Protein Alignment CG1801 and AgaP_AGAP012155

DIOPT Version :9

• Sequence 1: NP_728408.3
• Gene: CG1801 / 33104
• FlyBaseID: FBgn0031171
• Length: 1655
• Species: Drosophila melanogaster
• Sequence 2: XP_320377.4
• Gene: AgaP_AGAP012155 / 4577893
• VectorBaseID: AGAP012155
• Length: 1710
• Species: Anopheles gambiae
• Alignment Length: 1805
• Identity: 409/1805 - (22%)
• Similarity: 765/1805 - (42%)
• Gaps: 312/1805 - (17%)

  Fly     7 LLFKRYIRIELNLWRRTLFEI----VALVIMVLV-----------------IFLNPIAH-SKRLL 49
            ||:|.:| |:...:.:|||||    :|.|::::|                 :.:|.:.| |.||
Mosquito    12 LLWKNWI-IQKRHYVQTLFEILIPAIACVVLIVVRGLVDADVYDEPTTWKPLEINTVRHMSLRL- 74

  Fly    50 YTTTENENEQSIVS-HKLQDINILTRMADSKREKTKYILAFTPETTFTSEVTKN-VAKTLELSST 112
               ::.|.|..::: ..|:.| |...:..:......::||::|::..|..:.:. |.:.||....
Mosquito    75 ---SDQEEEDCVLTLLSLKSI-IRPELNPNITPPITFMLAYSPQSALTERIMRRAVDQILEPIDI 135

  Fly   113 VGYESESEMQNQFDERTTLAGIVF-NDLRD-DGTPLTLSISIRFPSEFRTIAPFLTEDRLWITRC 175
            .|:|:...|::.|....:|||:.| .:.:| |..|..:::::|||.|.||:....|  ..|....
Mosquito   136 AGFENTQRMEDFFRLNYSLAGVEFPENYKDLDTLPNNVTVALRFPGEMRTLQDDFT--AFWANWA 198

  Fly   176 SGRINP------GRDRAKHDKQQDI-YIREGFLQLQHQI---FVEWYHQLRKDIVSTYPE----- 225
            :..:.|      .|:|.:.|..... |..|.|:.:|..:   .:     |.:|.....|:
Mosquito   199 TELMFPAFQIAGARERERDDAGYPANYYNESFIAVQSAVSRAII-----LERDASFALPDIYLNR 258

  Fly   226 -PNVEVYNILLKAADEPCSVMSVAQLPTFLYNFIYLLPFLNIIRNVAAQVEDGVMVHQWHYGYSF 289
             |....|:..|....|  :::.:..:..|.|..|..:.::.:.:.  .|:::.:.:    .|...
Mosquito   259 FPYPPYYSDPLLTGFE--NLLPLIIVIAFFYTAINTVKYITVEKE--KQLKETMKI----MGLPS 315

  Fly   290 GMQWGIKFLVLFLRMCILGVIYTIML--------------LAFWGFGGREGEFSGTGTIAFVCFI 340
            .:.|...|:     .|:|.:|.:|.|              ||.:       |::....:.|..|:
Mosquito   316 WLHWSAWFV-----KCLLLLIVSISLIVVLLCVNITTNTDLAIF-------EYAEWTVVWFYLFV 368

  Fly   341 TLYTVEIIITGMVVAKLFANPTNAVLFALMLWLFMYAAFCIILERYWDIHKYYVFFILVAFCNCQ 405
              :::..|....:|:..|:....|...|.:||..:...:.|....|.|: .......|..|.|..
Mosquito   369 --FSITTICYCFMVSTFFSKANIAAGIAGLLWFILIVPYNIAFANYDDM-TAGAKTALCLFSNSA 430

  Fly   406 MHFSMSL------------FRNCIEKPEMVNTIDF------VLIFTSAISSALIYFLILLAIQWR 452
            |.|...|            :.|..| |..|:. ||      |::...||    ||..|.|.::..
Mosquito   431 MSFGFMLMMRHEGTATGLQWSNLFE-PVSVDD-DFSVGDTMVMLLVDAI----IYLSIALYVEKV 489

  Fly   453 MPGTF---------LSRRIVNNRPRKQQESDTTIMYLGRAPSFQNFEFGDVGSVELMRLRHVSTS 508
            .||.|         .:::......:::||...........|:.:....|....:::.:||    .
Mosquito   490 FPGEFGIAEPWYFLYTKKFWCKETQQKQEPAVLDFSNYNTPNIEREPDGKYAGIKIKKLR----K 550

