DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1801 and Abca3

DIOPT Version :9

Sequence 1:	NP_728408.3	Gene:	CG1801 / 33104	FlyBaseID:	FBgn0031171	Length:	1655	Species:	Drosophila melanogaster
Sequence 2:	XP_006246101.1	Gene:	Abca3 / 302973	RGDID:	1307174	Length:	1704	Species:	Rattus norvegicus

Alignment Length:	1777	Identity:	395/1777 - (22%)
Similarity:	742/1777 - (41%)	Gaps:	265/1777 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RIELNLWRRTLFEIVALVIMVLVIFLNPIAHSKRLLY--TTTENENEQSIVSHKLQDINILTRMA 76
            ::.|.||:....:...:::.||.:|| |:..|..|::  ...::||..:...:..|.|..|....
  Rat     6 QLRLLLWKNYTLKKRKVLVTVLELFL-PLLFSGILIWLRLKIQSENVPNATVYPDQHIQELPLFF 69

  Fly    77 DSKREKTKYILAFTPETTFTSE-VTKNVAKTLELSSTV-GYESESEMQN--QFDERTT--LAGIV 135
            ........:.||:.|..:..:. :|:.|.:...:...| |:.||.:.::  ::|..::  ||.:|
  Rat    70 SFPPPGGSWELAYVPSHSDAARTITEAVRREFMIKMRVHGFSSEKDFEDYVRYDNHSSNVLAAVV 134

  Fly   136 FN---DLRDDGTPLTLSISIRFPSEFR------TIAPFLTEDRLWITRCSGRI--NPG-RDRAKH 188
            |.   :...|..||.:...:||....|      |...||.|...|.|.....:  :|| |:.:..
  Rat   135 FEHTFNHSKDPLPLAVRYHLRFSYTRRNYMWTQTGNLFLKETEGWHTASLFPLFPSPGPREPSSP 199

  Fly   189 DKQQDIYIREGFLQLQHQI---FVEWY-----HQLRKD---IVSTYPEPNVEVYNILLKAADEPC 242
            |..:..|||||||.:||.:   .:.::     |||.:.   |...:|.|         ....:|.
  Rat   200 DGGEPGYIREGFLAVQHAVDKAIMHYHANASAHQLFQKLTVITKRFPFP---------PYISDPF 255

  Fly   243 SVMSVAQLPTFL-YNFIYLLPFLNIIRNVAAQVEDGVMVHQWHYGYSFGMQWGIKFLVLFLRMCI 306
            .:....|||..| .:|.|  ..|.|||.|..:.|..:..:....|.|..:.|...|| :||...:
  Rat   256 LIAIQYQLPLLLMLSFTY--TSLTIIRAVVQEKEKKLKEYMRMMGLSSWLHWSAWFL-MFLLFSL 317

  Fly   307 LGVIYTIMLLAFWGFGGRE-GEFSGTGTIAFVCFITLYTVEIIITGMVVAKLFANPTNAVLFALM 370
              ::.:.|.|.|.....:: ...|.:.....:.|:..:.:..|....:|:..|:....|......
  Rat   318 --IVVSFMTLLFCVKVKKDIAVLSNSDPSLVLAFLLCFAISSISFSFMVSTFFSKANMAATVGGF 380

  Fly   371 LWLFMYAAFCIILERY-WDIHKYYVFFILVAFCNCQMHFSMSLFRNCIEKPEM------------ 422
            |:.|.|..:..:..|| |......:...|::      :.:|::....|.|.|.
  Rat   381 LYFFTYTPYFFVAPRYNWMTLSQKLLSCLLS------NVAMAMGAQLIGKFEAKGTGIQWCDLLN 439

  Fly   423 -VNTID---FVLIFTSAISSALIYFLILLAIQWRMPGT---------FLSRRIVNNRPR----KQ 470
             ||..|   |..:....:..:::|.|:...::...||.         ||........||    |:
  Rat   440 PVNVDDDFCFGQVLGMLLLDSVLYGLVTWYVEAVFPGQFGVPQPWYFFLMPSYWCGNPRTVVGKE 504

  Fly   471 QESDTTIMYLGRAP--SFQNFEFGDVGSVEL---MRLRHVSTSHR--DSERKILKNISMRIYRGE 528
            :|        |..|  :|:. |:.:....:|   ::::|:|...:  :.::..::::::.:|.|:
  Rat   505 EE--------GGDPEKAFRT-EYFEAEPEDLAAGIKIKHLSKVFQVGNKDKMGIRDLTLNLYEGQ 560

