DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG1801 and ABCA4

DIOPT Version :9

Sequence 1:NP_728408.3 Gene:CG1801 / 33104 FlyBaseID:FBgn0031171 Length:1655 Species:Drosophila melanogaster
Sequence 2:NP_000341.2 Gene:ABCA4 / 24 HGNCID:34 Length:2273 Species:Homo sapiens


Alignment Length:1879 Identity:381/1879 - (20%)
Similarity:683/1879 - (36%) Gaps:452/1879 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    93 TTFTSEVTKNVAKTLELSSTVGYESESEMQNQ----FDERTTLAGIVFNDLRDDGTPLTLSISIR 153
            |..|..:.....:.|.|.....|..|:::..:    .:|....||:||.|:    .|.|.|:...
Human   506 TDRTLRLVNQYLECLVLDKFESYNDETQLTQRALSLLEENMFWAGVVFPDM----YPWTSSLPPH 566

  Fly   154 FPSEFRTIAPFL-----TEDRLWITRCSG-RINPGRDRAKHDKQQDIYIREGFLQLQHQIFVEWY 212
            ...:.|.....:     .:||.|   .|| |.:|..|..        ||..||..||..:     
Human   567 VKYKIRMDIDVVEKTNKIKDRYW---DSGPRADPVEDFR--------YIWGGFAYLQDMV----- 615

  Fly   213 HQLRKDIVSTYPEPNVEVYNILLKAADEPC----SVMSVAQ--LPTFL-YNFIYLLPFLNIIRNV 270
               .:.|..:..:....| .|.|:....||    |.|.:..  .|.|: ..:||.:..  .::::
Human   616 ---EQGITRSQVQAEAPV-GIYLQQMPYPCFVDDSFMIILNRCFPIFMVLAWIYSVSM--TVKSI 674

  Fly   271 AAQVEDGVMVHQWHYGYSFGMQWGIKFLVLFLRMCILGVIYTIMLLAFWGFGGREGEFSGTGTIA 335
            ..:.|..:.....:.|.|..:.|...||..|..|.:     :|.||..:...||...:|.    .
Human   675 VLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMSM-----SIFLLTIFIMHGRILHYSD----P 730

  Fly   336 FVCFITL--YTVEIIITGMVVAKLFANPTNAVLFALMLWLFMYAAFCIILERYW------DIHKY 392
            |:.|:.|  ::...|:...:::..|:..:.|...:.:::..:|...  ||...|      ::.|.
Human   731 FILFLFLLAFSTATIMLCFLLSTFFSKASLAAACSGVIYFTLYLPH--ILCFAWQDRMTAELKKA 793

  Fly   393 YVFFILVAF---CNCQMHF---SMSL-FRNCIEKPEMVNTIDFVLIFTSAISSALIYFLILLAIQ 450
            ......|||   ....:.|   .:.| :.|....|...:...|:|.....:..|.:|.|:...:.
Human   794 VSLLSPVAFGFGTEYLVRFEEQGLGLQWSNIGNSPTEGDEFSFLLSMQMMLLDAAVYGLLAWYLD 858

  Fly   451 WRMPGT--------FL----------------SRRIVNNRPRKQQESDTTIMYLGRAPSFQNFEF 491
            ...||.        ||                .|.:....|..::..|..... |...||  ||.
Human   859 QVFPGDYGTPLPWYFLLQESYWLGGEGCSTREERALEKTEPLTEETEDPEHPE-GIHDSF--FER 920

  Fly   492 GDVGSVELMRLRHVSTSHRDSERKILKNISMRIYRGEVFVILGHIGSGKLTLLRILAGLKFPLRG 556
            ...|.|..:.::::........|..:..:::..|..::...|||.|:||.|.|.||.||..|..|
Human   921 EHPGWVPGVCVKNLVKIFEPCGRPAVDRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSG 985

  Fly   557 NVYIMGNPFEPNGEARRLVDFRFDEHG-LNKHLTVEQTIDYHVRLKLSPSESDRYEIERRKWLAI 620
            .|.:.|...|.:.:|.|.......:|. |..||||.:.:.::.:||....|..:.|:|     |:
Human   986 TVLVGGRDIETSLDAVRQSLGMCPQHNILFHHLTVAEHMLFYAQLKGKSQEEAQLEME-----AM 1045

