DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1801 and Abca12

DIOPT Version :9

Sequence 1:	NP_728408.3	Gene:	CG1801 / 33104	FlyBaseID:	FBgn0031171	Length:	1655	Species:	Drosophila melanogaster
Sequence 2:	NP_780419.2	Gene:	Abca12 / 74591	MGIID:	2676312	Length:	2595	Species:	Mus musculus

Alignment Length:	1848	Identity:	378/1848 - (20%)
Similarity:	716/1848 - (38%)	Gaps:	396/1848 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 IFLNP---IAHSKRLLYTTTENENEQSIV--SHKLQDINILTRMADSKREKTKYI--LAFTPETT 94
            ||:|.   :..:..:|..|..|...|..|  |..|..:.:|.::.|....:.|.:  :....:..
Mouse   845 IFMNSFHLLNQTIPMLQNTLRNPFVQVFVKFSVGLDAVELLKQIDDLDVLRLKLVNNIDIIDQLN 909

  Fly    95 FTSEVTKNVAK-----TLELSSTVGYESESEMQNQFDERTTLAGIVFNDLRDDGT---------- 144
            ..|.:|.|::.     .::.|.||  |....:..|..:...|.|.|...|..:|:
Mouse   910 TLSSLTVNISSCVLYDRIQASDTV--EEMETVAEQLYKSNELFGSVIFKLPSNGSLHRGFDPEKV 972

  Fly   145 ---PL---TLSISIRFPSEFRTIAPFLTEDRLWITRCSGRINPGRDRAKHDKQQDIYIREGFLQL 203
               |:   |:.:|::.....|:|     ..::|.        ||...:....|  ||.| .|:.|
Mouse   973 SLPPIVRYTIRMSLKTAQTTRSI-----RTKIWA--------PGPHNSPSHNQ--IYGR-AFIYL 1021

  Fly   204 QHQIFVEWYHQLRKDIVSTYPEPNVEVYNILLKAADEPCSVMSVAQLPTFLYNFIYLLPFLNIIR 268
            |..|        .:.|:......|.:...:.::|...||.:..     .||.:..|.||.:.::.
Mouse  1022 QDSI--------ERAIIELQTGRNSQEVAVQVQAVPYPCFMKD-----NFLTSVSYSLPIVLMVA 1073

  Fly   269 ---NVAAQV-----EDGVMVHQW----------HYGYSFGMQWGIKFL-VLFLRMCILGVIYTIM 314
               .:||.|     |..:.:|::          |:     ..|.|:.: .|.:.:.||     |:
Mouse  1074 WVVFIAAFVKKLVYEKDLRLHEYMKMMGVNSCSHF-----FAWLIESIGFLLVTIAIL-----IV 1128

  Fly   315 LLAFWGFGGREGEFSGTGTIAFVCFITLYTVEIIITGMVVAKLFANPTNAVLFALMLWLFMYAAF 379
            :|.|.....:.     .|.|.|:.| :.|:..:|....:::..|.|...|.|...::::..:..|
Mouse  1129 ILKFGNILPKT-----NGFILFLYF-SDYSFSVIAMSYLISVFFNNTNIAALIGSLIYVIAFFPF 1187

  Fly   380 CIILERYWDIHKYY--VFFILV---AFCNCQMHFS------MSL-FRNCIEKPEMVNTIDFVLIF 432
             |:|....|...|.  ||..|:   ||.....:.:      :.| :.|..:.|...:|..|..:.
Mouse  1188 -IVLVTVEDELSYVIKVFMSLLSPTAFSYASQYIARYEEQGVGLQWENMYKSPVQDDTTSFGWLC 1251

  Fly   433 TSAISSALIYFLILLAIQWRMPGT----------------------------------FLSRRIV 463
            ...::.:.|||.|...::...|||                                  |.:..:.
Mouse  1252 CLILADSFIYFFIAWYVRNVFPGTYGMAAPWYFPILPSYWKERFGCAEVKHEKSNGLMFTNIMMQ 1316

  Fly   464 NNRPRKQQESDTTIMYLGRAPSFQNFEFGDVGSVELMRLRHVSTSHRDSERKILKNISMRIYRGE 528
            |..|...:.|..........|..::.:.|       :.|..|:..:  ..:..::|:::..|.|.
Mouse  1317 NTNPSASKTSPDCAFPSNIEPEPKDLQVG-------VALHGVTKIY--GSKTAVENLNLNFYEGH 1372

