DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1801 and Abca6

DIOPT Version :9

Sequence 1:	NP_728408.3	Gene:	CG1801 / 33104	FlyBaseID:	FBgn0031171	Length:	1655	Species:	Drosophila melanogaster
Sequence 2:	XP_006247716.1	Gene:	Abca6 / 303639	RGDID:	1308998	Length:	1630	Species:	Rattus norvegicus

Alignment Length:	1814	Identity:	383/1814 - (21%)
Similarity:	695/1814 - (38%)	Gaps:	402/1814 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPASKGLLFKRYIRIEL--NL---WRRTLFEIVALVIMVLV-IFLNPIAHSKRLLYTTTENENEQ 59
            |.:.|.|..::..|:.|  ||   ||.....::...|.|:: :::...::.|         ||.|
  Rat     4 MGSMKELSVRQQTRVLLHKNLLKKWRMKRESLLEWSIPVVIGLYMGLFSYFK---------ENNQ 59

  Fly    60 SIVSHKLQDINILTRMADSKREKTKYILAFTPETTFTSEVTKN--VAKTLELSSTVGYESESEMQ 122
             :.....||:..:.....|     ..::.:||.:..|.::...  .|.|::.:..||..||.::.
  Rat    60 -VPEVPPQDLGSIDEFNGS-----SIMVVYTPISNVTQQIMNKTITAPTMKGTRIVGVPSEKDLD 118

  Fly   123 NQFDERTTLA-GIVFNDLRDDGTPLT----LSISIRFPSEFRTIAPFLTEDRL---WITR----C 175
            ....:....| ||||||        |    |.:.:.:.:      |||.||.|   |.|.    |
  Rat   119 EMLLDHVPRAFGIVFND--------TFFYKLKVYLMYGN------PFLKEDLLAHCWDTYPHVFC 169

  Fly   176 SGRINPGRDRAKHDKQQDIYIREGFLQLQHQ-----IFVEWYHQLRKDIVSTYPEPNVEVYNILL 235
            |               ...|.:.||:.||..     |.|...|.:.::::|      |..:|  :
  Rat   170 S---------------LTRYWKRGFVALQTAINAAIIEVTTKHPVMEELMS------VNAFN--M 211

  Fly   236 KAADEPCSVMSVAQLPTF-LYNFIYLLPFLNII-RNVAAQVEDGVMVHQWHYGYSFGMQ------ 292
            |..  |.....:.|...| |:..:|...|:... |:|..:.:     |...:....|:|
  Rat   212 KTL--PFISKDIFQYEIFILFCLLYFSSFIYFASRSVTKERK-----HSKEFMKVMGLQDSAFWL 269

  Fly   293 -WGIKFL-VLFLRMCILGVIYT-IMLLAFWGFGGREGEFSGTGTIAFVCFITLYTVEIIITGMVV 354
             ||:.:: .:|:....:.||.| ..::...||           .:.|..|. ||.:.:|....::
  Rat   270 SWGLIYVGFIFIFSVFIAVIITSTRIIVMTGF-----------LVIFTLFF-LYGLSVIAVTFLM 322

  Fly   355 AKLFANPTNAVLFALMLWLFMYAAFCIILERYWDIHKYYVFFILVAFCNCQMHFSMSLFR----- 414
            |.|........||..:..||.......:|.:.......:|..|...|.     |:..:.:
  Rat   323 AVLLQKAIITNLFVFLFNLFWGCVGFTVLHKELPSSLEWVLSICSPFA-----FTSGMTKIIFLE 382

  Fly   415 ---NCIEKPE------MVNTIDFVLIFTSAISSAL-IYFLILL---AIQWRMPGTFLS-----RR 461
               |.:..|:      ::..:.|:|.|...:...| :||..:|   |.:...|..||:     |:
  Rat   383 YNLNGVVFPDPSGESYVMIAVFFILAFDGLLYLVLALYFDKILPCGADRRAAPLFFLNPVSCFRK 447

  Fly   462 IVNNRPRKQQESDTTIMYLGRAPSFQNFEFGD--VGSVELMRLRHVSTSHRDSERKI--LKNISM 522
            ..:.....:::.|..:      ||.:.||..|  ....|.:|:|::...::....|:  ||.:..
  Rat   448 RTSRNKVTERDIDPEL------PSDEYFEPVDPEYQGKEAIRIRNIRKEYKGKSGKVEALKGLFF 506

  Fly   523 RIYRGEVFVILGHIGSGKLTLLRILAGLKFPLRG--NVYIMG-NPFEPNGEARRLV------DFR 578
            .:|..::..:|||.|:||.:||.||.||..|..|  .||... :..:...|.|:::      :.:
  Rat   507 DVYESQITAVLGHGGAGKSSLLNILNGLSVPTSGLATVYNKNLSEMQDLKEIRKMIGVCPQHNVQ 571

