Protein Alignment Rpt6 and YME1L1

DIOPT Version :10

• Sequence 1: NP_608447.1
• Gene: Rpt6 / 33105
• FlyBaseID: FBgn0020369
• Length: 405
• Species: Drosophila melanogaster
• Sequence 2: NP_647473.1
• Gene: YME1L1 / 10730
• HGNCID: 12843
• Length: 773
• Species: Homo sapiens
• Alignment Length: 385
• Identity: 123/385 - (31%)
• Similarity: 204/385 - (52%)
• Gaps: 38/385 - (9%)

  Fly    42 RRLQAQRNELNAKVRMLREELQ---LLQEQGSYVGEVVKPMDKKKVLVKVHPEGKFVVDLDKNID 103
            ||||:....| |:.:.:.....   ||:::||.|..:.|.| |.|.:.:.|.:.......:..:.
Human   216 RRLQSTSERL-AETQNIAPSFVKGFLLRDRGSDVESLDKLM-KTKNIPEAHQDAFKTGFAEGFLK 278

  Fly   104 INDVTPNCRVALRNESYTLHKI-----------------------LPNKVDPLVSLMMVEKVPDS 145
            ...:|.....:||.....|..:                       |.:.|||:       ::.:.
Human   279 AQALTQKTNDSLRRTRLILFVLLLFGIYGLLKNPFLSVRFRTTTGLDSAVDPV-------QMKNV 336

  Fly   146 TYEMVGGLDKQIKEIKEVIELPVKHPELFDALGIAQPKGVLLYGPPGTGKTLLARAVAHHTECTF 210
            |:|.|.|:::..:|::||:|. :|:|:.|..||...|||:||.|||||||||||||||...:..|
Human   337 TFEHVKGVEEAKQELQEVVEF-LKNPQKFTILGGKLPKGILLVGPPGTGKTLLARAVAGEADVPF 400

  Fly   211 IRVSGSELVQKFIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRIESGSGGDSEVQRTMLEL 275
            ...||||..:.|:|.|:..:|.||..|:.:||.:||:||:||:|..||||.....|  ::|:.:|
Human   401 YYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPMHPYS--RQTINQL 463

  Fly   276 LNQLDGFEATKNIKVIMATNRIDILDPALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRG 340
            |.::|||:..:.:.:|.|||..:.||.||:||||.|.::..|.|:.:.|.:|||.:..|:...:.
Human   464 LAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFDQS 528

  Fly   341 INLRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSI 400
            ::...||....|.||||::.:..:|.:.|..:.:..||.::.|.:..|::.....:::.|
Human   529 VDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKELEFSKDKILMGPERRSVEI 588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rpt6	NP_608447.1	PRK03992	23..399	CDD:179699	122/382 (32%)
YME1L1	NP_647473.1	HflB	<332..767	CDD:440233	99/260 (38%)