DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG1801 and abca1a

DIOPT Version :9

Sequence 1:NP_728408.3 Gene:CG1801 / 33104 FlyBaseID:FBgn0031171 Length:1655 Species:Drosophila melanogaster
Sequence 2:NP_001296394.1 Gene:abca1a / 558924 ZFINID:ZDB-GENE-031006-12 Length:2268 Species:Danio rerio


Alignment Length:1995 Identity:397/1995 - (19%)
Similarity:709/1995 - (35%) Gaps:597/1995 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 LYTTTENENEQSIVSHKLQDINILTRMADSKREKTKYIL-------------------AFTPETT 94
            ::...||..|..:|...||: |...|..::|...|::.:                   |:|....
Zfish   428 IWNFMENSEEMDLVRTLLQN-NASARFFNAKLSGTEWRVEDVSRFLSKSSEDTRPHGTAYTWREV 491

  Fly    95 F--TSEVTKNVAKTLE---LSSTVGYESESEMQNQ----FDERTTLAGIVFNDLRDDGTPLTLSI 150
            |  |.:..:.:::.:|   |.......:|..:.|:    .|:|...|||||.|::.:.:.|.|::
Zfish   492 FNETDQAIQTISRFMECVNLDKLEPVANEERLVNKSMRLLDDRKFWAGIVFPDMQSNTSDLPLNV 556

  Fly   151 SIRFPSEFRTI-APFLTEDRLWITRCSGRINPGRDRAKHDKQQDI-YIREGFLQLQHQIFVEWYH 213
            :.:...:...: .....:|..|        :||   .:.|..:|: ||..||..||..|    .|
Zfish   557 NYKIRMDIDNVERTNKIKDGYW--------DPG---PRADPFEDLRYIWGGFTYLQDVI----EH 606

  Fly   214 QLRKDIVSTYPEPNVEVYNILLKAADEPCSVMSV------AQLPTFLYNFIYLLPFLNIIRNVAA 272
            .:.:.:..     :.|...:.::....||.|..:      ..:|.|: ...::.....||:.|..
Zfish   607 GIIRALTG-----SKEKTGVYIQQMPYPCYVDDIFLRVMSRSMPLFM-TLAWMYSVAIIIKGVVY 665

  Fly   273 QVEDGVMVHQWHYGYSFGMQWGIKFLVLFLRMCILGVIYTIMLLAFWGFGGREGEFSGTGTIAFV 337
            :.|..:.......|...|:.|...|:...:.:.|...:..::|..     |....:|..|.|  .
Zfish   666 EKEARLKETMRIMGLDNGILWLSWFISSLIPLLISAALLVLILKM-----GNLLPYSDPGVI--Y 723

  Fly   338 CFITLYTVEIIITGMVVAKLFANPTNAVLFALMLWLFMYAAF--CIILERYWDIHKYYVFFIL-- 398
            .|::.:.|..|:...:::.||:....|.....:::..:|..:  |:..:.|.......|..:|  
Zfish   724 LFLSSFAVVTIMQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVAWQNYVGFGAKIVVSLLSP 788

  Fly   399 VAF-CNCQMHFSMSLFR---------NCIEKPEMVNTIDFVLIFTSAISSALIYFLILLAIQWRM 453
            ||| ..|:.   .:||.         |.:..|...::.:........:..:::|.::...|:...
Zfish   789 VAFGFGCEY---FALFEEQGVGIQWSNLLSSPMQEDSYNLTTSICLMLFDSVLYAVMTWYIEAVF 850

  Fly   454 PGTFLSRRIVNNRPRKQQESDTTIMYLGRAPSFQNFEFGDVGSVELMRLRHVST-------SHRD 511
            ||.:       ..||......|...:.|.       :.|...||...|..:...       :|.|
Zfish   851 PGQY-------GIPRPWYFPFTKSYWCGE-------KCGWTTSVPSNRKENAEAVCIEEEPAHID 901

  Fly   512 ------SERKILKN-------ISMRIYRGEVFVILGHIGSGKLTLLRILAGLKFPLRGNVYIMGN 563
                  :..||..|       :::..|.|::...|||.|:||.|.:.||.||..|..|..||.|.
Zfish   902 PGVYIENLMKIYSNGKVAVDGLTLGFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYIQGK 966

  Fly   564 PFEPNGEARRLVDFRFDEHGLNKH-------------LTVEQTIDYHVRLKLSPSESDRYEIERR 615
                        |.|.|.:.:.::             ||||:.|.::.|||...:|..:.|:|: 
Zfish   967 ------------DIRTDLNAIRQNLGVCPQHNVLFSMLTVEEHIWFYARLKGLSAEKVKSEMEQ- 1018