  Fly   621 LDQ---HVESRGVRIGKLSSGSMKLVALCCCLAGDTPIIILEEPTTQLTGREAQIFWSIVHAEKE 682
            |:.   | ..|......||.|..:.:::.....||..::||:|||:.:.....:..|.::...:.
Human  1046 LEDTGLH-HKRNEEAQDLSGGMQRKLSVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRS 1109

  Fly   683 NRAFIIATYNVGEAEHVADRIGILSMGVLEASGTPFFLRSKFSSSVDLVIIKK------------ 735
            .|..|::|:::.||:.:.|||.|::.|.|..||||.||::.|.:.:.|.:::|            
Human  1110 GRTIIMSTHHMDEADLLGDRIAIIAQGRLYCSGTPLFLKNCFGTGLYLTLVRKMKNIQSQRKGSE 1174

  Fly   736 ---------------PHV----PDQPITDYINQFMQNI---EPENE----IGDSLTYRLP-VIYR 773
                           .||    |:|.:...:|:.|..:   .||.:    ||..|.:.|| ..::
Human  1175 GTCSCSSKGFSTTCPAHVDDLTPEQVLDGDVNELMDVVLHHVPEAKLVECIGQELIFLLPNKNFK 1239

  Fly   774 PRLQKLLIHLEIDRKM--LGIENVRVVGAELSDIYMTL--------VTSFRLQQQ---------- 818
            .|....|.. |::..:  ||:.:..:....|.:|::.:        :.:...||:          
Human  1240 HRAYASLFR-ELEETLADLGLSSFGISDTPLEEIFLKVTEDSDSGPLFAGGAQQKRENVNPRHPC 1303

  Fly   819 ----------------------------MIPDVTQTFKYQVVSQKQLTKQRMRAMFYKKMIHT-- 853
                                        ..|...:....|:.:..||..|.::|:..|:..||  
Human  1304 LGPREKAGQTPQDSNVCSPGAPAAHPEGQPPPEPECPGPQLNTGTQLVLQHVQALLVKRFQHTIR 1368

  Fly   854 ------APNVWPIIMIFTSFVLIAIIARLS------------------VLLDMPKERQNSIHIGF 894
                  |..|.|...:|.:.:|..:|....                  ..:|.|...|      |
Human  1369 SHKDFLAQIVLPATFVFLALMLSIVIPPFGEYPALTLHPWIYGQQYTFFSMDEPGSEQ------F 1427

  Fly   895 REPEDVVKYLPN-----LKD-------CGYIDIRSAVKVNKKKSVGVSRTFDDDSFV-------- 939
            ....||:...|.     ||:       ||    .|........|..:::.|....:.        
Human  1428 TVLADVLLNKPGFGNRCLKEGWLPEYPCG----NSTPWKTPSVSPNITQLFQKQKWTQVNPSPSC 1488

  Fly   940 -------------CEKGS-----------------------------------YRNNLRKK---N 953
                         |.:|:                                   .|::|:.|   |
Human  1489 RCSTREKLTMLPECPEGAGGLPPPQRTQRSTEILQDLTDRNISDFLVKTYPALIRSSLKSKFWVN 1553

  Fly   954 ELRSFGAVESDG--------DEHLNGYISQDM--------------------------------- 977
            |.| :|.:...|        .|.|.|::| |:                                 
Human  1554 EQR-YGGISIGGKLPVVPITGEALVGFLS-DLGRIMNVSGGPITREASKEIPDFLKHLETEDNIK 1616

  Fly   978 -------FHSAPMMLNLLQNVILRLSYPMQTDLVVLVENHPLPTQLSQKINVLDNKIAHIHV--- 1032
                   :|:....||:..|.|||.|.|....    .|.:.: |.:||.:|:...:::.|.|   
Human  1617 VWFNNKGWHALVSFLNVAHNAILRASLPKDRS----PEEYGI-TVISQPLNLTKEQLSEITVLTT 1676

  Fly  1033 ---PLVVGCII---PLTVSVFVIPLVEEEIYDVRFLQHMAGLGLKVFWGINLFWDWFTFFVYSVI 1091
               .:|..|:|   ....:.||:.|::|.:...:.||.::|:....:|..|..||...:.|.:.:
Human  1677 SVDAVVAICVIFSMSFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAGL 1741