  Fly   529 VFVILGHIGSGKLTLLRILAGLKFPLRGNVYIMGNPFEPN-GEARRLV------DFRFDEHGLNK 586
            :.|:|||.|:||.|.:.:|.||..|..|:.||.|.....: .:.|:.:      |..||
  Rat   561 ITVLLGHNGAGKTTTMSMLTGLFPPTSGHAYIRGYEISQDMVQIRKSLGLCPQHDVLFD------ 619

  Fly   587 HLTVEQTIDYHVRLKLSPSESDRYEIERRKWLAILDQHVESRGVRIGKLSSGSMK-LVALCCCLA 650
            :|||.:.:.::.:||....:....|:::......|:...:||    .|..||.|| .:|:...|.
  Rat   620 NLTVAEHLYFYAQLKGLSVQKCPEEVKQMLHTLGLEDKRDSR----SKFLSGGMKRKLAIGIALI 680

  Fly   651 GDTPIIILEEPTTQLTGREAQIFWSIVHAEKENRAFIIATYNVGEAEHVADRIGILSMGVLEASG 715
            ..:.:::|:|||:.:.....:..|.::..:|.:|..::.|:.:.||:.:.|||.||:.|.|:..|
  Rat   681 AGSKVLMLDEPTSGMDAVSRRAIWDLLQQQKSDRTVLLTTHFMDEADLLGDRIAILAKGELQCCG 745

  Fly   716 TPFFLRSKFSSSVDLVIIKKPHVPDQPITDYINQFMQNIEPENEIGDSLTYRLPVIYRPRLQKLL 780
            :..||:.|:.:...:.::|:||...:.|:..::..:.|...|:..|..|::.||.....|.:.|.
  Rat   746 SSLFLKQKYGAGYHMTLVKEPHCNPEGISQLVHHHVPNAMLESHAGAELSFILPKESTHRFESLF 810

  Fly   781 IHLEIDRKMLGIENVRVVGAELSDIYM---TLV-TSFRLQQQMIP-------------------- 821
            ..||..:|.|||.:.......:.::::   .|| ||..:|...:|
  Rat   811 AKLEKKQKELGIASFGASVTTMEEVFLRVGKLVDTSMDIQAIQLPALQYQHERRASDWALDSNLC 875

  Fly   822 ---DVTQTFKYQVVSQKQLTK---------QRMRAMFYKKMIHTAPNVWPI----IMIFTSFVLI 870
               |.|......:..::.|.|         |:..|||.||..::. ..|.:    |::..:.:.:
  Rat   876 GVMDPTNGIGALIEEEEVLVKLNTGLALHCQQFWAMFLKKAAYSW-REWRMVAAQILVPVTCLTL 939

  Fly   871 AIIA--RLSVLLDMPKERQNSIHIGFREPEDVVKY-LPNLKDCG------YIDIRSAVKVNKKKS 926
            |::|  ..|.:.|.|..:.:....|    ..||.: :|.....|      ..|:..|.:...::.
  Rat   940 ALLAINYTSEIFDDPPLKLSLNEYG----TTVVPFSVPGTSRLGQQLSEHLRDMLQAERQEPREV 1000

  Fly   927 VGVSRTFDDDSFVCEKGSYRNNLRKKNELRSFGAVESDGDEHLNGYISQDMFHSAPMMLNLLQNV 991
            :|     |.:.|:..:.|.......:..|.:....:|.....:....:...:||....|.::.|:
  Rat  1001 LG-----DLEEFLVFRASVEGGGFNERCLVATSFKDSGERTVVTALFNNQAYHSPATALAIVDNL 1060

  Fly   992 ILRLSYPMQTDLVVLVENHPLPTQLSQKINVLDN---KIAHIHVPLVVGCIIPLTVSVFVIPLVE 1053
            :.:|....:..  :.:.|:|.|....|......|   |...|.:.|::.  :....|.|.|..|.
  Rat  1061 LFKLLCGPRAS--IEISNYPQPRSTLQVAKDQFNEGRKGFDIALNLLIA--MAFLASTFSILAVS 1121

  Fly  1054 EEIYDVRFLQHMAGLGLKVFWGINLFWDWFTFFVYSVIIVVIMSLMGIGGF---GFYENAIMVVL 1115
            |.....:.:|.::|:.:..||...|.||..:|.|.|::::|:.....:..|   |  ..|.:::|
  Rat  1122 ERAVQAKHVQFVSGVHVATFWLSALLWDLISFLVPSLLLLVVFRAFDVHAFTRDG--HMADLLLL 1184

