DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1801 and PDR10

DIOPT Version :9

Sequence 1:	NP_728408.3	Gene:	CG1801 / 33104	FlyBaseID:	FBgn0031171	Length:	1655	Species:	Drosophila melanogaster
Sequence 2:	NP_014973.1	Gene:	PDR10 / 854506	SGDID:	S000005855	Length:	1564	Species:	Saccharomyces cerevisiae

Alignment Length:	1250	Identity:	222/1250 - (17%)
Similarity:	390/1250 - (31%)	Gaps:	474/1250 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   496 SVELMRLRHVSTSHRDSERKILKNISMRIYRGEVFVILGHIGSGKLTLLRILA----GLKFPLRG 556
            |..|....|..:...||..:|||.:...|..||:.|:||..|:|..|||:.::    |  |.:..
Yeast   175 SRRLFHRTHGKSEDNDSGFQILKPMDGCINPGELLVVLGRPGAGCTTLLKSISVNTHG--FKISP 237

  Fly   557 NVYIMGNPF---EPNGEARRLVDFRFDEHGLNKHLTVEQTIDYHVRLKLSPSESDRYEIERRKWL 618
            :..|..|.|   |.....|..|.:..:......||||.||:               |.:.|
Yeast   238 DTIITYNGFSNKEIKNHYRGEVVYNAESDIHIPHLTVFQTL---------------YTVAR---- 283

  Fly   619 AILDQHVESRGVRIGKLSSGSMKLVALCCCLAGDTPIIILEEPTTQLTGREAQIFWSIVHAEKEN 683
                                                   |:.|..::.|.:...|      .|..
Yeast   284 ---------------------------------------LKTPRNRIKGVDRDTF------AKHM 303

  Fly   684 RAFIIATYNVGEAEHVAD-RIGILSMGVLEASGTPFFLRSKFSSSVDLVIIKKPHVPDQPITDYI 747
            ....:|||.:   .|.|| ::|
Yeast   304 TEVAMATYGL---SHTADTKVG------------------------------------------- 322

  Fly   748 NQFMQNIEPENEIGDSLTYRLPVIYRPRLQKLLIHLEIDRKMLGIENVRVVGAEL---------- 802
            |.|::.:...                            :||.:.|..|.:.|::.
Yeast   323 NDFVRGVSGG----------------------------ERKRVSIAEVSICGSKFQCWDNATRGL 359

  Fly   803 -SDIYMTLVTSFRLQ------------QQMIPDVTQTFK--------YQVV--SQKQLTKQRMRA 844
             |...:..:.:.:.|            .|...|....|.        ||:.  ..||..|
Yeast   360 DSATALEFIKALKTQATITKSAATVAIYQCSKDAYDLFDKVCVLYDGYQIFFGPSKQAKK----- 419

  Fly   845 MFYKKMIHTAPNVWPIIMIFTSFVLIAIIARLSVLLDMPKERQNSIHIGFREPEDVVKYLPNLKD 909
             ::::|.:..|.........||             :..|.||        .:.:|:||:
Yeast   420 -YFQRMGYVCPERQTTADYLTS-------------ITSPSER--------IKDKDMVKH------ 456

  Fly   910 CGYIDIRSAVKVN---------KKKSVGVSRTFDDDSFVCEKGSYRNNLRKKNELRSFGAVESDG 965
             |.:..::|.::|         |:..|.|::..|.||           .:::.:::
Yeast   457 -GIMIPQTAYEMNQYWIQSEEYKQLQVQVNKHLDTDS-----------SQQREQIK--------- 500

  Fly   966 DEHLNGYISQDMFHSAPMMLNLLQNVILRLSYPMQTDLVVLVENHPLPTQLSQKINVLDNKIAHI 1030
                |.:|::....:.|.....: :..|::.|.:..| :..::|.|    ..|...||    :|.
Yeast   501 ----NAHIAKQSKRARPSSPYTV-SFFLQVKYILIRD-IWRIKNDP----SIQLFTVL----SHA 551

  Fly  1031 HVPLVVG-----CIIPLTVSVFVI---------------------------PLVEE-EIYDV--- 1059
            .:.|::|     .::..|.:.|..                           |:.|: :.|.:
Yeast   552 AMALILGSMFYEVMLSTTTTTFYYRGAAIFFAILFNAFSSLLEIFSLYETRPITEKHKTYSLYRP 616

