DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1801 and Abca8b

DIOPT Version :9

Sequence 1:	NP_728408.3	Gene:	CG1801 / 33104	FlyBaseID:	FBgn0031171	Length:	1655	Species:	Drosophila melanogaster
Sequence 2:	NP_038879.2	Gene:	Abca8b / 27404	MGIID:	1351668	Length:	1620	Species:	Mus musculus

Alignment Length:	1815	Identity:	366/1815 - (20%)
Similarity:	701/1815 - (38%)	Gaps:	394/1815 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLFKRYIRIELNLWRRTLFEIVALVIMVLVIFLNPIAHSKRLLYTTTENENEQSIVSHKLQDINI 71
            ||.|..:: :..|.|.:|.|.|:.::::|.::..|..|            ....:.|...:|:.
Mouse    15 LLQKNLLK-KWRLKRESLMEWVSSLLLLLFLYWYPHGH------------GATDLSSVPTKDLG- 65

  Fly    72 LTRMADSKREKTKYILAFTPETTFTSEVTKNVAKT--LELSSTVGYESESEMQNQFDERTTLAGI 134
               ..||.|: :.:::.:||.|:.|.::.:.||.|  :.....:|...|..::...:....:..:
Mouse    66 ---RVDSFRQ-SGFMIGYTPVTSMTQQIMEKVAATPFMADKKVLGLLDEENIKELTESHAEIIRV 126

  Fly   135 VFNDLRDDGTPLTLSISIRFPSEFRTIAPFLTEDRLWITRCSGRINPGRDRAKHDKQQD------ 193
            :|:|        |.|..::|                   :...||...|:...|:...|
Mouse   127 IFSD--------TFSYHLKF-------------------QFDQRIPTSRELRDHNAHCDGLYEDV 164

  Fly   194 -----IYIREGFLQLQHQI---FVE--WYHQLRKDIVSTYPE-----PNVEVYNILLKAADEPCS 243
                 |:.:|||:.||..|   .:|  ..|.:.::::|...:     |.|....||
Mouse   165 NCLIAIFWKEGFVALQAAINAAIIETTTNHSVMEELLSVSGKFMKIHPFVRQEGIL--------- 220

  Fly   244 VMSVAQLPTFLYNFIYLLPFLNIIRNVAAQVE------DGVMVHQWHYGYSFGMQWGIKF--LVL 300
                    |..:.|..::.|..|...|:..|.      .|:|:.......:|.:.||:.:  .|.
Mouse   221 --------TDFFIFTCIISFSPITYYVSINVARERKRMKGLMMMMGLRDPAFWLSWGLLYAGFVF 277

  Fly   301 FLRMCILGVIYTIMLLAFWGFGGREGEFSGTGTIAFVCFITLYTVEIIITGMVVAKLFANPTNAV 365
            .:.:.:..||.::.......|           .:.|..|: ||.:.:|....:::.|........
Mouse   278 IMALSLALVIKSVQFFILTSF-----------MVVFSLFL-LYGLSMITLAFLMSALVRKSVLTG 330

  Fly   366 LFALMLWLFMYAAFCIILERY------WDIHKYYVFFILVAFCNCQMHFSMSLFRNCIEKP---- 420
            |...:|.:|..:.....|.||      |.:..:..|...:..... :.....|..|....|
Mouse   331 LSVFLLTIFWGSLGFTSLYRYLPAPVEWTLSLFSPFAFTLGMAQL-LRVDYDLNSNAPPDPASGS 394

  Fly   421 EMVNTIDFVLIFTSAISSAL-IYFLILLA------------------IQWRMPGTFLSRRIVNNR 466
            .::...:|:|:|.:.:..|| :||..:|.                  :|.|.|...:....::..
Mouse   395 NLIIATNFMLVFDAFLYLALMMYFEKVLPNEYGHQHSPLFFLKSSFWLQTRKPAHVILEDGIDPV 459

  Fly   467 PRKQQESDTTIMYLGRAPSFQNFEFGDVGSVELMRLRHVSTSHRDSERKI--LKNISMRIYRGEV 529
            |......:..      :|.|.        ..|.:|:|::|..::....||  ||::::.||.|::
Mouse   460 PSSGDSFEPV------SPEFH--------GKESIRIRNISKEYKGKPNKIEALKDLTLDIYEGQI 510

