DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1801 and abca3b

DIOPT Version :9

Sequence 1:	NP_728408.3	Gene:	CG1801 / 33104	FlyBaseID:	FBgn0031171	Length:	1655	Species:	Drosophila melanogaster
Sequence 2:	XP_009297489.1	Gene:	abca3b / 564344	ZFINID:	ZDB-GENE-050517-2	Length:	1703	Species:	Danio rerio

Alignment Length:	1818	Identity:	413/1818 - (22%)
Similarity:	747/1818 - (41%)	Gaps:	323/1818 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLFKRYIRIELNLWRRTLFEIVALVIMVLVIFLNPIAHSKRLLYTTTENENEQSIVSHKLQDINI 71
            ||:|.||:.:..:       :|.||.:.|.:..:.|....|...:.|...|.....|..|..:..
Zfish    10 LLWKNYIQQKRQI-------LVTLVEIALPLLFSAILIVLRQKVSFTNYPNATHYQSFPLNGLPP 67

  Fly    72 LTRMADSKREKTKYILAFTP-ETTFTSEVTKNVAKTLE--LSSTVGYESESEMQNQFDE--RT-- 129
            |......:       ||:.| ..:...::.::|.:.|:  :.:..|:|:|    .||:|  :|
Zfish    68 LLCYQQLQ-------LAYVPANASVVQQIAQDVQQNLQSCIKNVRGFETE----EQFEEFVKTDP 121

  Fly   130 ----TLAGIVF-----NDLRDDGTPLTLSISIRFPSEFRTIAPFLTEDRLWITRCSGRINPGRD- 184
                .||.|||     :|  |:..||.:|..:||....|. ||         .|....:||..|
Zfish   122 ESGKILAAIVFEHPFSHD--DEPLPLQVSYHLRFTYSPRN-AP---------AREKSELNPNNDM 174

  Fly   185 ----------------RAKHDKQQDI--YIREGFLQLQHQI---FVEWYHQ--------LRKDIV 220
                            |.:||.....  |.||||||:|:.:   .:..|::        ..:.::
Zfish   175 DWHTLSLFPLFQMPGPREQHDPHGGTPGYYREGFLQVQYAVDRAIMMAYNRSAAMALFDQTQVLL 239

  Fly   221 STYPEPNVEVYNILLKAADEPCSVMSVAQLPTFL-YNFIYLLPFLNIIRNVAAQVEDGVMVHQWH 284
            |.:|.| ..:|::.:.|...        |||..| .:|.|..  |||:|.|..:.|..:..:...
Zfish   240 SRFPYP-AFIYDVFILAIQN--------QLPLLLVLSFTYTA--LNIVRAVVQEKERKLKEYMRM 293

  Fly   285 YGYSFGMQWGIKFLVLFLRMCILGVIYTIMLLAFWGFGGREGEFSGTGTIAFVCFITLYTVEIII 349
            .|.|..:.|...||:.||.:.|.....|::........|....:|.. |:.|| |:.::.:..|.
Zfish   294 MGLSNWLHWSAWFLMFFLFLSISIFFVTVLFCVKVSPNGAVLTYSDP-TLVFV-FLLVFAISTIN 356

  Fly   350 TGMVVAKLFANPTNAVLFALMLWLFMYAAFCIILERYWDI--HKYYVFFILVAFCNCQMHFSMSL 412
            ...:::..|:....|......::...|..:..:..|| |:  |...|...|::  |..|.....|
Zfish   357 FSFMISVFFSRANVAAAAGGFIYFLSYLPYVFLWPRY-DLLSHAQKVSACLIS--NVAMAMGAQL 418

  Fly   413 ------------FRNCIEKPEMVNTIDFVLIFTSAISSALIYFLILLAIQWRMPGT--------- 456
                        :.|..|...:.:......:....:..||:|.|:...::...||.
Zfish   419 IGMFEGKGTGIQWHNLFEAVTVDDDFSLAQVIGLLLLDALLYGLVAWYVEAVFPGEYGVPQPWYF 483

  Fly   457 FLSRRIVNNRPR----KQQESDTTIMYLGRAPSFQNFEFGDVGSVELMRLRHVSTSHRDSERKIL 517
            |:......:.||    |::|.:.......:....:....|.|..|::.||..|......| ::.:
Zfish   484 FILPSYWCSSPRVAFLKEKEDEEDAEKASKGEFMEEEPAGLVAGVKIKRLAKVFKVGNKS-KEAV 547

