DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1801 and haf-3

DIOPT Version :9

Sequence 1:	NP_728408.3	Gene:	CG1801 / 33104	FlyBaseID:	FBgn0031171	Length:	1655	Species:	Drosophila melanogaster
Sequence 2:	NP_506927.2	Gene:	haf-3 / 180056	WormBaseID:	WBGene00001813	Length:	666	Species:	Caenorhabditis elegans

Alignment Length:	744	Identity:	133/744 - (17%)
Similarity:	262/744 - (35%)	Gaps:	195/744 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 SIVSHKLQDINILTRMADSK----REKTKYILAFTPETTFTSEVTKNVAKTLELSSTVGYESESE 120
            |::||       |:|:..||    ...:..:..|.|:...::...|:   || :.|...:.:.|.
Worm     2 SLLSH-------LSRLCCSKCSSIPSSSTRLFCFAPQVGRSTGFLKS---TL-IKSKQAFRNVSV 55

  Fly   121 MQNQFDERTTLAGIVFNDLRDDGTPLTLSISIRFPSEFRTI--APFL---TEDRLWITRCSGRIN 180
            ::.: .|...|....:.||:       ..:|:..|.::|.:  ..||   :...|:..|..|::.
Worm    56 VETK-RESYKLKNASWKDLK-------AILSLAGPYKWRIMLGISFLGISSSIFLFTPRVLGKLI 112

  Fly   181 PGRDRAKHDKQQDIYIREGFLQLQHQIFVEWYHQLRKDIVSTYPEPNVEVYNILLKAADEPCSVM 245
            ...|..|.||.                                 :||.:...:.....:.|.::.
Worm   113 DEWDETKQDKM---------------------------------DPNDKALLLARFFKENPIALA 144

  Fly   246 SVAQLPT---------------FLYNFIYLLPFLNIIR--------NVAAQVEDGVMVHQWHYGY 287
            .|..|..               .:.|.:....|.:::|        |...::...:.......||
Worm   145 GVFMLGAIAIAARIYCMHTAGQLVINDLRKSVFNSVLRQDMAFFDKNKVGEIVSRLSTDALIVGY 209

  Fly   288 SFGMQ-----------WGIKFLVLF--LRMC-ILGVIYTIMLLAFWGFGGREGEF--------SG 330
            |..|.           :|...|:::  |.|| ::.|:..:::..|..||..:.::        :|
Worm   210 SVSMNLSDGARALITCFGSGGLMVYTSLAMCKVIFVVVPVIVGTFAVFGKLQRKYTLMMQEAVAG 274

  Fly   331 TGTIAFVCFITLYTVEIIITGMVVAKLFANPTNAVLFALMLWL----------FMYAAFCIILER 385
            ...:|.....::.||.:::........:::..|.:      |.          ||:.:|
Worm   275 ANQVATERLSSVRTVRMLVAERKELAAYSDKINEI------WQISKKEGLAKGFMFGSF------ 327

  Fly   386 YWDIHKYYVFFILVAFCNCQMHFSMSLFRNCIEKPEMVNTIDFVLIFTSAISSALIYFLILLAIQ 450
                    .|...:|..:...:.|..:.:..:...|:.:...:.::...::|:...::|.|
Worm   328 --------QFTGYLALSSILFYGSNLISQGLLTYGELSSFCLYAVLSAGSLSAMSGFYLEL---- 380

  Fly   451 WRMPGTFLSRRIV---NNRPRKQQESDTTIMYLGRAPSFQNFEFGDVGSV-ELMRLRHVSTSHRD 511
              |.|...|.|:.   |..||...|...                 .:|:| :.:|..||:..:.|
Worm   381 --MKGLGASSRLFELKNREPRIPLEGGV-----------------QIGNVKDTIRFEHVAFGYAD 426

  Fly   512 SERKILKNISMRIYRGEVFVILGHIGSGKLTLLRILAGLKFPLRGNVYIMG---NPFEPN----- 568
            .: .:..|||..:..|::..::|..||||.|:..:|..|..|..|.:.:.|   ...:|:
Worm   427 RD-PLFHNISFDVPAGKITAVVGSSGSGKSTIASLLLRLYDPTSGRILVDGTDLKDIDPSYWRRH 490

  Fly   569 ----GEARRLVDFRFDEHGLNKHLTVEQTIDYHVRLKLSPSESD----RYEIERRKWLAILDQHV 625
                |:...|......|:.:...|..|...|..:......|.:|    |:.|:       .|..|
Worm   491 IGTVGQEPVLFSTTIKENIIYGSLEPENVTDAEIVSAADQSNADEFISRFPIK-------YDTKV 548

  Fly   626 ESRGVRIGKLSSGSMKLVALCCCLAGDTPIIILEEPTTQLTGRE---AQIFWSIVHAEKENRAFI 687
            ...|   ..||.|..:.:|:...|.....|:|::|.|:.|....   .:|..:.:.|..:....|
Worm   549 GEHG---STLSGGQKQRIAIARALVNKPNILIMDEATSALDASSEYLVRIALNKLLANSKQTVMI 610

  Fly   688 IATYNVGEAEHVADRIGILSMGVLEASGT 716
            || :.:...:| ||:|.::..|.:..||:
Worm   611 IA-HRLSTIKH-ADQIVVVDRGSVAESGS 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1801	NP_728408.3	ABC2_membrane_3	<246..379	CDD:289468	27/187 (14%)
		ABC2_membrane_4	<293..448	CDD:289500	25/175 (14%)
		EcfA2	499..717	CDD:224047	55/237 (23%)
		P-loop_NTPase	500..721	CDD:304359	55/236 (23%)
		ABC2_membrane_3	<972..1254	CDD:289468
		EcfA2	1307..1521	CDD:224047
		P-loop_NTPase	1324..1524	CDD:304359
haf-3	NP_506927.2	MdlB	70..657	CDD:224055	117/664 (18%)
		ABC_membrane	96..366	CDD:279056	42/322 (13%)
		P-loop_NTPase	415..656	CDD:304359	55/236 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910