DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1801 and abch1

DIOPT Version :9

Sequence 1:	NP_728408.3	Gene:	CG1801 / 33104	FlyBaseID:	FBgn0031171	Length:	1655	Species:	Drosophila melanogaster
Sequence 2:	XP_021328839.1	Gene:	abch1 / 558667	ZFINID:	ZDB-GENE-050517-42	Length:	713	Species:	Danio rerio

Alignment Length:	716	Identity:	142/716 - (19%)
Similarity:	264/716 - (36%)	Gaps:	188/716 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   515 KILKNISMRIYRGEVFVILGHIGSGKLTLLRILAGLKFPLRGNVYIMGNP--FEPNGEARRLVDF 577
            |:|.|:::.:.:|:::.:||..|.||.|||:.:.|.....||::.::|.|  |..:....::|.:
Zfish    52 KVLNNLNLTLPQGQIYGLLGPSGCGKTTLLKCIVGTLKISRGHITVLGKPPAFPGHEVPGKMVGY 116

  Fly   578 RFDEHGLNKHLTVEQTIDYHVRLK-LSPSESDRYEIERRKWLA-ILDQHVESRGVRIGKLSSGSM 640
            ...:..|....|:..|:.:..|:. ||..|::    .|..:|. .||  :..:...:..||.|..
Zfish   117 MPQDIALYNEFTISNTLWFFGRIHGLSSKETE----ARMSFLIDFLD--LPQKHSLVKNLSGGQR 175

  Fly   641 KLVALCCCLAGDTPIIILEEPTTQLTG-REAQIFWSIVHAEKENRAFIIATYNVGEAEHVADRIG 704
            :.|:|...|..:..::||:|||..:.. ..|:|:..:|...:..:..||.|.:..|....|:.:|
Zfish   176 RRVSLGAALLQNPKLLILDEPTVGVDPVLRAKIWQHLVEIVRGGQVSIIITTHYIEEARQANTVG 240

  Fly   705 ILSMGVLEASGTP---------FFLRSKF-----------------------SSSVDLV------ 731
            ::..|.|.|.|.|         ..|.:.|                       |.|.|.:
Zfish   241 LMRNGRLLAEGPPDAVMKQHNAATLETAFLQLCEDSDQSGPKQSPQGRLLDSSPSPDSMRDEIRE 305

  Fly   732 -IIKKPHVPDQP-------------ITDYIN---------------------QFMQNI------- 754
             |::|....:.|             |..:.|                     ||:..:
Zfish   306 PILRKSTSEEMPKCKADWKVRARHIIPKWSNIAALMIKTMVRMRRLPGSLCFQFLLPVIQICLMC 370

  Fly   755 -----EPEN-EIGDSLTYRLPVIYRPRLQKLLIHLEIDRKML-------GIENVRVVGA-ELSDI 805
                 :|:| ::........|..:...|...|.:..|::..|       ||.|....|. |..:.
Zfish   371 LCIGGDPKNIDVAVVNNESSPSAFSRSLLSFLDNTSINQVSLSHSDAFDGIRNGEYWGVIEFGEN 435

  Fly   806 YMTLVTSFRLQQQMIPDVTQTFKYQVVSQKQLTKQRMRAMFYKKMIHTAPNVWPIIMIFTSFVLI 870
            :.:.:|...||.::..:|.:  ...|.:...||.:::..|..|| :|.|         |.:| :.
Zfish   436 FTSYLTKRMLQPRVSREVVE--GGSVHAWLDLTNRQIALMLQKK-LHQA---------FEAF-ME 487

  Fly   871 AIIARLSVLLDMPKERQNSIHIGFREPEDVVKYLPNLKDCGYIDIRSAVKVNKKKSVGVSRTFDD 935
            ..:..:|.::.:|        |.|.||   :....|.....::...:.:.:....:||::..
Zfish   488 KRLGSMSYMVAVP--------IKFEEP---IYGSKNTDFTTFVTPGAVLSITFYLAVGLTAL--- 538

  Fly   936 DSFVCEKGSYRNNLRKKNELRSFGAVESDGDEHLNGYISQDMFHSAPMMLNLLQNVILRLSYPMQ 1000
             |||.|        ||:..|...........|.:..::...:|..:..::.||...:|..:.|.:
Zfish   539 -SFVLE--------RKEGLLDRCWVAGVSSLETMLAHLFSQLFVISVQIILLLIFTLLVFNIPNE 594

  Fly  1001 TDLVVLVENHPLPTQLSQKINVLDNKIAHIHVPLVV---------------GCIIPLTVSVFVIP 1050
            ..|.:::           .:.||.. :..|...||:               |...|..:...||.
Zfish   595 GSLALVI-----------SLIVLQG-VTGISFGLVISSAIDDEQSANQAALGVFYPNLILSGVIW 647

  Fly  1051 LVEEEIYDVRFL-----QHMAGLGLKVF----WGIN--LFW-------DWFTFFVYSVIIVVIMS 1097
            .||...|.:|:|     |..|...|:..    ||::  :.|       .|.|||:  ::..:|:.
Zfish   648 PVECIPYPLRYLSLVLPQTYASEALRCIMYRGWGLSRMMVWRGFAVTLGWNTFFL--MLATIILK 710

  Fly  1098 L 1098
            |
Zfish   711 L 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1801	NP_728408.3	ABC2_membrane_3	<246..379	CDD:289468
		ABC2_membrane_4	<293..448	CDD:289500
		EcfA2	499..717	CDD:224047	54/206 (26%)
		P-loop_NTPase	500..721	CDD:304359	55/219 (25%)
		ABC2_membrane_3	<972..1254	CDD:289468	32/160 (20%)
		EcfA2	1307..1521	CDD:224047
		P-loop_NTPase	1324..1524	CDD:304359
abch1	XP_021328839.1	CcmA	38..>261	CDD:224054	55/214 (26%)
abch1	XP_021328839.1	ABC2_membrane_3	352..705	CDD:315386	75/402 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900