DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1801 and CG11147

DIOPT Version :9

Sequence 1:	NP_728408.3	Gene:	CG1801 / 33104	FlyBaseID:	FBgn0031171	Length:	1655	Species:	Drosophila melanogaster
Sequence 2:	NP_608954.1	Gene:	CG11147 / 33803	FlyBaseID:	FBgn0031734	Length:	711	Species:	Drosophila melanogaster

Alignment Length:	786	Identity:	172/786 - (21%)
Similarity:	296/786 - (37%)	Gaps:	216/786 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   510 RDSERKILKNISMRIYRGEVFVILGHIGSGKLTLLRILAGLKFPLRGNVYIMG-NPFEP-NGEAR 572
            :.:.:.:|..::|.:.||.::.:||..|.||.|||..:.|.:....|.|.::| .|.|| :|...
  Fly    16 KSNPKIVLNQLNMNVMRGSIYGLLGASGCGKTTLLSCIVGQRRLNGGEVVVLGAKPGEPGSGVPG 80

  Fly   573 RLVDFRFDEHGLNKHLTVEQTIDYHVRLKLSPSESDRYEIERRKWLAILDQHVESRGVRIGKLSS 637
            ..|.|...|..|.:.:||::||.|..|:.....|..|   |:.|.|..|.|...:|.: |.:.|.
  Fly    81 SRVGFMPQEIALVEEMTVKETIFYFGRIYGLTDERIR---EKFKLLKELLQLPPARQM-IKQCSG 141

  Fly   638 GSMKLVALCCCLAGDTPIIILEEPTTQLTGREAQIFWS-IVHAEKENR-AFIIATYNVGEAEHVA 700
            |..:.::..|.:..|..::||:|||..|.....:..|. :|...:.:: |.||.|:.:.||:. |
  Fly   142 GQQRRLSFACAMIHDPELLILDEPTVGLDPMLREKIWDFLVETTRNSKLAVIITTHYIEEAKQ-A 205

  Fly   701 DRIGILSMGVLEASGTPFFLRSKFSSSVDLVIIKKPHVPDQPITDYINQFMQNIEPENEIGDSLT 765
            :.||::..|||.|..||..:..||.:              |.|.|......|....|:|:...:.
  Fly   206 NCIGLMRNGVLLAEDTPTNIMIKFGT--------------QSIEDAFLILSQRQGNEDELAQIMD 256

  Fly   766 YR----LPVIYRPRLQKLLIHLEIDRKMLGIENVRVVGAELSDIYMTLVTSFRLQQQMIPDVTQT 826
            :.    ||....|                         .|:.|.:...:.    ::|.||
  Fly   257 HNKNQALPAAVLP-------------------------PEVIDTHEPNMP----EKQPIP----- 287

  Fly   827 FKYQVVSQKQ----LTKQRMRAMFYKKMIHTAPNVWPIIMIFTSFVLIAIIARLSVLLDMPKERQ 887
            |:..:...::    .||.|::|:..|..:........||     |:|:..|.:|:.......:..
  Fly   288 FEEPLNENRKKIFFTTKGRVKALMTKNFVQLFRQPSGII-----FMLLFPIIQLTCFYLAIGKTP 347

  Fly   888 NSIHIGFREPEDVVKYLPNLKDCGYIDIRSAVKVNKKKSVGVSRTFDDDSFVCEKGS--YRNNLR 950
            .::.||....|     :.|..:|  .|         :..|.|.:..|::|.:..|.|  |...|.
  Fly   348 TNLEIGVYSGE-----VENYGEC--FD---------ENLVTVYKDSDNESCLFNKLSCRYIRVLG 396

  Fly   951 KKNELRSFGAVESDGDEHLN--------GYI--SQDMFHSAPMMLNLLQNVILRLSYPMQTDLVV 1005
            .....|.:.|.|:|.   ||        ||:  :|:...|   :|:::::.|      ..:|..|
  Fly   397 DDVATRKYYASEADA---LNDAKRATTVGYLHFAQNFSDS---ILSVMEDGI------HSSDGAV 449

  Fly  1006 LVENHPLPTQLSQKINVLDNKIAHIHV------------PLVVGCIIPLTVSVFVIPL---VEEE 1055
               :|   .:||..|::.|.::|:...            .:|..|    .||..::.|   .:|.
  Fly   450 ---DH---AELSIHIDMTDQQVAYFMQRKLRDKFSTFMRSVVKDC----NVSTAIVDLPVQFQEP 504

  Fly  1056 IY---DVRFLQHMA-GLGL-KVFWGINL-------------FWD-------------WFTFFVYS 1089
            |:   |:.|.|:.| |:.: .||:...|             .||             | ...:..
  Fly   505 IFGSTDIEFQQYCAPGVVMTMVFFLATLMTAAVFISERMDGIWDRTLLAGVSATEMLW-AHLLTQ 568

  Fly  1090 VIIVVIMS---LMGIG-GFGFYEN---AIMVVLLTTFGLAALPLTYLVSMF------VNKSIVRA 1141
            :||:.:.|   :|.|| .|..|.|   ..::.|||......:.....:|:|      .|.....|
  Fly   569 LIIMALQSFEVIMYIGLVFDTYNNGDTTTLIGLLTLTAFCGMLFGLFISVFCKSHTEANFVATGA 633

  Fly  1142 FLVSVLLQG-----------VSGLVLYIIY--------------WDVANSN-----------TIF 1170
            |...::|.|           :..||:.:.:              |.:.:..           ||.
  Fly   634 FYPMIILCGLLWPLESMPQFLQDLVMVLPFTIPSISARNVIEKGWSITHEKVYNGFLVMAGWTII 698

  Fly  1171 FYAACM 1176
            |:..|:
  Fly   699 FFVLCL 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1801	NP_728408.3	ABC2_membrane_3	<246..379	CDD:289468
		ABC2_membrane_4	<293..448	CDD:289500
		EcfA2	499..717	CDD:224047	64/210 (30%)
		P-loop_NTPase	500..721	CDD:304359	66/214 (31%)
		ABC2_membrane_3	<972..1254	CDD:289468	57/302 (19%)
		EcfA2	1307..1521	CDD:224047
		P-loop_NTPase	1324..1524	CDD:304359
CG11147	NP_608954.1	CcmA	1..282	CDD:224054	79/313 (25%)
		P-loop_NTPase	4..222	CDD:304359	64/210 (30%)
		ABC2_membrane_3	322..702	CDD:289468	83/423 (20%)
		ABC2_membrane	469..664	CDD:279410	39/199 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900