DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1801 and ABCA5

DIOPT Version :9

Sequence 1:	NP_728408.3	Gene:	CG1801 / 33104	FlyBaseID:	FBgn0031171	Length:	1655	Species:	Drosophila melanogaster
Sequence 2:	NP_001326002.1	Gene:	ABCA5 / 823930	AraportID:	AT3G47760	Length:	936	Species:	Arabidopsis thaliana

Alignment Length:	879	Identity:	176/879 - (20%)
Similarity:	328/879 - (37%)	Gaps:	194/879 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   802 LSDIYMTLVTSFRLQQQMIPDVTQTFKYQVVSQKQLTKQRMRAMFYKKMIHTAP--NVWPIIMIF 864
            |||:.:     |.:|.:..||.| ||.:..         |...:.:.|.:....  |:|
plant   190 LSDLPI-----FNVQPRCTPDTT-TFSFPF---------RQSPLEFHKEVRCVEGLNLW------ 233

  Fly   865 TSFVLIAIIARLSVLLDMPKERQNSIHI------GFREP--EDVVKYLPNLKDCGYIDIRSAVKV 921
                                 |.|||.|      |:|:.  |:::..:....|....||.
plant   234 ---------------------RNNSIEISNEIFKGYRQGNLEEIINEVAAAYDLMDTDIN----- 272

  Fly   922 NKKKSVGVSRTFDDDSFVCEKGSYRNNLRKKNELRSFGAVESDGDEHLNGYISQDMFHSAPMMLN 986
            |...::..:.|:        ||..|:...|                    |:      ..|..:|
plant   273 NFNVTIWYNSTY--------KGDLRDRRVK--------------------YV------RVPRSVN 303

  Fly   987 LLQNVILRL----SYPMQTDLVVLVENHPLPTQLSQKINVLDNKIAHIHVPLVVGCIIPLTVSVF 1047
            |:.|..|..    ...|..|.|     ..:|.|.::    |..::|.:..|:....:|.|...|.
plant   304 LVSNAYLEFLQGSGTKMLFDFV-----KEMPKQETR----LRLEMASLIGPIFFTWVILLLFPVM 359

  Fly  1048 VIPLVEEEIYDVRFLQHMAGLGLKVFWGINLFWDWFTFFVYSVIIVVIMSLMGIGGFGFYENAIM 1112
            :..||.|:...:|.:..|.|||...:|.|...:......||.:.:::..|.:|:..|.|.:.:|.
plant   360 LTSLVYEKQQHLRIIMKMHGLGDGPYWMITYAYFLAISIVYIICLMIFGSAIGLKFFRFNDYSIQ 424

  Fly  1113 VVLLTTFGLAALPLTYLVSMFVNK---------------SIVRAFLVSVLLQGVSGLVLYIIYWD 1162
            .:.........:.:.:|||...:|               .::.|||...||:|:|    :...|
plant   425 FIFYFLCINLQISIAFLVSSAFSKIETASVAAYLYVFGSGLLGAFLFQFLLEGLS----FPRSW- 484

  Fly  1163 VANSNTIFFYAACMSPGFSLLDGV----SNVYAQNLEQAICIDKCEATDSCTEENMNEVVPNCKF 1223
                    .|...:.|||||..|:    ...:.:||..:..:...:..||..||....::
plant   485 --------IYIMELYPGFSLYRGLYEFSQYAFKRNLNGSGGMKWKDFNDSAMEEIFYIII----- 536

  Fly  1224 DTFFKW-------------AAPGILPPILYMVLSALIFLMLIFWIELHRREKKFHTSRDL-RKMR 1274
               .:|             ::.||.|               .|:::.....||..:...| |::.
plant   537 ---VEWFVALIAAYYTDKISSSGIDP---------------FFFLKNQNPFKKSPSPYGLQRQVS 583

  Fly  1275 TATYPFDDGDVADVKQKIAEADNTKAKQSVFLVDQVEARVPAAG-----KRIHTVSFALNKYMSM 1334
            ......:..|||..:.|:.:.....:.....:.|.::...|...     ..:..:|.|:......
plant   584 AIAIEMEKLDVAHERVKVEQLMLETSTGHAIVCDNLKKVYPCRDGNPQKMAVRGLSLAVPSGECF 648

  Fly  1335 GIFGPRNSGKSHLMRQLVGQRGFAFGEIYVRGLDFKYDLESIHTYMGYSPQHRGLLNELTPREHI 1399
            |:.||..:||:..:..:.|......|..:|.|||...|::.::|.:|..|||..|...||.|||:
plant   649 GMLGPNGAGKTSFINMMTGLMKPTSGAAFVHGLDICKDMDIVYTSIGVCPQHDLLWETLTGREHL 713

  Fly  1400 RLLCMIRGVPEAKIGEKMHDLCLMLNM--TGWMHRKCSLLTAEKRHKLKIALALVAYNKILVLDE 1462
            .....::.:..:.:.:.:.:....:|:  .|...:.....:...:.:|.:|::|:...|::.:||
plant   714 LFYGRLKNLKGSDLDQAVEESLKSVNLFRGGVADKPAGKYSGGMKRRLSVAISLIGSPKVVYMDE 778

  Fly  1463 PTCGMPATTRREIWNILRYIRYCGKTIIFATNDELECKILADFIILFQDSEMLAIGSLQYLRYKY 1527
            |:.|:...:||.:|..::..:. ...||..|:...|.:.|.|.:.:|.|..:..:|:.:.|:.:|
plant   779 PSTGLDPASRRSLWTAIKRAKN-HTAIILTTHSMEEAEFLCDRLGIFVDGRLQCVGNPKELKARY 842

  Fly  1528 SHGFYLEVRLIRDGATLAESEENLRKDVENLAKFVNFLHNRSELVGRLNNWFKFYVPVGHIVYSF 1592
            ...:.|.:      .|.:|.|    ||||.|.:.|:   ..::.:..:....||.:|...:..|.
plant   843 GGSYVLTM------TTPSEHE----KDVEMLVQDVS---PNAKKIYHIAGTQKFEIPKEEVRISE 894

  Fly  1593 LYGAMEKNKLRLNVSDYCIYQADMMSVVAQVQET 1626
            ::.|:||.|....|..:.:....:..|..:|..|
plant   895 VFQAVEKAKDNFRVFAWGLADTTLEDVFIKVART 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1801	NP_728408.3	ABC2_membrane_3	<246..379	CDD:289468
		ABC2_membrane_4	<293..448	CDD:289500
		EcfA2	499..717	CDD:224047
		P-loop_NTPase	500..721	CDD:304359
		ABC2_membrane_3	<972..1254	CDD:289468	63/317 (20%)
		EcfA2	1307..1521	CDD:224047	49/220 (22%)
		P-loop_NTPase	1324..1524	CDD:304359	47/201 (23%)
ABCA5	NP_001326002.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820