DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rpt6 and atad2b

DIOPT Version :9

Sequence 1:	NP_608447.1	Gene:	Rpt6 / 33105	FlyBaseID:	FBgn0020369	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_001352895.1	Gene:	atad2b / 100331225	ZFINID:	ZDB-GENE-110411-210	Length:	1402	Species:	Danio rerio

Alignment Length:	388	Identity:	128/388 - (32%)
Similarity:	200/388 - (51%)	Gaps:	53/388 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 EKHQNLR-RLQAQRNE------LNAKVRMLREELQLLQEQGSYVGEVVKPMDKKKVLVKVH---- 89
            ::..||| |...||.|      :|.|           |.:||.......|..:..:.:|.|
Zfish   275 DRPYNLRQRKTVQRYEAPPIEPVNRK-----------QSKGSLFDTHRSPARRSHIRIKKHAIHS 328

  Fly    90 -------PEGKFVVDLDKNIDINDVTPNC-RVALRNESYTLHKILPNKVDPLVSLMMVEKVPDST 146
                   .|.:|  :..|:..::.....| .:.||.|... ..:|.::|....||..|:.:...|
Zfish   329 SESTSSSDEERF--ERRKSKSMSRARNRCLPMNLRAEDLA-SGVLRDRVKVGASLADVDPMNLDT 390

  Fly   147 ---YEMVGGLDKQIKEIKEVIELPVKHPELFDALGIAQPKGVLLYGPPGTGKTLLARAVAHHTEC 208
               ::.||||...|:.:||::..|:.:|::|:...|..|:|.|.||||||||||:|||:|:  ||
Zfish   391 SVKFDSVGGLTHHIQSLKEMVVFPLLYPQVFEKFKIQPPRGCLFYGPPGTGKTLVARALAN--EC 453

  Fly   209 -------TFIRVSGSELVQKFIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRIESGSGGDS 266
                   :|....|::.:.|::||..|.:|.||..|....|||||.||||.:...|........|
Zfish   454 SQGDRKVSFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSSRQDQIHS 518

  Fly   267 EVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDPALLRPGRIDRKIEFPPPNEEARLDILKIH 331
            .:..|:|.|   :||.::...|.||.||||:|.:||||.||||.||:..|..|:::||..||:||
Zfish   519 SIVSTLLAL---MDGLDSRGEIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDKKARKHILEIH 580

  Fly   332 SRKMN--LTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRER--RVHVTQEDFEMAVAKVM 390
            :|..:  |.... :.::||...|..||::|.:||||.:.|||.|  :::.:.:.:::.||.::
Zfish   581 TRDWSPKLAEPF-IDELAERCVGYCGADIKALCTEAALAALRRRYPQIYGSSQRYQLDVASIV 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpt6	NP_608447.1	RPT1	17..403	CDD:224143	128/388 (33%)
		SlyX	<27..>69	CDD:294687	10/39 (26%)
		AAA_16	152..>205	CDD:289934	26/52 (50%)
		AAA	185..317	CDD:278434	61/138 (44%)
atad2b	NP_001352895.1	SpoVK	<341..657	CDD:223540	111/309 (36%)
		P-loop_NTPase	767..879	CDD:328724
		Bromo_AAA	957..1068	CDD:99957
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900