DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1801 and Abca17

DIOPT Version :9

Sequence 1:	NP_728408.3	Gene:	CG1801 / 33104	FlyBaseID:	FBgn0031171	Length:	1655	Species:	Drosophila melanogaster
Sequence 2:	NP_001026792.2	Gene:	Abca17 / 381072	MGIID:	3625331	Length:	1733	Species:	Mus musculus

Alignment Length:	1841	Identity:	412/1841 - (22%)
Similarity:	748/1841 - (40%)	Gaps:	346/1841 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RIELNLW-------RRTLFEIVALVI------MVLVIFLNPIAHSKRLLYTTTENENEQSIVSHK 65
            :::|.||       |:||..::.:::      :||.:.||.:...|             |..::.
Mouse     6 KLKLLLWKNFILKRRKTLITLLEMLMPLLFCAIVLYLRLNSMPRKK-------------SSTNYP 57

  Fly    66 LQDINILTRMADSKREKTKYILAFTPETTFTSEVTKNVAKTLELSSTV-----GYESESEMQNQF 125
            ..|:::|.....:...|:|:.||:.|.   .||..|.|.:.:|.:..|     |:.|....::..
Mouse    58 AVDVSLLPVYFYNYPLKSKFQLAYIPS---KSETLKAVTEVVEQTFAVDFEVLGFPSVPLFEDYI 119

  Fly   126 --DERT--TLAGIVF-NDLRDDGTPLTLSI--SIRFPSEFRT-IAP-----FLTEDRLWITRCSG 177
              |.::  .|.||:| :|......||.|.:  .:||....|. ::|     |..|...|   |:.
Mouse   120 IKDPKSFYILVGIIFHHDFNSSNEPLPLVVKYDLRFSYVQRNFVSPPRHLFFQEEIEGW---CTA 181

  Fly   178 RINP------GRDRAKHDKQQDIYIREGFLQLQHQI--FVEWYH------QLRKD---IVSTYP- 224
            .:.|      .|:.:..|.....|.:||||.:||.:  .:..:|      .:.||   :|..:|
Mouse   182 FLYPPNLSQAPREFSYADGGNPGYNKEGFLAIQHAVDKAIMRHHAPKAALNMFKDLHVLVQRFPF 246

  Fly   225 EPNVEVYNILLKAADEPCSVMSVAQLPTFLYNFIYLLPF----LNIIRNVAAQVEDGVMVHQWHY 285
            .|:::          :|..|:...:.|..|     :|.|    |.|..:|.::.|.....:....
Mouse   247 GPHIQ----------DPFLVILQNEFPLLL-----MLSFICVELIITNSVLSEKERKQKEYMSMM 296

  Fly   286 GYSFGMQWGIKFLVLFLRMCILGVIYTIMLLAFWGFGGREGEFSGTGTIAFVCFITLYTVEIIIT 350
            |....:.|...|:..|:.   :.:..::|.:.|.....|...|..:.......|:..:.:..|..
Mouse   297 GVESWLHWVAWFITFFIS---VSITVSVMTVLFCTKINRVAVFRNSNPTLIFIFLMCFAIATIFF 358

  Fly   351 GMVVAKLFANPTNAVLFALMLWLFMYAAFCIILERYWDIHK--YYVFFILVAFCNCQMHFS---M 410
            ..:::..|.......:....::.|.|..:..|...|   |:  |....:...|.|..|...   :
Mouse   359 AFMMSTFFQRAHVGTVIGGTVFFFTYLPYMYITFSY---HQRTYTQKILSCLFSNVAMATGVRFI 420

  Fly   411 SLF---------RNCIEKPEMVNTIDFVLIFTSAISSALIYFLILLAIQWRMPGTF--------L 458
            |||         ||.   ..:.....|..:....:..:.:|.||...::...|..|        .
Mouse   421 SLFEAEGTGIQWRNI---GSVWGDFSFAQVLGMLLLDSFLYCLIAFLVESLFPRKFGIPKSWYIF 482

  Fly   459 SRRIVNNRPRKQQESDTTIMYLG--RAPSFQNF----EFGDVGSVELMRLRHVSTSHRDSERKIL 517
            :::.|...|        .::.:|  ..||..||    ....:.::|:..|..|..|.| |:|..:
Mouse   483 AKKPVPEIP--------PLLNIGDPEKPSKGNFMQDEPTNQMNTIEIQHLYKVFYSGR-SKRTAI 538

