Protein Alignment CG1801 and Abca15

DIOPT Version :9

• Sequence 1: NP_728408.3
• Gene: CG1801 / 33104
• FlyBaseID: FBgn0031171
• Length: 1655
• Species: Drosophila melanogaster
• Sequence 2: NP_001099763.2
• Gene: Abca15 / 293442
• RGDID: 1305981
• Length: 1668
• Species: Rattus norvegicus
• Alignment Length: 1802
• Identity: 386/1802 - (21%)
• Similarity: 732/1802 - (40%)
• Gaps: 331/1802 - (18%)

  Fly     2 PASKGLLFKRYIRIELNLW------RRTLFEIVALVIMVLVIFLNPIAHSKRLLYTTTENENEQS 60
            ||||.||        |.||      ||....:|..:|::|...:        :|.||      :.
  Rat     4 PASKKLL--------LLLWKNFTLKRRKFGALVTEIILMLAFSI--------VLLTT------RH 46

  Fly    61 IVS-HKLQDINILTR-----------MADSKREKTKYILAFTPET-TFTSEVTKNVAKTLEL-SS 111
            ::| :|::.::...:           .|:|.|   .:.||:.|.. |....:.:||.|.|.. .:
  Rat    47 LLSINKMESLHFPDQPVGAVPFFFRVSANSSR---PWELAYVPSNITVVHNIVENVKKDLNFPMA 108

  Fly   112 TVGYESESEMQ----NQFDERTTLAGIVFN----DLRDDGTPLTLSISIRFPSEFRTI-APFLTE 167
            .:|:.|||:.:    :..:.|..||.|||:    :.||. .|..:..::||....:.| .....:
  Rat   109 VIGFPSESDFEDYARSSVNSRNILAAIVFDHNFANSRDP-LPKKIKYNLRFSDIKKNIHGMAYYQ 172

  Fly   168 DRLWIT-------RCSGRINPGRDRAKHDKQQDIYIREGFLQLQHQI--FVEWYH------QLRK 217
            ...|:|       |..|..||    .:.|.....||.||||.:||.:  .:..:|      .|..
  Rat   173 GHTWLTKFLFPPLRIVGPRNP----QEADGGSPGYITEGFLAVQHALDKAIMLHHGGAAATALFN 233

  Fly   218 DI---VSTYPEPNVEVYN---ILLKAADEPCSVMSVAQLPTFLYNFIYLLPFLNIIRNVAAQVED 276
            |:   :..:|.|  ..|:   .|......|.:|.|           |:.|..|.::.::..:.|:
  Rat   234 DVSLFIQRFPYP--AYYHDHFYLFANTFVPLTVAS-----------IFFLNHLILVWSIVWEKEN 285

  Fly   277 GVMVHQWHYGYSFGMQWGIKFLVLFLRMCILGVIYTIMLLAFWGFGGREGE--FSGTGTIAFVCF 339
            .:..:|...|....|.| |.:...|..:..:.:|:..::|    |...:..  |.....|.....
  Rat   286 RLKEYQLMIGLRNWMFW-IAYFFTFFCLYFINIIFMCIVL----FVKIDPAPIFQYNDPILVFIL 345

  Fly   340 ITLYTVEIIITGMVVAKLFANPTNAVLFALMLWLFMYAAFCIIL----------------ERYWD 388
            :..|.:..|....:::.||    |.|.||:.|..|::  |...|                :..|.
  Rat   346 LLFYAISSIFFSFMISTLF----NRVSFAVSLGSFLF--FLTYLPAITMNQSFEHMPPRQKLIWS 404

  Fly   389 IHKYYVFFILVAF-----CNCQMHFSMSLFRNCIEKPEMVNTIDFVLIFTSAISSALIYFLILLA 448
                :.|.:.:||     .|.:...:...:.| |..|...:::.|..:....:..|.||.|:...
  Rat   405 ----FDFNVGMAFGFRFLVNAETRKTGMKWNN-IFLPTDSDSLLFTYVLGMLLVDAFIYGLVAWY 464

  Fly   449 IQWRMPGT---------FLSRRIVNNRPRKQQESDTTIMYLGRAPSFQNFEFGDVGSVELMRLRH 504
            |:...||.         ||.........|:|:...|  .:..|..| :.||.........::::|
  Rat   465 IEAVFPGEYGVPKPWNFFLMHSYWFGESRQQKPEIT--QFCKRVES-KYFEVEPTDLTAGIQIKH 526

