DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1801 and Abca13

DIOPT Version :9

Sequence 1:	NP_728408.3	Gene:	CG1801 / 33104	FlyBaseID:	FBgn0031171	Length:	1655	Species:	Drosophila melanogaster
Sequence 2:	XP_038948786.1	Gene:	Abca13 / 289797	RGDID:	1305895	Length:	5037	Species:	Rattus norvegicus

Alignment Length:	1894	Identity:	375/1894 - (19%)
Similarity:	687/1894 - (36%)	Gaps:	434/1894 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 FLNPIAHSKRLLYTTTENENEQSI-----VSHKLQDINILT----RMADSKRE------------ 81
            ||.|:.|.| :|||....|..:.|     ..:.:..|.||:    :|:...:|
  Rat  3283 FLKPVLHGK-ILYTPNSPEINEVIQKANYTFYFVDKIKILSETFLKMSSLFQESGNGQMFKQLQD 3346

  Fly    82 --KTKYILAFTPET-------------------------------TFTSEVTKNVAKTLELSSTV 113
              :.|:|..|....                               .|...:..|::..:.|....
  Rat  3347 ALRNKFIRNFVESQLHIDMDKLTEDLQTYGQKLDKMFNHMEAGNFQFLGGILANLSSCVLLDRFQ 3411

  Fly   114 GYES----ESEMQNQFDERTTLAGIVFND------LRDDGTPLTLSISIRFPSEFRTIAPFLTED 168
            ..|:    |::......:.:.||.|:||.      :|  ..|..|...:.:......:....|:
  Rat  3412 AVETVDTLETKAHELMQQNSFLASIIFNSSLGHRHIR--SAPHKLPPHVTYTIRTNILYSMRTD- 3473

  Fly   169 RLWITRCSGRINPGRDRAKHDKQQDIYIREGFLQLQHQIFVEWYHQLRKDIVSTYP-----EPNV 228
              .|...|.:.:|....|           .||  ..:.|||.....:.:.|:....     ||..
  Rat  3474 --MIKNPSWKFHPQNLPA-----------SGF--KYNYIFVPLQDMIERAIIVVQTGQESLEPTA 3523

  Fly   229 EVYNILLKAADEPCSVMSVAQLPTFLYNFIYLLPFLNIIR---NVAAQV-----EDGVMVHQWHY 285
            :.     :||..||....:     ||.|..:..|.:.::.   :||:.|     |..:.:.:  |
  Rat  3524 QA-----QAAPYPCHTSDL-----FLNNVGFFFPLIMMLTWMVSVASMVRKLVYEREIQIEE--Y 3576

  Fly   286 GYSFGMQWGIKFLVLFL-RMCILGVIYTIMLLAFWGFGGREGEFSG--TGTIAFVCFITL--YTV 345
            ....|:...|.||..|| .|..|.:....:.|..        :.||  ..:.||:.|:.|  :.|
  Rat  3577 MRIMGLHPVIHFLSWFLENMATLALSSAALALIL--------KMSGIFMHSDAFIIFLYLLNFGV 3633

  Fly   346 EIIITGMVVAKLFANPTNAVLFALMLWLFMYAAFCIILERYWDIHKYYVFFILVAFCNCQ-MHFS 409
            ..::....::..|.....|.|...:.::..:..:.::|.    :|....|.:....|... ..|.
  Rat  3634 SAVMLSYFLSVFFNKANTAALCTSLGYMISFLPYVVLLV----LHNQLSFALQTLLCLLSTTAFG 3694

  Fly   410 MSLF--------------RNCIEKPE----MVNTIDFVLIFTSAISSALIYFLILLAIQWRMPGT 456
            ..:|              .|....||    ....:.::::|.|     ::|||........:|||
  Rat  3695 QGVFFITFLEGQEEGIQWGNMYRAPEPGGMTFGWVCWMILFDS-----ILYFLGGWYFSNLVPGT 3754

  Fly   457 F---------------------LSRRIVNNRPRKQQESDTTIMYLGRAPSFQNFEFGDVG----- 495
            |                     :.||..:               |.....|.|.:||:.|
  Rat  3755 FGLGKPWYFPFTASYWKSICGLMERRRCS---------------LSSGLFFFNEDFGNKGLSQQN 3804

  Fly   496 ----------SVELMRLRHVSTSHRDSERKILKNISMRIYRGEVFVILGHIGSGKLTLLRILAGL 550
                      .|.|:.:    |...:..:..::.:::..:|.::..:||..|:||.|::.:|.||
  Rat  3805 GPGEMEGGSPGVALISV----TKEYEDHKVAVQELTLTFHRDQITALLGTNGAGKTTIISMLMGL 3865

