||:.:.:.||:.|::.:.:|....|||...|..:
Mouse   373 NLQHLTALVDCRSLHLDYVQALTGFCYDGVEGLIYLALFSFVTALMFSSIVCSIPHTWQQKRGPD 437

  Fly   429 DYAQVDEPSYISHPAP-QNHQQM----MNAARTLPRNHNGHFSPPVISGSHTLQHPSKRQQHEMM 488
            |..:.:     :.|.| |.|..:    |.:..:...::....|.|  :.:||:   |.....|.|
Mouse   438 DDGEEE-----TAPGPRQAHDSLYRVHMPSLYSCGSSYGSEASIP--AAAHTV---SNAPVTEYM 492

  Fly   489 AHAHIQQNMRAMGTHTLGRLPSHNHSPTHMTGPNN-AAAVAAAANAAANMPPTTQA 543
            :.....||.|...|..:||     .||.    |:. .||:.:.::|.....|...|
Mouse   493 SQNANFQNPRCENTPLIGR-----ESPP----PSRYLAALDSGSHAGWQFKPMDSA 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tty	NP_542443.4	Tweety_N	10..429	CDD:143653	109/389 (28%)
Ttyh3	XP_030110765.1	Tweety	80..447	CDD:368183	101/379 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845562
Domainoid	1	1.000	170	1.000	Domainoid score	I3757
eggNOG	1	0.900	-	-		E1_KOG4433
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H18431
Inparanoid	1	1.050	188	1.000	Inparanoid score	I3894
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000987
OrthoInspector	1	1.000	-	-		mtm8906
orthoMCL	1	0.900	-	-		OOG6_111864
Panther	1	1.100	-	-	O	PTHR12424
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X806
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.750