DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1801 and ABCA3

DIOPT Version :9

Sequence 1:	NP_728408.3	Gene:	CG1801 / 33104	FlyBaseID:	FBgn0031171	Length:	1655	Species:	Drosophila melanogaster
Sequence 2:	NP_001080.2	Gene:	ABCA3 / 21	HGNCID:	33	Length:	1704	Species:	Homo sapiens

Alignment Length:	1803	Identity:	401/1803 - (22%)
Similarity:	739/1803 - (40%)	Gaps:	294/1803 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RIELNLWRRTLFEIVALVIMVLVIFLNPIAHSKRLLY--TTTENENEQSIVSHKLQDINILTRMA 76
            ::.|.||:....:...:::.||.:|| |:..|..|::  ...::||..:...:..|.|..|....
Human     6 QLALLLWKNYTLQKRKVLVTVLELFL-PLLFSGILIWLRLKIQSENVPNATIYPGQSIQELPLFF 69

  Fly    77 DSKREKTKYILAFTPETTFTSE-VTKNVAKTLELSSTV-GYESESEMQN--QFD--ERTTLAGIV 135
            ........:.||:.|..:..:: ||:.|.:.|.::..| |:.||.:.::  ::|  ..:.||.:|
Human    70 TFPPPGDTWELAYIPSHSDAAKTVTETVRRALVINMRVRGFPSEKDFEDYIRYDNCSSSVLAAVV 134

  Fly   136 FN---DLRDDGTPLTLSISIRFPSEFR------TIAPFLTEDRLWITRCSGRI--NPG-RDRAKH 188
            |.   :...:..||.:...:||....|      |.:.||.|...|.|.....:  ||| |:....
Human   135 FEHPFNHSKEPLPLAVKYHLRFSYTRRNYMWTQTGSFFLKETEGWHTTSLFPLFPNPGPREPTSP 199

  Fly   189 DKQQDIYIREGFLQLQHQI--FVEWYH------QLRKDIVST---YPEPNVEVYNILLKAADEPC 242
            |..:..|||||||.:||.:  .:..||      ||.:.:..|   :|.|..        .|| |.
Human   200 DGGEPGYIREGFLAVQHAVDRAIMEYHADAATRQLFQRLTVTIKRFPYPPF--------IAD-PF 255

  Fly   243 SVMSVAQLP-TFLYNFIYLLPFLNIIRNVAAQVEDGVMVHQWHYGYSFGMQWGIKFLVLFLRMCI 306
            .|....||| ..|.:|.|..  |.|.|.|..:.|..:..:....|.|..:.|...||:.||.:.|
Human   256 LVAIQYQLPLLLLLSFTYTA--LTIARAVVQEKERRLKEYMRMMGLSSWLHWSAWFLLFFLFLLI 318

  Fly   307 LGVIYTIMLLAFWGFGGREGEFSGTGTIAFVCFITLYTVEIIITGMVVAKLFANPTNAVLFALML 371
            .....|::...  .........|.:.....:.|:..:.:..|....:|:..|:....|..|...|
Human   319 AASFMTLLFCV--KVKPNVAVLSRSDPSLVLAFLLCFAISTISFSFMVSTFFSKANMAAAFGGFL 381

  Fly   372 WLFMYAAFCIILERY-WDIHKYYVFFILVAFCNCQM-HFSMSLFRNCIEKPEM------------ 422
            :.|.|..:..:..|| |       ..:....|:|.: :.:|::....|.|.|.
Human   382 YFFTYIPYFFVAPRYNW-------MTLSQKLCSCLLSNVAMAMGAQLIGKFEAKGMGIQWRDLLS 439

  Fly   423 -VNTID---FVLIFTSAISSALIYFLILLAIQWRMPGT---------FLSRRIVNNRPR-----K 469
             ||..|   |..:....:..:::|.|:...::...||.         |:.......:||     :
Human   440 PVNVDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQFGVPQPWYFFIMPSYWCGKPRAVAGKE 504

  Fly   470 QQESDTTIMYLGRAPSFQNFEFGDVGSVELMRLRHVSTSHR--DSERKILKNISMRIYRGEVFVI 532
            :::||..     :|...:.||......|..::::|:|...|  :.:|..::::::.:|.|::.|:
Human   505 EEDSDPE-----KALRNEYFEAEPEDLVAGIKIKHLSKVFRVGNKDRAAVRDLNLNLYEGQITVL 564