  Fly   529 VFVILGHIGSGKLTLLRILAGLKFPLRGNVYIMGNPFEPN-GEARRLVDFRFDEHGLNKHLTVEQ 592
            :..:||..|:||.|.:.:|.||.....|.:::.|...:.: ...|:.:........|..:||.::
Mouse  1373 ITSLLGPNGAGKTTTISMLTGLFGATAGTIFVYGKDIKTDLNTVRKNMGVCMQHDVLFSYLTTKE 1437

  Fly   593 TIDYHVRLKLSP-SESDRYEIERRKWLAILDQHVES-RGVRIGKLSSGSMKLVALCCCLAGDTPI 655
            .:..:..:|:.. :::..:|..:|   .:.|..:.| |..|:|.||.|..:.:::...|.|.:.:
Mouse  1438 HLLLYGSIKVPHWTKTQLHEEVKR---TLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRV 1499

  Fly   656 IILEEPTTQLTGREAQIFWSIVHAEKENRAFIIATYNVGEAEHVADRIGILSMGVLEASGTPFFL 720
            :||:||:|.:.....:..|.::...|..|..|::|:::.|||.::|||..|..|.|...|:||:|
Mouse  1500 VILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYL 1564

  Fly   721 RSKFSSSVDLVIIKK--PHVPDQPITD--YINQFMQNIEPE----NEIGDSLTYRLPVIYRPRLQ 777
            :..|.....|.:.||  |::....|.|  .:...:|:..||    .:||..|.|.||........
Mouse  1565 KEAFGDGYHLTLTKKKSPNLDTNAICDTVAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSG 1629

  Fly   778 KLLIHLEIDRKMLGIENVRVVG---AELSDIYMTLVTSFRLQQQM-IPDVTQ------------- 825
            ..|..|....|.:|..|:...|   ..:.::::.|....:....| :..:||
Mouse  1630 AYLSLLRALDKGMGKLNIGCYGISDTTVEEVFLNLTKDSQKSSNMSLEHLTQRKVGNPSANGTST 1694

  Fly   826 -------TFKYQVVSQKQLTK-----------QRMRAMFYKKMIHTAPNVWP--IIMIFTSFVLI 870
                   :..:.....|.||:           :::.|:..|:..||..| |.  |..:....|.:
Mouse  1695 PDDLSVSSSNFTDRDDKVLTRSEKLEGFGLLLKKIMAILIKRFHHTRRN-WKGLIAQVILPIVFV 1758

  Fly   871 AIIARLSVLLDMPK--------------ERQNSIHIGFREP--EDVVKYLPNLKDCGYIDIR-SA 918
            |....|..|.|...              ..|.:.:..| :|  ..:|..|.|......:.:. |.
Mouse  1759 ATAMGLGTLRDSSNSYPEIMISPSIYGTSEQTAFYANF-DPSTSGLVSALWNFPGIDNVCLNTSD 1822

  Fly   919 VKVNKKKSVGVSRTFDD--DSF-VCE-----------------------------KGSYRNN--- 948
            ::..||..:|...|..:  |:| ||.                             .|.:..|
Mouse  1823 LQCLKKDDLGKWNTSGEAIDNFGVCSCSDNVQECPKFNYHPPHRRTYSSQVIYNLTGKHMENYLI 1887

  Fly   949 -----------------LRKKNELRSFGAVESDGDEHLNGYISQDMFHSAPMMLNLLQNVILRLS 996
                             ::..|:||.......|.......:...:.:||.|..||.|.|.:||::
Mouse  1888 TTANHFVQKRYGGWSFGMKLTNDLRFDVTAVPDNRTLAKVWYDPEGYHSLPAYLNSLNNFLLRVN 1952

  Fly   997 YPMQTDLV---VLVENHPLP-------TQLSQKINVLDNKIAHIHVPLVVGCIIPLTVSVFVIPL 1051
            . .:.|..   :::.:||.|       ..:|..|::|      :.:.:::|  ..:|.:.||..:
Mouse  1953 M-SEYDAARHGIIMYSHPYPGVQDQEQATISSLIDIL------VALSILMG--YSVTTASFVTYI 2008

  Fly  1052 VEEEIYDVRFLQHMAGLGLKVFWGINLFWDWFTFFV---YSVIIVVIMSLMGIGGFGFYEN---A 1110
            |.|.....:.|||::|:|:..:|..|..:|...:.|   :|:.::.|..|.     .||..   .
Mouse  2009 VREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIGVIAIFKLP-----AFYSGNNLG 2068

  Fly  1111 IMVVLLTTFGLAALPLTYLVSMFVNKSIVRAFLVSV---LLQGVSGLV-LYIIYW---DVANSNT 1168
            .:.:||..||.|.....||::...:::.: ||:..|   |..|::.:| |.::|:   :..|..|
Mouse  2069 AVSLLLLLFGYATFSWMYLLAGLFHETGM-AFITYVCVNLFFGINSIVSLSVVYFLSKEKPNDPT 2132

