DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rpt6 and Katna1

DIOPT Version :9

Sequence 1:	NP_608447.1	Gene:	Rpt6 / 33105	FlyBaseID:	FBgn0020369	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_035965.2	Gene:	Katna1 / 23924	MGIID:	1344353	Length:	493	Species:	Mus musculus

Alignment Length:	314	Identity:	120/314 - (38%)
Similarity:	175/314 - (55%)	Gaps:	46/314 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 NKVD------PLVSLM---MVEKVPDSTYEMVGGLDKQIKEIKEVIELPVKHPELFDALGIAQP- 182
            ||.|      .||..:   ::.:.|:..:..:..|.:..|.::|.:.||:..||.|.  ||.:|
Mouse   182 NKFDGTGYDKDLVEALERDIISQNPNVRWYDIADLVEAKKLLQEAVVLPMWMPEFFK--GIRRPW 244

  Fly   183 KGVLLYGPPGTGKTLLARAVAHHTEC--TFIRVSGSELVQKFIGEGSRMVRELFVMAREHAPSII 245
            ||||:.|||||||||||:|||  |||  ||..||.|.|..|:.||..::||.||.|||.::|:.|
Mouse   245 KGVLMVGPPGTGKTLLAKAVA--TECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATI 307

  Fly   246 FMDEIDSIGSSRIESGSGGDSEVQRTM-LELLNQLDGF-------EATKNIKVIMATNRIDILDP 302
            |:||||||.|.|   |:..:.|..|.| .|||.|:||.       :.:|.:.|:.|||....:|.
Mouse   308 FIDEIDSICSRR---GTSEEHEASRRMKAELLVQMDGVGGASENDDPSKMVMVLAATNFPWDIDE 369

  Fly   303 ALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGM 367
            ||.|  |::::|..|.|:.:.|.::|:|..|::.|...:||..|||.|.|.|||::..||.:|.:
Mouse   370 ALRR--RLEKRIYIPLPSAKGREELLRISLRELELADDVNLASIAENMEGYSGADITNVCRDASL 432

  Fly   368 YALRER---------------RVHV--TQEDFEMAVAKVMQKDSEKNMSIKKLW 404
            .|:|.|               .:|:  |.||||||:.|:.:..|..::...:.|
Mouse   433 MAMRRRIEGLTPEEIRNLSREAMHMPTTMEDFEMALKKISKSVSAADIERYEKW 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpt6	NP_608447.1	RPT1	17..403	CDD:224143	119/311 (38%)
		SlyX	<27..>69	CDD:294687
		AAA_16	152..>205	CDD:289934	29/53 (55%)
		AAA	185..317	CDD:278434	67/141 (48%)
Katna1	NP_035965.2	AAA	243..384	CDD:214640	71/147 (48%)
		AAA	247..383	CDD:278434	67/142 (47%)
		Vps4_C	<458..491	CDD:286426	10/29 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900