  Fly   533 LGHIGSGKLTLLRILAGLKFPLRGNVYIMGNPFEPN-GEARRLV------DFRFDEHGLNKHLTV 590
            |||.|:||.|.|.:|.||..|..|..||.|.....: .:.|:.:      |..||      :|||
Human   565 LGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQIRKSLGLCPQHDILFD------NLTV 623

  Fly   591 EQTIDYHVRLKLSPSESDRYEIERRKWLAILDQHVESRGVRIGKLSSGSMKLVALCCCLAGDTPI 655
            .:.:.::.:||....:....|:::...:..|:....||. |.  ||.|..:.:::...|...:.:
Human   624 AEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRS-RF--LSGGMRRKLSIGIALIAGSKV 685

  Fly   656 IILEEPTTQLTGREAQIFWSIVHAEKENRAFIIATYNVGEAEHVADRIGILSMGVLEASGTPFFL 720
            :||:|||:.:.....:..|.::..:|.:|..::.|:.:.||:.:.|||.|::.|.|:..|:..||
Human   686 LILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTTHFMDEADLLGDRIAIMAKGELQCCGSSLFL 750

  Fly   721 RSKFSSSVDLVIIKKPHVPDQPITDYINQFMQNIEPENEIGDSLTYRLPVIYRPRLQKLLIHLEI 785
            :.|:.:...:.::|:||...:.|:..::..:.|...|:..|..|::.||.....|.:.|...||.
Human   751 KQKYGAGYHMTLVKEPHCNPEDISQLVHHHVPNATLESSAGAELSFILPRESTHRFEGLFAKLEK 815

  Fly   786 DRKMLGIENVRVVGAELSDIYM---TLV-TSFRLQQQMIPDVTQTFKYQ---------------- 830
            .:|.|||.:.......:.::::   .|| :|..:|...:|    ..:||
Human   816 KQKELGIASFGASITTMEEVFLRVGKLVDSSMDIQAIQLP----ALQYQHERRASDWAVDSNLCG 876

  Fly   831 -----------VVSQKQLTK---------QRMRAMFYKKMIHTAPNVWPI----IMIFTSFVLIA 871
                       :..::...|         |:..|||.||..::. ..|.:    :::..:.|.:|
Human   877 AMDPSDGIGALIEEERTAVKLNTGLALHCQQFWAMFLKKAAYSW-REWKMVAAQVLVPLTCVTLA 940

  Fly   872 IIA--RLSVLLDMPKER-----------------------------QNSIHIGFREPEDVVKYLP 905
            ::|  ..|.|.|.|..|                             ::::....:||.:|   |.
Human   941 LLAINYSSELFDDPMLRLTLGEYGRTVVPFSVPGTSQLGQQLSEHLKDALQAEGQEPREV---LG 1002

  Fly   906 NLKDCGYIDIRSAVKVNKKKSVGVSRTFDDDSFVCEKGSYRNNLRKKNELRSFGAVESDGDEH-- 968
            :|::  ::..|::|                     |.|.:       ||.....|...|..|.
Human  1003 DLEE--FLIFRASV---------------------EGGGF-------NERCLVAASFRDVGERTV 1037

  Fly   969 LNGYISQDMFHSAPMMLNLLQNVILRLSYPMQTDLVVLVENHPLPTQLSQKINVLDN---KIAHI 1030
            :|...:...:||....|.::.|::.:|.......:|  |.|.|.|....|......|   |...|
Human  1038 VNALFNNQAYHSPATALAVVDNLLFKLLCGPHASIV--VSNFPQPRSALQAAKDQFNEGRKGFDI 1100

  Fly  1031 HVPLVVGCIIPLTVSVFVIPLVEEEIYDVRFLQHMAGLGLKVFWGINLFWDWFTFFVYSVIIVVI 1095
            .:.|:..  :....|.|.|..|.|.....:.:|.::|:.:..||...|.||..:|.:.|::::|:
Human  1101 ALNLLFA--MAFLASTFSILAVSERAVQAKHVQFVSGVHVASFWLSALLWDLISFLIPSLLLLVV 1163

  Fly  1096 MSLMGIGGF---GFYENAIMVVLLTTFGLAALPLTYLVSMF---VNKSIVRAFLVSVLLQGVSGL 1154
            .....:..|   |...:.::::||  :|.|.:||.||::.|   ...:..|..:.::|    ||:
Human  1164 FKAFDVRAFTRDGHMADTLLLLLL--YGWAIIPLMYLMNFFFLGAATAYTRLTIFNIL----SGI 1222