  Fly   518 KNISMRIYRGEVFVILGHIGSGKLTLLRILAGLKFPLRGNVYIMGNPFEPN-GEARRLV------ 575
            :::||.:|:|:|.|:|||.|:||.|:..:|.||..|.:|:.||.|.....: .:.|:.:
Mouse   539 RDLSMNLYKGQVTVLLGHNGAGKTTVCSVLTGLITPSKGHAYIHGCEISKDMVQIRKSLGWCPQH 603

  Fly   576 DFRFDEHGLNKHLTVEQTIDYHVRLK-LSPSESDRYEIERRKWLAILDQHVESRGVRIGKLSSGS 639
            |..||...:..||.      ::.:|| |||.:......|....|.:.|:. .||    .|..||.
Mouse   604 DILFDNFTVTDHLY------FYGQLKGLSPQDCHEQTQEMLHLLGLKDKW-NSR----SKFLSGG 657

  Fly   640 MK-LVALCCCLAGDTPIIILEEPTTQLTGREAQIFWSIVHAEKENRAFIIATYNVGEAEHVADRI 703
            || .:::...|...:.::||:|||:.|.....:..|.::..:|.:|..::.|:.:.||:.:.|||
Mouse   658 MKRKLSIGIALIAGSKVLILDEPTSGLDSPSRRAIWDLLQQQKGDRTVLLTTHFMDEADLLGDRI 722

  Fly   704 GILSMGVLEASGTPFFLRSKFSSSVDLVIIKKPHVPDQPITDYINQFMQNIEPENEIGDSLTYRL 768
            .||:.|.|:..|:|.||:.|:.:...:.|||.|......:::.|...:.|...|:.||:.:...|
Mouse   723 AILAKGELQCCGSPSFLKQKYGAGYYMTIIKTPLCDTSKLSEVIYHHIPNAVLESNIGEEMIVTL 787

  Fly   769 PVIYRPRLQKLLIHLEIDRKMLGI----------ENVRVVGAELSDIYMTLVTSFRLQQQMIPD- 822
            |.....|.:.|...||:.:..|||          |.|.:...:|:|....::|..|.....:|.
Mouse   788 PKKTIHRFEALFNDLELRQTELGISTFATSVTTMEEVFIRVCKLADPSTNVLTEKRHSLHPLPRH 852

  Fly   823 -----------VTQTFKYQVVSQKQ---------LTKQRMRAMFYKKMIHTAPNVWPIIMIFTSF 867
                       .:.||.   ||.:|         |..|:..||..||:.::..| |.:::.....
Mouse   853 HRVPVDRIKCLHSGTFP---VSTEQPMRLNTGFCLLCQQFYAMLLKKITYSRRN-WMLVLSVQVL 913

  Fly   868 VLIAIIA--------RLSVLLDMPKE---------------RQNSIHIGFREPEDVVKYLPNLKD 909
            :.:|||.        :|..|.::|.|               .:|| |:..:..:|.||.   |..
Mouse   914 LPLAIIMLSLTFFNFKLRKLDNVPLELTLQTYGQTIVPFFIAENS-HLDPQLSDDFVKM---LVA 974

  Fly   910 CGYIDIRSAVKVNKKKSVGVSRTFDDDSFVCEKGSYRNNLRKK--------NELRSFGAVESDGD 966
            .|.:.:|.                        :||..:.|.||        ::|....|...|.:
Mouse   975 AGQVPLRI------------------------QGSVEDFLLKKAKEAPEGFDKLYVVAASFEDVN 1015

  Fly   967 EH--LNGYISQDMFHSAPMMLNLLQNVILRLSYPMQTDLVVLVENHPLP---TQLSQKINVLDNK 1026
            .|  :....:...:||..:.|.|:.|::.:|.  ...:..:...|:|.|   .::|:.|.....|
Mouse  1016 NHTTVKALFNNQAYHSPSLALTLVDNLLFKLL--SGANASITTTNYPQPQTAIEVSESILYQGPK 1078

  Fly  1027 IAHIHVPLVVGCIIPLTVSVFVIPLVEEEIYDVRFLQHMAGLGLKVFWGINLFWDWFTFFVYSVI 1091
            ..::.|..:.|  |....|.|.|..|.|:....:.||.::|:...|||...|.||..:|.|.:::
Mouse  1079 GHYLVVNFLFG--IAFLSSSFSILTVGEKSVKSKSLQFVSGVSTAVFWLSALLWDLISFLVPTLL 1141

  Fly  1092 IVVIMSLMGIGGFGFYENAIMVVL-LTTFGLAALPLTYLVSMFVNK--SIVRAFLVSVLLQGVSG 1153
            :|::........|..:|:...||| :..:|.|.:||.|.||...|.  |.....:|.:....:|.
Mouse  1142 LVLVFLWYKEEAFAHHESIPAVVLIMMLYGWAVIPLVYTVSFSFNTPGSACVKLVVMLTFLSISP 1206