  Fly  1169 ------------IFFYAACMSPGFSLLDGVSNVYAQNLEQAICIDKCEATDSCTEENMNEVVPNC 1221
                        :.|...|.  |:.|::       .:.:||: :|..:|..   .|..:|.....
Mouse  2133 LELISETLKRIFLIFPQFCF--GYGLIE-------LSQQQAV-LDFLKAYG---VEYPSETFEMD 2184

  Fly  1222 KFDTFFKWAAPGILPPILYMVLSALIFLMLIF---WIELHRREKKFHTSRDLRKMRTATYPFDDG 1283
            |....|          :..:....:.||:.:.   |:              ::|:|.....|..
Mouse  2185 KLGAMF----------VALVSQGTMFFLLRLLINEWL--------------IKKLRLFFRKFTS- 2224

  Fly  1284 DVADVKQKIAEADNTKAKQSVFLVDQVEA--------RVPAAGKRIHTVSFALNKYMSMGI---- 1336
              :.:.:.:.|.::.:|::  |.|:...|        |:....:.||....|:|. :|:||
Mouse  2225 --SPIMETVDEDEDVRAER--FRVESGAAEFDLVQLHRLTKTYQLIHKKIIAVNN-ISLGIPAGE 2284

  Fly  1337 ----FGPRNSGKSHLMRQLVGQRGFAFGEIYVRGLDFKY-DLESIHTYMGYSPQHRGLLNELTPR 1396
                .|...:||:.:.:.|.|....:.|.|.:|...... .::|..:.:||.||...|.:.:|..
Mouse  2285 CFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKSGSLGHVDSHSSLVGYCPQEDALDDLVTVE 2349

  Fly  1397 EHIRLLCMIRGVPEAKIGEKMHDLCLMLNMTGWMHRKCSLLTAEKRHKLKIALALVAYNKILVLD 1461
            ||:.....:.|:||..|.:.:|.|...|::..:..|..|:.:...:.||..||||:....||:||
Mouse  2350 EHLYFYARVHGIPEKDIKDTVHKLLRRLHLMAYKDRSTSMCSYGTKRKLSTALALIGKPSILLLD 2414

  Fly  1462 EPTCGMPATTRREIWNILRYIRYCGKTIIFATNDELECKILADFIILFQDSEMLAIGSLQYLRYK 1526
            ||:.||...::|.:|.|:........::|..::...||:.|...:.:..:.....|||||:::.:
Mouse  2415 EPSSGMDPKSKRHLWRIISEEVQNKCSVILTSHSMEECEALCTRLAIMVNGRFQCIGSLQHIKSR 2479

  Fly  1527 YSHGFYLEVRLIRDGATLAESEENLRKDVENLAKFVNFLHNRSELVGRLNNWFKFYVPVGHIVYS 1591
            :..||.::|.|           :|.:..:|.|.||:.....::.|..:..:..:::|||.....:
Mouse  2480 FGRGFTVKVHL-----------KNNKVSMETLTKFMQLHFPKTYLKDQHLSMLEYHVPVTAGGVA 2533

  Fly  1592 FLYGAMEKNKLRLNVSDYCIYQADMMSV 1619
            .::..:|.||..||::::.:.|..:..|
Mouse  2534 NIFDLLETNKTALNITNFLVSQTTLEEV 2561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1801	NP_728408.3	ABC2_membrane_3	<246..379	CDD:289468	29/151 (19%)
		ABC2_membrane_4	<293..448	CDD:289500	37/167 (22%)
		EcfA2	499..717	CDD:224047	53/220 (24%)
		P-loop_NTPase	500..721	CDD:304359	55/223 (25%)
		ABC2_membrane_3	<972..1254	CDD:289468	67/319 (21%)
		EcfA2	1307..1521	CDD:224047	60/230 (26%)
		P-loop_NTPase	1324..1524	CDD:304359	57/208 (27%)
Abca12	NP_780419.2	ABC2_membrane_3	<1006..1267	CDD:289468	61/293 (21%)
		NosY	<1108..1269	CDD:224196	37/177 (21%)
		ZnuC	1346..1570	CDD:224046	57/228 (25%)
		ABC_subfamily_A	1350..1565	CDD:213230	54/219 (25%)
		ABC2_membrane_3	<1913..2174	CDD:289468	62/288 (22%)
		CcmA	2253..2567	CDD:224054	80/321 (25%)
		ABC_subfamily_A	2254..2477	CDD:213230	60/223 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838433
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840