  Fly   616 KWLAILDQHV-ESRGVRIGKLSSGSMKLVALCCCLAGDTPIIILEEPTTQLTGREAQIFWSIVHA 679
               .::|..: ..|..|..:||.|..:.:::.....|.:.::||:|||..:.....:..|.::..
Zfish  1019 ---IVMDLGLPHKRTSRSNQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYARRGIWDLLLK 1080

  Fly   680 EKENRAFIIATYNVGEAEHVADRIGILSMGVLEASGTPFFLRSKFSSSVDLVIIKK--------- 735
            .::.|..|::|:::.||:.:.|||.|:|.|.|...|:..||:::..:...|.::||         
Zfish  1081 YRQGRTIILSTHHMDEADILGDRIAIISHGKLCCVGSSLFLKTQLGTGYYLTLVKKDFDLSASSC 1145

  Fly   736 --------------------------------------------------PHVPDQPITDYINQF 750
                                                              .|||...:.:     
Zfish  1146 RTSSSTVSYSKGSLKKDDSVSESSSDAGLGSDHESETTTIDISLISNVIFKHVPTARLVE----- 1205

  Fly   751 MQNIEPENEIGDSLTYRLPVIYRPRLQKLLIHL--EIDRKM--LGIENVRVVGAELSDIYMTLVT 811
                    ::|..:||.||  |........:.|  |||.::  |.|.:..:....|.:|::.:..
Zfish  1206 --------DLGHEITYVLP--YESAKDGAFVELFHEIDDRLTDLSISSYGISDTTLEEIFLKVAE 1260

  Fly   812 ---------------------SFRLQQQMI----------------PDVTQT---------FKYQ 830
                                 :|...|..:                |:..:|         ..||
Zfish  1261 DCGVDAETSDGTLPARRNRRHAFGDHQSCLKPFTEDDFDFNDSEGDPESRETDWLDGADGKGSYQ 1325

  Fly   831 VVSQKQLTKQRMRAMFYKKMIHT--------APNVWPIIMIFTSFVLIAIIARL---------SV 878
            |... .|.:|:..|:.:|::::.        |..|.|.:     ||.||::..|         |:
Zfish  1326 VKGW-SLKRQQFVALLWKRLLYARRSRKGFFAQIVLPAV-----FVCIALVFSLIVPPFGKYPSL 1384

  Fly   879 LLDMPKERQNSIHIGFREPED--VVKYLPNLKDC-GYIDIRSAVKVNKKKSVGV----------- 929
            .|:.....:....|....|||  ..:.|..|||. .|.|..:..|....:|..:           
Zfish  1385 ALEPSMYEEQFTFISNDAPEDRHTNRLLDALKDSPAYTDQCTDGKNTASRSCPIKDGEWLVPEVT 1449

  Fly   930 ----------SRTFDDDSFVCE---KG-------------------------------SYRN--- 947
                      :.:.::.|.:||   :|                               |.||   
Zfish  1450 ESIEAIFLNGNWSMENPSPLCECSCEGRKKMLPECPPGAGGLPPPQIKVTHDETLQNLSGRNISD 1514

  Fly   948 ------------NLRKK---NELR----SFGAVESD----GDE------HLNGYIS------QDM 977
                        :|:.|   ||.|    |.||..:.    |||      |:....|      .|.
Zfish  1515 YLVKTYAQIIGKSLKNKLWVNEFRYGGFSLGARNTQALPPGDELTDAISHIRSRFSLESGTAADR 1579

  Fly   978 F--------------------------HSAPMMLNLLQNVILRLSYPMQTD---LVVLVENHPLP 1013
            |                          ||....||::.|.:||.:.|...|   ..:...|||| 
Zfish  1580 FLGSLSTFIRGLDTNNNVKIWFNNKGWHSIGSFLNVMNNAVLRANLPPGLDRSKFGINAFNHPL- 1643

  Fly  1014 TQLSQKINVLDNKIAHIHV------PLVVGCII---PLTVSVFVIPLVEEEIYDVRFLQHMAGLG 1069
                   |:...:::|:.:      .||..|:|   ....:.||:.|::|.:...:.:|.::|:.
Zfish  1644 -------NLTKEQLSHVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVNKAKHMQFISGVQ 1701

  Fly  1070 LKVFWGINLFWDWFTFFVYSVIIVVIMSLMGIGGFGFYENA--------IMVVLLTTFGLAALPL 1126
            ..::|..|..||...:.|.:.::::|...       |.:.|        ::.:||..:|.:..||
Zfish  1702 PFLYWLANFVWDMCNYIVPATLVIIIFVC-------FQQEAYVSSTNLPVLALLLLLYGWSITPL 1759