  Fly   530 FVILGHIGSGKLTLLRILAGLKFPLRGNVYIMGNPFEPNGEARRLV---------DFRFDEHGLN 585
            ..:|||.|:||.|||.||:||..|.:|:|.|..|......:...::         :.:||
Mouse   511 TAVLGHSGAGKSTLLNILSGLSVPTKGSVTIYNNNLSEMADLENILRIAGVCPQANVQFD----- 570

  Fly   586 KHLTVEQTIDYHVRLKLSPSESDRYEIERRKWLAILDQHVES-RGVRIGKLSSGSMKLVALCCCL 649
             .|||.:.:....:::..|.:....|::|    .:|:..::: :.:....||.|..:.:.....:
Mouse   571 -FLTVRENLRLFAKIRGIPPQDVEKEVQR----VLLELEMKNIQNILAQNLSGGQKRKLTFGIAI 630

  Fly   650 AGDTPIIILEEPTTQLTGREAQIFWSIVHAEKENRAFIIATYNVGEAEHVADRIGILSMGVLEAS 714
            .||:.|.:|:|||..|........|:::...:.:|..:.:|..:.||:.:|||...:|.|.|:.:
Mouse   631 LGDSQIFLLDEPTAGLDPFSRHRVWNLLKERRADRVVLFSTQFMDEADILADRKVFISNGRLKCA 695

  Fly   715 GTPFFLRSKFSSSVDLVI-IKKPHVPDQPITDYINQFMQNIEPENEIGDSLTYRLPVIYRPRLQK 778
            |:..||:.|:.....|.: :|:..||:. ||..:.|.:...:...|....|.|.||:....|..:
Mouse   696 GSSLFLKKKWGVGYHLSLQLKEVCVPEN-ITSLVKQHIPAAKLSAEGEGKLLYTLPLETTYRFPE 759

  Fly   779 LLIHLEIDRKMLGIENVRVVGAELSDIYMTLVTSFRLQQ-----------------QMIPDVTQT 826
            |...|: ....|||||..|....|:::::.|.....:.:                 :.:.::.||
Mouse   760 LCQSLD-SCPGLGIENYGVSMTTLNEVFLKLEGKASIDEPEVDIVGEGQTERSGDTERLMEMEQT 823

  Fly   827 FKYQVVSQK----QLTKQRMRAMFYKKMI---HTAPNVWPIIMIFTSFVLIAIIARLSVLLDMPK 884
            ......::|    .|.:|:..|:...:::   |....:..:::|....:...:...:|.     |
Mouse   824 LSSLRETEKTDGMALWRQQTCAIAKVRLLKLKHERKTLLSVLLILVVGICPFLFENIST-----K 883

  Fly   885 ERQNSI------HIGF----REPEDVVKYL--PNLKDCGYID-IRSAVKVNKKKSVGVSRTFD-- 934
            .||:|.      |..|    ::|:.::..|  .|..:....| |.|..:.|....|..|.|.|
Mouse   884 IRQSSYTWELSPHDYFLAPGQQPQGMLTQLLIINKTEASIDDFIHSVERQNIALEVDASGTRDGT 948

  Fly   935 DDSFVCEKGSYRNNL----RKKNELRSFGAVESDGDEHLNGYISQDMFHSAPMMLNLLQNVILRL 995
            ||.      ||...|    .:||...||..    ..:.||.:         |:::::|.|.:|.:
Mouse   949 DDP------SYNGALIVSGNEKNHSFSFAC----NTKRLNCF---------PVLMDILSNGLLGM 994

  Fly   996 SYP---MQTDLVVLVENHPLPTQLSQKINVLDN--KIAHIHVPLVVGCIIPLTVSVFVIPLVEEE 1055
            ..|   :|||....:        :.:.|:.|::  |.|..   |::....|..:::..:...:..
Mouse   995 VKPSARIQTDRSTYL--------MDETIHPLEDLWKTAFW---LILTSACPPYIAMSSVTDYKNR 1048

  Fly  1056 IYDVRFLQHMAGLGLKVFW------GINLFWDWFTFFVYSVIIVVIMSLMGI------GGFGFYE 1108
            .:   |...::||....:|      .|.|:...|.|          ||||..      ..|....
Mouse  1049 AW---FQLRVSGLFPSAYWVGQAMVDIPLYCFVFLF----------MSLMDYLFRFPDTMFSIIS 1100

