DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rpt6 and KATNA1

DIOPT Version :9

Sequence 1:	NP_608447.1	Gene:	Rpt6 / 33105	FlyBaseID:	FBgn0020369	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_008975.1	Gene:	KATNA1 / 11104	HGNCID:	6216	Length:	491	Species:	Homo sapiens

Alignment Length:	393	Identity:	135/393 - (34%)
Similarity:	200/393 - (50%)	Gaps:	73/393 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 NELNAKVRMLREELQLLQEQGSYVGEVVKPMDKKKVLVKVHPEGKFVVDLDKNIDINDVTPNCRV 113
            |..:..||:.|...|.:....   |:.|:..:||              :.:|..:..:.:|
Human   128 NRPSTTVRVHRSSAQNVHNDR---GKAVRCREKK--------------EQNKGREEKNKSP---- 171

  Fly   114 ALRNESYTLHKILPNKVD------PLVSLM---MVEKVPDSTYEMVGGLDKQIKEIKEVIELPVK 169
            |...|..|      ||.|      .||..:   ::.:.|:..::.:..|.:..|.:||.:.||:.
Human   172 AAVTEPET------NKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMW 230

  Fly   170 HPELFDALGIAQP-KGVLLYGPPGTGKTLLARAVAHHTEC--TFIRVSGSELVQKFIGEGSRMVR 231
            .||.|.  ||.:| ||||:.|||||||||||:|||  |||  ||..||.|.|..|:.||..::||
Human   231 MPEFFK--GIRRPWKGVLMVGPPGTGKTLLAKAVA--TECKTTFFNVSSSTLTSKYRGESEKLVR 291

  Fly   232 ELFVMAREHAPSIIFMDEIDSIGSSRIESGSGGDSEV-QRTMLELLNQLDGFEAT-------KNI 288
            .||.|||.::|:.||:||||||.|.|   |:..:.|. :|...|||.|:||...|       |.:
Human   292 LLFEMARFYSPATIFIDEIDSICSRR---GTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMV 353

  Fly   289 KVIMATNRIDILDPALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGA 353
            .|:.|||....:|.||.|  |::::|..|.|:.:.|.::|:|..|::.|...::|..|||.|.|.
Human   354 MVLAATNFPWDIDEALRR--RLEKRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGY 416

  Fly   354 SGAEVKGVCTEAGMYALRER---------------RVHV--TQEDFEMAVAKVMQKDSEKNMSIK 401
            |||::..||.:|.:.|:|.|               .:|:  |.||||||:.||.:..|..::...
Human   417 SGADITNVCRDASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSAADIERY 481

  Fly   402 KLW 404
            :.|
Human   482 EKW 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpt6	NP_608447.1	RPT1	17..403	CDD:224143	134/390 (34%)
		SlyX	<27..>69	CDD:294687	5/19 (26%)
		AAA_16	152..>205	CDD:289934	30/53 (57%)
		AAA	185..317	CDD:278434	67/141 (48%)
KATNA1	NP_008975.1	Interaction with microtubules	1..185		17/83 (20%)
		Interaction with dynein and NDEL1. /evidence=ECO:0000250	1..75
		Interaction with KATNB1. /evidence=ECO:0000269\|PubMed:10751153	1..29
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	87..185		17/83 (20%)
		AAA	241..382	CDD:214640	71/147 (48%)
		AAA	245..381	CDD:278434	67/142 (47%)
		Vps4_C	<456..489	CDD:286426	11/29 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810