  Fly  1155 VLYIIYWDVANSNTIFFYAA--------------CMSPGFSLLDGVSNVYAQNLEQAICIDKCEA 1205
            ..:::.       ||....|              .:.|...|...||:.|.....:..|.....|
Human  1223 ATFLMV-------TIMRIPAVKLEELSKTLDHVFLVLPNHCLGMAVSSFYENYETRRYCTSSEVA 1280

  Fly  1206 TDSCTEENMNEVVPNCKFDTFFKWAAPGILPPILYMVLSALIFLMLIFWIELHRREKKFHTSRDL 1270
            ...|.:.|:...      :.|:.|:|||:...:..|..|...:|:|:|.||.:..::.......|
Human  1281 AHYCKKYNIQYQ------ENFYAWSAPGVGRFVASMAASGCAYLILLFLIETNLLQRLRGILCAL 1339

  Fly  1271 RKMRTATYPF-------DDGDVADVKQKIAEADNTKAKQSVFLVDQV----EARVPAAGKRIHTV 1324
            |:.||.|..:       :|.||||.:.:|..........:..::.::    |.|||...  :..:
Human  1340 RRRRTLTELYTRMPVLPEDQDVADERTRILAPSPDSLLHTPLIIKELSKVYEQRVPLLA--VDRL 1402

  Fly  1325 SFALNKYMSMGIFGPRNSGKSHLMRQLVGQRGFAFGEIYVRGLDFKYDLESIHTYMGYSPQHRGL 1389
            |.|:.|....|:.|...:||:...:.|.|:.....|:.:|.|.....|:..:...:||.||...|
Human  1403 SLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISSDVGKVRQRIGYCPQFDAL 1467

  Fly  1390 LNELTPREHIRLLCMIRGVPEAKIGEKMHDLCLMLNMTGWMHRKCSLLTAEKRHKLKIALALVAY 1454
            |:.:|.||.:.:...:||:||..||..:.:....|.:....::.....:...:.||...:||:..
Human  1468 LDHMTGREMLVMYARLRGIPERHIGACVENTLRGLLLEPHANKLVRTYSGGNKRKLSTGIALIGE 1532

  Fly  1455 NKILVLDEPTCGMPATTRREIWNILRYIRYCGKTIIFATNDELECKILADFIILFQDSEMLAIGS 1519
            ..::.||||:.||....||.:|:.:...|..||.||..::...||:.|...:.:....:...:||
Human  1533 PAVIFLDEPSTGMDPVARRLLWDTVARARESGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGS 1597

  Fly  1520 LQYLRYKYSHGFYLEVRLIRDGATLAESEENLRKDVENLAKFVNFLHNRSELVGRLNNWFKFYVP 1584
            .|:|:.|:..|:.|..::         ..|..::.:|....||:.....|.|.........:::|
Human  1598 PQHLKSKFGSGYSLRAKV---------QSEGQQEALEEFKAFVDLTFPGSVLEDEHQGMVHYHLP 1653

  Fly  1585 VGHIVYSFLYGAMEKNKLRLNVSDYCIYQADMMSV---VAQVQETRAQ 1629
            ...:.::.::|.:||.|.:..|.||.:.|..:..|   .|.:|...|:
Human  1654 GRDLSWAKVFGILEKAKEKYGVDDYSVSQISLEQVFLSFAHLQPPTAE 1701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1801	NP_728408.3	ABC2_membrane_3	<246..379	CDD:289468	30/133 (23%)
		ABC2_membrane_4	<293..448	CDD:289500	32/172 (19%)
		EcfA2	499..717	CDD:224047	59/226 (26%)
		P-loop_NTPase	500..721	CDD:304359	60/229 (26%)
		ABC2_membrane_3	<972..1254	CDD:289468	66/304 (22%)
		EcfA2	1307..1521	CDD:224047	56/217 (26%)
		P-loop_NTPase	1324..1524	CDD:304359	53/199 (27%)
ABCA3	NP_001080.2	ABC2_membrane_3	<271..469	CDD:289468	41/208 (20%)
		CcmA	530..839	CDD:224054	80/317 (25%)
		ABC_subfamily_A	530..751	CDD:213230	60/229 (26%)
		ABC2_membrane_3	923..1261	CDD:289468	74/387 (19%)
		ABC_subfamily_A	1381..1602	CDD:213230	57/222 (26%)
		drrA	1397..1692	CDD:130256	73/305 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148313
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.850