Protein Alignment CG1801 and Abca9

DIOPT Version :9

• Sequence 1: NP_728408.3
• Gene: CG1801 / 33104
• FlyBaseID: FBgn0031171
• Length: 1655
• Species: Drosophila melanogaster
• Sequence 2: NP_671753.2
• Gene: Abca9 / 217262
• MGIID: 2386796
• Length: 1623
• Species: Mus musculus
• Alignment Length: 1862
• Identity: 341/1862 - (18%)
• Similarity: 685/1862 - (36%)
• Gaps: 476/1862 - (25%)

  Fly    10 KRYIRIELNLW--------------RRTLFE-IVALVIMVLVIFLNPIAHSKRLLYTTTENENEQ 59
            ||::|:...:|              |.||.| :.:|::::.|..|:...|.       ..:..|.
Mouse     3 KRHLRLGQQMWALLCKNWLRKFRMRRETLLEWLFSLLLILFVYQLSSNLHQ-------VHDAPEM 60

  Fly    60 SIVSHKLQDINILTRMADSKREKTKYILAFTPETTFTSEVTKNVAKT--LELSSTVGYESESEMQ 122
            |:|     |:..:....||     .|::.|.||:..|.|:...||..  ::..:.|....|..|
Mouse    61 SVV-----DLGRVDNFNDS-----NYMMVFAPESEATHEIMNKVASAPFMKGRTIVACPDEKSM- 114

  Fly   123 NQFDERTTL--AGIVFNDLRDDGTPLTLSISIRFPSEFRTIAPFLTEDRLWITRCSGRINPGRDR 185
            |:.|...::  ..::|.|        |.|..::|.               |    ..||...::.
Mouse   115 NELDLNYSIDAVRVIFKD--------TFSYHLKFS---------------W----GQRIPKTKEH 152

  Fly   186 AKHDK-----------QQDIYIREGFLQLQHQI---FVEWY--HQLRKDIVSTYPEPNVEVYNIL 234
            ..|..           :...:..:||:..|..|   .:|..  |.:.::::|.
Mouse   153 KDHSAPCEPLNNKMICENSAFWEKGFVAFQAAINAGIIEMITNHSVMEELMSV------------ 205

  Fly   235 LKAADEPCSVMSVAQLPTFL---------YNFIYLLPFLNIIRNVAAQVED------GVMVHQWH 284
                     :.|..::|.|:         :.|..::.|.::|..::..:..      .:|.....
Mouse   206 ---------IGSNMKMPPFIAQGGVATDFFIFFCVISFSSLIYYLSVNITQERQYMTTLMAMMGL 261

  Fly   285 YGYSFGMQWGIKFLVLFLRMCILG--VIYTIMLLAFWGFGGREGEFSGTGTIAFVCFITLYTVEI 347
            ...:|.:.|.:.:....|.:.:|.  ::.:..::...||           .:.|:.|: .|.:.:
Mouse   262 RESAFWLSWSLMYAGFILVVAVLMSLIVKSAQVVVLTGF-----------MVVFLLFL-FYGLSL 314

  Fly   348 IITGMVVAKLFANPTNAVLFALMLWLFMYAAFCIILERYWD------IHKYYVFFILVAFCNCQ- 405
            |....:::.|...|            |:......||..:|.      ::|:...|:....|...
Mouse   315 ITLSFLMSVLIKKP------------FLTGLAIFILTVFWGSLGFTALYKHLPAFVEWTLCFLSP 367

  Fly   406 ----------MHFSMSLFRNC-IEKPE---MVNTIDFVLIFTSAISSALIYFLILLAI------- 449
                      :|....:..|. :..|.   ::....|:|:.     .||:|.::.|..
Mouse   368 FAFTTGMAQLIHLDYDVNSNVNLNSPNNSYLIMATLFMLVL-----DALLYLVLALYFDKITLSK 427

  Fly   450 --QWRMPGTFL-----------SRRIVNNRPRKQQESDTTI--MYLGRAPSFQNFEFGDVGSVEL 499
              ..|.|..||           |..::.|    :.:||.::  .....:|.||        ..|.
Mouse   428 YGHQRSPLFFLKSSYWFKRRGASHVVLEN----EIDSDPSLNDSLEPVSPEFQ--------GKEA 480