  Fly   579 FDEHGLNKHLT--------VEQTIDYHVRLKLSPSESDRYEIERRKWLAILDQHVESRGVRIGKL 635
            ||...:.::||        |.|::...|:..|  ||.|...|:..     |.:|          |
  Rat   572 FDALTVKENLTLFANIKGIVPQSVAQEVQQIL--SELDMQTIQDE-----LAEH----------L 619

  Fly   636 SSGSMKLVALCCCLAGDTPIIILEEPTTQLTGREAQIFWSIVHAEKENRAFIIATYNVGEAEHVA 700
            |.|..:.:.....:.||..|::|:|||..|.....|..|..:...:.:|..:.:|....||:.:|
  Rat   620 SEGQKRKLTFGVAILGDPRILLLDEPTAGLDPFSRQRVWGFLKERRADRVILFSTQFTDEADILA 684

  Fly   701 DRIGILSMGVLEASGTPFFLRSKFSSSVDLVIIKKPHVPDQPITDYINQFMQNIEPENEIGDSLT 765
            ||..|||.|.|:.:|:..||:.|:.....|.:........:.:|.:||..:...:.:.:..:.|.
  Rat   685 DRKVILSNGALKCTGSSVFLKRKWGLGYHLSLFMNETCDSEQLTSFINHHIPGAKLKAKTKEKLV 749

  Fly   766 YRLPVIYRPRLQKLLIHLEIDRKMLGIENVRVVGAELSDIYMTLVTSFRLQQQMIPDVTQTFK-- 828
            |.||:....:..:....|: .....|:.|..|..:.|::::|.|        :..|..||.|:
  Rat   750 YTLPLEKTSKFPEFFSDLD-KYSGQGLMNYEVSMSTLNEVFMNL--------EGEPSTTQDFEKG 805

  Fly   829 ----------YQVVSQKQLTKQRMRAMFYKKMIHTAPNVWPIIMIFTSFVLIAIIARLSVLLDMP 883
                      ...|:...|:|.:      |.|  :|.::|.        :.:..||||.| |.:.
  Rat   806 ETLTDSDSLNEMEVAPPSLSKAQ------KTM--SAMSLWR--------MQVCAIARLRV-LKLR 853

  Fly   884 KERQNSIH----IGFREPEDVVKYLPNLKDCGYIDIR-----------------------SAVKV 921
            :||:..:.    :|......:.:|:.|    ..|:::                       |.:.:
  Rat   854 RERKAFLTFLPLLGISLIPLITEYMAN----ALIEVKTNWEFKTDLYFLSPGQLPQGLRTSLLVI 914

  Fly   922 NKKKS--VGVSRTFDDDSFVCEKGSYRNNLRKKNELRSF-GAVESDG---DEHLNGYISQDMFHS 980
            |..:|  ....::....:.|.|...:.|  |...|..|: ||:...|   |...:...:....|.
  Rat   915 NNTESNIEDFVQSLKHQNIVLEVDDFEN--RNATESLSYNGAIIVSGRQKDYRFSAVCNTKRLHC 977

  Fly   981 APMMLNLLQNVILRLSYPMQTDLVVLVENHPLPTQLSQKINVLDNKIAHIHVPLVVGCIIPLTVS 1045
            .|:::|::.|.|||:.            ||....:|.:  :||.:.|..:...::...:..|.:.
  Rat   978 FPILMNVISNGILRML------------NHTQHIRLEE--DVLSSGIVVVWFGILEASLSILFIV 1028

  Fly  1046 VFVIP-LVEEEIYDVRFLQH----MAGLGLKVFW-GINLFWDWFTFFVYSVIIVVIMSLMGIGGF 1104
            ..|.| :....|.|.:....    ::||....:| |..|           |.|.::..::..|..
  Rat  1029 CSVSPHIAMSSISDFKKKADSQLWISGLYPSAYWCGQAL-----------VDITLLSGILLTGYI 1082

  Fly  1105 GFYENAIMVVLLT----------TFGLAA--LPLTYLVSMFVNKSIVRAFLVSVLLQGVSGLVLY 1157
            ..|...:|.:.||          .||.||  :.|||::|....|....:.|.|:....|..::..
  Rat  1083 TLYTTKLMHIYLTGEIVLSIVLLAFGCAASLVFLTYVISFVFGKKRKNSGLWSICFFIVITIMFD 1147

