Protein Alignment CG1801 and ABCA6

DIOPT Version :9

• Sequence 1: NP_728408.3
• Gene: CG1801 / 33104
• FlyBaseID: FBgn0031171
• Length: 1655
• Species: Drosophila melanogaster
• Sequence 2: NP_525023.2
• Gene: ABCA6 / 23460
• HGNCID: 36
• Length: 1617
• Species: Homo sapiens
• Alignment Length: 1836
• Identity: 364/1836 - (19%)
• Similarity: 704/1836 - (38%)
• Gaps: 470/1836 - (25%)

  Fly     4 SKGLLFKRYIRIELNLWRRTLFEIVALVIMVLVIFLNPIAHSKRLLYTTTENENEQSIVSHKLQD 68
            :|.||.|.::: :..:.|.:|.|....:::.|.|         .|..::..|.....:....|..
Human    12 TKALLCKNFLK-KWRMKRESLLEWGLSILLGLCI---------ALFSSSMRNVQFPGMAPQNLGR 66

  Fly    69 INILTRMADSKREKTKYILAFTPETTFTSEVTKN--VAKTLELSSTVGYESESEMQNQFDERTTL 131
            ::        |...:..::.:||.:..|.::...  :|..|:.:|.:|..:::.|.....|....
Human    67 VD--------KFNSSSLMVVYTPISNLTQQIMNKTALAPLLKGTSVIGAPNKTHMDEILLENLPY 123

  Fly   132 A-GIVFNDLRDDGTPLTLSISIRFPSEFRTIAPFLTED---RLW---------ITRCSGRINPGR 183
            | ||:||:        |.|..:.|...:.  :|...||   ..|         :|:
Human   124 AMGIIFNE--------TFSYKLIFFQGYN--SPLWKEDFSAHCWDGYGEFSCTLTK--------- 169

  Fly   184 DRAKHDKQQDIYIREGFLQLQHQI---FVEWYHQLRKDIVSTYPEPNVEVYNILLKAADEPCSVM 245
                       |...||:.||..|   .:|        |.:.:|            ..:|..||.
Human   170 -----------YWNRGFVALQTAINTAIIE--------ITTNHP------------VMEELMSVT 203

  Fly   246 SVAQ--LP----TFLYNFIYLLPFL----------------------NIIRNVAAQVEDGVMVHQ 282
            ::..  ||    ..|:|.:::|.||                      |:::.:..|
Human   204 AITMKTLPFITKNLLHNEMFILFFLLHFSPLVYFISLNVTKERKKSKNLMKMMGLQ--------- 259

  Fly   283 WHYGYSFGMQWGIKFLVLFLRMCILGVIYTIMLLAFWGFGGREGEFSGTGTIAFVCFITLYTVEI 347
               ..:|.:.||:.:         .|.|:.|.:                    ||..|..:|..|
Human   260 ---DSAFWLSWGLIY---------AGFIFIISI--------------------FVTIIITFTQII 292

  Fly   348 IITG-MVVAKLFANPTNAVLFALMLWLFMYAAFCIILERYWDIHKYYVFFILVAFCNC------- 404
            ::|| ||:..||      .|:.|.|...:: ...::|::  .:....|.|:|..|..|
Human   293 VMTGFMVIFILF------FLYGLSLVALVF-LMSVLLKK--AVLTNLVVFLLTLFWGCLGFTVFY 348

  Fly   405 -QMHFSMSLFRN-C------------IEKPEMVNTIDF----------VLIFTSAISSALIYFLI 445
             |:..|:....| |            |:....:|.:.|          :..|:..:...|||.|:
Human   349 EQLPSSLEWILNICSPFAFTTGMIQIIKLDYNLNGVIFPDPSGDSYTMIATFSMLLLDGLIYLLL 413

  Fly   446 LLAIQWRMP----------------GTFLSRR----IVNNRPRKQQESDTTIMYLGRAPSFQNFE 490
            .|.....:|                ..|..:|    ::......:..||.  .:...||.||
Human   414 ALYFDKILPYGDERHYSPLFFLNSSSCFQHQRTNAKVIEKEIDAEHPSDD--YFEPVAPEFQ--- 473

  Fly   491 FGDVGSVELMRLRHVSTSHRDSERKI--LKNISMRIYRGEVFVILGHIGSGKLTLLRILAGLKFP 553
                 ..|.:|:|:|...::....|:  ||.:...||.|::..||||.|:||.:||.||.||..|
Human   474 -----GKEAIRIRNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVP 533