  Fly   500 MRLRHVSTSHRDSERKI--LKNISMRIYRGEVFVILGHIGSGKLTLLRILAGLKFPLRGNVYIMG 562
            :|::::...:.....|:  |:.:...||.|::..:|||.|:||.||:..|:||..|..|:|.|..
Mouse   481 IRIKNLKKEYSGKHGKVEALRGLGFDIYEGQITALLGHSGAGKTTLINTLSGLSPPTTGSVTIYN 545

  Fly   563 NPFEPNGEARRL-----------VDFRFDEHGLNKHLTVEQTIDYHVRLK-LSPSESDRYEIERR 615
            .......::..:           |.|.|        |||.:.:....::| :.|     :|:|:.
Mouse   546 QTVSEMDDSDAVLTITGVCPQSNVQFGF--------LTVRENLRLFAKIKGILP-----HEVEQE 597

  Fly   616 KWLAILDQHVES-RGVRIGKLSSGSMKLVALCCCLAGDTPIIILEEPTTQLTGREAQIFWSIVHA 679
            ....:.|..:|: :.:....||.|..:.:.|...:.||..:::|:|||..|........|:::..
Mouse   598 VQQVLQDLEMENIQDILAQNLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKE 662

  Fly   680 EKENRAFIIATYNVGEAEHVADRIGILSMGVLEASGTPFFLRSKFSSSVDLVI------------ 732
            .:..|..:.:|..:.||:.:|||...:|.|.|:.:|:..||:.|:.....|.:
Mouse   663 RRAGRVIVFSTQFMDEADILADRKVFISNGRLKCAGSSLFLKKKWGIGYHLSLHLNEACDPEGIT 727

  Fly   733 -IKKPHVPDQPITDYINQFMQNIEPENEIGDSLTYRLPVIYRPRLQKLLIHLEIDR-KMLGIENV 795
             :.|.|:.|..:|....:.:..|.|...     |.:.|.:||          ::|| ...|||:.
Mouse   728 SLVKKHISDARLTTQSEERLVYILPLER-----TNKFPDLYR----------DLDRCSNQGIEDY 777

  Fly   796 RVVGAELSDIYMTLVTSF-----------RLQQQMIPDVTQTFKYQ----------VVSQKQLTK 839
            .|....|:::::.|....           |||.....|:....:.:          .||...|.:
Mouse   778 GVSMTTLNEVFLKLEGKSMADESDVGICGRLQSDGARDMESLVELEQVLSLDSSGSSVSGMALWR 842

  Fly   840 QRMRAM----FYKKMIHTAPNVWPIIMIF-TSFVLIAIIARLSVLLD--MPKERQNSIHIGF--- 894
            |::.|:    |: |:.:...::..::::| .|||        ..||:  :.|....|...|.
Mouse   843 QQLCAVAKVRFF-KLKNERKSLMTVLLLFGISFV--------PQLLEHLVYKVYHKSYSWGLSPS 898

  Fly   895 -------REPEDVVKYLPNLKDCGYIDIRSAVK--VNKKKSVGVSRTFDDDSFVCEKGSYRNNLR 950
                   :.|:|.:.:|..:...|     |::.  |:..:..|::  .|.|:.....|:
Mouse   899 MYFLSPGQPPQDPLTHLLVINRTG-----SSIDNFVHALRQQGIA--LDLDALGTRNGT------ 950

  Fly   951 KKNELRSFGAVESDGDE------------HLNGYISQDMFHSAPMMLNLLQNVILRL---SYPMQ 1000
              .|....||:...|:|            .||.:         |::::::.|.:|.:   |..:|
Mouse   951 --EEALYNGAITVLGEEKALRFSVACNAKRLNCF---------PVLMDIISNGLLGIFNSSERIQ 1004

  Fly  1001 TDLVVLVENHPLPTQLSQKINVLDNKIAHIHVPLVVGCIIPLTVSVFVIPLVEEEIYDVRFLQHM 1065
            ||...:.|.|.|     .:...:.|  |...:| |...:.|      .|.:.....:..:.|..:
Mouse  1005 TDRSTVFEEHML-----YEYGFMSN--AFFWIP-VAASLTP------YIAMGSISDHKKKVLSQL 1055

  Fly  1066 --AGLGLKVFWGINLFWDWFTFFVYSVIIVVIMSLMGIGGFGFYENAIMVVLLTTFGLAA--LPL 1126
              :||....:|......|...:|:...::.::.|:.....|.....::::.:..:.|.|:  :.:
Mouse  1056 WTSGLYPSAYWCGQALVDIPIYFLILFLMQIMDSVFSSEEFISVMESLLIQIPCSIGYASSLIFM 1120

