DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1801 and rbbA

DIOPT Version :9

Sequence 1:	NP_728408.3	Gene:	CG1801 / 33104	FlyBaseID:	FBgn0031171	Length:	1655	Species:	Drosophila melanogaster
Sequence 2:	YP_026225.1	Gene:	rbbA / 947998	ECOCYCID:	EG12223	Length:	911	Species:	Escherichia coli

Alignment Length:	761	Identity:	166/761 - (21%)
Similarity:	301/761 - (39%)	Gaps:	160/761 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   458 LSRRIVNNRPRKQQESDTTIMYLGRAPSFQ--NFEFGDVGSVELMRL-RHVSTSHRDSERKILKN 519
            |....:|..|:.|:::...::    .|.:|  |.|.........||. ..|:..|
E. coli   244 LEEAFINLLPQAQRQAHQAVV----IPPYQPENAEIAIEARDLTMRFGSFVAVDH---------- 294

  Fly   520 ISMRIYRGEVFVILGHIGSGKLTLLRILAGLKFPLRGNVYIMGNPFEPNG-EARRLVDFRFDEHG 583
            ::.||.|||:|..||..|.||.|.:::|.||.....|..::.|.|.:|.. :.||.|.:......
E. coli   295 VNFRIPRGEIFGFLGSNGCGKSTTMKMLTGLLPASEGEAWLFGQPVDPKDIDTRRRVGYMSQAFS 359

  Fly   584 LNKHLTVEQTIDYHVRLKLSPSESDRYEI----ERRKWLAILDQHVESRGVRIGKLSSGSMKLVA 644
            |...|||.|.::.|.||...|.......:    ||.|...:.|...||       |..|..:.::
E. coli   360 LYNELTVRQNLELHARLFHIPEAEIPARVAEMSERFKLNDVEDILPES-------LPLGIRQRLS 417

  Fly   645 LCCCLAGDTPIIILEEPTTQLTGREAQIFWSI-VHAEKENRAFI-IATYNVGEAEHVADRIGILS 707
            |...:.....::||:|||:.:......:||.: |...::::..| |:|:.:.|||. .|||.::.
E. coli   418 LAVAVIHRPEMLILDEPTSGVDPVARDMFWQLMVDLSRQDKVTIFISTHFMNEAER-CDRISLMH 481

  Fly   708 MGVLEASGTP-FFLRSKFSSSVDLVIIKKPHVPDQPITDYINQFM-QNIEPENEIGDSLTYRLPV 770
            .|.:.||||| ..:..:.::|::...|.           |:.:.. |:.|.|..         ||
E. coli   482 AGKVLASGTPQELVEKRGAASLEEAFIA-----------YLQEAAGQSNEAEAP---------PV 526

  Fly   771 I----YRPR----LQKLLIHLEIDRKMLGIENVRVVGAELSDIYMTLVTSFRLQQQM------IP 821
            :    :.||    |::|..:...:...|..:.||...|.:..:.:.|:..:.:...:      :.
E. coli   527 VHDTTHAPRQGFSLRRLFSYSRREALELRRDPVRSTLALMGTVILMLIMGYGISMDVENLRFAVL 591

  Fly   822 DVTQTFKYQV-----------VSQKQLTK-----QRMRAMFYKKMIHTAPNVWPIIMIFTSFVLI 870
            |..||...|.           :.|..||.     :||||......|...||       |...:..
E. coli   592 DRDQTVSSQAWTLNLSGSRYFIEQPPLTSYDELDRRMRAGDITVAIEIPPN-------FGRDIAR 649

  Fly   871 AIIARLSVLLD--MPKERQNSIHIGFREPEDVVKYLPNLKDCGYIDIRSAVKVNKKKSVGVSRTF 933
            .....|.|.:|  ||.           ..|.|..|:..:......|:.|      ::|...|::
E. coli   650 GTPVELGVWIDGAMPS-----------RAETVKGYVQAMHQSWLQDVAS------RQSTPASQS- 696

  Fly   934 DDDSFVCEKGSYRNNLRKKNELRSFGAVESDGDEHLNGYISQDMFHSAPMMLNLLQNVILRLSYP 998
               ..:..:..||.|    .:::|..|:       :...|        |::|.::.:::..||..
E. coli   697 ---GLMNIETRYRYN----PDVKSLPAI-------VPAVI--------PLLLMMIPSMLSALSVV 739

  Fly   999 MQTDLVVLVENHPLPTQLSQKINVLDNKIAHIHVPLV-VGCIIPLTVSVFVIP----LVEEEIYD 1058
            .:.:|..::..:..||..|:.:  |..::.:|.:.:: ...:..|:|.||.:|    .:...:..
E. coli   740 REKELGSIINLYVTPTTRSEFL--LGKQLPYIALGMLNFFLLCGLSVFVFGVPHKGSFLTLTLAA 802

  Fly  1059 VRFLQHMAGLGLKV--FWGINLFWDWFTFFV-------YSVIIVVIMSLMGIG---GFGFYENAI 1111
            :.::....|:||.:  |....:...:.|..:       :|.:|..:.||.|.|   |..:..:..
E. coli   803 LLYIIIATGMGLLISTFMKSQIAAIFGTAIITLIPATQFSGMIDPVASLEGPGRWIGEVYPTSHF 867

  Fly  1112 MVVLLTTFGLAALPLTYLVSMFVNKSIVRAFLVSV-LLQGVSGLVL 1156
            :.:...||. .||.||.|..:|:      ..|::: |:.|:|.|:|
E. coli   868 LTIARGTFS-KALDLTDLWQLFI------PLLIAIPLVMGLSILLL 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1801	NP_728408.3	ABC2_membrane_3	<246..379	CDD:289468
		ABC2_membrane_4	<293..448	CDD:289500
		EcfA2	499..717	CDD:224047	65/225 (29%)
		P-loop_NTPase	500..721	CDD:304359	67/229 (29%)
		ABC2_membrane_3	<972..1254	CDD:289468	42/203 (21%)
		EcfA2	1307..1521	CDD:224047
		P-loop_NTPase	1324..1524	CDD:304359
rbbA	YP_026225.1	ABC2_perm_RbbA	12..910	CDD:411426	166/761 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	228	1.000	Inparanoid score	I138
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
	1	1.050