  Fly   509 HRDSERKILKNISMRIYRGEVFVILGHIGSGKLTLLRILAGLKFPLRGNVYIMGNPFEPNGEARR 573
            .....:..::.:.:.:|..::.|:|||.|:||.|.:.:|.|:..|..|...:.|.....|.:|.|
Mosquito   551 EFQKNKVAVQGLDLNMYEDQITVLLGHNGAGKTTTMSMLTGMFSPSSGTALVNGYDIRNNIDAVR 615

  Fly   574 LVDFRFDEHG-LNKHLTVEQTIDYHVRLKLSPSESDRYEIERRKWLAILD--------QHVESRG 629
            .......:|. |...:||.:.|::..|||..|....:.||  |.::.:|:        .|..|.|
Mosquito   616 GSLGLCPQHNVLFNEMTVAEHIEFFARLKGVPRSKIKDEI--RHYVQLLELEDKLNKQSHTLSGG 678

  Fly   630 VRIGKLSSGSMKLVALCCCLAGDTPIIILEEPTTQLTGREAQIFWSIVHAEKENRAFIIATYNVG 694
            :: .|||.|    :|||    |.:.:::.:|||:.:.....:..|.::..||:.|..:::|:.:.
Mosquito   679 MK-RKLSVG----IALC----GGSKVVLCDEPTSGMDPSARRALWDLLIKEKQGRTILLSTHFMD 734

  Fly   695 EAEHVADRIGILSMGVLEASGTPFFLRSKFSSSVDLVIIKKPHVPDQPITDYINQFMQNIEPENE 759
            ||:.:.|||.|::.|.|:|.|:.|||:.:|.....|:.:|..:.....:|..:.|.:.||..:.:
Mosquito   735 EADILGDRIAIMAEGELKACGSSFFLKKRFGVGYRLICVKGANCDRARLTGILRQHIPNINIDTD 799

  Fly   760 IGDSLTYRLPVIYRPRLQKLLIHLEIDRKMLGIENVRVVGAELSDIYMTLVT-SFRLQQQ----- 818
            ||..|:|.|...|....|.||..||.:.:..||.:..:....|.::::.:.: |:.|.|:
Mosquito   800 IGSELSYVLNEDYTAVFQDLLRDLEDNVEQCGITSYGISLTTLEEVFLRVGSDSYALDQKKGSSD 864

  Fly   819 ---------------MIPDVTQTFKYQ-VVSQKQLTKQRMRAMFYKKMIHTAPN-----VWPIIM 862
                           ....:.||...| ::....|...::.||..||.|.|..:     |..:|.
Mosquito   865 SEQDSSNGLDSSYGSSTVTMNQTSDTQPLLGGSSLMWNQLFAMLLKKFISTKRSWIQMLVQALIP 929

  Fly   863 IFTSFVLIAIIARLSVLLDMPKERQNSIHI------------------GFR-------------- 895
            |:...|.:.|:.......|:|....|..:.                  |||
Mosquito   930 IYFVIVTVIIVRTFPGQTDLPAIPINVYNYSTTTTILQASAPGSPFVDGFRAVFEAFPSTHQLRI 994

  Fly   896 EPEDVVKYLPNLKDCGYIDIRSAVKVNKKKSVGVSRTFDDDSFVCEKGSYRNNLRKKNELRSFGA 960
            ..:|:|.|:        :|:.:       :::|:..                        |.|.|
Mosquito   995 TDKDMVDYI--------LDVST-------ENIGLVN------------------------REFMA 1020

  Fly   961 VESDGDEHLNGYISQDMFHSAPMMLNLLQNVILRLSYPMQTDLVVLVENHPLPTQLSQKINVLD- 1024
            ..|..:.:...:.:...||:||:.||.:.|.|::   .:..:..:.:.|.|||.:...:...|.
Mosquito  1021 AASITNTNHTVWWNPTGFHTAPLALNFMYNAIIK---SINKNFEITIINKPLPFKAETRFTQLQA 1082

  Fly  1025 -NKIAHIHVPLVVGCIIPLTVSVFVIPLVEEEIYDVRFLQHMAGLGLKVFWGINLFWDWFTFFVY 1088
             |.:. ..:....|..:....:::::..::|.....:.||.::|:.:..||.::..||:.|:.:.
Mosquito  1083 GNNLG-FQISFNTGFAMSFIAALYIMFYIKERTSRAKLLQFVSGINVFTFWIVSFVWDFLTYVIT 1146

  Fly  1089 SVIIVVIMSLMGIGGFGFYENAIMVVL-LTTFGLAALPLTYLVSM--------FVNKSIVR---- 1140
            ::|.:..::.....|:..:|....|.| |..||:|.||:|||.|.        ||...||.
Mosquito  1147 ALIYIATLAAFQEDGWSSFEELGRVFLVLIVFGIAFLPVTYLFSFWFEVPATGFVKMMIVNIFSG 1211