  Fly   505 VSTSHRDSE--RKILKNISMRIYRGEVFVILGHIGSGKLTLLRILAGLKFPLRGNVYIMGNPFEP 567
            :....:::.  :..:.::|:.:|.|::.|:|||.|:||.|.|.||:||..|..|..|:.|.....
  Rat   527 LHKVFQENNITKVAINDLSLNVYEGQITVLLGHNGAGKSTTLSILSGLYPPTSGEAYVHGEDISQ 591

  Fly   568 N-GEARRLVDFRFDEHGLNKHLTVEQTIDYHVRLKLSPSESDRYEIERRKWLAILDQHVESRGVR 631
            : .:.|..:.....::.|..||||.:.:.::.|:|..|....   :|....:.......|.|...
  Rat   592 HMDQIRNFLGLCPQQNLLFDHLTVSEHLYFYCRVKGVPQNMC---LEETNNMLSAFNLTEKRDAF 653

  Fly   632 IGKLSSGSMKLVALCCCLAGDTPIIILEEPTTQLTGREAQIFWSIVHAEKENRAFIIATYNVGEA 696
            ...||.|..:.:|:...|.|.:.::||:|||:.:.....:..|.:|...|:||..::.|:.:.||
  Rat   654 SKSLSGGMKRKLAIIIALIGGSKVVILDEPTSGMDPASRRSTWDVVQTYKQNRTILLTTHYMDEA 718

  Fly   697 EHVADRIGILSMGVLEASGTPFFLRSKFSSSVDLVIIKKPHVPDQPITDYINQFMQNIEPENEIG 761
            :.:.|||.|:..|.|...|:..||:..:.....:|::|:|......|:..|:.::.....:..:|
  Rat   719 DMLGDRIAIMVQGTLRCCGSSVFLKRLYGVGSHIVMVKEPVCDVDEISKLIHYYIPTATLKTNVG 783

  Fly   762 DSLTYRLPVIYRPRLQKLLIHLEIDRKMLGIENVRVVGAELSDIYMTLVTSFRLQQQMIPDVTQT 826
            :.|::.||..|..:.:.||..||.:::.|||.:..:....:.::::.:    ...:...||:..|
  Rat   784 NELSFILPKEYTHKFEALLTALEENQENLGISSFGMSITTMEEVFLRV----SKMEDSKPDMEAT 844

  Fly   827 ----------------------FKYQVVSQK-------QLTKQRMRAMFYKKMIHTAPNVWPII- 861
                                  |..|...|.       .|..|:..|||.|::::...| |.::
  Rat   845 QSPSAGSKGNRNRDVESSMRAGFPTQSEDQTIVFNTGCPLYLQQFHAMFMKRLMYNWRN-WRVLS 908

  Fly   862 -----MIFTSFVLI-------------------------AIIARLSVLLDMPKERQNSIHIG--- 893
                 ::.::|:|:                         :|:.:.::...:....:|.:..|
  Rat   909 VQILGLVISTFLLLKSHEFRHKRIRQMNLDDYGQTIVPFSILGKSNLTTSLLIHLENMLKPGNHQ 973

  Fly   894 FREPE-DVVKYLPNLKDCGYIDIRSAVKVNKKKSVGVSRTFDDDSFVCEKGSYRNNLRKKNELRS 957
            .:|.: |::|||...::|.::.|   |.::.|.:.|.::
  Rat   974 LKEVQGDLLKYLEGNEECIHLCI---VALSIKVAAGRAK-------------------------- 1009

  Fly   958 FGAVESDGDEHLNGYISQDMFHSAPMMLNLLQNVILRLSYPMQTDLVVLVENHPLPTQLSQKINV 1022
                       |....:.:.:||..:.|.:|.|::..........:.|..:..|.||......:.
  Rat  1010 -----------LTVLFNNEAYHSPSLSLAVLDNILFMSLSGANASITVFHKPQPRPTSKEWPRST 1063

  Fly  1023 LDNKIAHIHVPLVVGCIIPLTVSVFVIPLVEEEIYDVRFLQHMAGLGLKVFWGINLFWDWFTFFV 1087
            . .||....:.|.:.    |.||.|.|..|.|.|...:.:|.::|..:.|:|...|.:|:..||:
  Rat  1064 Y-GKIVAFKIQLGMA----LLVSGFCILTVTERITKAKHMQFLSGASVLVYWLSALVFDFIIFFI 1123

  Fly  1088 YSVIIVVIMSLMGIGGFGFYENAIMV---------VLLTTFGLAALPLTYLVSMFVNKSIVR--A 1141
            ....::|:        |.:|:..|.|         ::|..||.:|:|||||:|...:|||..  .
  Rat  1124 SCCFLLVM--------FKYYKIDIYVTDYHILETMLILILFGWSAIPLTYLMSFLFSKSIPAYIQ 1180

