DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1801 and abt-1

DIOPT Version :9

Sequence 1:	NP_728408.3	Gene:	CG1801 / 33104	FlyBaseID:	FBgn0031171	Length:	1655	Species:	Drosophila melanogaster
Sequence 2:	NP_001293854.1	Gene:	abt-1 / 182849	WormBaseID:	WBGene00000019	Length:	1558	Species:	Caenorhabditis elegans

Alignment Length:	1735	Identity:	307/1735 - (17%)
Similarity:	590/1735 - (34%)	Gaps:	554/1735 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KRYIRIELNLWRRTL--------FEIVALVIMVLVIFLNPIAHSKRLLYTTTENENEQSIVSHKL 66
            :|.||   |:|::.|        |.|:..:::.|. |.|...|:     :.|.:::..:...|..
Worm    12 RRSIR---NIWQKDLNYFRSNHPFFILIFIVLSLA-FYNVWWHN-----SPTRDQSGDASKFHLF 67

  Fly    67 QDINILTRMADSKREKTKYILAFTPETT----FTS---------------EVTKNVAKT------ 106
            .:..:      ||::..|.|:.. |||.    |::               |.||.:.|.
Worm    68 DNFRL------SKQKFVKMIVCI-PETVVDYRFSTVIDAIHLTHLDYPHLEFTKKLEKAKNKLED 125

  Fly   107 ------------LELSSTVGYESESEMQNQFDERTTLAGIVFNDLRDDGTPLTLSISI-RFPSEF 158
                        :|....:.|:..|| |..||:......:  :..:..|..:...:.: ||
Worm   126 GEVDFLVLFKTLIETGKKIEYKIISE-QGVFDKHCIQCDV--HRKKTWGNAVEAQVVVNRF---- 183

  Fly   159 RTIAPFLTEDRLWITRCSGRINPGRDRAKHDKQQDIYIREG-----FLQLQHQIFVEWYHQLRKD 218
                      ..|:.:..|    ...|:.|.:..::|::..     ||:.|..:|:.|
Worm   184 ----------LYWLVKSRG----FNKRSPHWQLSNVYVKHSGNDPMFLKRQSDLFLLW------- 227

  Fly   219 IVSTYPEPNVEVYNILLKAADEPCSVMSVAQLPTFLYNFIYLLPFLNIIRNVAAQVEDGVMVHQW 283
                                                   |.|||..:            .::..|
Worm   228 ---------------------------------------ILLLPICS------------RLIDLW 241

  Fly   284 HYGYSFGMQWGIKFLVLFLRMCILGVIYTIMLLAFWGFGGREGEFSGTGTIAFVCFITLYTVEII 348
            :...|.|      :..:||.:......|.|....|| :|           ||.:..:.::.|.::
Worm   242 NNDRSSG------YYNMFLSLHARRFHYFIAKFVFW-YG-----------IALIISLIVFIVNVL 288

  Fly   349 ITGMVVAKLFANPTNAVLFALMLWLFMYAA----FCIILERYWD----IHKYYVFFILVA----- 400
            :...|....:           :.::..|||    |.|.|...:.    ..|...|..:||
Worm   289 VVPAVFCSTY-----------LQFVVCYAACIISFAIFLATTFPGSPLFAKIVGFLSMVAGEFGF 342

  Fly   401 ---------FCNCQMHFSMSLF--------------RNCIEKPEMVNTID-----FVLIFTSAIS 437
                     |..|..||..|.|              .||:    ::.|:.     :..:||   .
Worm   343 GTVYHGIGFFQLCVRHFGKSEFDGPWIDAVCTLCMTGNCV----LLITVSIYFDTYFCLFT---M 400

  Fly   438 SALIYFLILLAIQW----RMP--GTFLSRRIVNNRPRKQQ-------------ESDTTIMYLGRA 483
            ..|.::..|....|    |.|  .||..::|:..:|.:.:             ::.|...|:...
Worm   401 EPLAFYFPLEKDYWMPEARSPQLDTFFVKQIILLKPGRSEITVKKAHDEILPAKTSTGSKYIPPT 465