  Fly  1127 TYLVSMFV-----NKSIVRAFLVSVLLQGVSGLVLYIIYWDVANSNTIFFYAAC--MSPGFSLLD 1184
            ||::|...     |..|...|.:.|       .:.:||..|: |.........|  :.|.|:|:
Mouse  1121 TYVISFIFRNGRKNSGIWSFFFLIV-------TIFFIIATDI-NEYGFLELLICTFLVPPFTLI- 1176

  Fly  1185 GVSNVYAQNLEQAICIDKCEATDSCTEENMNEVVPNCKFDTFFKWAAPGILPPILYMVLSALIFL 1249
            |...::::     :..|..:...  |.|:....:              .:|.|.|:.    |:|.
Mouse  1177 GSLLIFSE-----VSYDSVDYLG--TSESQLVFL--------------ALLIPYLHF----LLFF 1216

  Fly  1250 MLIFWIELHRREKK------FHTSRDLRKMRTATYPFDDGDV-ADVKQKIAEADNTKAKQSVFLV 1307
            .::..:|.:.|:|.      |..|.  |.......|.:.|:. .||:.   |...|....:....
Mouse  1217 FILRCLERYLRKKSLRVDPVFRISP--RSCPAVPNPEEPGEEDEDVQM---ERVRTTGAMATLQT 1276

  Fly  1308 DQVEARVPAA----------------GKRIHT--VSFALNKYMSMGIFGPRNSGKSHLMRQLVGQ 1354
            |:....:.:.                .|:|.|  :||.:.|...:|:.|...:|||..:..:.|.
Mouse  1277 DEKPVIIASCLRKEYIGRTKRCFSKMKKKIATRNISFCVKKGEVLGLLGHNGAGKSTTISMITGD 1341

  Fly  1355 RGFAFGEIYVRG------LDFKYDLESIHTYMGYSPQHRGLLNELTPREHIRLLCMIRGVPEAKI 1413
            .....|:::::|      |.|          :||.||...|...||.:||:.|...::|:.:...
Mouse  1342 TIPTAGQVFLKGSGGGAALGF----------LGYCPQENVLWPNLTVKEHLELYAAVKGLKKKDA 1396

  Fly  1414 GEKMHDLCLMLNMTGWMHRKCSLLTAEKRHKLKIALALVAYNKILVLDEPTCGMPATTRREIWNI 1478
            ...:..|...|.:...:......|:...:.||...|:::....:::||||:.||....::::|..
Mouse  1397 VVTITRLVNALKLQDHLKALVRTLSEGVKRKLCFVLSILGNPPVVLLDEPSTGMDPEGQQQMWQA 1461

  Fly  1479 LR-YIRYCGKTIIFATNDELECKILADFIILFQDSEMLAIGSLQYLRYKYSHGFYLEVRLIRDGA 1542
            :| ......:..:..|:...|.:.:.|.:.:.....:..|||:|:|:.|:...:.||:::
Mouse  1462 IRATFTNTERGALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKV----- 1521

  Fly  1543 TLAESEENLRKDVENLAKFVNFLHNRSELVGRLNNWFKFYVPVGHI-VYSFLYGAMEKNKLRLNV 1606
                   .....||.|...:..|..::....|.::...:.:||..: ..|..:..:|:.|...::
Mouse  1522 -------KTPSQVEPLNTEIMRLFPQAARQERYSSLMVYKLPVEDVRPLSEAFFKLERLKENFDL 1579

  Fly  1607 SDYCIYQADMMSVVAQV----------QETRAQLKHHLVQTE 1638
            .:|.:.|:.:..|..::          :|..:.:|..|:..|
Mouse  1580 EEYSLSQSTLEQVFLELSKEQELDDFGEEANSSVKWKLLPQE 1621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1801	NP_728408.3	ABC2_membrane_3	<246..379	CDD:289468	20/149 (13%)
		ABC2_membrane_4	<293..448	CDD:289500	26/177 (15%)
		EcfA2	499..717	CDD:224047	56/232 (24%)
		P-loop_NTPase	500..721	CDD:304359	57/235 (24%)
		ABC2_membrane_3	<972..1254	CDD:289468	50/295 (17%)
		EcfA2	1307..1521	CDD:224047	48/238 (20%)
		P-loop_NTPase	1324..1524	CDD:304359	45/206 (22%)
Abca9	NP_671753.2	rim_protein	<128..1600	CDD:130324	306/1696 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838469
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.750