DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rpt6 and ATAD2B

DIOPT Version :9

Sequence 1:	NP_608447.1	Gene:	Rpt6 / 33105	FlyBaseID:	FBgn0020369	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	XP_011531220.1	Gene:	ATAD2B / 54454	HGNCID:	29230	Length:	1511	Species:	Homo sapiens

Alignment Length:	428	Identity:	133/428 - (31%)
Similarity:	220/428 - (51%)	Gaps:	54/428 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VTNRMEIESAYHKG-EGFRSYYIQKIEELQLVVAEKHQNLRRLQAQRNELNAKVRMLREELQLLQ 66
            :.|..|:.:   :| |..|:..:..:|::.:...|:..::...:|:..| |.:...||:.    :
Human   248 IQNHHEVST---EGEEEARTSKLLPLEKISIESQEEDGDIEVEEAEGEE-NDRPYNLRQR----K 304

  Fly    67 EQGSYVGEVVKPMDKKK---VLVKVH--PEGKFVVDLDKN-IDINDVTPNCRVAL-RNESYTL-- 122
            ....|....:.|..:||   .|..:|  |..:..:...|: |..:|.|.:..... |.:|.::
Human   305 TVDRYQAPPIVPAHQKKRENTLFDIHRSPARRSHIRRKKHAIHSSDTTSSDEERFERRKSKSMAR 369

  Fly   123 --HKILPN--KVDPLVSLMMVEKVP-------------DST--YEMVGGLDKQIKEIKEVIELPV 168
              ::.||.  :.:.|.|.::.|:|.             |.:  ::.:|||...|..:||::..|:
Human   370 ARNRCLPMNFRAEDLASGILRERVKVGASLADVDPMNIDKSVRFDSIGGLSHHIHALKEMVVFPL 434

  Fly   169 KHPELFDALGIAQPKGVLLYGPPGTGKTLLARAVAHHTECT-------FIRVSGSELVQKFIGEG 226
            .:||:|:...|..|:|.|.||||||||||:|||:|:  ||:       |....|::.:.|::||.
Human   435 LYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALAN--ECSQGDKKVAFFMRKGADCLSKWVGES 497

  Fly   227 SRMVRELFVMAREHAPSIIFMDEIDSIGSSRIESGSGGDSEVQRTMLELLNQLDGFEATKNIKVI 291
            .|.:|.||..|....|||||.||||.:...|........|.:..|:|.|   :||.:....|.||
Human   498 ERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLAL---MDGLDNRGEIVVI 559

  Fly   292 MATNRIDILDPALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMN--LTRGINLRKIAELMPGAS 354
            .||||:|.:||||.||||.||:..|..|:::||..||:||:|..|  |:... |.::||...|..
Human   560 GATNRLDSIDPALRRPGRFDREFLFNLPDQKARKHILQIHTRDWNPKLSDAF-LGELAEKCVGYC 623

  Fly   355 GAEVKGVCTEAGMYALRER--RVHVTQEDFEMAVAKVM 390
            ||::|.:||||.:.|||.|  :::.:....::.|:.::
Human   624 GADIKALCTEAALIALRRRYPQIYASSHKLQLDVSSIV 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpt6	NP_608447.1	RPT1	17..403	CDD:224143	130/413 (31%)
		SlyX	<27..>69	CDD:294687	7/41 (17%)
		AAA_16	152..>205	CDD:289934	27/52 (52%)
		AAA	185..317	CDD:278434	61/138 (44%)
ATAD2B	XP_011531220.1	AAA	447..588	CDD:214640	64/145 (44%)
		AAA	452..586	CDD:278434	62/138 (45%)
		COG5076	866..>1100	CDD:227408
		Bromo_AAA	974..1085	CDD:99957
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810