DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1801 and PDR12

DIOPT Version :9

Sequence 1:	NP_728408.3	Gene:	CG1801 / 33104	FlyBaseID:	FBgn0031171	Length:	1655	Species:	Drosophila melanogaster
Sequence 2:	NP_015267.1	Gene:	PDR12 / 856049	SGDID:	S000005979	Length:	1511	Species:	Saccharomyces cerevisiae

Alignment Length:	1267	Identity:	236/1267 - (18%)
Similarity:	405/1267 - (31%)	Gaps:	475/1267 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   461 RIVNNRPRKQQES----------DTTIMYLGRAPSFQNFEFGDVG-------------------S 496
            |:::::.:|:.:|          .:.:.||......|..|.||.|                   |
Yeast    69 RVISHKTKKEMDSFEINDLDFDLRSLLHYLRSRQLEQGIEPGDSGIAFKNLTAVGVDASAAYGPS 133

  Fly   497 VELMRLRHVST--SHRDSE---------RKILKNISMRIYRGEVFVILGHIGSGKLTLLRILAGL 550
            ||.| .|::::  :|..|:         |.|::|.:..:..||:..::|..|:|..|.|:.|
Yeast   134 VEEM-FRNIASIPAHLISKFTKKSDVPLRNIIQNCTGVVESGEMLFVVGRPGAGCSTFLKCL--- 194

  Fly   551 KFPLRGNVYIMGNPFEPNGEARRLVDFR--FDEHGLNK----------------------HLTVE 591
                             :||...|||.:  |...||::                      .:||:
Yeast   195 -----------------SGETSELVDVQGEFSYDGLDQSEMMSKYKGYVIYCPELDFHFPKITVK 242

  Fly   592 QTIDYHVRLKLSPSESDRYEIE------RRKWLAILD-QHVESRGVRIGK-----LSSGSMKLVA 644
            :|||:.::.|......|:...:      |..|..:.. :|  :...::|.     :|.|..|.|:
Yeast   243 ETIDFALKCKTPRVRIDKMTRKQYVDNIRDMWCTVFGLRH--TYATKVGNDFVRGVSGGERKRVS 305

  Fly   645 LCCCLAGDTPIIILEEPTTQLTGREAQIFWSIVHAEKE--NRAFIIATYNVGE-AEHVADRIGIL 706
            |....|.:..|...:..|..|....|..|...:.....  |.:.|:|.|..|| ...:.|:..:|
Yeast   306 LVEAQAMNASIYSWDNATRGLDASTALEFAQAIRTATNMVNNSAIVAIYQAGENIYELFDKTTVL 370

  Fly   707 SMG-------VLEASGTPFFLR-----------SKFSSSVDL-----VIIKKPHVPD-------- 740
            ..|       ..:|.|  :|.|           ::|.:||.:     .:..||...|
Yeast   371 YNGRQIYFGPADKAVG--YFQRMGWVKPNRMTSAEFLTSVTVDFENRTLDIKPGYEDKVPKSSSE 433

  Fly   741 ---------------QPITDYINQFMQNIEPENEIGDSLTYRLPVIYRPRLQKLLIHLEIDRKML 790
                           :...||     |:..|.||..|    ||.|..:.|||:
Yeast   434 FEEYWLNSEDYQELLRTYDDY-----QSRHPVNETRD----RLDVAKKQRLQQ------------ 477

  Fly   791 G-IENVRVVGAELSDIYMTLVTSFRLQQQMIPDVTQTFKYQVVSQKQLTKQRMRAMFYKKMIHTA 854
            | .||.:.|....:.:|..::..|   |::..|.|.|..|
Yeast   478 GQRENSQYVVNYWTQVYYCMIRGF---QRVKGDSTYTKVY------------------------- 514

  Fly   855 PNVWPIIMIFTSFVLIAIIARLSVLLDMPKERQNSIHIGFREPEDVVKYLPNLKDCGYIDIRSAV 919
                     .:||::.|:|                  ||
Yeast   515 ---------LSSFLIKALI------------------IG-------------------------- 526

  Fly   920 KVNKKKSVGVSRTFDDDSFVCEKGSYRNN--------LRKKNELRSFGAVESDGDEHLNGYISQD 976
                    .:....||.|.....|:|...        ......|...|                :
Yeast   527 --------SMFHKIDDKSQSTTAGAYSRGGMLFYVLLFASVTSLAEIG----------------N 567

