DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dd and CTDNEP1

DIOPT Version :9

Sequence 1:	NP_608449.1	Gene:	Dd / 33107	FlyBaseID:	FBgn0029067	Length:	243	Species:	Drosophila melanogaster
Sequence 2:	NP_001137247.1	Gene:	CTDNEP1 / 23399	HGNCID:	19085	Length:	244	Species:	Homo sapiens

Alignment Length:	234	Identity:	168/234 - (71%)
Similarity:	199/234 - (85%)	Gaps:	0/234 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RALLLLLSKVWTCICFMFNRQVRAFIQYQPVKYELFPLSPVSRHRLSLVQRKTLVLDLDETLIHS 74
            |..:...:|:|:...::..||:|..||||.|:|::.|||||||:||:.|:||.||||||||||||
Human    11 RTFVAFAAKLWSFFIYLLRRQIRTVIQYQTVRYDILPLSPVSRNRLAQVKRKILVLDLDETLIHS 75

  Fly    75 HHNAMPRNTVKPGTPHDFTVKVTIDRNPVRFFVHKRPHVDYFLDVVSQWYDLVVFTASMEIYGAA 139
            ||:.:.|.||:||||.||.:||.||::|||||||||||||:||:||||||:||||||||||||:|
Human    76 HHDGVLRPTVRPGTPPDFILKVVIDKHPVRFFVHKRPHVDFFLEVVSQWYELVVFTASMEIYGSA 140

  Fly   140 VADKLDNGRNILRRRYYRQHCTPDYGSYTKDLSAICSDLNRIFIIDNSPGAYRCFPNNAIPIKSW 204
            |||||||.|:||:|||||||||.:.|||.||||.:.|||:.|.|:||||||||..|:||||||||
Human   141 VADKLDNSRSILKRRYYRQHCTLELGSYIKDLSVVHSDLSSIVILDNSPGAYRSHPDNAIPIKSW 205

  Fly   205 FSDPMDTALLSLLPMLDALRFTNDVRSVLSRNLHLHRLW 243
            ||||.|||||:|||||||||||.|||||||||||.||||
Human   206 FSDPSDTALLNLLPMLDALRFTADVRSVLSRNLHQHRLW 244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dd	NP_608449.1	HIF-SF_euk	60..228	CDD:274055	131/167 (78%)
CTDNEP1	NP_001137247.1	HIF-SF_euk	61..229	CDD:274055	131/167 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158657
Domainoid	1	1.000	278	1.000	Domainoid score	I1725
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9100
Inparanoid	1	1.050	354	1.000	Inparanoid score	I2253
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54256
OrthoDB	1	1.010	-	-		D1176152at2759
OrthoFinder	1	1.000	-	-		FOG0002783
OrthoInspector	1	1.000	-	-		oto89125
orthoMCL	1	0.900	-	-		OOG6_105071
Panther	1	1.100	-	-	LDO	PTHR12210
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2457
SonicParanoid	1	1.000	-	-		X1870
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.900