DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1486 and Pdxdc1

DIOPT Version :9

Sequence 1:	NP_608450.1	Gene:	CG1486 / 33108	FlyBaseID:	FBgn0031174	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	NP_001128433.1	Gene:	Pdxdc1 / 304721	RGDID:	1562597	Length:	785	Species:	Rattus norvegicus

Alignment Length:	837	Identity:	248/837 - (29%)
Similarity:	387/837 - (46%)	Gaps:	162/837 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 LAELELRSSQVLQRLENVKVSTTPESPNPVENEEEAGERVTSEDLLPAKHRVPSDILKSLEQLVS 106
            |||:.....:.::.|||        ||..:  |||:|::...|| :|...:.....:.|:.|||.
  Rat    13 LAEMGKNLKEAMRMLEN--------SPRRI--EEESGKKPVPED-IPGPLQGSGQDMVSILQLVQ 66

  Fly   107 ---YTDSDDDPEFP-LPALDDVSHLALISHSIVAYLSHLDRQQLLRVTNSISGDATRWLGTLFHF 167
               :.|.|::|:.. :..:.:..|:||:.||:.||:|.||:::|.::|..|..|.|.||..:|.:
  Rat    67 NLMHGDEDEEPQSTRIQNIGEQGHMALLGHSLGAYISTLDKEKLRKLTTRILSDTTLWLCRIFRY 131

  Fly   168 AHPASSFHADNADAVLRTVRLAIVARCPGYLEGGIPAL--AQPTFYISENTTPMRLHYACRQLGI 230
            .:..:.||....:.:.:..||||.:|...::..|...|  .:|..|:|....|....|.|.|||:
  Rat   132 ENGCAYFHEKEREGLAKICRLAIHSRYEDFVVDGFNVLYNKKPIIYLSAAARPGLGPYLCNQLGL 196

  Fly   231 PLEAIKVIPEHSQSGT---MDVTLLQKQIQQDVGNNRTPLLVVADIGASLCGYVDNLLRLRDVCK 292
            |...:..:|.::..|:   |||..|:|.|:.||...|.|||:||:.|.:..|:.|.:.||:::|:
  Rat   197 PFPCLCRVPCNTMFGSQHQMDVAFLEKLIKDDVERGRLPLLLVANAGTAAVGHTDKIGRLKELCE 261

  Fly   293 AHNMWLHASGHGLAALVCAQNQGHVEEVL------HSMALNLGSWLGVPSLPIVLLHRPLQNSAL 351
            .:.:|||..|..||.|..    |:|...:      .||.|..|.|||:|::|.|.|::
  Rat   262 QYGIWLHVEGVNLATLAL----GYVSSSVLAATKCDSMTLTPGLWLGLPAVPAVTLYK------- 315

  Fly   352 SAFESDPIL-----------SRRLNALSLWTSLQALGRKAIAERLHVAFQTCSILFEIASKCEGI 405
               ..||.|           :.:|.||.||.|||.||...|..|:..|.|....|.|...|.:.|
  Rat   316 ---HDDPALTLIAGLTSNKPADKLRALPLWLSLQYLGLDGIVGRIKHACQLSQRLQESLKKVDHI 377

  Fly   406 RVLSHTPGAQTGASLSDVIQSPFDVQALF------DAAAPVVAYQFDGSTTIPLGGSGSSAAAAA 464
            ::|           :.|.:.||..|...|      |.|..|.|.            |..:|||..
  Rat   378 KIL-----------VEDELSSPVVVFRFFQELPTLDPAFKVAAV------------SNIAAAAVG 419

  Fly   465 AERETAEGLKPLEKINNASYFDRLNSWLGQILQRDCPNFDFEVIEHPTHGSCIRYCPLEL--GLG 527
            .||.:.               |.||.|||:.|::..|.....|::....|:|:|:.||..  .||
  Rat   420 RERHSC---------------DALNRWLGEQLKQLVPQCGLTVMDLDIDGTCVRFSPLMTAEALG 469

  Fly   528 EQPPSSENLESFAQSLEAHVDILRATIKHKARFIHLVECSDVLRLVPLPEWAGMGGVRFV----- 587
            .:   .|:::.....:::.:.:|..|::.:..|...||.:..|..|..|.|.|:|.||:.
  Rat   470 TR---GEDVDQLITCIQSKLPVLTCTLQLREEFKKEVEGTAGLLYVDDPNWPGIGVVRYEHANDD 531

  Fly   588 -------PEGWESLLTDQAKTELNKLNIDLVEALKSTDNAFSLG-EGTDGLICVRFGMVTHETEV 644
                   ||| |.:.|...| :||:|..||         .|.:| |......|:..||.:.:.:|
  Rat   532 NTSLQSDPEG-EKIHTGLLK-KLNELESDL---------TFKMGPEYKSMKSCIYIGMASDDVDV 585

  Fly   645 EELLDLVVTVGKSVQENSRVLDTMSEIVKKGIEAVTADLQRESEEKLWQEGILRHVPVVGRVFNW 709
            .||::.:....:.::||||:|:.|:|:|:|||:.....||:.:||:|.:||:||.:||||.|.||
  Rat   586 SELVETIAITAREIEENSRLLENMTEVVRKGIQEAQVQLQKANEERLLEEGVLRQIPVVGSVLNW 650

  Fly   710 WSPPAKESGIKGRSLNLTQGVVESTENIYKYHMQMTGATAHQLPANRSPPTPMVQTPVVAPALPP 774
            :||  .::..||||.|||.|.:||||..|.|.:|.||.|        .||||
  Rat   651 FSP--VQASQKGRSFNLTAGSLESTEYTYVYKVQGTGVT--------PPPTP------------- 692

  Fly   775 VFPTVEPVPGNGNGSGASEGTPVQSGEASGSMPAASGAAPSAAPTQNHVDHARTVSQ 831
                        :|:.:.:..|   |:........|..|.|...:.:|::....|.|
  Rat   693 ------------SGTRSKQRLP---GQKPFKRSLRSSDAVSETSSVSHIEDLEKVEQ 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1486	NP_608450.1	AAT_I	159..>384	CDD:302748	78/246 (32%)
CG1486	NP_608450.1	WWbp	<725..801	CDD:304964	20/75 (27%)
Pdxdc1	NP_001128433.1	AAT_I	<203..394	CDD:302748	68/215 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341684
Domainoid	1	1.000	189	1.000	Domainoid score	I3203
eggNOG	1	0.900	-	-		E1_KOG0630
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22858
Inparanoid	1	1.050	318	1.000	Inparanoid score	I2458
OMA	1	1.010	-	-		QHG45833
OrthoDB	1	1.010	-	-		D348224at33208
OrthoFinder	1	1.000	-	-		FOG0005841
OrthoInspector	1	1.000	-	-		otm44462
orthoMCL	1	0.900	-	-		OOG6_108096
Panther	1	1.100	-	-	LDO	PTHR42735
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4234
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770