DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rpt6 and RPT6

DIOPT Version :9

Sequence 1:	NP_608447.1	Gene:	Rpt6 / 33105	FlyBaseID:	FBgn0020369	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_011467.1	Gene:	RPT6 / 852834	SGDID:	S000003016	Length:	405	Species:	Saccharomyces cerevisiae

Alignment Length:	388	Identity:	297/388 - (76%)
Similarity:	345/388 - (88%)	Gaps:	0/388 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GFRSYYIQKIEELQLVVAEKHQNLRRLQAQRNELNAKVRMLREELQLLQEQGSYVGEVVKPMDKK 82
            |.:.|:.|||:|.:|.:..|.:|:|||:||||.||.|||.:::||:||||.|||||||:|.:..|
Yeast    18 GIKPYFEQKIQETELKIRSKTENVRRLEAQRNALNDKVRFIKDELRLLQEPGSYVGEVIKIVSDK 82

  Fly    83 KVLVKVHPEGKFVVDLDKNIDINDVTPNCRVALRNESYTLHKILPNKVDPLVSLMMVEKVPDSTY 147
            ||||||.||||::||:.|:|::.|:..:.||.||::||.|||:|.||.|||||||||||||||||
Yeast    83 KVLVKVQPEGKYIVDVAKDINVKDLKASQRVCLRSDSYMLHKVLENKADPLVSLMMVEKVPDSTY 147

  Fly   148 EMVGGLDKQIKEIKEVIELPVKHPELFDALGIAQPKGVLLYGPPGTGKTLLARAVAHHTECTFIR 212
            :|||||.||||||||||||||||||||::|||||||||:||||||||||||||||||||:|.|||
Yeast   148 DMVGGLTKQIKEIKEVIELPVKHPELFESLGIAQPKGVILYGPPGTGKTLLARAVAHHTDCKFIR 212

  Fly   213 VSGSELVQKFIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRIESGSGGDSEVQRTMLELLN 277
            |||:|||||:|||||||||||||||||||||||||||||||||:|:|...|||||||||||||||
Yeast   213 VSGAELVQKYIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSTRVEGSGGGDSEVQRTMLELLN 277

  Fly   278 QLDGFEATKNIKVIMATNRIDILDPALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGIN 342
            ||||||.:||||:||||||:||||||||||||||||||||||:..||.:||:|||||||||||||
Yeast   278 QLDGFETSKNIKIIMATNRLDILDPALLRPGRIDRKIEFPPPSVAARAEILRIHSRKMNLTRGIN 342

  Fly   343 LRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK 405
            |||:||.|.|.|||:|||||||||||||||||:||||||||:||.|||.|:.|..:|:.||:|
Yeast   343 LRKVAEKMNGCSGADVKGVCTEAGMYALRERRIHVTQEDFELAVGKVMNKNQETAISVAKLFK 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpt6	NP_608447.1	RPT1	17..403	CDD:224143	294/384 (77%)
		SlyX	<27..>69	CDD:294687	23/41 (56%)
		AAA_16	152..>205	CDD:289934	48/52 (92%)
		AAA	185..317	CDD:278434	117/131 (89%)
RPT6	NP_011467.1	RPT1	12..403	CDD:224143	294/384 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343117
Domainoid	1	1.000	244	1.000	Domainoid score	I367
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2098
Inparanoid	1	1.050	601	1.000	Inparanoid score	I132
Isobase	1	0.950	-	0	Normalized mean entropy	S42
OMA	1	1.010	-	-		QHG53670
OrthoFinder	1	1.000	-	-		FOG0003106
OrthoInspector	1	1.000	-	-		otm46573
orthoMCL	1	0.900	-	-		OOG6_101513
Panther	1	1.100	-	-	LDO	PTHR23073
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1002
SonicParanoid	1	1.000	-	-		X2077
TreeFam	1	0.960	-	-
	16	15.740