  Fly   554 LRGNVYIMG---NPFEPNGEARRLV------DFRFDEHGLNKHLTVEQTIDYHVRLKLSPSESDR 609
            ..|:|.|..   :..:...|.|::.      :.:||      .|||::.:....::|....:...
Human   534 TEGSVTIYNKNLSEMQDLEEIRKITGVCPQFNVQFD------ILTVKENLSLFAKIKGIHLKEVE 592

  Fly   610 YEIERRKWLAILDQHVESRGVRIGK-LSSGSMKLVALCCCLAGDTPIIILEEPTTQLTGREAQIF 673
            .|::|    .:|:..:::....:.| ||.|..:.:.....:.||..|::|:||||.|........
Human   593 QEVQR----ILLELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQV 653

  Fly   674 WSIVHAEKENRAFIIATYNVGEAEHVADRIGILSMGVLEASGTPFFLRSKFSSSVDLVIIKKPHV 738
            ||::...:.:...:.:|.::.||:.:|||..|:|.|.|:.:|:..||:.::.....|.:.:....
Human   654 WSLLRERRADHVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSLHRNEIC 718

  Fly   739 PDQPITDYINQFMQNIEPENEIGDSLTYRLPVIYRPRLQKLLIHLE--IDRKMLGIENVRVVGAE 801
            ..:.||.:|...:.:.:.:.|..:.|.|.||:........|...|:  .|:   |:....:..:.
Human   719 NPEQITSFITHHIPDAKLKTENKEKLVYTLPLERTNTFPDLFSDLDKCSDQ---GVTGYDISMST 780

  Fly   802 LSDIYMTLVTSFRLQQ-----QMIPDVTQTFKYQV-----------VSQKQLTKQRMRAM----F 846
            |::::|.|.....::|     :||.|.....:.::           ||...|.:.::.||    |
Human   781 LNEVFMKLEGQSTIEQDFEQVEMIRDSESLNEMELAHSSFSEMQTAVSDMGLWRMQVFAMARLRF 845

  Fly   847 YK-----KMIHTAPNVWPIIMIFTSFVLIAIIARLSVLLDMPKERQNSIHIGF-------REPED 899
            .|     |::.|...|:. |.||...|...:.|.|:..:|.  |.:|.::  |       :||..
Human   846 LKLKRQTKVLLTLLLVFG-IAIFPLIVENIMYAMLNEKIDW--EFKNELY--FLSPGQLPQEPRT 905

  Fly   900 VVKYLPNLKDCGYIDIRSAVKVNKKKSVGVSRTFDDDSFVCEKGSYRNNLRKKNELRSFGAVESD 964
            .:..:.|.:.    :|...:|..|.:::    ..:.|.|....|:        :.|...||:...
Human   906 SLLIINNTES----NIEDFIKSLKHQNI----LLEVDDFENRNGT--------DGLSYNGAIIVS 954

  Fly   965 G---DEHLNGYISQDMFHSAPMMLNLLQNVILRLSYPMQTDLVVLVENHPLPTQLSQKINVLDNK 1026
            |   |...:...:....|..|:::|::.|.:|::....|.   :.:|:.|.|..
Human   955 GKQKDYRFSVVCNTKRLHCFPILMNIISNGLLQMFNHTQH---IRIESSPFPLS----------- 1005

  Fly  1027 IAHIHVPLVVGC--------IIPLTVSVFV-IPLVEEEIYDVRFLQHMAGLGLKVFWGINLFWDW 1082
                |:.|..|.        ::..::|.:: :..:.:...:.:....::||....:|......|
Human  1006 ----HIGLWTGLPDGSFFLFLVLCSISPYITMGSISDYKKNAKSQLWISGLYTSAYWCGQALVD- 1065

  Fly  1083 FTFFVYSVIIVVIMSLMGIGGFGFYENAIMVVLLTT---FGLAALPLTYLVSMFVNKSIVRAFLV 1144
            .:||   ::|:::|.|:      ||...:..:|:|:   |.|..:...|..|:     :...:::
Human  1066 VSFF---ILILLLMYLI------FYIENMQYLLITSQIVFALVIVTPGYAASL-----VFFIYMI 1116