  Fly   551 KFPLRGNVYIMGNPFEPNGEARRLVDFRFDEHG-------LNKHLTVEQTIDYHVRLKLSP---S 605
            ..|..|.:.:.|...:.:....|      :|.|       |..:|||.:.:.....:| :|   :
  Rat  3866 FPPTSGTIIVNGKNLQTDFSKVR------EELGVCPQHDVLLDNLTVREHLMLFASIK-APWWTN 3923

  Fly   606 ESDRYEIERRKWLAILDQHVESRGVRIGKLSSGSMKLVALCCCLAGDTPIIILEEPTTQLTGREA 670
            :..|.::.:......|.|| :.:..|:  ||.|..:.:::.....|.:..::|:||::.:.....
  Rat  3924 KELRQQVNKTLEEVELTQH-QHKPARV--LSGGMKRKLSIGIAFMGMSKTVVLDEPSSGVDPCSR 3985

  Fly   671 QIFWSIVHAEKENRAFIIATYNVGEAEHVADRIGILSMGVLEASGTPFFLRSKFSSSVDLVIIKK 735
            :..|:|:...::.|..|..|:::.|||.::|.:.:|..|.|.....|..|:..:...:.|.:.|:
  Rat  3986 RSLWNILLKYRKGRTIIFTTHHLDEAEVLSDHVAVLQQGRLRCYAPPAGLKETYGQGLTLTLSKQ 4050

  Fly   736 PHV--PDQP-----ITDYINQFMQNIEPENEIGDSLTYRLP-----VIYRPRLQKL---LIHLEI 785
            |.|  ..:|     :|..|..::.....::..|..|||.:|     ..::...|.|   |.||.:
  Rat  4051 PSVLESQEPKDVARVTSLIQVYIPQAFLKDSNGGELTYTIPKDADKTCFKGLCQALDQNLQHLHL 4115

  Fly   786 DRKMLGIENVRVVGAELSDIYMTLVTSFRLQQQMIPDVTQTFKYQVVSQK--------------- 835
            ..  .||.:     ..|.::::.|:.....:..:.||    .|.:..::|
  Rat  4116 TG--YGISD-----TTLEEVFLMLLQDTNKKSYITPD----NKLESQNEKPVGPCLRHCGSLMRT 4169

  Fly   836 ------------QLTKQRMRAMFYKKMIHTAPNVW---------PIIMIFTSFVLIAIIARLSVL 879
                        ||...:..|:..|:::||. ..|         |::.:..:..|..:   ..:.
  Rat  4170 LPDSLPEPMGGCQLLLGQAGALLRKRLLHTL-RAWKSTTSDLFLPVLFVALAMGLFMV---QPLA 4230

  Fly   880 LDMPKERQNSIHI----------GFREPEDVVKYL-----------------------------P 905
            :..|..:....|.          |..:| |:...|                             |
  Rat  4231 ITYPPLKLTPGHYETAEAYFFSSGNHDP-DLTHVLLRRFGDQDPVCSDAQWVNSSSWHRDPYSGP 4294

  Fly   906 NLKD-CGYIDIRSAVKVNKKKSVG-------VSRT------FDDDSFVC------EKGSYRNNLR 950
            ..:| ||.:..       ..||.|       :..|      :|.:.::.      ..|.:...::
  Rat  4295 EFQDSCGCLKC-------PNKSAGAPYLTNCLGHTLLNLSGYDVEEYLLVPSAKPRLGGWSFGVQ 4352

  Fly   951 KKNELRSFGAVESDGDEHLNGYISQDMFHSAPMMLNLLQNVILRLSYPMQT----DLVVLVENHP 1011
            ..||........|........:.:|..|||.|..||.|.|:||..:.|...    ...:.:.:||
  Rat  4353 IPNEAEDVKTNTSKPKTLAKVWYNQKGFHSLPSYLNHLNNLILWQNLPAHAADWRQYGITLYSHP 4417

  Fly  1012 LPTQLSQKINVLDNKIAHIHVPLVVGCIIPLTVSVFVIPL----VEEEIYDVRFLQHMAGLGLKV 1072
            ....|..:..:|:: |....|.|   ||: |..|:....:    |::.:...:.|||::|||.:.
  Rat  4418 YGGALLNEDRILES-IRQCGVAL---CIV-LGFSILSASIGSSVVKDRVTGAKRLQHISGLGYRT 4477

  Fly  1073 FWGINLFWDWFTFFVYSVIIVVIMSLMGIGGFGFYEN-AIMVVLLTTFGLAALPLTYLVSMFVNK 1136
            :|.||..:|...:.|...:.|.|::...:..|.|.|| |...:||..||.|.:|..||:|...:.
  Rat  4478 YWLINFLYDMLFYLVSVCLCVAIIAAFQLTAFTFRENLAATALLLALFGYAMIPWMYLISRIFSS 4542