  Fly  1141 -AFLVSVLLQGVSGLVLYIIYWDVANSNTIFFYAACMSPGFSLLDGVSNVYAQNLEQAICIDKC- 1203
             .|..:|.|....|..|.    ||||.   ..:|..:.|.|||...:||:...:...::|:::|
Mosquito  1212 TIFFTAVFLLKFDGFDLK----DVANG---LEWAFMIFPLFSLSQSLSNINVLSTTASVCLEQCT 1269

  Fly  1204 -EATDSCTEENMNEVVPNCKFDTFFKWAAPGILPPILYMVLSALIFLMLIFWIE-------LHRR 1260
             |....|::|.:..::|.|.....|.|.:.||...::||....|:..:::..||       |.||
Mosquito  1270 EETASLCSQEYLCSLLPQCCDTNIFSWESTGINRQLMYMGGVGLVGFLILMGIEFRVVERVLKRR 1334

  Fly  1261 EKKFHT-----SRDLRKMRTATYPFDDGDVADVKQKIAE-ADNTKAKQSVFLVDQVEARVPAAGK 1319
            ::....     |.|         |..|.||.:.|:::.. :|...|.:::...|..:    ..||
Mosquito  1335 KRSSGAITPAGSED---------PTQDDDVLEEKRRVKSLSDGELANKNLVASDLTK----YYGK 1386

  Fly  1320 --RIHTVSFALNKYMSMGIFGPRNSGKSHLMRQLVGQRGFAFGEIYVRGLDFKYDLESIHTYMGY 1382
              .::.:|.::......|:.|...:||:...:.|.|....:.||.:|:|:..|.:|..:|..:||
Mosquito  1387 FLAVNQLSVSVEGSECFGLLGVNGAGKTSTFKMLTGDENISAGEAWVKGISLKSNLNQVHKVIGY 1451

  Fly  1383 SPQHRGLLNELTPREHIRLLCMIRGVPEAKIGEKMHDLCLMLNMTGWMHRKCSLLTAEKRHKLKI 1447
            .||...||.:||.||.:::..::||:|:.:|..:...|...||....:.::....:...:.||..
Mosquito  1452 CPQFDALLEDLTGRETMKIFALLRGIPQQEIALETVRLAEELNFMKHIDKRVKEYSGGNKRKLST 1516

  Fly  1448 ALALVAYNKILVLDEPTCGMPATTRREIWNILRYIRYCGKTIIFATNDELECKILADFIILFQDS 1512
            ||||:|...::.|||||.||....:|.:||::..::..||:|:..::...||:.|...:.:..:.
Mosquito  1517 ALALLANPAVVYLDEPTTGMDPGAKRHLWNVIINVKKAGKSIVLTSHSMEECEALCTRLAIMVNG 1581

  Fly  1513 EMLAIGSLQYLRYKYSHGFYLEVRLIRDGATLAESEENLRKDV-ENLAKFVNF-------LHNRS 1569
            |...|||.|:|:.|:|.|::|.::|.|.|.....:.|.:|:.| :|.|:..:.       |..|.
Mosquito  1582 EFKCIGSTQHLKNKFSKGYFLTIKLNRTGDGSTANAEPVRQFVAQNFAQAYSHWALGLIPLFTRF 1646

  Fly  1570 ELVGRLNNWFKFYVPVGHIVYSFLYGAMEKNKLRLNVSDYCIYQADMMSV 1619
            ......::...:::....:.:|.::|.||:.|..|::.||.:.|..:..|
Mosquito  1647 NCREEYHDSLTYHITQSELKWSSMFGLMEEAKRTLDIEDYALGQTSLEQV 1696

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1801	NP_728408.3	ABC2_membrane_3	<246..379	CDD:289468	24/146 (16%)
		ABC2_membrane_4	<293..448	CDD:289500	40/186 (22%)
		EcfA2	499..717	CDD:224047	61/226 (27%)
		P-loop_NTPase	500..721	CDD:304359	63/229 (28%)
		ABC2_membrane_3	<972..1254	CDD:289468	73/299 (24%)
		EcfA2	1307..1521	CDD:224047	61/215 (28%)
		P-loop_NTPase	1324..1524	CDD:304359	59/199 (30%)
AgaP_AGAP012155	XP_320377.4	ABC2_membrane_3	<225..485	CDD:289468	56/293 (19%)
		CcmA	543..849	CDD:224054	85/320 (27%)
		ABC_subfamily_A	543..761	CDD:213230	63/232 (27%)
		ABC2_membrane_3	919..1255	CDD:289468	79/385 (21%)
		ABC_subfamily_A	1375..1593	CDD:213230	62/221 (28%)
		drrA	1382..1701	CDD:130256	86/319 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X215
TreeFam	0	0.000	Not matched by this tool.
	6	5.920