  Fly   484 PSFQNFEFGDVGSVELMRLRHVSTSHRDSERKILKNISMRIYRGEVFVILGHIGSGKLTLLRILA 548
            |.        |..|.|:.|..:.....:..|  :|.:|:.::.|||..:.||.|.|...:|.|:|
Worm   466 PI--------VKGVPLVVLYGICKRIENHWR--VKQVSLTVHLGEVVTLYGHHGCGSGEILSIIA 520

  Fly   549 GLKFPLRGNVYIMGNPFEPNGEARRLVDFRFDEHGLNKHLTVEQTIDYHVRLK-LSPSESDRYEI 612
            |...|..|.|.:      ...:...::....|...:| :|.|.|.:....::: :|.|.|...|:
Worm   521 GQMKPEYGEVMM------EQSQRPLMISKTTDVPNVN-YLNVIQYLRLISKMRGVSASTSHIDEM 578

  Fly   613 ERRKWLAILDQ-HVESRGVRIGKLSSGSMKLVALCCCLAGDTPIIILEEPTTQLTGREAQIFWSI 676
                 |..||. .|::|.:.:  ||:...:.:.:.....|...:::::.||.:.......:.:..
Worm   579 -----LEELDLIKVKNRSLDL--LSTTQKERLRIAAVFVGQPDLVLIDFPTMECLPEWKFMVFRF 636

  Fly   677 VHAEKENRAFIIATYNVGEAEHVADRIGILSMGVLEASGTPFFLRSKFSSSVDLVIIKKPHVPDQ 741
            :...||.|:.|:::|:..|.|.::|::.::|.|.:..:|:....:...:|..::.|.......|:
Worm   637 IEKRKEKRSIIVSSYDPEETEAISDKVVLMSEGYVVLNGSCEAFKHSINSVFEIRIWPNNRFTDE 701

  Fly   742 PITDYI-------NQFMQN----IEPENEIGDSLTYRLPVIYRPRLQKLLIHLEIDRKMLGIENV 795
            .|...:       || |:|    .|..|   ..:...||::||..:..:|..|:...:...||..
Worm   702 QIKGMMKTLTLGDNQ-MKNDARFFETPN---GKIRVTLPILYRRSIPLILRELDAVHEKFRIEFY 762

  Fly   796 RVVGAELSDIYMTLVTSFRLQQQMIPDVTQTF---KYQVVSQKQLTKQRMRAMFYKKMIH----- 852
            .:....:.|||......   .||:  |...||   :.....|:.|.|   :..|:|.|||
Worm   763 ELGKPNIHDIYANACYE---HQQL--DPLSTFDQLRDHYTKQQPLNK---KTYFFKNMIHIFKDG 819

  Fly   853 -----TAPNVWPIIMIFTSFVLIAIIARLSVLLDMPKERQNSIHIGFREPEDVVKYLPNLKDCGY 912
                 ||    .::.:|....:|.:::..||..|..:.|:.|: ..:..|..:           |
Worm   820 RFLIETA----AVVGLFLILTVIILLSYHSVESDSHQTREISL-TSYESPITI-----------Y 868

  Fly   913 IDIRSAVKVNKKKSVGVSRTFDDDSFVCEKGS------YRNNLRKKNELRSFGAVESDGDEHLNG 971
            .|     :..|:...||  ||:..|.|.:..:      :::..:...||    ...|.||
Worm   869 CD-----ECEKEVIEGV--TFEKKSRVLQLENNQAVLYWKDTAKADKEL----ITVSRGD----- 917

  Fly   972 YISQDMFHSAPMMLNLLQN-----VILRLS--YPMQTDLVVLVENHPLPTQLSQKINVLDNKIAH 1029
                      .:...::||     :|.:::  :| |..|.:..||....|::|....|.::
Worm   918 ----------ALFTMIVQNFAVSQMISKITGKHP-QIKLFLESENVRTATEISGFSTVFND---- 967

  Fly  1030 IHVPLVVGCIIPLTVSVFVIPLVEEEIYDVRFLQHMAGLGLKVFWGINLFWDWFTFFVYSVIIVV 1094
                          :|.....::..|.|.:.::..:                 |..|||:..:|:
Worm   968 --------------ISSSKAAMILTESYSLMYITAV-----------------FQMFVYTFSVVL 1001