  Fly   977 MFHSAPMMLNLLQNVILRLSYPMQTDLVVLVENHPLPTQLSQKINVLDNKIAHIHVPLVVGCIIP 1041
            .|.|.|:       ::...||.|.         |.....|.:.|.....|.    |.:|:.|:|
Yeast   568 SFSSRPV-------IVKHKSYSMY---------HLSAESLQEIITEFPTKF----VAIVILCLI- 611

  Fly  1042 LTVSVFVIPLVEEEIYDVRFLQHMAGLGLKVFWGINLFWDWFTFFVYSVII----------VVIM 1096
                          .|.:.|:::.||.             :|.:.:|.:.:          |..|
Yeast   612 --------------TYWIPFMKYEAGA-------------FFQYILYLLTVQQCTSFIFKFVATM 649

  Fly  1097 SLMG-----IGGFGFYENAIMVVLLTTFGLAAL----------------PLTYLVSMFVNKSI-V 1139
            |..|     :||       :.|::|..:....|                ||||.....|:... .
Yeast   650 SKSGVDAHAVGG-------LWVLMLCVYAGFVLPIGEMHHWIRWLHFINPLTYAFESLVSTEFHH 707

  Fly  1140 RAFLVSVLLQGVSGLVLYIIYWDVANSNTIFFYAACMSPGFSLLDGVSNVYAQNLEQAICIDKCE 1204
            |..|.|.|:.  ||                        ||:   :|:|          |....|:
Yeast   708 REMLCSALVP--SG------------------------PGY---EGIS----------IANQVCD 733

  Fly  1205 ATDSCTEENM-----NEVVPNCKFDTFFKWAAPGILPPILYMVLSALIFLMLIFWIELHRREKKF 1264
            |. ...:.|:     :.::....|.....|...|:  .|::      .|..::|.:.|....|..
Yeast   734 AA-GAVKGNLYVSGDSYILHQYHFAYKHAWRNWGV--NIVW------TFGYIVFNVILSEYLKPV 789

  Fly  1265 HTSRDLRKMRTATYPFDDGDVADV----KQKIAEA--------DNTKAKQSVFLVDQVEARVPAA 1317
            ....||...:....|....:.||.    ::::.||        :...|::.||..:.::..:|..
Yeast   790 EGGGDLLLYKRGHMPELGTENADARTASREEMMEALNGPNVDLEKVIAEKDVFTWNHLDYTIPYD 854

  Fly  1318 GKRIHTVSFALNKYMSMG----IFGPRNSGKSHLMRQLVGQR---GFAFGEIYVRGLDFKYDLES 1375
            |.....:|.... |:..|    :.|...:||:.|: .::.||   |...|::.|......   .|
Yeast   855 GATRKLLSDVFG-YVKPGKMTALMGESGAGKTTLL-NVLAQRINMGVITGDMLVNAKPLP---AS 914

  Fly  1376 IHTYMGYSPQHRGLLNELTPREHIRLLCMIRGVPEAKIGEKMHDLCLMLNMTGWMHRKCSL---- 1436
            .:...||..|....:.||:.||.:|....:|......:.||...:..::.:.|..:...:|
Yeast   915 FNRSCGYVAQADNHMAELSVRESLRFAAELRQQSSVPLEEKYEYVEKIITLLGMQNYAEALVGKT 979

  Fly  1437 ---LTAEKRHKLKIALALVAYNKILV-LDEPTCGMPATTRREIWNILRYIRY---CGKTIIFATN 1494
               |..|:|.||.|.:.|||...:|: |||||.|:.:   :..|:|::::|.   .|::|:
Yeast   980 GRGLNVEQRKKLSIGVELVAKPSLLLFLDEPTSGLDS---QSAWSIVQFMRALADSGQSIL---- 1037

  Fly  1495 DELECKILADFIILFQDSEMLAI----GSLQY 1522
                |.|......||:..:.|.:    |.:.|
Yeast  1038 ----CTIHQPSATLFEQFDRLLLLKKGGKMVY 1065

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1801	NP_728408.3	ABC2_membrane_3	<246..379	CDD:289468
		ABC2_membrane_4	<293..448	CDD:289500
		EcfA2	499..717	CDD:224047	56/274 (20%)
		P-loop_NTPase	500..721	CDD:304359	57/277 (21%)
		ABC2_membrane_3	<972..1254	CDD:289468	53/318 (17%)
		EcfA2	1307..1521	CDD:224047	55/235 (23%)
		P-loop_NTPase	1324..1524	CDD:304359	54/221 (24%)
PDR12	NP_015267.1	3a01205	89..1468	CDD:273362	233/1247 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	105	1.000	Inparanoid score	I1418
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050