Protein Alignment CG1801 and AgaP_AGAP006380

DIOPT Version :9

• Sequence 1: NP_728408.3
• Gene: CG1801 / 33104
• FlyBaseID: FBgn0031171
• Length: 1655
• Species: Drosophila melanogaster
• Sequence 2: XP_001688862.1
• Gene: AgaP_AGAP006380 / 5666864
• VectorBaseID: AGAP006380
• Length: 1652
• Species: Anopheles gambiae
• Alignment Length: 1751
• Identity: 410/1751 - (23%)
• Similarity: 758/1751 - (43%)
• Gaps: 260/1751 - (14%)

  Fly     7 LLFKRYIRIELNLWRRTLFEIVALVIMVLVIFLNPIAHSKRLLYTTTENENEQSIVSHKLQDINI 71
            ||:|.:| ::...:.:|||||:..|:...::.         |:....:.|...|....|..:|:.
Mosquito    12 LLWKNWI-LQKRHYIQTLFEILIPVLCCSILL---------LVRGLVDPEFIDSNSEFKPLEIDR 66

  Fly    72 LT---RMADSKREKTKYILAFTPETTFTSEVTKNVAKTLELS------STVGYESESEMQNQFDE 127
            ||   ::|::|..:.|  :|::|.......|.:...:.|..:      :...:....||::...|
Mosquito    67 LTHLEKLAEAKNFEFK--IAYSPRNDLLEAVVQEAVRALNANDPKARLTYASFADAREMESVLAE 129

  Fly   128 RTTLAGIVFND-----LRDDGTPL-TLSISIRFPSEFRTIAPFLTEDRL----WITRC-----SG 177
            .:.|||:.|:|     ...:|.|. .|:.::|:|:|.|       :|..    |:|..     |.
Mosquito   130 SSFLAGVEFDDSWASWTAANGVPTDNLTFAVRYPAELR-------DDEFQFSNWVTNLLVVPFSP 187

  Fly   178 RI-NPGRDRAKHDKQQDIYIREGFLQLQHQIF------------VEWYHQLRKDIVSTYPEPNVE 229
            |: ||..|    |.....|..||||.:|..|.            :...|      |..||.|  .
Mosquito   188 RLRNPLLD----DGGSPSYYSEGFLGIQGAISRALLGRRLPGVDLPTVH------VQRYPYP--P 240

  Fly   230 VY-NILLKAADEPCSVMSVAQLPTFLYNFIYLLPFLNIIRNVAAQVEDGVMVHQWHYGYSFGMQW 293
            .| :.:|:|..:..:::.|.   :|.|..|..:.::.|.:.  .|:::.:.:    .|.|..:.|
Mosquito   241 YYDDAILEALQQLLALIIVI---SFFYTCINTVKYITIEKE--KQLKEAMKI----MGLSNWLHW 296

  Fly   294 GIKFLVLFLRMCILGVIYTIMLLAFWGFGGREGEFSGTG-------TIAFVCFITLYTVEIIITG 351
            ...|:...:.:.:...:.||:|..         .||...       |:.:| |..:|::..|...
Mosquito   297 SAWFVKCLILLTVSLSLITILLCV---------PFSSAAIFENSDWTLIWV-FFFVYSISTICFC 351

  Fly   352 MVVAKLFANPTNAVLFALMLWLFMYAAFCIILERYWDIHKYYVFFILVAFC---NCQMHFSMSL- 412
            .:::..|:....|...|.:||......|.:..:.|.::..    ...:..|   |..|..:|.|
Mosquito   352 FMISVFFSKANTAAGIAGLLWFVTQLPFNVSQQNYDEMGT----GAKLGMCLLSNSGMSLAMFLT 412

  Fly   413 -----------FRNCIEKPEMVNTIDFVLIFTSAISSALIYFLILLAIQWRMPGTFLSRR----- 461
                       :.|..|...:.:..:..||....:..|:||.||.|.|:..|||.|...|
Mosquito   413 VRLEATAVGLRWSNLFEPATIDDGFNVGLIIIMLLVDAVIYLLIALYIEQIMPGEFGIARPWYFP 477

  Fly   462 ------IVNNRPRK----QQESDTTIMYLGRAPSFQNFEFGDVGSVELMRLRHVSTSHRDSERKI 516
                  :....|.:    |....|...|:.:.|:      |..| ||:.:||.|...::.:
Mosquito   478 FTKEFWVRTQTPSRDTLFQANGSTESRYIEQDPA------GYAG-VEIKQLRKVYKGNKAA---- 531

