DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tty and Ttyh2

DIOPT Version :9

Sequence 1:	NP_542443.4	Gene:	tty / 33109	FlyBaseID:	FBgn0015558	Length:	970	Species:	Drosophila melanogaster
Sequence 2:	NP_444503.2	Gene:	Ttyh2 / 117160	MGIID:	2157091	Length:	532	Species:	Mus musculus

Alignment Length:	542	Identity:	142/542 - (26%)
Similarity:	250/542 - (46%)	Gaps:	61/542 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 QYKVPVIAKLLHALPHYNITFHKINSTFRPNDEIYLESLGILGSVPAALLIVSLLGLLFYLMTRC 74
            :|..|.....||::||..:...:::|||.|.||.|.|||..||.:.|..|.::|:.|..||:..|
Mouse     7 EYIAPWWVVWLHSVPHLGLRLQRVDSTFSPGDETYQESLLFLGVLAAIGLGLNLIFLTVYLVCTC 71

  Fly    75 CDRKPRPAHSITSLKVALSIVT-------VMCCAAIGLGLYGNDDLHNGLLEVLTAGRKVDNLVT 132
            |.|:.   |::.:.:.....||       ::||||:|:|.|||.:.::|:.:::.:   :||...
Mouse    72 CCRRD---HTVQTKQQESCCVTWTAVVAGLLCCAAVGVGFYGNSETNDGMHQLIYS---LDNANH 130

  Fly   133 TIRNQTHILE-NTLTNRI--RPQLVELADIFDQPVSNQTALSKLFVSLNIVQGNVTLATNAASDI 194
            |......::. ||...::  ...|..|::|.       .|......:|..:|   .:|.|..|.:
Mouse   131 TFSGMDELVSANTQRMKVDLEQHLARLSEII-------AARGDYIQTLKFMQ---QMAGNVVSQL 185

  Fly   195 RRPLMGISMTHFLTRGDQW----ELIRWPGTVATLALLLVLCAVLLVGVARHSRCALILFSVCGL 255
            ....:...:|..||:....    |..||...:....|.||:|.|..:|:||.|:|.|.....||:
Mouse   186 SGLPVWREVTTQLTKLSHQTAYVEYYRWLSYLLLFILDLVICLVTCLGLARRSKCLLASMLCCGI 250

  Fly   256 LAVTGSWLMSGLYLSSSVAVGDLCISPADFLVSTAPRDLPTNVLLHYTQCEPGHTNPFTQRLRES 320
            |.:..||.......:::|...|.|::|..::::.....:.:.|..:|..|.....:||.|.|...
Mouse   251 LTLILSWASLAADAAAAVGTSDFCMAPDIYILNNTGSQINSEVTRYYLHCSQSLISPFQQSLTTF 315

  Fly   321 QNSLNNARSAMATVMKISLVLFKSSGLQPKLGAVNADLNSSERLLTQLTALVDCKAVHHNFLAAA 385
            |.||...:..:..:::.::.||.::  :..|..:...||:||..|.||||::||:.:|.::|.|.
Mouse   316 QRSLTTMQIQVGGLLQFAVPLFPTA--EKDLLGIQLLLNNSEISLHQLTAMLDCRGLHKDYLDAL 378

  Fly   386 RGLCEGGLLGLVLMLIASFIAAILLTIMVWVDSHTWIY-IRKRNDYAQVDEPSYISHPAPQNHQQ 449
            .|:|..|:.||:.:.:.|.:||:..:.:.......|.| |.:..||..:|:..      |.|.|.
Mouse   379 TGICYDGIEGLLFLGLFSLLAALAFSTLTCAGPRAWKYFINRDRDYDDIDDDD------PFNPQA 437

  Fly   450 MMNAARTLPRN--HNGHFSPPVISGSHTLQHPSKRQQHEMMAHAHIQQ----------NMRAMGT 502
            ...||....|.  |:.......:....:||.||     :.:::|.:.:          |.|....
Mouse   438 RRIAAHNPTRGQLHSFCSYSSGLGSQCSLQPPS-----QTISNAPVSEYMNQAILFGGNPRYENV 497

  Fly   503 HTLGR---LPSHNHS--PTHMT 519
            ..:||   .|:::.|  ||:|:
Mouse   498 PLIGRGSPPPTYSPSMRPTYMS 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tty	NP_542443.4	Tweety_N	10..429	CDD:143653	118/433 (27%)
Ttyh2	NP_444503.2	Tweety	27..419	CDD:282726	111/409 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845564
Domainoid	1	1.000	170	1.000	Domainoid score	I3757
eggNOG	1	0.900	-	-		E1_KOG4433
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	188	1.000	Inparanoid score	I3894
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D318605at33208
OrthoFinder	1	1.000	-	-		FOG0000987
OrthoInspector	1	1.000	-	-		mtm8906
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12424
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7666
SonicParanoid	1	1.000	-	-		X806
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.890