DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rpt6 and FGGY

DIOPT Version :9

Sequence 1:	NP_608447.1	Gene:	Rpt6 / 33105	FlyBaseID:	FBgn0020369	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_001106882.1	Gene:	FGGY / 55277	HGNCID:	25610	Length:	575	Species:	Homo sapiens

Alignment Length:	287	Identity:	52/287 - (18%)
Similarity:	91/287 - (31%)	Gaps:	106/287 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 LVKVHPEGKFVVDLD--------------KNIDINDVTPNCRVALRNESYTLHKILPNKVDPLVS 135
            |:..|..|..|:..|              ..:.:...|.:|.:.:..:..    .:|....|..|
Human   258 LIDAHAGGLGVIGADVRGHGLICEGQPVTSRLAVICGTSSCHMGISKDPI----FVPGVWGPYFS 318

  Fly   136 LMMVEKVPDSTYEMVGGLDKQIKEIKEVIELPVKHPEL------------------FDALGIAQP 182
            .|    || ..:...||.....|.|..:::.....|||                  .|.:..|||
Human   319 AM----VP-GFWLNEGGQSVTGKLIDHMVQGHAAFPELQVKATARCQSIYAYLNSHLDLIKKAQP 378

  Fly   183 KGVL---------------------LYGPPGTGKTLLARAVAHHTECTFI--RVSGSELVQ---- 220
            .|.|                     |.|...||...:....|.|:..:.:  :|:|.:|.|
Human   379 VGFLTVDLHVWPDFHGNRSPLADLTLKGMRTTGYLYIPALAALHSPSSLLSPQVTGLKLSQDLDD 443

  Fly   221 ---------KFIGEGSRMVRELFVMAREHAPSIIFM-------------------------DEID 251
                     :.|..|:|.:.|. :.|..|:.|.:|:                         .|::
Human   444 LAILYLATVQAIALGTRFIIEA-MEAAGHSISTLFLCGGLSKNPLFVQMHADITGMPVVLSQEVE 507

  Fly   252 S--IGSSRIESGSGGD-SEVQRTMLEL 275
            |  :|::.:.:.:.|| :.||..|.::
Human   508 SVLVGAAVLGACASGDFASVQEAMAKM 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpt6	NP_608447.1	RPT1	17..403	CDD:224143	52/287 (18%)
		SlyX	<27..>69	CDD:294687
		AAA_16	152..>205	CDD:289934	17/91 (19%)
		AAA	185..317	CDD:278434	27/155 (17%)
FGGY	NP_001106882.1	FGGY_YpCarbK_like	10..568	CDD:212663	52/287 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900