  Fly  1095 IMSLMGIG--------------GFGF---YENAIMVVLLTTFGLAALPLTYLVSMFVNKSIVRAF 1142
            .:.|:...              .|||   ::..:.:|:....|.|.|.:.:..:.  ..|....|
Worm  1002 PLRLVSTNMGPQSMILPWPRYVYFGFIYVFQLVVFLVIAIILGFAVLSMGFFATN--TTSCYLRF 1064

  Fly  1143 LVSVLLQGVSGL-VLYIIYWDVANSNTIF-FYAACMSPGFSLLDGVSNVYAQNLEQAICIDKCEA 1205
            |.:..|...|.| ::|.:.:::.|:.::. ...|..|...:..:.|::..|:|
Worm  1065 LSAWFLSYASTLPLIYFLVFNIQNTKSVIPIILAISSLSVTFPNLVASFSAEN------------ 1117

  Fly  1206 TDSCTEENMNEVVPNCKFDTFFKWAAPGILPPILYMVLSA------------------------- 1245
                 :.::..::      .|..|:.. :.||....||:|
Worm  1118 -----QVSLQSLI------QFVSWSCM-LNPPSSLQVLAAFLNAGESLEKNSGTITSLILFCGAQ 1170

  Fly  1246 ----LIFLMLIF----------WIE----LHRREKKFHTSRDLRKMRTA----TYPFDDGDVADV 1288
                :||:::||          |.:    |:...::..|.:...:::.:    |.|.  |.:.|.
Worm  1171 FWIIVIFVLVIFQPGFSYIQQYWFKSSTVLYSSFERGTTLKPGARIKNSYIFVTNPL--GTMEDA 1233

  Fly  1289 KQKIAEAD--NTKAKQSVFLVDQVEARVPAAGKRIHTVSFALN-------KYMSMG--------- 1335
            :.|.|..:  |..|..:..:.......:..:...|..:|:..|       |..:|.
Worm  1234 QDKGASGNIPNRPAAGTEPVQKPTSDYIAGSSMSIDDMSYITNYEENLVEKMATMTSWNDKQEVP 1298

  Fly  1336 -------IFGPRNSGKSHLMRQLV---GQRGFAFGEIYVRGLDFKYDLESIHTYMGYSP----QH 1386
                   :.|.:...||.|:..:.   .....||..|          :|:|.|.  |:|    ::
Worm  1299 VDNSATFLMGDQTKLKSALLTTIAKINKNEHIAFVPI----------VENISTI--YTPFELLEN 1351

  Fly  1387 RGLLN--ELTPREHIRLLCMIRGVPEAKIGEKMHDLCLMLNMTGWMHRKCSLLTAEKRHKLKIAL 1449
            ....|  |:|. :||..|.....:.|       |           .:.:..||....|..|.:..
Worm  1352 AAYCNGFEITD-DHISYLLDAFDLKE-------H-----------ANTQIKLLPCIDRRILMLLA 1397

  Fly  1450 ALVAYNKILVLDEPTCGMPATTRREIWNILRYIRYCGKTIIFATN 1494
            .||....|:::|:....:|.:....:|:....:|..|..||:.::
Worm  1398 KLVIKPNIVIIDQLEMFLPHSKMMTVWSFCARLRKNGLGIIYTSH 1442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1801	NP_728408.3	ABC2_membrane_3	<246..379	CDD:289468	21/136 (15%)
		ABC2_membrane_4	<293..448	CDD:289500	34/195 (17%)
		EcfA2	499..717	CDD:224047	49/219 (22%)
		P-loop_NTPase	500..721	CDD:304359	48/222 (22%)
		ABC2_membrane_3	<972..1254	CDD:289468	51/346 (15%)
		EcfA2	1307..1521	CDD:224047	39/220 (18%)
		P-loop_NTPase	1324..1524	CDD:304359	38/203 (19%)
abt-1	NP_001293854.1	rim_protein	<256..>676	CDD:130324	92/473 (19%)
		P-loop_NTPase	474..677	CDD:393306	48/218 (22%)
		ABC2_membrane_3	<917..1176	CDD:378925	48/335 (14%)
		CcmA	<1328..1491	CDD:224054	30/146 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160141
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850