DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rpt6 and rpt6

DIOPT Version :9

Sequence 1:	NP_608447.1	Gene:	Rpt6 / 33105	FlyBaseID:	FBgn0020369	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_595870.1	Gene:	rpt6 / 2540487	PomBaseID:	SPBC23G7.12c	Length:	403	Species:	Schizosaccharomyces pombe

Alignment Length:	390	Identity:	315/390 - (80%)
Similarity:	351/390 - (90%)	Gaps:	1/390 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 EGFRSYYIQKIEELQLVVAEKHQNLRRLQAQRNELNAKVRMLREELQLLQEQGSYVGEVVKPMDK 81
            |....||.|||::.:|.:.:|.||||||:||||.|||:||:||||:|||||.|||||||:|.|.|
pombe    14 ENIVQYYTQKIQDAELAILQKTQNLRRLEAQRNGLNARVRLLREEIQLLQEPGSYVGEVIKTMGK 78

  Fly    82 KKVLVKVHPEGKFVVDLDKNIDINDVTPNCRVALRNESYTLHKILPNKVDPLVSLMMVEKVPDST 146
            .|||||||||||:|||:..:|||.::.||.||||||:||.|.||||||||||||||||||:||||
pombe    79 NKVLVKVHPEGKYVVDISPDIDIKEIKPNIRVALRNDSYQLIKILPNKVDPLVSLMMVEKIPDST 143

  Fly   147 YEMVGGLDKQIKEIKEVIELPVKHPELFDALGIAQPKGVLLYGPPGTGKTLLARAVAHHTECTFI 211
            |||||||:||||||||||||||||||||::|||.||||:|||||||||||||||||||||:|.||
pombe   144 YEMVGGLEKQIKEIKEVIELPVKHPELFESLGIPQPKGILLYGPPGTGKTLLARAVAHHTDCKFI 208

  Fly   212 RVSGSELVQKFIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRIE-SGSGGDSEVQRTMLEL 275
            ||||||||||:|||||||||||||||||||||||||||||||||||.: ||..||||||||||||
pombe   209 RVSGSELVQKYIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRSDSSGGSGDSEVQRTMLEL 273

  Fly   276 LNQLDGFEATKNIKVIMATNRIDILDPALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRG 340
            ||||||||||||||||||||||||||||||||||||||||||||:.|||.:||:||||.||||||
pombe   274 LNQLDGFEATKNIKVIMATNRIDILDPALLRPGRIDRKIEFPPPSAEARAEILRIHSRSMNLTRG 338

  Fly   341 INLRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK 405
            |:|:.|||.|.||||||:|||||||||:|||||||||||||||:|||||:.|.....||::||:|
pombe   339 IDLKSIAEKMNGASGAELKGVCTEAGMFALRERRVHVTQEDFELAVAKVLNKGDSGEMSLQKLFK 403

Fly 406 405
pombe 404 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpt6	NP_608447.1	RPT1	17..403	CDD:224143	312/386 (81%)
		SlyX	<27..>69	CDD:294687	27/41 (66%)
		AAA_16	152..>205	CDD:289934	47/52 (90%)
		AAA	185..317	CDD:278434	123/132 (93%)
rpt6	NP_595870.1	RPT1	3..401	CDD:224143	312/386 (81%)
		AAA_16	149..>202	CDD:289934	47/52 (90%)
		AAA	182..315	CDD:278434	123/132 (93%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	245	1.000	Domainoid score	I423
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2098
Inparanoid	1	1.050	624	1.000	Inparanoid score	I146
OMA	1	1.010	-	-		QHG53670
OrthoFinder	1	1.000	-	-		FOG0003106
OrthoInspector	1	1.000	-	-		otm47048
orthoMCL	1	0.900	-	-		OOG6_101513
Panther	1	1.100	-	-	LDO	PTHR23073
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1002
SonicParanoid	1	1.000	-	-		X2077
TreeFam	1	0.960	-	-
	14	13.860