DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rpt6 and KATNAL2

DIOPT Version :9

Sequence 1:	NP_608447.1	Gene:	Rpt6 / 33105	FlyBaseID:	FBgn0020369	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_001340828.1	Gene:	KATNAL2 / 83473	HGNCID:	25387	Length:	564	Species:	Homo sapiens

Alignment Length:	498	Identity:	135/498 - (27%)
Similarity:	215/498 - (43%)	Gaps:	135/498 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VTNRMEIESAYHKGEGFRSYYIQKIEELQLVVAEKHQNLRRLQAQRNELNAKVRMLREELQLLQE 67
            |.:.:::|:...:   :.|||..|.::...:|.:..........||:....: ||:.:..|.|.:
Human    88 VCDNIDLETILME---YESYYFVKFQKYPKIVKKSSDTAENNLPQRSRGKTR-RMMNDSCQNLPK 148

  Fly    68 QGSYVGEVVKPMDK--------KKVLVKVHPEGKFVVDLDKNIDINDVTPNCRVALRNESYTLH- 123
            ....     :|..|        .|.|.|.||.             .:|..|.|  |.:.::.||
Human   149 INQQ-----RPRSKTTAGKTGDTKSLNKEHPN-------------QEVVDNTR--LESANFGLHI 193

  Fly   124 ---------------------------------------KILPNKVDP----------------- 132
                                                   ....:..||
Human   194 SRIRKDSGEENAHPRRGQIIDFQGLLTDAIKGATSELALNTFDHNPDPSERLLKPLSAFIGMNSE 258

  Fly   133 ------LVSLMMVEKVPDSTYEMVGGLDKQIKEIKEVIELPVKHPELFDALGIAQP-KGVLLYGP 190
                  :||..:....|:..:..:.|||...:.:||.:..|:::|:||  .||..| ||:|||||
Human   259 MRELAAVVSRDIYLHNPNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLF--TGILSPWKGLLLYGP 321

  Fly   191 PGTGKTLLARAVAHHTEC--TFIRVSGSELVQKFIGEGSRMVRELFVMAREHAPSIIFMDEIDSI 253
            |||||||||:|||  |||  ||..:|.|.:|.|:.|:..::||.||.:||.||||.||:||::|:
Human   322 PGTGKTLLAKAVA--TECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESV 384

  Fly   254 GSSRIESGSGGDSEVQ-RTMLELLNQLDGFEATKNIKVIMATNRID-ILDPALLRPGRIDRKIEF 316
            .|.| .:.|||:.|.. |...|||.|:||...::::..::|.:.:. .||.|:||  |::::|..
Human   385 MSQR-GTASGGEHEGSLRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLR--RLEKRILV 446

  Fly   317 PPPNEEARLDILKIH-------SRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRE-- 372
            ..|:.|||..:: .|       ||.:.|...:....:::...|.||:::|.||.||.|..:|:
Human   447 DLPSREARQAMI-YHWLPPVSKSRALELHTELEYSVLSQETEGYSGSDIKLVCREAAMRPVRKIF 510

  Fly   373 -------------RRVH---VTQEDFEMAVAKVMQKDSEKNMS 399
                         .|:.   ||..||...:...  |.|.||::
Human   511 DALENHQSESSDLPRIQLDIVTTADFLDVLTHT--KPSAKNLA 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpt6	NP_608447.1	RPT1	17..403	CDD:224143	133/484 (27%)
		SlyX	<27..>69	CDD:294687	7/41 (17%)
		AAA_16	152..>205	CDD:289934	31/53 (58%)
		AAA	185..317	CDD:278434	63/135 (47%)
KATNAL2	NP_001340828.1	LisH	51..81	CDD:128913
KATNAL2	NP_001340828.1	SpoVK	<264..559	CDD:223540	107/298 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810