Protein Alignment tty and Ttyh2

DIOPT Version :9

• Sequence 1: NP_542443.4
• Gene: tty / 33109
• FlyBaseID: FBgn0015558
• Length: 970
• Species: Drosophila melanogaster
• Sequence 2: XP_221081.9
• Gene: Ttyh2 / 287803
• RGDID: 1562969
• Length: 566
• Species: Rattus norvegicus
• Alignment Length: 620
• Identity: 149/620 - (24%)
• Similarity: 260/620 - (41%)
• Gaps: 119/620 - (19%)

  Fly    10 QYKVPVIAKLLHALPHYNITFHKINSTFRPNDEIYLESLGILGSVPAALLIVSLLGLLFYLMTRC 74
            :|..|.....||::||..:...:::|||.|:||.|.|||..||.:.|..|.::|:.|..||:..|
  Rat    41 EYIAPWWVVWLHSVPHLGLRLQRVDSTFSPSDETYQESLLFLGMLAAIGLGLNLIFLAIYLVCTC 105

  Fly    75 CDRKPRPAHSITSLKVALSIVT-------VMCCAAIGLGLYGNDDLHNGLLEVLTAGRKVDNLVT 132
            |.|:.   |::.:.:.....||       ::||||:|:|.|||.:.::|          |..|:.
  Rat   106 CCRRD---HTVQTKQPDSCCVTWTAVMAGLLCCAAVGVGFYGNSETNDG----------VHQLIY 157

  Fly   133 TIRNQTHI---LENTLTNRIRPQLVELADIFDQPVSNQTALSKLFVSLNIVQGNVTLATNAASDI 194
            ::.|..|.   ::..::...:...|:|    :|.::.   ||::|.:.......:......|.:|
  Rat   158 SLDNANHTFSGMDELVSGNTQKMKVDL----EQHLAR---LSEIFAARGDYMQTLKFMQQMAGNI 215

  Fly   195 RRPLMGI----SMTHFLT----RGDQWELIRWPGTVATLALLLVLCAVLLVGVARHSRCALILFS 251
            ...|.|:    .:|..||    :....|..||...:....|.||:|.|..:|:||.|:|.|....
  Rat   216 VNQLSGLPVWREVTEELTALSHQTAYVEHYRWLSYLLLFILDLVICLVTCLGLARRSKCLLASML 280

  Fly   252 VCGLLAVTGSWLMSGLYLSSSVAVGDLCISPADFLVSTAPRDLPTNVLLHYTQCEPGHTNPFTQR 316
            .||:||:..||.......:::|...|.|:.|..::::.....:.:.|..:|..|.....:||.|.
  Rat   281 CCGILALVLSWASLAADAAAAVGTSDFCMVPDVYILNNTQNQISSEVTRYYLHCSQSQISPFQQS 345

  Fly   317 LRESQNSLNNARSAMATVMKISLVLFKSSGLQPKLGAVNADLNSSERLLTQLTALVDCKAVHHNF 381
            |...|.||...:..:..:::.::.||.::  :..|..:...||:||..|.||||::||:.:|.::
  Rat   346 LTIFQRSLTTMQIQVVGLLQFAVPLFPTA--EKDLLGIQLLLNNSETSLHQLTAMLDCRGLHKDY 408

  Fly   382 LAAARGLCEGGLLGLVLMLIASFIAAILLTIMVWVDSHTW-IYIRKRNDYAQVDEPSYISHPAPQ 445
            |.|..|:|..|:.||:.:.:.|.:||:..:.:.......| .:|.:..||..:|:..      |.
  Rat   409 LDALTGICYDGIEGLLFLGLFSLLAALAFSTLTCAGPRAWKHFINRDRDYDDIDDDD------PF 467

  Fly   446 NHQQMMNAARTLPRNHNGHFSPPVISGSHTLQHPSKRQQHEMMAHAHIQQNMRAMGTHTLGRLPS 510
            |.|....||      ||                |::.|.|...:::
  Rat   468 NPQARRIAA------HN----------------PARGQLHSFCSYS------------------- 491

  Fly   511 HNHSPTHMTGPNNAAAVAAAANAAANMPPTTQAAQQQQQQQAQQQQQQAQQQLGGPQPIYCHHP- 574
                             :...:..:..|||      |....|...:...|..|.|..|.|.:.|
  Rat   492 -----------------SGLGSQCSLQPPT------QTISNAPVSEYMNQAILFGGNPRYENVPL 533

  Fly   575 --HQHPHPHPHQHPHSHSAAAVAAAVQHQHAIYHQ 607
              ...|.|     .:|.|..|...:|..:|..:::
  Rat   534 IGRGSPPP-----TYSPSMRATYMSVADEHLRHYE 563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tty	NP_542443.4	Tweety_N	10..429	CDD:143653	118/437 (27%)
Ttyh2	XP_221081.9	Tweety	61..453	CDD:368183	111/413 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348977
Domainoid	1	1.000	170	1.000	Domainoid score	I3662
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	187	1.000	Inparanoid score	I3821
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D318605at33208
OrthoFinder	1	1.000	-	-		FOG0000987
OrthoInspector	1	1.000	-	-		mtm9152
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12424
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X806
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.000