DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1801 and CG6052

DIOPT Version :9

Sequence 1:	NP_728408.3	Gene:	CG1801 / 33104	FlyBaseID:	FBgn0031171	Length:	1655	Species:	Drosophila melanogaster
Sequence 2:	NP_649002.3	Gene:	CG6052 / 39971	FlyBaseID:	FBgn0036747	Length:	1725	Species:	Drosophila melanogaster

Alignment Length:	1798	Identity:	430/1798 - (23%)
Similarity:	747/1798 - (41%)	Gaps:	305/1798 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KGLLFKRYIRIELNLWRRTLFEIVALVIMVLVIFLNPIAHSKRLLYTTTENENEQSIVSHKLQDI 69
            |.|::|.:|.    .|.:.:..:.|||:.||.:.|..:..    :....|..:|....:..:.|:
  Fly    23 KLLMWKNWIL----QWNQKMQIVFALVLPVLFLCLILVLR----IIVLPEKMDEIRYPTVSISDL 79

  Fly    70 NILTRMA---------DSKREKTKYILAFTPETTFTSEVTKNVAKTLELSSTVGYESESEMQNQF 125
            |:..||.         :......:..|.:||.....|.:....|..|.|..|..|::...|:...
  Fly    80 NLYMRMVPLGNRILHENGSLNIPRNFLCYTPNNPINSAIVGATAIRLRLLGTRAYDTALHMEQDM 144

  Fly   126 DERTTLAGIVFND-----LRDDGTPLTLSISIRFPSEFRTI-APFL---TEDRLWIT-RCSGRIN 180
            .....|||:.|.|     ..|.|.||.|:.|:|||||.||: .|.:   ...||::: ..||
  Fly   145 VLHNFLAGVQFEDNENVNTNDAGYPLNLNYSLRFPSELRTMQGPIIDTWRTSRLFLSYDTSG--- 206

  Fly   181 PGRDRAKHDKQQDI-YIREGFLQLQHQIFVEWYHQLRKDIVSTYPEPNVEVYNILLKAADEPCSV 244
             .|:|..:|....: |||||||.:||.:.:.|. .|...:..| ..|.:.:.....:|......:
  Fly   207 -SRNRLDNDGGVPVGYIREGFLPIQHALTMSWL-ALASGVTDT-GIPAIHLQRFPYRAYTYDQLL 268

  Fly   245 MSVAQLPTF--LYNFIYLLPFLNIIRNVAAQVE---DGVM----VHQW-HYGYSFGMQWGIK-FL 298
            ..:.||..|  |.:|||  |...:.:.|.::.|   ..:|    ||.| |:     :.|.:| ::
  Fly   269 SGLRQLLPFVILLSFIY--PASTVTKYVTSEKELQLKEIMKLIGVHNWLHW-----VAWFVKSYI 326

  Fly   299 VLFLRMCILGVIYTIMLLAFWGFGGREGEFSGTGTIAFVCFITLYTVEIIITGMVVAKLFANPTN 363
            :|.|      |::.||.|....|.......:.:..:..:.|:..|.|..:....::|.||:..:.
  Fly   327 MLML------VVFLIMSLIMVKFYASVAVLTFSSWVPVLLFLHTYVVTSVCLCFMLAVLFSKAST 385

  Fly   364 AVLFALMLWLFMYAAFCIILERYWDIHKYYVFFILVAFCNCQMHFSMSL------------FRNC 416
            |...|.:.|...|..:......|..:.......|.:.|.|..:.|.:.:            :||.
  Fly   386 ASAVAAIFWFLTYIPYSFGYYYYERLSLMSKLLISLIFSNSALGFGIHVIVMWEGTGEGITWRNM 450

  Fly   417 IEKPEMVNTID----FVLIFTSAISSALIYFLILLAIQWRMPGTFLSRRIVN-----NRPRKQQE 472
            ...   |:|.|    |.:|.|.:..| :::..|.|.::...||.:...|..|     |..|:...
  Fly   451 FHP---VSTDDSLTLFYIIMTMSFGS-IMFISICLYVEQVFPGEYGVPRRWNFMCHKNYWRQYVP 511

  Fly   473 SDTTIMYLGRAPSFQNFEFGDVGSVELMRLRHVSTSHRDSER-----KILKNISMRIYRGEVFVI 532
            |      |...||||....|...:....|.|.|.....:.::     |.:|.||::::|.|:.|:
  Fly   512 S------LNIVPSFQTILHGSAKAKSCRRAREVGIQLFNLQKNYGKLKAVKGISLKMHRNEITVL 570