  Fly   518 KNISMRIYRGEVFVILGHIGSGKLTLLRILAGLKFPLRGNVYIMGNPF-EPNGEARRLV------ 575
            :::::.::.|::.|:|||.|:||.|.|.:|.||..|..|..||.|... :.....||.:
Zfish   548 RDLTLNMFEGQITVLLGHNGAGKTTTLSMLTGLFPPSSGRAYINGYDICQDMALIRRSLGLCPQH 612

  Fly   576 DFRFDEHGLNKHLTVEQTIDYHVRLKLSPSESDRYEIERRKWLAILDQHVESRGVRIGKLSSGSM 640
            |..||      :|||.:.:.::.:||..|.|....|::|  .:.||:.. :.|..:...||.|..
Zfish   613 DVLFD------NLTVREHLLFYTQLKGYPREKIPGEVDR--IIRILNLE-DKRNAKCKTLSGGMK 668

  Fly   641 KLVALCCCLAGDTPIIILEEPTTQLTGREAQIFWSIVHAEKENRAFIIATYNVGEAEHVADRIGI 705
            :.:::...|.||:.:::|:|||:.:.....:..|.::..||..|..::.|:.:.||:.:.|||.|
Zfish   669 RKLSIGIALIGDSKVVMLDEPTSGMDPSARRATWDLLQGEKRGRTILLTTHFMDEADLLGDRIAI 733

  Fly   706 LSMGVLEASGTPFFLRSKFSSSVDLVIIKKPHVPDQPITDYINQFMQNIEPENEIGDSLTYRLPV 770
            ::.|.|:..|:|.||::|:.:...:||:|........||..::.::.:...|:..|..|:|.||.
Zfish   734 MASGELQCCGSPLFLKNKYGAGYHMVIVKDAFCNVSEITRLVHMYVPDATLESSAGAELSYILPK 798

  Fly   771 IYRPRLQKLLIHLEIDRKMLGIENVRVVGAELSDIYM---TLV-TSFRLQQQMIP---------- 821
            ....|.:.|...||::|..|||.:.......:.::::   .|| :|..:|...:|
Zfish   799 ESTSRFELLFAELEMNRDELGIASYGASVTTMEEVFLRVGKLVDSSLDIQAIQLPALQYQHERRS 863

  Fly   822 ---------------DVTQ-TFKYQVVSQ----------KQLTKQRMRAMFYKKMIHTAPNVWPI 860
                           |||. |....::|:          .:|..|:..|||.|:.:::..| |.:
Zfish   864 HDWTMDDSSSISGMTDVTDFTDSCTMISEDGSNIKLNTGARLYMQQFYAMFLKRALYSWRN-WKV 927

  Fly   861 I-------MIFTSFVLIAIIARLSVLLDMPKERQN-SIHIGFREPEDVVKYLPNLKDCGYIDIRS 917
            :       :|||  ||..::||     .:|....: .:.:.             ||..|...:..
Zfish   928 MVAQFLVPLIFT--VLALVVAR-----SLPSSHSSPQLRLA-------------LKQYGQTHVPV 972

  Fly   918 AVKVN-----------------KKKSVGVSRTFDDDSFVC-----EKGSYRNNLRKKNELRSFGA 960
            ||:.|                 .:.::......|...:|.     |.|::       ||....||
Zfish   973 AVEANAGPLASLLAEIYTTQLPSQNAIAAPNITDFSEYVLYNAQREGGAF-------NEHCVVGA 1030

  Fly   961 VESDGDEHLNGYISQDMFHSAPMMLNLLQNVILRL----SYPMQTDLVVLVENHPLPTQLSQ--- 1018
            .....|  :.||.:...:|:....|.|:.|.:.:|    :..:||.      |.|:|..:|:
Zfish  1031 AFRSSD--VIGYFNNQGYHTPATALMLVDNALFKLLAGPNASIQTG------NDPMPRNVSETAQ 1087

  Fly  1019 -KINVLDNKIAHIHVPLVVGCIIPLTVSVFVIPLVEEEIYDVRFLQHMAGLGLKVFWGINLFWDW 1082
             :::......| |.:.|:.|  :....|.|.:.||.|.....:.:|.::|:.|..||...|.||.
Zfish  1088 SQLSESQTGFA-IAINLMYG--MASLASTFALLLVSERSVKSKHVQQVSGVYLTNFWFSALLWDL 1149

  Fly  1083 FTFFVYSVIIVVIMSLMGIGGFGFYENAIMVV-LLTTFGLAALPLTYLVSMFVNKSIVRAFLVSV 1146
            ..|.:..::::|:..:..:..|....:.:.|: ||..:|.|.:||.||:|          ||.|.
Zfish  1150 INFLLPCLLMLVVFRVFSVKAFVAQNHLVDVLFLLLLYGWAVIPLMYLMS----------FLFST 1204

