DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1801 and ABCA8

DIOPT Version :9

Sequence 1:	NP_728408.3	Gene:	CG1801 / 33104	FlyBaseID:	FBgn0031171	Length:	1655	Species:	Drosophila melanogaster
Sequence 2:	NP_190363.3	Gene:	ABCA8 / 823933	AraportID:	AT3G47790	Length:	901	Species:	Arabidopsis thaliana

Alignment Length:	823	Identity:	176/823 - (21%)
Similarity:	336/823 - (40%)	Gaps:	156/823 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   850 MIHTAPNVWPIIMIFTSFVLIAIIARLSVLLDMPKERQNSIHIGFRE--PEDVVKYLPNLKDCGY 912
            :||.:|..:|        ..:..:..|::..:...:..|.:..|:|:  |:..:.     :..|.
plant   188 LIHQSPLAFP--------KEVNCVQGLNLWRNSSSDVNNELFKGYRKGNPDKKIN-----EFAGA 239

  Fly   913 IDIRSAVKVNKKKSVGVSRTFDDDSFVCEKGSYRNNLRKKNELRSFGAVESDGDEHLNGYISQDM 977
            .|.::....|...||..:.|:.:|:.|......|
plant   240 FDFQNTNGNNLNVSVWYNSTYKNDTVVRPMALIR------------------------------- 273

  Fly   978 FHSAPMMLNLLQNVILRLSYPMQTDLVV-LVENHPLP-TQLSQKINVLDNKIAHIHVPLVVGCII 1040
               .|.::||..|..|......:|.::. .|:..|.| |:||     ||  ||.:..||....:|
plant   274 ---VPRLVNLASNAYLEFLKGSETKILFEYVKEMPKPETKLS-----LD--IASLIGPLFFTWVI 328

  Fly  1041 PLTVSVFVIPLVEEEIYDVRFLQHMAGLGLKVFWGINLFWDWFTFF-----VYSVIIVVIMSLMG 1100
            .|...|.:..||.|:...:|.:..|.|||...:|.::     :|:|     :|.:...:..||:|
plant   329 LLLFPVILTTLVYEKQQRLRIMMKMHGLGDVPYWIVS-----YTYFLLISILYMLCFAIFGSLIG 388

  Fly  1101 IGGFGFYENAIMVVLLTTFGLAALPLTYLVS-MF--VNKSIVRAFLVSVLLQGVSGLVLYIIY-- 1160
            :..|...:.:|.:|.........:.:.:|.| ||  |..:.|.|: :.|...|:.|:.|:..:
plant   389 LNFFRLNDYSIQLVFFFICINLQISVAFLASAMFSDVKTATVIAY-IYVFGTGLLGIFLFQFFLE 452

  Fly  1161 -------WDVANSNTIFFYAACMSPGFSLLDGVSNVYAQNLEQAICIDKCEATDSCTEENMNEVV 1218
                   |.:|..         :.|||||..|:     ..|.|:.........|.
plant   453 DPLFPRGWIIAME---------LYPGFSLYRGL-----YELSQSAFAGDYRGIDG---------- 493

  Fly  1219 PNCKFDTFFKWA--APGILPPILYMVLSALIFLMLIFWIE--LHRR------------EKKFHTS 1267
                    .||.  ..|:......|::..|:.|.|.::|:  ::.|            :||.|.|
plant   494 --------MKWRDFGNGMKEVTCIMLIEWLLLLGLAYYIDQIIYSRKHPLFFLLQSTSKKKQHFS 550

  Fly  1268 RDLRKMRTATYPFDDGDVADVKQKIAEADNTKAKQSVFLVDQVEARVPAAGK-------RIHTVS 1325
            .:  |:.......:..||...::|:.:......:.|..|.:.:  :...:||       .:..:|
plant   551 DN--KISKVVVEMEKPDVCREREKVEQCLLKSTRDSAVLCNNL--KKVYSGKDGNPQKLAVRGLS 611

  Fly  1326 FALNKYMSMGIFGPRNSGKSHLMRQLVGQRGFAFGEIYVRGLDFKYDLESIHTYMGYSPQHRGLL 1390
            .||.:....|:.||..:||:..:..:.|....:.|..:|:|||...|::.|:|.:|..|||..|.
plant   612 LALPQGECFGMLGPNGAGKTSFINMMTGIIKPSSGTAFVQGLDILTDMDRIYTTIGVCPQHDLLW 676

  Fly  1391 NELTPREHIRLLCMIRGVPEAKIGEKMHDLCLMLNM--TGWMHRKCSLLTAEKRHKLKIALALVA 1453
            .:|:.|||:.....::.:..:.:.:.:.:....:|:  .|...::.|..:...:.:|.:|::|:.
plant   677 EKLSGREHLLFYGRLKNLKGSVLTQAVEESLRSVNLFHGGIGDKQVSKYSGGMKRRLSVAISLIG 741

  Fly  1454 YNKILVLDEPTCGMPATTRREIWNILRYIRYCGKTIIFATNDELECKILADFIILFQDSEMLAIG 1518
            ..|::.:|||:.|:...:|:.:|::::..:..| .||..|:...|.:||.|.|.:|.|..:..||
plant   742 SPKVVYMDEPSTGLDPASRKSLWDVVKRAKRKG-AIILTTHSMEEAEILCDRIGIFVDGSLQCIG 805

  Fly  1519 SLQYLRYKYSHGFYLEVRLIRDGATLAESEENLRKDVENLAKFVNFLHNRSELVGRLNNWFKFYV 1583
            :.:.|:.:|...:.|         |:..|||: .|:||.|   |:.:...::.:.|.....||.:
plant   806 NPKELKSRYGGSYVL---------TVTTSEEH-EKEVEQL---VHNISTNAKKIYRTAGTQKFEL 857

  Fly  1584 PVGHIVYSFLYGAMEKNKLRLNVSDYCIYQADMMSVVAQVQET 1626
            |...:....::.|:||.|....|..:.:....:..|..:|.:|
plant   858 PKQEVKIGEVFKALEKAKTMFPVVAWGLADTTLEDVFIKVAQT 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1801	NP_728408.3	ABC2_membrane_3	<246..379	CDD:289468
		ABC2_membrane_4	<293..448	CDD:289500
		EcfA2	499..717	CDD:224047
		P-loop_NTPase	500..721	CDD:304359
		ABC2_membrane_3	<972..1254	CDD:289468	68/302 (23%)
		EcfA2	1307..1521	CDD:224047	54/222 (24%)
		P-loop_NTPase	1324..1524	CDD:304359	52/201 (26%)
ABCA8	NP_190363.3	ABC2_membrane_3	<247..488	CDD:289468	67/301 (22%)
		BI-1-like	367..>451	CDD:294323	20/84 (24%)
		CcmA	585..897	CDD:224054	77/327 (24%)
		ABC_subfamily_A	590..811	CDD:213230	54/223 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810