  Fly   517 LKNISMRIYRGEVFVILGHIGSGKLTLLRILAGLKFPLRGNVYIMGNPFEPNGEARRLVDFRFDE 581
            :..:::|:|..::.|:|||.|:||.|.:.:|.|:..|..|...|.|:            |.|.|.
Mosquito   532 VDGLNLRMYENQISVLLGHNGAGKTTTMSMLTGVFAPTSGTALINGH------------DIRTDI 584

  Fly   582 HGLNKHLTV---------EQTIDYHV----RLKLSPSESDRYEIERRKWLAILDQHVESRGVRIG 633
            .|:...|.:         |.|:|.|:    |||..|:|:...||:|  :|.:|:. .:.|..:..
Mosquito   585 DGVRSSLGLCPQHNVLFDEMTVDEHLKFFSRLKGVPTEAVSGEIDR--YLKLLEL-TDKRDAQSQ 646

  Fly   634 KLSSGSMKLVALCCCLAGDTPIIILEEPTTQLTGREAQIFWSIVHAEKENRAFIIATYNVGEAEH 698
            .||.|..:.:|:...|.|.:.:::|:|||:.:.....:..|:::..||:||..:::|:.:.||:.
Mosquito   647 TLSGGMKRKLAVGMALCGGSKVVLLDEPTSGMDPSARRALWNLLQKEKQNRTMLLSTHFMDEADV 711

  Fly   699 VADRIGILSMGVLEASGTPFFLRSKFSSSVDLVIIKKPHVPDQPITDYINQFMQNIEPENEIGDS 763
            :.|||.|::.|.|:|.|:||||:..|.....|:.:|......|.:...:.:::.::..:.:||..
Mosquito   712 LGDRIAIMAEGKLKAVGSPFFLKKTFGVGYRLICVKDARCDKQRLLGILRKYIPDVTIDTDIGSE 776

  Fly   764 LTYRLPVIYRPRLQKLLIHLEIDRKMLGIENVRVVGAELSDIYMTLVT-SFRLQQQMIPDVTQTF 827
            |::.|...|....|:||..:|......||.:..:....:.::::...: ||        |.|.|.
Mosquito   777 LSFILKEDYLDVFQRLLEDIEQQMVSCGITSYGISLTTMEEVFLKAGSDSF--------DETGTH 833

  Fly   828 ----------------KYQVVSQKQLTKQRMRAMFYKKMIHTAPNVW---------PIIMIFTSF 867
                            :..:::.|:|...:::|...||.: ::...|         ||..:..:|
Mosquito   834 TNGTVVETGSSEYALDRLHLLTGKELLFNQIQAQLLKKYL-SSIRAWVQLVMMFVIPIFFVCMTF 897

  Fly   868 VLIAIIARLSVLLDMPKERQNSIHIGFREPEDVVKYLPNLKDCGYIDIRSAVKVNKKKSVGVSRT 932
            :   |...:|...|:|     ::.|.....|   |.:..|:..|....|.....|.....|...|
Mosquito   898 I---ITRSISAGKDLP-----ALEITIDSYE---KAITVLERAGGETARVEAFQNMFTDRGELVT 951

  Fly   933 FDDD--SFVCEKGSYRNNLRKKNELRSFGAVESDGDEHLNGYISQDMFHSAPMMLNLLQNVILRL 995
            .|:|  .::..|..  .::...|.....||....|..:: |:.:...||:||:.|||:.:.||:.
Mosquito   952 IDEDMTEYIVRKSI--EDIAAVNTRYFVGATIRSGAPYV-GWFNNKAFHTAPLALNLVYSAILQA 1013

  Fly   996 SYPMQTDLVVLVENHPLPTQLSQKINVLDNKI-AHIHVPLVVGCIIPLTVSVFVIPLVEEEIYDV 1059
            ..   |:..:.|.|.|||.:|..::..|:..: |...:....|..:....:::::..::|.....
Mosquito  1014 QC---TECQLHVINKPLPYRLDTQLKKLNTGLNAGFQLAFNTGFAMAFVAALYIMFYIKERTSRA 1075

  Fly  1060 RFLQHMAGLGLKVFWGINLFWDWFTFFVYSVIIVVIMSLMGIGGFG-FYENAIMVVLLTTFGLAA 1123
            :.||.::|..:.:||.:...||:..|.:.|::.:..:::....|:. |.|.....:||..||.|.
Mosquito  1076 KLLQFVSGTNVTMFWLLAFMWDFTLFVLNSLVYIATVAIFQEEGWSTFEELGRAFLLLLFFGYAT 1140

  Fly  1124 LPLTYLVSMFVNKS---IVRAFLVSVLLQGVSGLVLYIIYWD------VANS-NTIFFYAACMSP 1178
            ||:|||.|...:.|   .||...|:||...:....:.::.:|      ||.. ..:|.:    .|
Mosquito  1141 LPVTYLFSFLFSVSATGFVRMMFVNVLSGAIFFTAVNVLKFDGIDLVEVAEGLEWVFMF----FP 1201