  Fly   533 LGHIGSGKLTLLRILAGLKFPLRGNVYIMGNPFEPN-GEARRLVDFRFDEHGLNKHLTVEQTIDY 596
            |||.|:||.|.:.::.|:..|..|...:.|.....: .:||..:......:.|.|.::|...|.:
  Fly   571 LGHNGAGKTTTINMITGIVKPTSGTAIVNGYDIRTHLAKARESLGICPQNNILFKEMSVRDHIIF 635

  Fly   597 HVRLKLSPSESDRYEIERRKWLAILDQHVESRGVRIGKLSSGSMKLVALCCCLAGDTPIIILEEP 661
            ..:|| ....:...|.|..|::.:|....:|. |....||.|..:.::|||.|.|:..:::.:||
  Fly   636 FSKLK-GIRGTKAVENEVGKYMTMLKLQDKSY-VAAKNLSGGMKRKLSLCCALCGNAKVVLCDEP 698

  Fly   662 TTQLTGREAQIFWSIVHAEKENRAFIIATYNVGEAEHVADRIGILSMGVLEASGTPFFLRSKFSS 726
            ::.:.....:..|.::.:||:.|..::.|:.:.||:.:.|||.|||.|.|:..||.|:|:.:|.:
  Fly   699 SSGIDAAGRRSLWDLLQSEKDGRTILLTTHYMDEADVLGDRIAILSEGKLQCQGTSFYLKKRFGT 763

  Fly   727 SVDLVIIKKPHVPDQPITDYINQFMQNIEPENEIGDSLTYRLPVIYRPRLQKLLIHLEIDRKMLG 791
            ...||.|.:.......:|..|.:::..|:||..:|..||||||..|..:..:||..|:.....|.
  Fly   764 GYLLVCIMQSGCDVGAVTQLIRKYVPPIKPERVLGTELTYRLPTEYSKKFAELLQDLDEKCAQLQ 828

  Fly   792 IENVRVVGAELSDIYMTLVTSFRLQ---QQMIPDVTQTFKYQVVSQKQLTKQRMR-------AMF 846
            :....:.||.|.|::|.:.|..|:|   :....|.:..||..|...|...|:|:|       |:|
  Fly   829 LVGYGLSGATLEDVFMAVNTDKRVQGGAEGPPVDGSIDFKELVFDSKTREKRRIRRCFMFWQALF 893

  Fly   847 YKKMIHTAPNVWPIIMIFTSFVLIAIIARLSVLLDMPKERQNSIHIGFREPEDVVKYLPNLKDCG 911
            .||...|..|.|   ::....||...:..|::|    ..|...|:.          .||.:
  Fly   894 LKKFYTTTRNYW---LLGIQLVLPIAVMALTIL----NSRGGRIYY----------ELPAM---- 937

  Fly   912 YIDIRSAVKVNKKKSVGV---SRTFDDDSFVCEKGSYRNNL----RKKNELRSFGAVESDGDEHL 969
                  .:.:|:..|..|   ..|.|..|.:.:  :|..:|    |:...||:       ||...
  Fly   938 ------PISINQYSSAYVVLEDNTTDKTSSLAD--AYSKHLEHYARRCTLLRT-------GDLKF 987

  Fly   970 NGYI-SQDM-----------------------------FHSAPMMLNLLQNVI-LRLSYPMQTDL 1003
            ..|| |.|:                             .|:||:.||||.|.: ::|   :..|.
  Fly   988 EDYILSHDVNHSRRIDFHFLAGLTVSENNFIVWLNNKPLHTAPLTLNLLHNALAIKL---LGQDA 1049

  Fly  1004 VVLVENHPLP------TQLSQKINVLDNKIAHIHVPLVVGCIIPLTVSVFVIPLVEEEIYDVRFL 1062
            ...|.|.|||      |....|..||..:|: |::.|.: |.|   .:.:.||::.|.....:.|
  Fly  1050 STYVTNEPLPYSDDTRTLRLNKGQVLGAEIS-INLSLTM-CFI---TAFYAIPIIRERETRAKLL 1109

  Fly  1063 QHMAGLGLKVFWGINLFWDWFTFFVYSVIIVVIMSLMGIGGFG-------------FYENAIMVV 1114
            |.::|:.:..:|..::.||:..|     ::..:.|::.|..|.             ||
  Fly  1110 QFLSGVDVCAYWTSHIVWDYLVF-----VLSALSSILTIAAFKEIGYITPLDLSRYFY------- 1162