  Fly  1154 LVLYII-------YWDVANS-NTIFFYAACMSPGFSLLDGVSNVY----------AQNLEQAICI 1200
            :||..:       |.::::| :.||.    :.||..|...:||:|          |:||....|.
Mouse  1207 VVLVTVTSEKDLGYTELSDSLDHIFL----ILPGHCLGMALSNLYYNFELKKFCSAKNLSDIDCN 1267

  Fly  1201 DKCEATDSCTEENMNEVVPNCKFDTFFKWAAPGILPPILYMVLSALIFLMLIFWIELHRREKKFH 1265
            |..|.  ...:||:            :.|.:.||...:..:.:...:::.::|..|.:    .|:
Mouse  1268 DVLEG--YVVQENI------------YAWESLGIGKYLTALAVLGPVYITMLFLTEAN----AFY 1314

  Fly  1266 TSRDLRKMRTATYP----------FD-----DGDVADVKQKIAEADNTKAKQSVFLVDQV----E 1311
            .   |:...:..:|          ||     |.||.:..:.|.....|..|::..:|.:|    :
Mouse  1315 V---LKSRLSGFFPSFWKEKSGMIFDVAEPEDEDVLEEAETIKRYLETLVKKNPLVVKEVSKVYK 1376

  Fly  1312 ARVPAAGKRIHTVSFALNKYMSMGIFGPRNSGKSHLMRQLVGQRGFAFGEIYVRGLDFKYDLESI 1376
            .:||...  ::.|||.:.:....|:.|...:||:.:...|..::....|:.:|:|.:.|.|:..:
Mouse  1377 DKVPLLA--VNKVSFVVKEEECFGLLGLNGAGKTSIFNMLTSEQPITSGDAFVKGFNIKSDIAKV 1439

  Fly  1377 HTYMGYSPQHRGLLNELTPREHIRLLCMIRGVPEAKIGEKMHDLCLMLNMTGWMHRKCS-----L 1436
            ..::||.|:...|||.:|.||.:.:...|||:||..|     ..|:.|.:...:...|:     .
Mouse  1440 RQWIGYCPEFDALLNFMTGREMLVMYARIRGIPECHI-----KACVDLILENLLMCVCADKLVKT 1499

  Fly  1437 LTAEKRHKLKIALALVAYNKILVLDEPTCGMPATTRREIWNILRYIRYCGKTIIFATNDELECKI 1501
            .:...:..|...:|||....:::||||:.||....||.:|:.:..:|..||||:..::...||:.
Mouse  1500 YSGGNKRMLSTGIALVGEPAVILLDEPSTGMDPVARRLLWDTVERVRESGKTIVITSHSMEECEA 1564

  Fly  1502 LADFIILFQDSEMLAIGSLQYLRYKYSHGFYLEVRLIRDGATLAESEENLRKDVENLAKFVNFLH 1566
            |...:.:....:...:||.|:|:.|:...:.|:.::.|...         ::.:|....||:...
Mouse  1565 LCTRLAIMVQGQFKCLGSPQHLKSKFGISYSLQAKVRRKWQ---------QQMLEEFKAFVDLTF 1620

  Fly  1567 NRSELVGRLNNWFKFYVPVGHIVYSFLYGAMEKNKLRLNVSDYCIYQADMMSVVAQVQETRAQLK 1631
            ..|.|.....|..::|:|..::.::.::..||:.|....:.||.|.|..:..:........:..|
Mouse  1621 PGSNLEDEHQNMLQYYLPGPNLSWAKVFSIMEQAKKDYMLEDYSISQLSLEDIFLNFTRPESSTK 1685

  Fly  1632 HHLVQTE----GPLPLDTTSP 1648
            ..:.|.:    .|.|...:.|
Mouse  1686 EQIQQEQAVLASPSPPSNSRP 1706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1801	NP_728408.3	ABC2_membrane_3	<246..379	CDD:289468	21/136 (15%)
		ABC2_membrane_4	<293..448	CDD:289500	28/168 (17%)
		EcfA2	499..717	CDD:224047	69/226 (31%)
		P-loop_NTPase	500..721	CDD:304359	71/229 (31%)
		ABC2_membrane_3	<972..1254	CDD:289468	71/305 (23%)
		EcfA2	1307..1521	CDD:224047	58/222 (26%)
		P-loop_NTPase	1324..1524	CDD:304359	55/204 (27%)
Abca17	NP_001026792.2	rim_protein	<209..1684	CDD:130324	358/1595 (22%)
Abca17	NP_001026792.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1681..1733		5/26 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838409
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.850