  Fly  1147 LLQGVSGLVLYIIYWDVANSNTIFFYAACMS--PGFS------LLDGVSNV---YAQNLEQAICI 1200
            .....:.|.::.|.     |.|..|.|..:.  |..:      |||.|..:   |...:......
Zfish  1205 AATAYTRLTIFNII-----SGTATFLAVTIMTIPELNLLHLSHLLDKVFLIFPNYCLGMSFTEFY 1264

  Fly  1201 DKCEATDSCTEENMNEVVPNCKF------DTFFKWAAPGILPPILYMVLSALIFLMLIFWIELH- 1258
            ...|....||...:.:.:  ||:      ..:|....||:...::.:.|..::|::|:|.|||.
Zfish  1265 QNYEMITFCTSSPLAKYI--CKYYNITYQMNYFSMEEPGVGRFLVALSLQGVVFIILLFLIELRC 1327

  Fly  1259 --------RREKKFHTSRDLRKMRTATYPFDDGDVADVKQKIAEADNTKAKQSVF---LVDQVEA 1312
                    ||.||     .|.....|..| :|.|||:.::::.|..  ...:|:.   ||.|..:
Zfish  1328 IRLLLNLCRRRKK-----ALLLAEEALQP-EDRDVAEERKRVLECQ--PVVESMVGSPLVVQELS 1384

  Fly  1313 RVPAAGKRIHTV---SFALNKYMSMGIFGPRNSGKSHLMRQLVGQRGFAFGEIYVRGLDFKYDLE 1374
            ::.:.|:.:..|   |.|:.|....|:.|...:||:...:.|.|......|:.::.|.....|::
Zfish  1385 KMYSGGQSLLAVDRLSLAVGKGECFGLLGFNGAGKTTTFKMLTGDESITSGDAFIDGYSILTDVK 1449

  Fly  1375 SIHTYMGYSPQHRGLLNELTPREHIRLLCMIRGVPEAKIGEKMHDLCLMLNMTGWMHRKCSLLTA 1439
            .:...:||.||...:|:.:|.||.:.:...:||:||..:...:.::...|.:.....:.....:.
Zfish  1450 KVQQRIGYCPQFDAVLDHMTGRETLSMYARLRGIPEKYVTACVENVLRSLLLEPHADKLVRSYSG 1514

  Fly  1440 EKRHKLKIALALVAYNKILVLDEPTCGMPATTRREIWNILRYIRYCGKTIIFATNDELECKILAD 1504
            ..:.||...:||:....::.||||:.||....||.:|:.:...|..||.||..::...||:.|..
Zfish  1515 GNKRKLSAGMALIGGPPVIFLDEPSTGMDPVARRLLWDAITRTRESGKAIIITSHSMEECEALCT 1579

  Fly  1505 FIILFQDSEMLAIGSLQYLRYKYSHGFYLEVRLIRDGATLAESEENLRKDVENLAKFVNFLHNRS 1569
            .:.:..:.:...:||.|:|:.|:..|:.|..: :|....|.||:..|.||      |:......|
Zfish  1580 RLAVMVNGQFKCLGSPQHLKSKFGSGYTLLAK-VRVETELEESDLQLFKD------FIESTFPGS 1637

  Fly  1570 ELVGRLNNWFKFYVPVGHIVYSFLYGAMEKNKLRLNVSDYCIYQADMMSVVAQVQETRAQLKH 1632
            .|.........:::....:.::.::|.:|..|.:.::.|||:.|..:    .||..:.||.:|
Zfish  1638 LLKDEHQGMVHYHLTDKTLTWAQVFGVLETAKEKYSIEDYCVSQISL----EQVFLSFAQFQH 1696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1801	NP_728408.3	ABC2_membrane_3	<246..379	CDD:289468	31/133 (23%)
		ABC2_membrane_4	<293..448	CDD:289500	32/168 (19%)
		EcfA2	499..717	CDD:224047	63/224 (28%)
		P-loop_NTPase	500..721	CDD:304359	65/227 (29%)
		ABC2_membrane_3	<972..1254	CDD:289468	68/307 (22%)
		EcfA2	1307..1521	CDD:224047	52/216 (24%)
		P-loop_NTPase	1324..1524	CDD:304359	50/202 (25%)
abca3b	XP_009297489.1	AAA	1..>95	CDD:333001	20/98 (20%)
abca3b	XP_009297489.1	AAA	<122..1695	CDD:333001	384/1685 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582223
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.950