  Fly  1137 SIVRAFLVSVLLQGVSGLVLYIIYWDVANSNTIFFYAACMSPGFSLLDGVSNVYAQNLEQAICID 1201
            |.| ||:..:.|..:.||.. ::...:.....|...|..:...:.:|..|..::.|
  Rat  4543 SDV-AFISYISLNFIFGLCT-MLMTTMPRLLAIISKAQSLQKIYDVLKWVFTIFPQ--------- 4596

  Fly  1202 KCEATDSCTEENMNEVVPN-CKFDTFFKWAAPGILPPI-------LYMVLSALIFLMLIFWIELH 1258
                  .|..:.:.|:..| .|:|....:.....:.|.       :::.|:.....:|:..|.||
  Rat  4597 ------FCLGQGLIELCYNQIKYDLTHNFGIDSYVSPFEINFLGWIFVELTLQGTFLLLLRILLH 4655

  Fly  1259 ---RREKKFHTS-RDLRKMRTATYPFDDGDVADVKQKIAEADNTKAKQSVFLVDQVEARVPAAGK 1319
               .|..:.|:: :|:.|      |..|.||...:.::.|. .|.....|........|....||
  Rat  4656 GDCLRWPRGHSALQDIVK------PVKDIDVEKEQMRVLEG-RTGGDMLVLCNLSKSYRGVCRGK 4713

  Fly  1320 --RIHTVSFALNKYMSMGIFGPRNSGKSHLMRQLVGQRGFAFGEIYVR-GLDFKYDLES---IHT 1378
              .:|.:|..:::....|:.|...:|||...:.|.|:...:.|...:| ......||.|   :..
  Rat  4714 TTAVHGISLGISRGECFGLLGVNGAGKSTTFKILNGETPPSSGYATIRTPQGDMVDLASAGKVGV 4778

  Fly  1379 YMGYSPQHRGLLNELTPREHIRLLCMIRGVPEAKIGEKMHDLCLMLNMTGWMHRKCSLLTAEKRH 1443
            .:||.||...|...||..||::..|.:||:|:..|.|...||...|::...:.:..:..:...|.
  Rat  4779 LIGYCPQQDALDELLTGWEHLQYYCRLRGIPKQNIPEVAADLVRRLHLELHVDKPVATYSGGTRR 4843

  Fly  1444 KLKIALALVAYNKILVLDEPTCGMPATTRREIWNILRYIRYCGKTIIFATNDELECKILADFIIL 1508
            ||..|||||....||:||||:.||...::|.:|..:......|...:..::...||:.|...:.:
  Rat  4844 KLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTITQEVRDGCAAVLTSHSMEECEALCTRLAI 4908

  Fly  1509 FQDSEMLAIGSLQYLRYKYSHGFYLEVRLIRDGATLAESEENLRKDVENLAKFVNFLHNRSELVG 1573
            ..|.....:||.|:::.::..|:.::|.|.::|:..:...:.|:.....:           :..|
  Rat  4909 MVDGSFRCLGSPQHIKNRFGDGYTVKVWLHKEGSQPSAVSDCLKLHFPGI-----------QFKG 4962

  Fly  1574 RLNNWFKFYVPVGHIVYSFLYGAMEKNKLRLNVSDYCIYQADMMSVVAQVQETRAQLKHHLVQTE 1638
            :..|..:::|.........|:..:|.||..|.:..|.|.|..:..|.  |.....|..|
  Rat  4963 QRLNLLEYHVQKSWECLPDLFRVLETNKSLLKIEHYSISQTALEQVF--VNFATEQTPH------ 5019

  Fly  1639 GPLPLDTTS 1647
              .|:|..|
  Rat  5020 --FPVDPPS 5026

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1801	NP_728408.3	ABC2_membrane_3	<246..379	CDD:289468	28/145 (19%)
		ABC2_membrane_4	<293..448	CDD:289500	32/178 (18%)
		EcfA2	499..717	CDD:224047	48/227 (21%)
		P-loop_NTPase	500..721	CDD:304359	48/230 (21%)
		ABC2_membrane_3	<972..1254	CDD:289468	71/298 (24%)
		EcfA2	1307..1521	CDD:224047	60/219 (27%)
		P-loop_NTPase	1324..1524	CDD:304359	57/203 (28%)
Abca13	XP_038948786.1	rim_protein	1..>82	CDD:130324
Abca13	XP_038948786.1	rim_protein	3042..5029	CDD:130324	375/1894 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342256
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.950