  Fly  1158 IIYWDVANSNTIFFYAACMSPGFSLLDGVSNVYAQNLEQAICIDKCEATDSCTEENMNEVVPNCK 1222
            .:..|..| ..:...|..:.|.|||     |.....||........|..:|
  Rat  1148 TVLMDPFN-EALLISAMMLVPSFSL-----NALLIVLEMRAYQYYREFGES-------------- 1192

  Fly  1223 FDTFFKWAAPGI-LPPILYMVLSALIFLMLIFWIELH------RREKKFHTS-RDLRKMRTATYP 1279
                 |:...|: |...|......|:|:.::..:||.      |::..|..: :.|........|
  Rat  1193 -----KYGLSGVDLLLCLIPYFHTLLFIFVLRCLELKYGKNVVRKDPLFRIAPQSLHVQPNPEEP 1252

  Fly  1280 FDDGDVADVKQKIAEADNTKAKQSVFLVDQVEARVPA-------------AGKR-----IHTVSF 1326
            .|:.:  ||:   ||...|....|...:|:..|.:.:             ..||     :..:||
  Rat  1253 VDEDE--DVQ---AERMRTSDALSTVNLDEKPAIIASCLHKEYTGQKKWCCSKRRKKIAVRNISF 1312

  Fly  1327 ALNKYMSMGIFGPRNSGKSHLMRQLVGQRGFAFGEIYVRGLDFKYDLESIHTY---------MGY 1382
            .:||...:|:.||..:|||..:|.:.|......||:.::      :|.|...:         :||
  Rat  1313 CVNKGEILGLLGPEGAGKSSSLRMIAGIMKPTAGEVELK------ELSSAVAHQGEGHGAAKLGY 1371

  Fly  1383 SPQHRGLLNELTPREHIRLLCMIRGV--PEAKI-------GEKMHDLCLMLNMTGWMHRKCSLLT 1438
            .||...|...||.:||:.:...::|:  .:|.|       ..|:||   .||:      :...|.
  Rat  1372 CPQENVLWPILTVKEHLEVYAAVKGLRKKDAVIAISRLVNAFKLHD---QLNV------QARNLV 1427

  Fly  1439 AEKRHKLKIALALVAYNKILVLDEPTCGMPATTRREIWNILR-YIRYCGKTIIFATNDELECKIL 1502
            .....||..||:::..:.:|:||||:.|:..:.::::|..:: .::...|.::.:|:|..|.:.|
  Rat  1428 VGLTRKLCFALSILGNSPVLILDEPSTGLDVSGKQQMWQAIQAAVKDNKKGVLLSTHDLAEAEAL 1492

  Fly  1503 ADFIILFQDSEMLAIGSLQYLRYKYSHGFYLEVRLIRDGATLAESEENLRKDVENLAKFVNFLHN 1567
            .|...:.....:..|||:|:|:.::...:.||:|:..........:|.||            |..
  Rat  1493 CDRAAIMVSGRLRLIGSIQHLKRRFGKDYILELRVKEISQEPLVHKEILR------------LFP 1545

  Fly  1568 RSELVGRLNNWFKFYVPVGHI-VYSFLYGAMEKNKLRLNVSDYCIYQADMMSVVAQVQE 1625
            ::....|..:...:.:||..: ..|..:..:|..|...|:.||.:.|..:..|..::.:
  Rat  1546 QAARQDRCFSLLTYKLPVTDVHPLSQAFHKLEAVKRGFNLDDYSLSQCTLDRVFLELSK 1604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1801	NP_728408.3	ABC2_membrane_3	<246..379	CDD:289468	29/143 (20%)
		ABC2_membrane_4	<293..448	CDD:289500	33/174 (19%)
		EcfA2	499..717	CDD:224047	64/236 (27%)
		P-loop_NTPase	500..721	CDD:304359	65/239 (27%)
		ABC2_membrane_3	<972..1254	CDD:289468	60/300 (20%)
		EcfA2	1307..1521	CDD:224047	58/250 (23%)
		P-loop_NTPase	1324..1524	CDD:304359	55/218 (25%)
Abca6	XP_006247716.1	ABC2_membrane_3	35..420	CDD:289468	90/460 (20%)
		ABC2_membrane_4	220..409	CDD:289500	38/210 (18%)
		CcmA	480..795	CDD:224054	83/340 (24%)
		ABC_subfamily_A	482..705	CDD:213230	65/239 (27%)
		ABC2_membrane_3	859..1171	CDD:289468	64/343 (19%)
		ABC2_membrane_4	1007..1178	CDD:289500	38/187 (20%)
		CcmA	1279..1605	CDD:224054	77/353 (22%)
		ABC_subfamily_A	1300..1514	CDD:213230	57/228 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342231
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.750