  Fly  1115 LLTTFGLAALPLTYLVSMFVNKS---IVRAFLVSVLLQGVSGLVLYIIYW----------DVANS 1166
            :|..||...:.|:|..|...:.:   ..|..:::.|:    |..|::::.          |||..
  Fly  1163 MLLIFGFPGIMLSYAASGCFSDAATGFTRISIINTLM----GTGLFLMFMTLNFEAFQLKDVAEK 1223

  Fly  1167 NTIFFYAACMSPGFSLLDGVSNVY-AQNLEQAICID---------KCEATDSCTEENMNEVVPNC 1221
            ...:|.   :||.:||.....::: ..|:.:...|.         :|.....|           |
  Fly  1224 LAWYFR---LSPHYSLASSTHSIHIGYNIRRGCSIGGIRKLPKQLRCRNVPIC-----------C 1274

  Fly  1222 KFDTFFKWAAPGILPPILYMV-LSALIFLMLIFWIELHR-------REKKFHTSRDLRKMRTATY 1278
            ....::.|..||:|..|.||: |.:.:||:::    :|.       .||..:.....:::...|.
  Fly  1275 DIPGYYGWRKPGVLVEITYMIMLGSTLFLLIV----MHDAKVCNLIAEKLGNCFSKRKRVEGGTS 1335

  Fly  1279 PFDDGDVADVKQKIAEADNTKAKQSVFLVDQVEARVPAAGKRIHTVSFALNKYMSMGIFGPRNSG 1343
            ..:|..||: ::.:.|..|:..|....||.::..|. .:...:..:||.:......|:.|...:|
  Fly  1336 IENDSVVAE-QRVVREMINSGRKDVPLLVYKISKRY-RSKLAVKAISFHVPHAECFGLLGINGAG 1398

  Fly  1344 KSHLMRQLVGQRGFAFGEIYVRGLDFKYDLESIHTYMGYSPQHRGLLNELTPREHIRLLCMIRGV 1408
            |:...:.|.|......||.|:.|.:.  ....::..:||.||...|..:||.||.:.:.|::|||
  Fly  1399 KTSTFKMLAGDEKITSGEAYIDGTNI--STHKVYRKIGYCPQFDALFEDLTGRETLNIYCLLRGV 1461

  Fly  1409 PEAKIGEKMHDLCLMLNMTGWMHRKCSLLTAEKRHKLKIALALVAYNKILVLDEPTCGMPATTRR 1473
            ....:......|.:.......|.::....:...|.||..|::::....:|.|||||.||....||
  Fly  1462 QRRHVTPICWGLAISFGFAKHMDKQTKHYSGGNRRKLSTAISVLGNPSVLYLDEPTSGMDPAARR 1526

  Fly  1474 EIWNILRYIRYCGKTIIFATNDELECKILADFIILFQDSEMLAIGSLQYLRYKYSHGFYLEV--- 1535
            ::|.|:..||..||:|:..::...||:.|...:.:..|.|...:||:|.|:.::|.|..|:|
  Fly  1527 QLWQIIGLIRTAGKSIVLTSHSMDECEALCSRLAIMVDGEFKCLGSVQSLKNQFSKGLILKVKVK 1591

  Fly  1536 -------RLIRDGATLAE----SEENLR----------KDVENLAKFVNFLHNR---SELVGRLN 1576
                   |::.|.::..:    ||.:|:          ...:.:.|...|:...   :||....|
  Fly  1592 HKKKTFQRVVEDSSSSNDKKSISETDLKFLQMASVMESSQADRILKVNRFISKEIPDAELKEEYN 1656

  Fly  1577 NWFKFYVPVGHIVYSFLYGAMEKNKLRLNVSDYCIYQADMMSV 1619
            ....:|:|....: |.::..:|.|..:||:.||.|.|..:..:
  Fly  1657 GLITYYIPHSKTL-SKIFQLLETNSHKLNIEDYLIMQTRLEEI 1698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1801	NP_728408.3	ABC2_membrane_3	<246..379	CDD:289468	34/143 (24%)
		ABC2_membrane_4	<293..448	CDD:289500	34/171 (20%)
		EcfA2	499..717	CDD:224047	61/223 (27%)
		P-loop_NTPase	500..721	CDD:304359	63/226 (28%)
		ABC2_membrane_3	<972..1254	CDD:289468	76/355 (21%)
		EcfA2	1307..1521	CDD:224047	57/213 (27%)
		P-loop_NTPase	1324..1524	CDD:304359	56/199 (28%)
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324	10/34 (29%)
CG6052	NP_649002.3	rim_protein	<149..1709	CDD:130324	403/1664 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451226
Domainoid	1	1.000	40	1.000	Domainoid score	I3722
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	228	1.000	Inparanoid score	I138
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	1	1.000	-	-		otm51427
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X215
	9	9.000