  Fly  1145 SVLL---QGVSGLVLYIIYWDVANSNTIFFYAACMSPGFSLLDGVSNVYAQNLEQAICIDKCEAT 1206
            |.:.   :..|||      |     :..||:|:.:....:|::        :.:.:|.|......
Human  1117 SFIFRKRRKNSGL------W-----SFYFFFASTIMFSITLIN--------HFDLSILITTMVLV 1162

  Fly  1207 DSCT------------EENMNEVVPNCKFDTFFKWAAPGILPPILYMVLSALIFLMLIFWIELH- 1258
            .|.|            :|:..| .|...|:..   |...::..|.|  ...|:|:.::..:||.
Human  1163 PSYTLLGFKTFLEVRDQEHYRE-FPEANFELS---ATDFLVCFIPY--FQTLLFVFVLRCMELKC 1221

  Fly  1259 -----RREKKFHTSRDLRKMR-TATYPFD-DGDVADVKQKIAEADNTKAKQSVFLVDQVEARVPA 1316
                 |::..|..|...|..: ....|.| |.|:...:.:.|.|..|.      ::|:....:.:
Human  1222 GKKRMRKDPVFRISPQSRDAKPNPEEPIDEDEDIQTERIRTATALTTS------ILDEKPVIIAS 1280

  Fly  1317 ------AGKR------------IHTVSFALNKYMSMGIFGPRNSGKSHLMRQLVGQRGFAFGEIY 1363
                  ||::            ...:||.:.:...:|:.||..:|||..:|.:.|......||:.
Human  1281 CLHKEYAGQKKSCFSKRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVE 1345

  Fly  1364 VRGLDFKYDLESIHTYMGYSPQHRGLLNELTPREHIRLLCMIRGVPEAKI---------GEKMHD 1419
            ::|      ..|:..::||.||...|...||.|||:.:...::|:.:|..         ..|:|:
Human  1346 LKG------CSSVLGHLGYCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIARLVSAFKLHE 1404

  Fly  1420 LCLMLNMTGWMHRKCSLLTAEKRHKLKIALALVAYNKILVLDEPTCGMPATTRREIWNILR-YIR 1483
               .||:      ....|||....||...|:|:..:.:|:||||:.|:..|.::::|..:: .::
Human  1405 ---QLNV------PVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVK 1460

  Fly  1484 YCGKTIIFATNDELECKILADFIILFQDSEMLAIGSLQYLRYKYSHGFYLEVRLIRDG-ATLAES 1547
            ...:.::..|::..|.:.|.|.:.:.....:..|||:|:|:.|....:.||:::.... .||..:
Human  1461 NTERGVLLTTHNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILELKVKETSQVTLVHT 1525

  Fly  1548 EENLRKDVENLAKFVNFLHNRSELVG--RLNNWFKFYVPVGHIV-YSFLYGAMEKNKLRLNVSDY 1609
            |               .|....:..|  |.::...:.:||..:. .|..:..:|..|...|:.:|
Human  1526 E---------------ILKLFPQAAGQERYSSLLTYKLPVADVYPLSQTFHKLEAVKHNFNLEEY 1575

  Fly  1610 CIYQADMMSVVAQVQE 1625
            .:.|..:..|..::.:
Human  1576 SLSQCTLEKVFLELSK 1591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1801	NP_728408.3	ABC2_membrane_3	<246..379	CDD:289468	29/161 (18%)
		ABC2_membrane_4	<293..448	CDD:289500	37/186 (20%)
		EcfA2	499..717	CDD:224047	63/229 (28%)
		P-loop_NTPase	500..721	CDD:304359	64/232 (28%)
		ABC2_membrane_3	<972..1254	CDD:289468	52/308 (17%)
		EcfA2	1307..1521	CDD:224047	55/241 (23%)
		P-loop_NTPase	1324..1524	CDD:304359	53/209 (25%)
ABCA6	NP_525023.2	ABC2_membrane_3	34..375	CDD:289468	79/457 (17%)
		CcmA	476..788	CDD:224054	81/324 (25%)
		ABC_subfamily_A	478..701	CDD:213230	64/232 (28%)
		ABC2_membrane_3	866..1167	CDD:289468	65/372 (17%)
		CcmA	1275..1592	CDD:224054	74/347 (21%)
		ABC_subfamily_A	1296..1501	CDD:213230	53/219 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148345
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750