DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG1801 and ABCA12

DIOPT Version :9

Sequence 1:NP_728408.3 Gene:CG1801 / 33104 FlyBaseID:FBgn0031171 Length:1655 Species:Drosophila melanogaster
Sequence 2:XP_011509253.1 Gene:ABCA12 / 26154 HGNCID:14637 Length:2598 Species:Homo sapiens


Alignment Length:1852 Identity:387/1852 - (20%)
Similarity:713/1852 - (38%) Gaps:429/1852 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    48 LLYTTTENENEQSIV--SHKLQDINILTRM--ADSKREKTKYILAFTPETTFTSEVTKNV----- 103
            :|..|..|...|..|  |..|..:.:|.::  .|..|.|.:..:....:....|.:|.|:     
Human   862 MLQNTLRNPFVQVFVKFSVGLDAVELLKQIDELDILRLKLENNIDIIDQLNTLSSLTVNISSCVL 926

  Fly   104 ------AKTLELSSTVGYESESEMQNQFDERTTLAGIVF--------NDLRDDGT----PL---T 147
                  |||::       |.|.|.:..:........::|        :...|.|.    |:   |
Human   927 YDRIQAAKTID-------EMEREAKRLYKSNELFGSVIFKLPSNRSWHRGYDSGNVFLPPVIKYT 984

  Fly   148 LSISIRFPSEFRTIAPFLTEDRLWITRCSGRINPGRDRAKHDKQQDIYIREGFLQLQHQIFVEWY 212
            :.:|::.....|::     ..::|.        ||...:....|  ||.| .|:.||..|     
Human   985 IRMSLKTAQTTRSL-----RTKIWA--------PGPHNSPSHNQ--IYGR-AFIYLQDSI----- 1028

  Fly   213 HQLRKDIVSTYPEPNVEVYNILLKAADEPCSVMSVAQLPTFLYNFIYLLPFLNIIR---NVAAQV 274
               .:.|:......|.:...:.::|...||.:..     .||.:..|.||.:.::.   .:||.|
Human  1029 ---ERAIIELQTGRNSQEIAVQVQAIPYPCFMKD-----NFLTSVSYSLPIVLMVAWVVFIAAFV 1085

  Fly   275 -----EDGVMVHQW----------HYGYSFGMQWGIKFLVLFLRMCILGVIYTIMLLAFWGFGGR 324
                 |..:.:|::          |:     ..|    |:..:...::.::..|::|.|.....:
Human  1086 KKLVYEKDLRLHEYMKMMGVNSCSHF-----FAW----LIESVGFLLVTIVILIIILKFGNILPK 1141

  Fly   325 EGEFSGTGTIAFVCFITLYTVEIIITGMVVAKLFANPTNAVLFALMLWLFMYAAFCIILERYWDI 389
            .     .|.|.|:.| :.|:..:|....:::..|.|...|.|...::::..:..|.:::....::
Human  1142 T-----NGFILFLYF-SDYSFSVIAMSYLISVFFNNTNIAALIGSLIYIIAFFPFIVLVTVENEL 1200

  Fly   390 -HKYYVFFILV---AFCNCQMHFS------MSL-FRNCIEKPEMVNTIDFVLIFTSAISSALIYF 443
             :...||..|:   ||.....:.:      :.| :.|....|...:|..|..:....::.:.|||
Human  1201 SYVLKVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTSFGWLCCLILADSFIYF 1265

  Fly   444 LILLAIQWRMPGT--------------FLSRRI--VNNRPRKQQE-SDTTIMYLGRAPSFQNFEF 491
            ||...::...|||              :...|.  ...:|.|... ..|.||.....||      
Human  1266 LIAWYVRNVFPGTYGMAAPWYFPILPSYWKERFGCAEVKPEKSNGLMFTNIMMQNTNPS------ 1324

  Fly   492 GDVGSVELMRLRHVSTSHRD--------------SERKILKNISMRIYRGEVFVILGHIGSGKLT 542
            ....|.|.|...::....:|              ..:..:.|:::..|.|.:..:||..|:||.|
Human  1325 ASKTSPEYMFSSNIEPEPKDLTVGVALHGVTKIYGSKVAVDNLNLNFYEGHITSLLGPNGAGKTT 1389