  Fly  1116 LTTFGLAALPLTYLVSMF---VNKSIVRAFLVSVLLQGVSGLVLYIIYWDVANSNTIFFYAA--- 1174
            |..:|.|.:||.||:|.|   .:.:..|..:.::|    ||:..:|:.       ||....|
  Rat  1185 LMLYGWAIIPLMYLLSFFFSAASTAYTRLTIFNIL----SGIATFIVV-------TIMRIPAVKL 1238

  Fly  1175 -----------CMSPGFSLLDGVSNVYAQNLEQAICIDKCEATDSCTEENMNEVVPNCKFDTFFK 1228
                       .:.|...|...|||.|.....:..|.....||..|.:.|:...      :.|:.
  Rat  1239 EELSRTLDHVFLVLPNHCLGMAVSNFYENYETRRYCTSSEVATHYCKKYNIQYQ------ENFYA 1297

  Fly  1229 WAAPGILPPILYMVLSALIFLMLIFWIELH------------RREKKFHTSRDLRKMRTATYPFD 1281
            |:.|||...:..|..|..|:|.|:|.||.:            ||.   .|..:|:. ||:..| :
  Rat  1298 WSTPGIGKFVTSMAASGGIYLTLLFLIETNLLWRLRTFVCAFRRR---WTLAELQN-RTSVLP-E 1357

  Fly  1282 DGDVADVKQKIAEADNTKAKQSVFLVDQV----EARVPAAGKRIHTVSFALNKYMSMGIFGPRNS 1342
            |.||||.:.::..........:..:::::    :.|.|...  :..:|.|:.|....|:.|...:
  Rat  1358 DQDVADERSRVLVPSLDSMLDTPLIINELSKVYDQRAPLLA--VDRISLAVQKGECFGLLGFNGA 1420

  Fly  1343 GKSHLMRQLVGQRGFAFGEIYVRGLDFKYDLESIHTYMGYSPQHRGLLNELTPREHIRLLCMIRG 1407
            ||:...:.|.|:.....|:.:|.|.....|:..:...|||.||...||:.:|.||.:.:...:||
  Rat  1421 GKTTTFKMLTGEETITSGDAFVGGYSISSDIGKVRQRMGYCPQFDALLDHMTGREMLVMYARLRG 1485

  Fly  1408 VPEAKIGEKMHDLCLMLNMTGWM-----HRKCSLLTAEKRHKLKIALALVAYNKILVLDEPTCGM 1467
            :|     |::.|.|:...:.|.:     ::.....:...:.||...:||:....::.||||:.||
  Rat  1486 IP-----ERLIDACVENTLRGLLLEPHANKLVKTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGM 1545

  Fly  1468 PATTRREIWNILRYIRYCGKTIIFATNDELECKILADFIILFQDSEMLAIGSLQYLRYKYSHGFY 1532
            ....||.:|:.:...|..||.|:..::...||:.|...:.:....:...:||.|:|:.|:..|:.
  Rat  1546 DPVARRLLWDTVARARESGKAIVITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYS 1610

  Fly  1533 LEVRLIRDGATLAESEENLRKDVENLAKFVNFLHNRSELVGRLNNWFKFYVPVGHIVYSFLYGAM 1597
            |:.::..:|.         ::.:|....||:.....|.|.....:...:::|...:.::.::|.:
  Rat  1611 LQAKVRSEGK---------QEVLEEFKAFVDLTFPGSVLEDEHQDMVHYHLPGCDLSWAKVFGIL 1666

  Fly  1598 EKNKLRLNVSDYCIYQADMMSV 1619
            ||.|.:..|.||.:.|..:..|
  Rat  1667 EKAKEKYGVDDYSVSQISLEQV 1688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1801	NP_728408.3	ABC2_membrane_3	<246..379	CDD:289468	31/134 (23%)
		ABC2_membrane_4	<293..448	CDD:289500	31/172 (18%)
		EcfA2	499..717	CDD:224047	59/230 (26%)
		P-loop_NTPase	500..721	CDD:304359	59/230 (26%)
		ABC2_membrane_3	<972..1254	CDD:289468	71/304 (23%)
		EcfA2	1307..1521	CDD:224047	54/222 (24%)
		P-loop_NTPase	1324..1524	CDD:304359	53/204 (26%)
Abca3	XP_006246101.1	rim_protein	<206..1699	CDD:130324	350/1576 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342207
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.950