  Fly  1127 TYLVSMFVN-KSIVRAFLVSV-LLQGVSGLVLYIIYWDVANSNTI------------FFYAACMS 1177
            .|..|.|.. .|.....|.|| :|.|::|.|...:. ::..||.|            .|...|:.
Zfish  1760 MYPASFFFKIPSTAYVVLTSVNILIGINGSVSTFVL-ELFGSNEIGGINDILKNVFLIFPHFCLG 1823

  Fly  1178 PGFSLLDGVSNVYAQNLEQAICIDKCEATDSCTEENMNEVVPNCKFDTFFKWAAPGILPPILYMV 1242
            .|  |:|.|.|   |.:..|:             |...|    .:|.:...|...|  ..:..|.
Zfish  1824 RG--LIDMVKN---QAMADAL-------------ERFGE----NRFRSPLAWDMVG--KNLFAMA 1864

  Fly  1243 LSALIFLMLIFWIELHRREKKFHTSRDLRKMRTATYPF--DDGDVADVKQKI----AEADNTKAK 1301
            :..:||..:...|:       :......|.:.|...|.  :|.|||..:|:|    .:.|..:.:
Zfish  1865 IEGVIFFSITVLIQ-------YRFCIKARSLSTKLKPIGEEDEDVARERQRILGGGGQTDILELR 1922

  Fly  1302 Q--SVF------LVDQVEARVPAAGKRIHTVSFALNKYMSMGIFGPRNSGKSHLMRQLVGQRGFA 1358
            |  .|:      .||::...:|..              ...|:.|...:||:...:.|.|.....
Zfish  1923 QLTKVYKRKQKPAVDRLCVGIPPG--------------ECFGLLGVNGAGKTSTFKMLTGDSVVT 1973

  Fly  1359 FGEIYVRGLDFKYDLESIHTYMGYSPQHRGLLNELTPREHIRLLCMIRGVPEAKIGEKMHDLCLM 1423
            .||.|:.|.....:::.:|..|||.||...:.:.||.|||:....::|||||.::       |  
Zfish  1974 SGEAYLAGNSVLTEIDEVHQNMGYCPQFDAINDLLTGREHLEFYAILRGVPEKEV-------C-- 2029

  Fly  1424 LNMTGWMHRKCSLL----------TAEKRHKLKIALALVAYNKILVLDEPTCGMPATTRREIWNI 1478
             .:..|..||..|:          :.....||..|:||:....::.|||||.||....||.:||.
Zfish  2030 -KVADWGIRKLGLMKYVDKAAGSYSGGNMRKLSTAMALIGGPPVVFLDEPTTGMDPKARRALWNC 2093

  Fly  1479 LRYIRYCGKTIIFATNDELECKILADFIILFQDSEMLAIGSLQYLRYKYSHGFYLEVRLI----- 1538
            :..|...|::::..::...||:.|...:.:..:.....:||:|:|:.|:..|:.:.:|:.     
Zfish  2094 ILSIIKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNKFGDGYTIILRVAGADPR 2158

  Fly  1539 ---------RD--GATLAESEEN-----LRKDVENLAKFVNFLHNRSELVGRLNNWFKFYVPVGH 1587
                     |:  |:||.|...|     |...:.:||:..|.|                      
Zfish  2159 LEPVMEFIERELPGSTLKEKHRNMLQYQLSSSLTSLARIFNIL---------------------- 2201

  Fly  1588 IVYSFLYGAMEKNKLRLNVSDYCIYQADMMSVVAQVQETRAQLKH 1632
                      .|||.:|::.||.:.|..:..|.....:.::...|
Zfish  2202 ----------SKNKEQLHIEDYSVSQTTLDQVFVNFAKDQSDEDH 2236

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1801NP_728408.3 ABC2_membrane_3 <246..379 CDD:289468 23/138 (17%)
ABC2_membrane_4 <293..448 CDD:289500 28/168 (17%)
EcfA2 499..717 CDD:224047 64/251 (25%)
P-loop_NTPase 500..721 CDD:304359 65/254 (26%)
ABC2_membrane_3 <972..1254 CDD:289468 72/347 (21%)
EcfA2 1307..1521 CDD:224047 57/223 (26%)
P-loop_NTPase 1324..1524 CDD:304359 55/209 (26%)
abca1aNP_001296394.1 rim_protein 1..2233 CDD:130324 396/1990 (20%)
ABC_subfamily_A 904..1122 CDD:213230 62/233 (27%)
ABC_subfamily_A 1919..2139 CDD:213230 60/243 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.920

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