Protein Alignment tty and Ttyh3

DIOPT Version :9

• Sequence 1: NP_542443.4
• Gene: tty / 33109
• FlyBaseID: FBgn0015558
• Length: 970
• Species: Drosophila melanogaster
• Sequence 2: XP_038945308.1
• Gene: Ttyh3 / 304315
• RGDID: 1309549
• Length: 536
• Species: Rattus norvegicus
• Alignment Length: 559
• Identity: 149/559 - (26%)
• Similarity: 245/559 - (43%)
• Gaps: 58/559 - (10%)

  Fly    11 YKVPVIAKLLHALPHYNITFHKINSTFRPNDEIYLESLGILGSVPAALLIVSLLGLLFYLMTRCC 75
            |..|....|||.|||:::.:...:|.|||.|..|.::|.:||:...|.|.:.||.||||....||
  Rat     6 YAAPWWVSLLHRLPHFDLRWEATSSQFRPEDADYQQALLLLGAAALACLALDLLFLLFYSFWLCC 70

  Fly    76 DRKPRPAH---SITSLKVALSIVTVMCCAAIGLGLYGNDDLHNGLLEVLTAGRKVDNLVTTIRNQ 137
            .|:....|   ........:.|.|::|.|.|.:|.|||.:..:|:.....:.|..:..|..::::
  Rat    71 RRRKTDEHLDADCCCTAWCVIIATLVCSAGIAVGFYGNGETSDGVHRATYSLRHANRTVAGVQDR 135

  Fly   138 THILENTLTNRIRPQLVELADIFDQPVSNQTALSKLFVSLNIVQGNVTLATNAASDIRRPLMGIS 202
            .......|.....|.|..|    ::.::.:....:....|..:.|.:...|.|....|.|  |:|
  Rat   136 VWDTAAALNRTAEPNLQSL----EKQLAGRPEPLRAVQRLQTLLGTLLGYTAAIPFWRNP--GVS 194

  Fly   203 MTHFLTRGDQWELIRWPGTVATLALLLVLCAVLLVGVARHSRCALILFSVCGLL----------- 256
            :.....:.|.::..||.|.:..|.|.:::|.::|||:.|.|:..|:.....|.:
  Rat   195 LEVLAEQVDLYDWYRWLGYLGLLLLDVIICLLVLVGLIRSSKGILVGSCPGGRIFLRTPGGPGFP 259

  Fly   257 ----AVTGSWLMSGLYLSSSVAVGDLCISPADFLVSTAPR--DLPTNVLLHYTQCEPGHTNPFTQ 315
                .||..:|.| |...||    |.||.|..|:......  .|..::|.:|..|.|..||||.|
  Rat   260 LRPCLVTSPFLPS-LPQGSS----DFCIDPDTFVTKMVEEYSVLSGDILQYYLACSPRATNPFQQ 319

  Fly   316 RLRESQNSLNNARSAMATVMKISLVLFKSSGLQPKLGAVNADLNSSERLLTQLTALVDCKAVHHN 380
            :|..|..:|...:..:|.::|  .|..:....:..|..|...||.:|..|..|||||||:::|.:
  Rat   320 KLSGSHKALVEMQDVVAELLK--NVPREHPATKDPLLRVQEVLNGTEVNLQHLTALVDCRSLHLD 382

  Fly   381 FLAAARGLCEGGLLGLVLMLIASFIAAILLTIMVWVDSHTWIYIRKRNDYAQVDEPSYISHPAP- 444
            ::.|..|.|..|:.||:.:.:.||:.|::.:.:|....|||...|..::..:.:     :.|.|
  Rat   383 YVQALTGFCYDGVEGLIYLALFSFVTALMFSSIVCSIPHTWQQKRGADEDGEEE-----TAPGPR 442

  Fly   445 QNHQQM----MNAARTLPRNHNGHFSPPVISGSHTLQHPSKRQQHEMMAHAHIQQNMRAMGTHTL 505
            |.|..:    |.:..:...::....|.|  :.:||:   |.....|.|:.....||.|...|..:
  Rat   443 QAHDSLYRVHMPSLYSCGSSYGSEASIP--AAAHTV---SNAPVTEYMSQNANFQNPRCENTPLI 502

  Fly   506 GRLPSHNHSPTHMTGPNN-AAAVAAAANAAANMPPTTQA 543
            ||     .||.    |:. .||:.:.::|.....|...|
  Rat   503 GR-----ESPP----PSRYLAALDSGSHAGWQFKPMDSA 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tty	NP_542443.4	Tweety_N	10..429	CDD:143653	123/437 (28%)
Ttyh3	XP_038945308.1	Tweety	25..440	CDD:368183	115/432 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348975
Domainoid	1	1.000	170	1.000	Domainoid score	I3662
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H18431
Inparanoid	1	1.050	187	1.000	Inparanoid score	I3821
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D318605at33208
OrthoFinder	1	1.000	-	-		FOG0000987
OrthoInspector	1	1.000	-	-		mtm9152
orthoMCL	1	0.900	-	-		OOG6_111864
Panther	1	1.100	-	-	O	PTHR12424
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X806
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.900