  Fly  1060 ---RFLQHMAGLGLKV----------FWGINLFWDWFTFFVYSVIIVVIMSLMG-----IGGFGF 1106
               .|....:.:..|:          ::.|||..|...||.|.:|.::.:..|.     ||.
Yeast   617 SADAFASTFSDVPTKLATAVTFNIPYYFLINLKRDAGAFFFYFLINIITVFAMSHLFRCIGS--- 678

  Fly  1107 YENAIMVVLLTTFGLAALPLTYLV---SMFVNKSIVRAFLVSVLLQGVSGLVLYIIYWDVANSNT 1168
                    :..|...|.:|.:.|:   :|:...:|.|     |.:.|.|..:.||      |..:
Yeast   679 --------VSKTLPQAMVPASVLLLAFAMYTGFAIPR-----VQMLGWSKWISYI------NPLS 724

  Fly  1169 IFFYAACMSPGFSLLDGVSNVYAQNLEQAICIDK-------------CEATDSCTEENM----NE 1216
            ..|.        ||:  ::..:.:|...|..|..             |.|..|....|.    :.
Yeast   725 YLFE--------SLM--INEFHGRNFPCAQYIPSGPNYVNATGDEVTCSALGSIPGNNYVSGDDF 779

  Fly  1217 VVPNCKFDTFFKWAAPGI-LPPILYMVLSALIFL-----------MLIFWIELHRREKKFHTSRD 1269
            :..|..:....||.:.|| |..|::.:...|.|.           ||:|...:.::.||.....:
Yeast   780 IQTNYGYRHKNKWRSVGIGLAYIIFFLFLYLFFCEYNEGAKQNGEMLVFPHSVVKKMKKKGIVSE 844

  Fly  1270 LRKMRTATYPFDDGDVADVKQKIAEADNTKAKQSVFLVDQVEARVPAAGKRI------------- 1321
            .:|....|.     ..:|.::.:...:|:.|..|.||.|. :|.:....|.:
Yeast   845 KKKKNQPTL-----STSDAEKDVEMNNNSSATDSRFLRDS-DAAIMGNDKTVAKEHYSSPSSSAS 903

  Fly  1322 HTVSFA------LNKYMSMGIF-----------------------------------GPRNSGKS 1345
            .:.||:      |:|  |..||                                   |...:||:
Yeast   904 QSNSFSKSDDIELSK--SQAIFHWKNLCYDIPIKNGKRRILDNVDGWVKPGTLTALIGASGAGKT 966

  Fly  1346 HLMRQLVGQ--RGFAFGEIYVRGLDFKYDLESIHTYMGYSPQHRGLLNELTPREHIRLLCMIRGV 1408
            .|:..|..:  .|...|:::|.|   :...:|....:||..|....|...|.||.:|....:|..
Yeast   967 TLLDCLAERTTMGLITGDVFVDG---RPRDQSFPRSIGYCQQQDLHLKTATVRESLRFSAYLRQA 1028

  Fly  1409 PEAKIGEK---MHDLCLMLNMTGWMHRKCSL----LTAEKRHKLKIALALVAYNKILV-LDEPTC 1465
            .:..|.||   :.::..:|.|..:......:    |..|:|.:|.|.:.|.|..|:|| |||||.
Yeast  1029 DDVSIEEKDKYVEEVIEVLEMKLYADAIVGVPGEGLNVEQRKRLTIGVELAAKPKLLVFLDEPTS 1093

  Fly  1466 GMPATTRREIWNILRYIRYCGKTIIFATNDELECKILADFIILFQDSEMLAI------------- 1517
            |:.:.|......:::.:...|:.|:        |.|.....:|.|:.:.|..
Yeast  1094 GLDSQTAWSTCQLMKKLASRGQAIL--------CTIHQPSALLMQEFDRLLFLQEGGQTVYFGEL 1150

  Fly  1518 --GSLQYLRYKYSHG 1530
              |....:.|..:||
Yeast  1151 GKGCKTMINYFEAHG 1165

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1801	NP_728408.3	ABC2_membrane_3	<246..379	CDD:289468
		ABC2_membrane_4	<293..448	CDD:289500
		EcfA2	499..717	CDD:224047	46/225 (20%)
		P-loop_NTPase	500..721	CDD:304359	45/228 (20%)
		ABC2_membrane_3	<972..1254	CDD:289468	65/367 (18%)
		EcfA2	1307..1521	CDD:224047	59/292 (20%)
		P-loop_NTPase	1324..1524	CDD:304359	56/265 (21%)
PDR10	NP_014973.1	3a01205	110..1556	CDD:273362	221/1249 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	105	1.000	Inparanoid score	I1418
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050