DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rpt6 and SHPK

DIOPT Version :9

Sequence 1:	NP_608447.1	Gene:	Rpt6 / 33105	FlyBaseID:	FBgn0020369	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_037408.2	Gene:	SHPK / 23729	HGNCID:	1492	Length:	478	Species:	Homo sapiens

Alignment Length:	258	Identity:	53/258 - (20%)
Similarity:	85/258 - (32%)	Gaps:	76/258 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 LRNESYTLHKILPNKVDP-----LVSLMMVEKVPDST-------------YEMVGGLDKQIKEIK 161
            ||:..:.:| :||:..:|     ..|.|..| :|..|             |..:......:..|.
Human   217 LRSSGFPVH-LLPDIAEPGSVAGRTSHMWFE-IPKGTQVGVALGDLQASVYSCMAQRTDAVLNIS 279

  Fly   162 EVIELPVKHPELFDALGIAQPKGVLLYGPPGTGKTLLARAVA---HHTECTFIRVSGSELVQKFI 223
            ..::|....|..|.......|...:.|. |...:|.|..|.:   .:...||:.:    |||...
Human   280 TSVQLAASMPSGFQPAQTPDPTAPVAYF-PYFNRTYLGVAASLNGGNVLATFVHM----LVQWMA 339

  Fly   224 GEG---------SRMVRELF------------VMAREHAPSIIFMDEIDSIGSSRIESGSGGDSE 267
            ..|         |||::...            |:...|.|     |::.|:  :||.|.......
Human   340 DLGLEVEESTVYSRMIQAAVQQRDTHLTITPTVLGERHLP-----DQLASV--TRISSSDLSLGH 397

  Fly   268 VQR-----------TMLELLNQLDGFEATKNIKVIMATNRIDILDPALLRPGRIDRKIEFPPP 319
            |.|           :||. :.||..:...:.:....|.:|.|:|...:.|        .||.|
Human   398 VTRALCRGIVQNLHSMLP-IQQLQEWGVERVMGSGSALSRNDVLKQEVQR--------AFPLP 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpt6	NP_608447.1	RPT1	17..403	CDD:224143	53/258 (21%)
		SlyX	<27..>69	CDD:294687
		AAA_16	152..>205	CDD:289934	10/55 (18%)
		AAA	185..317	CDD:278434	33/166 (20%)
SHPK	NP_037408.2	FGGY_SHK_like	5..468	CDD:212661	53/258 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900