  Fly  1092 IVVIMSLMGIGGFGFYENA--------IMVVLLTTFGLAALPLTYLVSMF--VNKSIVRAFLVSV 1146
            :|.|.       .||.:.|        .:|.||..:|.|.:|:.|..|..  |..:...|...:.
Human  1742 VVGIF-------IGFQKKAYTSPENLPALVALLLLYGWAVIPMMYPASFLFDVPSTAYVALSCAN 1799

  Fly  1147 LLQGVSGLVLYIIYWDVANSNTIFFYAA------------CMSPG---FSLLDGVSNVYAQNLEQ 1196
            |..|::...:..|.....|:.|:..:.|            |:..|   .:|...|::|||:..| 
Human  1800 LFIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYARFGE- 1863

  Fly  1197 AICIDKCEATDSCTEENMNEVVPNCKFDTFFKWAAPGILPPILYMVLSALIFLMLIFWIELHRRE 1261
                          |.:.|.          |.|...|  ..:..||:..:::.:|...::.|   
Human  1864 --------------EHSANP----------FHWDLIG--KNLFAMVVEGVVYFLLTLLVQRH--- 1899

  Fly  1262 KKFHTSRDLRKMRTATYPFDDGDVADVKQKIAEADNTKAKQSVFLVDQVEARVP-AAGKRIHTVS 1325
              |..|:.:.:........:|.|||:.:|:|....|   |..:..:.::....| .:...:..:.
Human  1900 --FFLSQWIAEPTKEPIVDEDDDVAEERQRIITGGN---KTDILRLHELTKIYPGTSSPAVDRLC 1959

  Fly  1326 FALNKYMSMGIFGPRNSGKSHLMRQLVGQRGFAFGEIYVRGLDFKYDLESIHTYMGYSPQHRGLL 1390
            ..:......|:.|...:||:...:.|.|......|:..|.|.....::..:|..|||.||...:.
Human  1960 VGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAID 2024

  Fly  1391 NELTPREHIRLLCMIRGVPEAKIGEKMHDLCL-MLNMTGWMHRKCSLLTAEKRHKLKIALALVAY 1454
            ..||.|||:.|...:||||..:| ||:.:..: .|.:|.:........:...:.||..|:||:..
Human  2025 ELLTGREHLYLYARLRGVPAEEI-EKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIGC 2088

  Fly  1455 NKILVLDEPTCGMPATTRREIWNILRYIRYCGKTIIFATNDELECKILADFIILFQDSEMLAIGS 1519
            ..:::|||||.||....||.:||::..|...|:.::..::...||:.|...:.:........:|:
Human  2089 PPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKGAFRCMGT 2153

  Fly  1520 LQYLRYKYSHGFYLEVRLIRDGATLAESEENLRKDVENLAKFVNFLHNRSELVGRLNNWFKFYVP 1584
            :|:|:.|:..|:.:.::       :...:::|..|:..:.:|  |..|....|.|..::......
Human  2154 IQHLKSKFGDGYIVTMK-------IKSPKDDLLPDLNPVEQF--FQGNFPGSVQRERHYNMLQFQ 2209

  Fly  1585 VGHIVYSFLYGAMEKNKLRLNVSDYCIYQADMMSVVAQVQETRAQLKHHLVQTEGPLPL 1643
            |.....:.::..:..:|..|.:.:|.:.|..:..|.  |...:.|.:.|      .|||
Human  2210 VSSSSLARIFQLLLSHKDSLLIEEYSVTQTTLDQVF--VNFAKQQTESH------DLPL 2260

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1801NP_728408.3 ABC2_membrane_3 <246..379 CDD:289468 25/137 (18%)
ABC2_membrane_4 <293..448 CDD:289500 34/169 (20%)
EcfA2 499..717 CDD:224047 60/221 (27%)
P-loop_NTPase 500..721 CDD:304359 63/224 (28%)
ABC2_membrane_3 <972..1254 CDD:289468 70/355 (20%)
EcfA2 1307..1521 CDD:224047 53/215 (25%)
P-loop_NTPase 1324..1524 CDD:304359 53/200 (27%)
ABCA4NP_000341.2 rim_protein 1..2272 CDD:130324 381/1879 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 891..911 3/19 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1284..1345 4/60 (7%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165148358
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.750

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