  Fly  1142 FLVSVLLQGVSGLVLYIIY-----WDVANSNTIFFYAACM-SPGFSLLDGVSNVYAQNLEQAICI 1200
            .||...|.|.|||::..|.     ..::||...|..::.: .|.::|...:|........:.:||
  Rat  1181 LLVFYYLSGTSGLLIDTIIEAGLSTIISNSTQTFLLSSLLFFPTYNLGKCISEYTVIYQRKILCI 1245

  Fly  1201 DKCEATD--SCTEENMNEVVPNCKFDTFFKWAAPGILPPILYMVLSALIFLMLIFWIE------- 1256
            .:.....  :|::|...:.:.:.|        .|.|...::.|.::..::|:.||:.|
  Rat  1246 QQKNVLKYLNCSKEYTKKNIYSLK--------KPMIGKYLIAMSIAGFVYLLFIFFWENISWKLR 1302

  Fly  1257 --LHRRE-----KKFHTSRDLRKMRTATYPFDDGDVADVKQKIAEADNTKAKQSVFL--VDQVEA 1312
              :|:..     ||:.:.....::...:   :|.||.:.:::|...........|.:  :.::..
  Rat  1303 MLIHQHIYFGVCKKYKSDIISNELSGTS---EDNDVENERREILYQPEKFLNCPVLIKQLTKIYF 1364

  Fly  1313 RVPAAGKRIHTVSFALNKYMSMGIFGPRNSGKSHLMRQLVGQRGFAFGEIYVRGLDFKYDLESIH 1377
            :.|.. ..:..:|.|:.:....|:.|...:||:...:.|.|:.....|::::.|:....|:..:.
  Rat  1365 KSPLI-LAVKNISLAIQERECFGLLGFNGAGKTTTFQILTGEITPTAGDVFIDGISITKDVLKVR 1428

  Fly  1378 TYMGYSPQHRGLLNELTPREHIRLLCMIRGVPEAKIGEKMHDLCLMLNMTGWMHRKCSLLTAEKR 1442
            :.:||.||...||..||..|.:.:...|.|:.|.:|...::.....|.:....:...|..:...:
  Rat  1429 SKIGYCPQFDALLEYLTGWEIMVMYARIWGISERQIRPYVNTYLNSLELEPHANSLISTYSEGNK 1493

  Fly  1443 HKLKIALALVAYNKILVLDEPTCGMPATTRREIWNILRYIRYCGKTIIFATNDELECKILADFII 1507
            .:|..|:|::....::.||||:.||....||.:|:.:..||..||.||..::...||:.|...:.
  Rat  1494 RRLSTAIAMMGKPSVIFLDEPSTGMDPRARRLLWDAVIKIRESGKAIIITSHSMEECEALCTRLS 1558

  Fly  1508 LFQDSEMLAIGSLQYLRYKYSHGFYLEVRLIRDGATLAESEENLRKDVENLAKFVNFLHNRSELV 1572
            :....::..:||.|||:.|:...:.|:.: ::.|.||        |:.:|   |:......|||.
  Rat  1559 IMVHGKLTCLGSPQYLKNKFGDIYILKTK-VKSGETL--------KEFKN---FITLTFPGSELK 1611

  Fly  1573 GRLNNWFKFYVPVGHIVYSFLYGAMEKNKLRLNVSDYCIYQADMMSV 1619
            ........:|:|.....:..::|.:||.|.:.::.||.|.|..:..|
  Rat  1612 QENQGILNYYIPSKDNSWGKVFGILEKAKEQYDLEDYSISQITLDQV 1658

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1801	NP_728408.3	ABC2_membrane_3	<246..379	CDD:289468	26/134 (19%)
		ABC2_membrane_4	<293..448	CDD:289500	33/177 (19%)
		EcfA2	499..717	CDD:224047	59/220 (27%)
		P-loop_NTPase	500..721	CDD:304359	60/223 (27%)
		ABC2_membrane_3	<972..1254	CDD:289468	70/300 (23%)
		EcfA2	1307..1521	CDD:224047	50/213 (23%)
		P-loop_NTPase	1324..1524	CDD:304359	51/199 (26%)
Abca15	NP_001099763.2	ABC2_membrane_3	<255..464	CDD:289468	43/235 (18%)
		CcmA	522..834	CDD:224054	78/318 (25%)
		ABC_subfamily_A	522..743	CDD:213230	60/223 (27%)
		ABC2_membrane_3	<1007..1195	CDD:289468	54/237 (23%)
		ABC_subfamily_A	1354..1575	CDD:213230	53/221 (24%)
		drrA	1369..1662	CDD:130256	74/303 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342244
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.850