  Fly   543 LLRILAGLKFPLRGNVYIMGNPFEPNGEARRLVDFRFDEHGLNK-------------HLTVEQTI 594
            .:.:|.||.....|.:::.|.            |.:.|.|.:.|             :||.::.:
Human  1390 TISMLTGLFGASAGTIFVYGK------------DIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHL 1442

  Fly   595 DYHVRLKLSPSESDRY---EIERRKWLAILDQHVES-RGVRIGKLSSGSMKLVALCCCLAGDTPI 655
            ..:..:|: |..:.:.   |::|    .:.|..:.| |..|:|.||.|..:.:::...|.|.:.:
Human  1443 LLYGSIKV-PHWTKKQLHEEVKR----TLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRV 1502

  Fly   656 IILEEPTTQLTGREAQIFWSIVHAEKENRAFIIATYNVGEAEHVADRIGILSMGVLEASGTPFFL 720
            :||:||:|.:.....:..|.::...|..|..|::|:::.|||.::|||..|..|.|...|:||:|
Human  1503 VILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYL 1567

  Fly   721 RSKFSSSVDLVIIKK--PHVPDQPITD--YINQFMQNIEPE----NEIGDSLTYRLPVIYRPRLQ 777
            :..|.....|.:.||  |::....:.|  .:...:|:..||    .:||..|.|.||    |...
Human  1568 KEAFGDGYHLTLTKKKSPNLNANAVCDTMAVTAMIQSHLPEAYLKEDIGGELVYVLP----PFST 1628

  Fly   778 KLL-IHLEIDRKM---LGIENVRVVG---AELSDIYMTLVTSFR---------LQQQMI------ 820
            |:. .:|.:.|.:   :|..|:...|   ..:.::::.|....:         |.|:.|      
Human  1629 KVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTKESQKNSAMSLEHLTQKKIGNSNAN 1693

  Fly   821 ----PD--VTQTFKYQVVSQKQLTK-----------QRMRAMFYKKMIHTAPN--------VWPI 860
                ||  ...:..:.....|.||:           :::.|:..|:..||..|        :.||
Human  1694 GISTPDDLSVSSSNFTDRDDKILTRGERLDGFGLLLKKIMAILIKRFHHTRRNWKGLIAQVILPI 1758

  Fly   861 IMIFT------------SFVLIAII---------------------ARLSVLLDMP---KERQNS 889
            :.:.|            |:..|.|.                     |.:|.:.|.|   ....|:
Human  1759 VFVTTAMGLGTLRNSSNSYPEIQISPSLYGTSEQTAFYANYHPSTEALVSAMWDFPGIDNMCLNT 1823

  Fly   890 IHIGFREPEDVVKY------LPNLKDCGYID-IRSAVKVNKKKSVGVSRTFDDDSFVCEKGSYRN 947
            ..:.....:.:.|:      :.|...|...: ::...|.|  .|....||:.........|....
Human  1824 SDLQCLNKDSLEKWNTSGEPITNFGVCSCSENVQECPKFN--YSPPHRRTYSSQVIYNLTGQRVE 1886

  Fly   948 N---------LRKKNELRSFG-AVESDGDEHLNG----------YISQDMFHSAPMMLNLLQNVI 992
            |         ::|:....||| .:..|....:.|          :...:.:||.|..||.|.|.:
Human  1887 NYLISTANEFVQKRYGGWSFGLPLTKDLRFDITGVPANRTLAKVWYDPEGYHSLPAYLNSLNNFL 1951

  Fly   993 LRLSYPMQTDLV---VLVENHPLP-------TQLSQKINVLDNKIAHIHVPLVVGCIIPLTVSVF 1047
            ||::. .:.|..   :::.:||.|       ..:|..|::|      :.:.:::|  ..:|.:.|
Human  1952 LRVNM-SKYDAARHGIIMYSHPYPGVQDQEQATISSLIDIL------VALSILMG--YSVTTASF 2007

  Fly  1048 VIPLVEEEIYDVRFLQHMAGLGLKVFWGINLFWDWFTFFV---YSVIIVVIMSLMGIGGFGFY-E 1108
            |..:|.|.....:.|||::|:|:..:|..|..:|...:.|   :|:.|:.|..|.     .|| |
Human  2008 VTYVVREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIGIIAIFKLP-----AFYSE 2067