  Fly  1179 GFSLLDGVSNVYAQNLEQAICIDKCEATDS-CTEENMNEVVPNCKFDTFFKWAAPGILPPILYMV 1242
            .|.|..|::|:.|.:...:.|...|:...: |..:::..|...|.....|.:...||:..:|:.|
Mosquito  1202 NFVLSHGLNNLNAASSTASSCKKFCDLLGAQCVVDDLCSVDARCCDLEVFSFGNVGIIRNLLFCV 1266

  Fly  1243 LSALIFLMLIFWIELHRREKKFHTSRDLRKMRTATYPF---------DDGDVADVKQKIAEADNT 1298
            |...:...|:|.:|....::.|.     ||.:.:..|.         .|.||.:.|::||....|
Mosquito  1267 LIGTVSFSLLFMLEYGVLQRLFQ-----RKPKGSASPAGPQGTVGSEQDSDVLEEKRRIANLSRT 1326

  Fly  1299 KAKQSVFLVDQVEARVPAAGKRIHTVSFALNKYMSMGIFGPRNSGKSHLMRQLVGQRGFAFGEIY 1363
            .......|:..| .:.....:.::.:|..:|.....|:.|...:||:...:.:.|....:.|..:
Mosquito  1327 DIDGHNLLLRDV-TKYYGNFQAVNNLSIGINHSECFGLLGINGAGKTTTFKMMTGDEEISSGNAW 1390

  Fly  1364 VRGLDFKYDLESIHTYMGYSPQHRGLLNELTPREHIRLLCMIRGVPEAKIGEKMHDLCLMLNMTG 1428
            |:|:..:.|:...|..:||.||...||.:||.||.:|:..::|||.:.::....:.|...||.|.
Mosquito  1391 VKGISLREDMNRAHRQIGYCPQFDALLEDLTGRETLRIFALLRGVRKQEVKNVSYILAEELNFTK 1455

  Fly  1429 WMHRKCSLLTAEKRHKLKIALALVAYNKILVLDEPTCGMPATTRREIWNILRYIRYCGKTIIFAT 1493
            .:.::....:...:.||..||||:....::.|||||.||....:|:.|:::..:|..||:|:..:
Mosquito  1456 HLDKRTKAYSGGNKRKLSTALALLGNPSVVYLDEPTTGMDPGAKRQFWDVICKVRSTGKSIVLTS 1520

  Fly  1494 NDELECKILADFIILFQDSEMLAIGSLQYLRYKYSHGFYLEVRLIRDGATLAESEENLRKDVENL 1558
            :...||:.|...:.:..:.|...:||.|:|:.|:|.||.|.|::.| |:|.|:     :|.|..:
Mosquito  1521 HSMEECEALCTRLAIMVNGEFKCLGSTQHLKNKFSKGFLLTVKVAR-GSTDAQ-----QKRVAGV 1579

  Fly  1559 AKFVNFLHNRSELVGRLNNWFKFYVPVGHIVYSFLYGAMEKNKLRLNVSDYCIYQADMMSV 1619
            ..||....:.:.|.....:...|::||..:.:|.::|.||.:|..|.:.||.:.|..:..|
Mosquito  1580 KDFVMSRFSGAVLKEEYEDSLTFHIPVTDLKWSQMFGLMESSKQELEIEDYALGQTSLEQV 1640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1801	NP_728408.3	ABC2_membrane_3	<246..379	CDD:289468	25/139 (18%)
		ABC2_membrane_4	<293..448	CDD:289500	33/176 (19%)
		EcfA2	499..717	CDD:224047	65/230 (28%)
		P-loop_NTPase	500..721	CDD:304359	68/233 (29%)
		ABC2_membrane_3	<972..1254	CDD:289468	71/294 (24%)
		EcfA2	1307..1521	CDD:224047	56/213 (26%)
		P-loop_NTPase	1324..1524	CDD:304359	56/199 (28%)
AgaP_AGAP006380	XP_001688862.1	ABC2_membrane_3	<257..459	CDD:289468	41/224 (18%)
		CcmA	516..796	CDD:224054	83/298 (28%)
		ABC_subfamily_A	516..734	CDD:213230	70/236 (30%)
		ABC2_membrane_3	879..1213	CDD:289468	83/354 (23%)
		ABC_subfamily_A	1333..1551	CDD:213230	58/218 (27%)
		drrA	1340..1645	CDD:130256	85/307 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X215
TreeFam	0	0.000	Not matched by this tool.
	6	5.920