DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rpt6 and PSMC1

DIOPT Version :9

Sequence 1:	NP_608447.1	Gene:	Rpt6 / 33105	FlyBaseID:	FBgn0020369	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_002793.2	Gene:	PSMC1 / 5700	HGNCID:	9547	Length:	440	Species:	Homo sapiens

Alignment Length:	372	Identity:	179/372 - (48%)
Similarity:	253/372 - (68%)	Gaps:	4/372 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 IQKIEELQLVVAEKHQNLRRLQAQRNELNAKVRMLREELQLLQEQGSYVGEVVKPMDKKKVLVKV 88
            :::|::..|:..|..:|    |.|...|..|....|.::..|:.....||.:.:.:|....:|..
Human    65 LERIKDYLLMEEEFIRN----QEQMKPLEEKQEEERSKVDDLRGTPMSVGTLEEIIDDNHAIVST 125

  Fly    89 HPEGKFVVDLDKNIDINDVTPNCRVALRNESYTLHKILPNKVDPLVSLMMVEKVPDSTYEMVGGL 153
            ....:..|.:...:|.:.:.|.|.|.|.::.:.:..:|.:..||||::|.|||.|..||..:|||
Human   126 SVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGL 190

  Fly   154 DKQIKEIKEVIELPVKHPELFDALGIAQPKGVLLYGPPGTGKTLLARAVAHHTECTFIRVSGSEL 218
            |.||:||||.:|||:.|||.::.:||..||||:|||||||||||||:|||:.|..||:||.||||
Human   191 DNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSEL 255

  Fly   219 VQKFIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRIESGSGGDSEVQRTMLELLNQLDGFE 283
            :||::|:|.::|||||.:|.||||||:|:||||:||:.|.:|.|||:.|:||||||||||||||:
Human   256 IQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFD 320

  Fly   284 ATKNIKVIMATNRIDILDPALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAE 348
            :..::|||||||||:.|||||:||||||||||||.|:|:.:..|.:||:.:|.|...:.|..:..
Human   321 SRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIM 385

  Fly   349 LMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSE 395
            .....|||::|.:|||||:.||||||:.||.|||:.:...|:.|..|
Human   386 AKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSKENVLYKKQE 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpt6	NP_608447.1	RPT1	17..403	CDD:224143	179/372 (48%)
		SlyX	<27..>69	CDD:294687	10/41 (24%)
		AAA_16	152..>205	CDD:289934	37/52 (71%)
		AAA	185..317	CDD:278434	93/131 (71%)
PSMC1	NP_002793.2	PTZ00361	1..440	CDD:185575	179/372 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	84..104		5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D298123at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820