Protein Alignment tty and Ttyh2

DIOPT Version :10

• Sequence 1: NP_542443.4
• Gene: tty / 33109
• FlyBaseID: FBgn0015558
• Length: 970
• Species: Drosophila melanogaster
• Sequence 2: NP_444503.2
• Gene: Ttyh2 / 117160
• MGIID: 2157091
• Length: 532
• Species: Mus musculus
• Alignment Length: 542
• Identity: 142/542 - (26%)
• Similarity: 250/542 - (46%)
• Gaps: 61/542 - (11%)

  Fly    10 QYKVPVIAKLLHALPHYNITFHKINSTFRPNDEIYLESLGILGSVPAALLIVSLLGLLFYLMTRC 74
            :|..|.....||::||..:...:::|||.|.||.|.|||..||.:.|..|.::|:.|..||:..|
Mouse     7 EYIAPWWVVWLHSVPHLGLRLQRVDSTFSPGDETYQESLLFLGVLAAIGLGLNLIFLTVYLVCTC 71

  Fly    75 CDRKPRPAHSITSLKVALSIVT-------VMCCAAIGLGLYGNDDLHNGLLEVLTAGRKVDNLVT 132
            |.|:.   |::.:.:.....||       ::||||:|:|.|||.:.::|:.:::.:   :||...
Mouse    72 CCRRD---HTVQTKQQESCCVTWTAVVAGLLCCAAVGVGFYGNSETNDGMHQLIYS---LDNANH 130

  Fly   133 TIRNQTHILE-NTLTNRI--RPQLVELADIFDQPVSNQTALSKLFVSLNIVQGNVTLATNAASDI 194
            |......::. ||...::  ...|..|::|.       .|......:|..:|   .:|.|..|.:
Mouse   131 TFSGMDELVSANTQRMKVDLEQHLARLSEII-------AARGDYIQTLKFMQ---QMAGNVVSQL 185

  Fly   195 RRPLMGISMTHFLTRGDQW----ELIRWPGTVATLALLLVLCAVLLVGVARHSRCALILFSVCGL 255
            ....:...:|..||:....    |..||...:....|.||:|.|..:|:||.|:|.|.....||:
Mouse   186 SGLPVWREVTTQLTKLSHQTAYVEYYRWLSYLLLFILDLVICLVTCLGLARRSKCLLASMLCCGI 250

  Fly   256 LAVTGSWLMSGLYLSSSVAVGDLCISPADFLVSTAPRDLPTNVLLHYTQCEPGHTNPFTQRLRES 320
            |.:..||.......:::|...|.|::|..::::.....:.:.|..:|..|.....:||.|.|...
Mouse   251 LTLILSWASLAADAAAAVGTSDFCMAPDIYILNNTGSQINSEVTRYYLHCSQSLISPFQQSLTTF 315

  Fly   321 QNSLNNARSAMATVMKISLVLFKSSGLQPKLGAVNADLNSSERLLTQLTALVDCKAVHHNFLAAA 385
            |.||...:..:..:::.::.||.::  :..|..:...||:||..|.||||::||:.:|.::|.|.
Mouse   316 QRSLTTMQIQVGGLLQFAVPLFPTA--EKDLLGIQLLLNNSEISLHQLTAMLDCRGLHKDYLDAL 378

  Fly   386 RGLCEGGLLGLVLMLIASFIAAILLTIMVWVDSHTWIY-IRKRNDYAQVDEPSYISHPAPQNHQQ 449
            .|:|..|:.||:.:.:.|.:||:..:.:.......|.| |.:..||..:|:..      |.|.|.
Mouse   379 TGICYDGIEGLLFLGLFSLLAALAFSTLTCAGPRAWKYFINRDRDYDDIDDDD------PFNPQA 437

  Fly   450 MMNAARTLPRN--HNGHFSPPVISGSHTLQHPSKRQQHEMMAHAHIQQ----------NMRAMGT 502
            ...||....|.  |:.......:....:||.||     :.:::|.:.:          |.|....
Mouse   438 RRIAAHNPTRGQLHSFCSYSSGLGSQCSLQPPS-----QTISNAPVSEYMNQAILFGGNPRYENV 497

  Fly   503 HTLGR---LPSHNHS--PTHMT 519
            ..:||   .|:::.|  ||:|:
Mouse   498 PLIGRGSPPPTYSPSMRPTYMS 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tty	NP_542443.4	Tweety_N	10..429	CDD:143653	118/433 (27%)
Ttyh2	NP_444503.2	Tweety	10..436	CDD:461475	122/449 (27%)
		RGD. /evidence=ECO:0000269|PubMed:34824283	164..166		0/1 (0%)
		PY-motif, mediates interaction with NEDD4L. /evidence=ECO:0000250|UniProtKB:Q9BSA4	506..509		1/2 (50%)