  Fly  1109 NAIMVVLLTTFGLAALPLTYLVSMFVNKS------------IVRAFLVSVLLQG--VSGLVLYII 1159
            :.|.:.....:.::.:.|||::|....|.            |:..|.|:|:|..  |.|...|||
Mouse  1101 HVIQIPCSVGYAISLIFLTYVISFISRKGKKNSGIWSLSFYIITVFSVAVILLAFDVDGTQYYII 1165

  Fly  1160 YWDVANSNTIFFYAACMSPGFSLLDGVSNVYAQNLEQAICIDKCEATDSCTEENMNEVVPNCKFD 1224
            :  :...:|:   ..|:.....|..|      |..|:...|:
Mouse  1166 F--LIPPSTL---VGCLILSLHLFIG------QIFEEGQVIE----------------------- 1196

  Fly  1225 TFFKWAAPGILPPILYMV--LSALIFLMLI------FWIELHRREKKFHTS-RDLRKMRTATYPF 1280
                       |.:::::  |...||:..:      |..:..|::..|..| |:....:....|.
Mouse  1197 -----------PFLVFLIPFLHVFIFIFTLRCLEWKFGKKTMRKDPIFRISPRNNDVYQNPEEPE 1250

  Fly  1281 D-DGDVADVKQKIAEA-DNTKAKQSVFLVDQVEARVPAAGKRIH------------TVSFALNKY 1331
            | |.||...:.:.|.| .:|...:...::... .|...|||:.|            .|||.:.|.
Mouse  1251 DEDEDVQMERMRTANALVSTSFDEKPVIIASC-LRKEYAGKQKHCLSKKKAKIATRNVSFCVRKG 1314

  Fly  1332 MSMGIFGPRNSGKSHLMRQLVGQRGFAFGEIYVRGLDFKYDLESIHTYMGYSPQHRGLLNELTPR 1396
            ..:|:.|...:|||..::.:.|......|::.::| ..:.|...   ::||.||...|...||.:
Mouse  1315 EILGLLGHNGAGKSTSLKMISGDTKVTAGQVLLKG-SREGDTPG---FLGYCPQENALWPNLTVK 1375

  Fly  1397 EHIRLLCMIRGVPEAKIGEKMHDLCLMLNMTGWMHRKCSLLTAEKRHKLKIALALVAYNKILVLD 1461
            ||:.:...:||:.::.....:..|...|.:...:......|:...:.||...|:::....||:||
Mouse  1376 EHLEIFAAVRGLRKSHAAVAITRLADALKLQDQLKSPVKTLSEGVKRKLCFVLSILGNPSILLLD 1440

  Fly  1462 EPTCGMPATTRREIWNILR-YIRYCGKTIIFATNDELECKILADFIILFQDSEMLAIGSLQYLRY 1525
            ||:.|:....:::||..:| .|:...:..:..|:...|.:.|.|.:.:.....:..|||:|:|:.
Mouse  1441 EPSTGLDPEGQQQIWQAIRAIIKNTDRGALLTTHYMAEAEALCDRVAILVSGRLRCIGSIQHLKS 1505

  Fly  1526 KYSHGFYLEVRLIRDGATLAESEENLRKDVENLAKFVNFLHNRSELVGRLNNWFKFYVPVGHI-V 1589
            |:...:.||:::    .|| |..|.|..::..|....    :|.|   |.::...:.:||..: .
Mouse  1506 KFGKDYLLEMKV----KTL-EQVEPLNTEILRLFPQA----SRQE---RYSSLMAYKLPVEAVQP 1558

  Fly  1590 YSFLYGAMEKNKLRLNVSDYCIYQADMMSVV-----------AQVQETRAQLKHHLVQTE 1638
            .|..:..:||.|...::.:|.:.|:.:..|.           .:::|..:.:|..|:..|
Mouse  1559 LSQAFFKLEKVKQTFDLEEYSLSQSTLEQVFLELSKEQELDGLELEELDSSIKWKLLPQE 1618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1801	NP_728408.3	ABC2_membrane_3	<246..379	CDD:289468	24/140 (17%)
		ABC2_membrane_4	<293..448	CDD:289500	30/167 (18%)
		EcfA2	499..717	CDD:224047	60/229 (26%)
		P-loop_NTPase	500..721	CDD:304359	61/232 (26%)
		ABC2_membrane_3	<972..1254	CDD:289468	54/320 (17%)
		EcfA2	1307..1521	CDD:224047	53/226 (23%)
		P-loop_NTPase	1324..1524	CDD:304359	49/200 (25%)
Abca8b	NP_038879.2	rim_protein	<265..1596	CDD:130324	304/1479 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838396
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.750