  Fly  1109 NAIMVV--LLTTFGLAALPLTYLVSMFVNKSIVRAFLVSV---LLQGVSGLV-LYIIYW---DVA 1164
            |.:..|  ||..||.|.....||::...:::.: ||:..|   |..|::.:| |.::|:   :..
Human  2068 NNLGAVSLLLLLFGYATFSWMYLLAGLFHETGM-AFITYVCVNLFFGINSIVSLSVVYFLSKEKP 2131

  Fly  1165 NSNT------------IFFYAACMSPGFSLLDGVSNVYAQNLEQAICIDKCEATDSCTEENMNEV 1217
            |..|            :.|...|.  |:.|:: :|       :|...:|..:|..   .|..||.
Human  2132 NDPTLELISETLKRIFLIFPQFCF--GYGLIE-LS-------QQQSVLDFLKAYG---VEYPNET 2183

  Fly  1218 VPNCKFDTFFKWAAPGILPPILYMVLSALIFLMLIFWIELHRREKKFHTS---------RDLRKM 1273
            ....|....|   ...:....::..|..||...||..:.|..|  ||::|         .|:|..
Human  2184 FEMNKLGAMF---VALVSQGTMFFSLRLLINESLIKKLRLFFR--KFNSSHVRETIDEDEDVRAE 2243

  Fly  1274 RTATYPFDDGDVADVKQKIAEAD------NTKAKQ----SVFLVDQVEARVPAAGKRIHTVSFAL 1328
            |..           |:...||.|      .||..|    .:..|:.:...:||.           
Human  2244 RLR-----------VESGAAEFDLVQLYCLTKTYQLIHKKIIAVNNISIGIPAG----------- 2286

  Fly  1329 NKYMSMGIFGPRNSGKSHLMRQLVGQRGFAFGEIYVRGLDFKY-DLESIHTYMGYSPQHRGLLNE 1392
               ...|:.|...:||:.:.:.|.|....:.|.|.:|...... .::|..:.:||.||...|.:.
Human  2287 ---ECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLGHVDSHSSLVGYCPQEDALDDL 2348

  Fly  1393 LTPREHIRLLCMIRGVPEAKIGEKMHDLCLMLNMTGWMHRKCSLLTAEKRHKLKIALALVAYNKI 1457
            :|..||:.....:.|:||..|.|.:|.|...|::..:..|..|:.:...:.||..||||:....|
Human  2349 VTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATSMCSYGTKRKLSTALALIGKPSI 2413

  Fly  1458 LVLDEPTCGMPATTRREIWNILRYIRYCGKTIIFATNDELECKILADFIILFQDSEMLAIGSLQY 1522
            |:||||:.||...::|.:|.|:........::|..::...||:.|...:.:..:.:...|||||:
Human  2414 LLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQH 2478

  Fly  1523 LRYKYSHGFYLEVRLIRDGATLAESEENLRKDVENLAKFVNFLHNRSELVGRLNNWFKFYVPVGH 1587
            ::.::..||.::|.|           :|.:..:|.|.||:.....::.|..:..:..:::|||..
Human  2479 IKSRFGRGFTVKVHL-----------KNNKVTMETLTKFMQLHFPKTYLKDQHLSMLEYHVPVTA 2532

  Fly  1588 IVYSFLYGAMEKNKLRLNVSDYCIYQADMMSV 1619
            ...:.::..:|.||..||::::.:.|..:..|
Human  2533 GGVANIFDLLETNKTALNITNFLVSQTTLEEV 2564

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1801NP_728408.3 ABC2_membrane_3 <246..379 CDD:289468 26/150 (17%)
ABC2_membrane_4 <293..448 CDD:289500 31/165 (19%)
EcfA2 499..717 CDD:224047 56/248 (23%)
P-loop_NTPase 500..721 CDD:304359 58/251 (23%)
ABC2_membrane_3 <972..1254 CDD:289468 75/316 (24%)
EcfA2 1307..1521 CDD:224047 55/214 (26%)
P-loop_NTPase 1324..1524 CDD:304359 54/200 (27%)
ABCA12XP_011509253.1 ABC2_membrane_3 <1026..1270 CDD:289468 48/271 (18%)
ZnuC 1349..1573 CDD:224046 58/240 (24%)
ABC_subfamily_A 1353..1568 CDD:213230 56/231 (24%)
ABC2_membrane_3 <1916..2177 CDD:289468 66/288 (23%)
ABC_subfamily_A 2257..2480 CDD:213230 60/236 (25%)
CcmA 2262..2570 CDD:224054 80/328 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165148329
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR19229
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.850

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